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Article ; Online: Vitamin D

Sayegh, Souraya / Fantecelle, Carlos Henrique / Laphanuwat, Phatthamon / Subramanian, Priya / Rustin, Malcom H A / Gomes, Daniel C O / Akbar, Arne N / Chambers, Emma S

Aging cell

2024 Volume 23, Issue 4, Page(s) e14093

Abstract: Vitamin D ...

Abstract	Vitamin D
MeSH term(s)	Adult ; Humans ; Aged ; Cellular Senescence/genetics ; Cholecalciferol/pharmacology ; Cholecalciferol/metabolism ; p38 Mitogen-Activated Protein Kinases/metabolism ; Aging ; Fibroblasts/metabolism ; Inflammation Mediators/metabolism ; Immunity
Chemical Substances	Cholecalciferol (1C6V77QF41) ; p38 Mitogen-Activated Protein Kinases (EC 2.7.11.24) ; Inflammation Mediators
Language	English
Publishing date	2024-01-29
Publishing country	England
Document type	Journal Article
ZDB-ID	2113083-8
ISSN	1474-9726 ; 1474-9718
ISSN (online)	1474-9726
ISSN	1474-9718
DOI	10.1111/acel.14093
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Zs.A 6581: Show issues

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Article ; Online: Experimental Infection of Horses with Influenza D Virus.

Sreenivasan, Chithra C / Uprety, Tirth / Reedy, Stephanie E / Temeeyasen, Gun / Hause, Ben M / Wang, Dan / Li, Feng / Chambers, Thomas M

Viruses

2022 Volume 14, Issue 4

Abstract: Antibodies to influenza D virus (IDV) have been detected in horses, but no evidence of disease ... four 2-year-old horses seronegative for both influenza A (H3N8) and D viruses were intranasally ...

Abstract	Antibodies to influenza D virus (IDV) have been detected in horses, but no evidence of disease in the field has been reported. To determine whether IDV is infectious, immunogenic, and pathogenic in horses, four 2-year-old horses seronegative for both influenza A (H3N8) and D viruses were intranasally inoculated with 6.25 × 10
MeSH term(s)	Animals ; Antibodies, Viral ; Cattle ; Horse Diseases ; Horses ; Influenza A Virus, H3N8 Subtype ; Orthomyxoviridae ; Orthomyxoviridae Infections ; Thogotovirus
Chemical Substances	Antibodies, Viral
Language	English
Publishing date	2022-03-23
Publishing country	Switzerland
Document type	Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
ZDB-ID	2516098-9
ISSN	1999-4915 ; 1999-4915
ISSN (online)	1999-4915
ISSN	1999-4915
DOI	10.3390/v14040661
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Article ; Online: Vitamin D

Chambers, Emma S / Vukmanovic-Stejic, Milica / Turner, Carolin T / Shih, Barbara B / Trahair, Hugh / Pollara, Gabriele / Tsaliki, Evdokia / Rustin, Malcolm / Freeman, Tom C / Mabbott, Neil A / Noursadeghi, Mahdad / Martineau, Adrian R / Akbar, Arne N

Immunotherapy advances

2020 Volume 1, Issue 1, Page(s) ltaa008

Abstract: ... recall responses to varicella zoster virus (VZV) challenge in the skin of older adults. Vitamin D ... In addition, vitamin D increases immunoregulatory mechanisms and therefore has the potential to inhibit ... inflammageing.: Objectives: We investigated the use of vitamin D: Methods: Vitamin D insufficient older ...

Abstract	Introduction: Ageing is associated with increased number of infections, decreased vaccine efficacy and increased systemic inflammation termed inflammageing. These changes are reflected by reduced recall responses to varicella zoster virus (VZV) challenge in the skin of older adults. Vitamin D deficiency is more common in the old and has been associated with frailty and increased inflammation. In addition, vitamin D increases immunoregulatory mechanisms and therefore has the potential to inhibit inflammageing. Objectives: We investigated the use of vitamin D Methods: Vitamin D insufficient older adults ( Results: We showed that older adults had reduced VZV-specific cutaneous immune response and increased non-specific inflammation as compared to young. Increased non-specific inflammation observed in the skin of older adults negatively correlated with vitamin D sufficiency. We showed that vitamin D Conclusion: Vitamin D
Language	English
Publishing date	2020-11-25
Publishing country	England
Document type	Journal Article
ISSN	2732-4303
ISSN (online)	2732-4303
DOI	10.1093/immadv/ltaa008
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Article ; Online: Imaging of surface microdomains on individual extracellular vesicles in 3-D.

McNamara, Ryan P / Zhou, Yijun / Eason, Anthony B / Landis, Justin T / Chambers, Meredith G / Willcox, Smaranda / Peterson, Tiffany A / Schouest, Blake / Maness, Nicholas J / MacLean, Andrew G / Costantini, Lindsey M / Griffith, Jack D / Dittmer, Dirk Peter

Journal of extracellular vesicles

2022 Volume 11, Issue 3, Page(s) e12191

Abstract: Extracellular vesicles (EVs) are secreted from all cell types and are intimately involved in tissue homeostasis. They are being explored as vaccine and gene therapy platforms, as well as potential biomarkers. As their size is below the diffraction limit ... ...

Abstract	Extracellular vesicles (EVs) are secreted from all cell types and are intimately involved in tissue homeostasis. They are being explored as vaccine and gene therapy platforms, as well as potential biomarkers. As their size is below the diffraction limit of light microscopy, direct visualizations have been daunting and single-particle studies under physiological conditions have been hampered. Here, direct stochastic optical reconstruction microscopy (dSTORM) was employed to visualize EVs in three-dimensions and to localize molecule clusters such as the tetraspanins CD81 and CD9 on the surface of individual EVs. These studies demonstrate the existence of membrane microdomains on EVs. These were confirmed by Cryo-EM. Individual particle visualization provided insights into the heterogeneity, structure, and complexity of EVs not previously appreciated.
MeSH term(s)	Biological Transport ; Biomarkers/analysis ; Extracellular Vesicles/chemistry ; Microscopy ; Tetraspanins/analysis
Chemical Substances	Biomarkers ; Tetraspanins
Language	English
Publishing date	2022-03-01
Publishing country	United States
Document type	Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
ZDB-ID	2683797-3
ISSN	2001-3078 ; 2001-3078
ISSN (online)	2001-3078
ISSN	2001-3078
DOI	10.1002/jev2.12191
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Article ; Online: Unbound vitamin D concentrations are not decreased in critically ill patients.

Palmer, David / Soule, Steven / Gaddam, Ravinder R / Elder, Peter / Chambers, Stephen / Doogue, Matthew

Internal medicine journal

2020 Volume 52, Issue 1, Page(s) 89–94

Abstract: ... hydroxyvitamin D (25(OH)D) concentration is decreased in critical illness, but the free concentration of 25(OH)D ... has had less attention.: Aim: To compare total and calculated free 25(OH)D concentrations ... with critical illness were compared with 68 healthy controls; 25(OH)D was measured by liquid chromatography ...

Abstract	Background: Free concentrations of highly protein bound hormones, such as cortisol and thyroxine, are unchanged in critical illness despite substantial decreases in total concentration. Total 25-hydroxyvitamin D (25(OH)D) concentration is decreased in critical illness, but the free concentration of 25(OH)D has had less attention. Aim: To compare total and calculated free 25(OH)D concentrations in critically ill patients with healthy controls. Methods: In this case-control study, 38 patients with critical illness were compared with 68 healthy controls; 25(OH)D was measured by liquid chromatography tandem mass spectrometry (LCMS/MS) and vitamin D binding protein (VDBP) by direct sandwich enzyme-linked immunosorbent assay. Total and calculated free 25(OH)D concentrations were compared using unpaired t-tests. Results: Total 25(OH)D concentrations were significantly lower in critically ill patients than controls (37 (95% confidence interval 31-43) vs 57 (53-60) nmol/L). Calculated free concentrations of 25(OH)D were not lower in critically ill patients than healthy controls (26 (22-29) vs 19 (18-20) pmol/L). Conclusions: Calculated free 25(OH)D concentrations are not decreased in critical illness. Measuring total 25(OH)D concentrations in patients with critical illness potentially underestimates vitamin D and overestimates the number of patients who are deficient in vitamin D.
MeSH term(s)	Case-Control Studies ; Critical Illness ; Humans ; Vitamin D ; Vitamin D Deficiency/epidemiology ; Vitamins
Chemical Substances	Vitamins ; Vitamin D (1406-16-2)
Language	English
Publishing date	2020-10-15
Publishing country	Australia
Document type	Journal Article
ZDB-ID	2045436-3
ISSN	1445-5994 ; 1444-0903
ISSN (online)	1445-5994
ISSN	1444-0903
DOI	10.1111/imj.15096
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Zs.A 792: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular Jg. 1995 - 2021: Lesesall (1.OG) ab Jg. 2022: Lesesaal (EG)
Zs.MO 424: Show issues

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Article ; Online: Operationalizing equity during local pandemic response (submission eclinm-d-21-00233R1).

Raymond, Nathaniel / Chambers, Andrew / Polatty, David / Khoshnood, Kaveh / Xu, Rachel

EClinicalMedicine

2021 Volume 36, Page(s) 100937

Language	English
Publishing date	2021-06-07
Publishing country	England
Document type	Journal Article
ISSN	2589-5370
ISSN (online)	2589-5370
DOI	10.1016/j.eclinm.2021.100937
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Article ; Online: Vitamin D Deficiency in Pregnant Ukrainian Women: Effects of Alcohol Consumption on Vitamin D Status.

Carlson, Charles R / Uriu-Adams, Janet Y / Chambers, Christina D / Yevtushok, Lyubov / Zymak-Zakutnya, Natalya / Chan, Priscilla H / Schafer, Jordan J / Wertelecki, Wladimir / Keen, Carl L

Journal of the American College of Nutrition

2017 Volume 36, Issue 1, Page(s) 44–56

Abstract: Objective: Heavy alcohol consumption can alter vitamin D status; however, the relationships ... between alcohol consumption and vitamin D concentrations in pregnant women have not been well studied ... The aim of this study was to investigate the vitamin D status in a population of alcohol-exposed (N = 180 ...

Abstract	Objective: Heavy alcohol consumption can alter vitamin D status; however, the relationships between alcohol consumption and vitamin D concentrations in pregnant women have not been well studied. The aim of this study was to investigate the vitamin D status in a population of alcohol-exposed (N = 180) and low/unexposed control (N = 179) Ukrainian pregnant women. Methods: Women who attended prenatal care facilities in 2 regions of Ukraine (Rivne and Khmelnytsky) for a routine prenatal visit were screened for the study. At the time of enrollment (20.4 ± 7.0 weeks of gestation), blood samples and alcohol consumption data (during a typical week around conception and the most recent 2 weeks) were collected. Vitamin D status was assessed by 25-hydroxyvitamin D [25(OH)D] concentrations. Results: A high prevalence of suboptimal vitamin D status in pregnant Ukrainian women was observed. Overall, 50.1% and 33.4% of the women were classified as vitamin D deficient [25(OH)D < 20 ng/mL] or insufficient [25(OH)D ≥ 20 ng/mL and ≤30 ng/mL], respectively, based on 2011 Endocrine Society guidelines. Alcohol-exposed women had significantly lower 25(OH)D concentrations than low/unexposed women in Spring (p = 0.006) and Winter (p = 0.022). When vitamin D concentrations were grouped into sunny season (Summer + Fall) compared to not sunny season (Winter + Spring), there was a significant ethanol by season interaction (p = 0.0028), with alcohol-drinking women having lower circulating vitamin D compared to low/unexposed women in seasons of low sun availability. Conclusions: These data suggest that when vitamin D concentrations are generally low (e.g., during seasons of low sun availability), alcohol consumption during pregnancy has a negative impact on vitamin D status.
MeSH term(s)	Adolescent ; Adult ; Alcohol Drinking/adverse effects ; Female ; Humans ; Pregnancy ; Pregnancy Complications/epidemiology ; Prenatal Care ; Seasons ; Sunlight ; Ukraine/epidemiology ; Vitamin D/analogs & derivatives ; Vitamin D/blood ; Vitamin D Deficiency/blood ; Vitamin D Deficiency/epidemiology ; Young Adult
Chemical Substances	Vitamin D (1406-16-2) ; 25-hydroxyvitamin D (A288AR3C9H)
Language	English
Publishing date	2017-02-04
Publishing country	United States
Document type	Journal Article ; Research Support, N.I.H., Extramural
ZDB-ID	603204-7
ISSN	1541-1087 ; 0731-5724
ISSN (online)	1541-1087
ISSN	0731-5724
DOI	10.1080/07315724.2016.1174091
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Zs.A 1759: Show issues

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Article ; Online: Behavioral and cellular dopamine D

Lanza, Kathryn / Meadows, Samantha M / Chambers, Nicole E / Nuss, Emily / Deak, Molly M / Ferré, Sergi / Bishop, Christopher

Neuropharmacology

2018 Volume 138, Page(s) 304–314

Abstract: Individually, D1 and D3 dopamine receptors (D ...

Abstract	Individually, D1 and D3 dopamine receptors (D
MeSH term(s)	2,3,4,5-Tetrahydro-7,8-dihydroxy-1-phenyl-1H-3-benzazepine/pharmacology ; Animals ; Antiparkinson Agents/adverse effects ; Antiparkinson Agents/pharmacology ; Benzopyrans/pharmacology ; Corpus Striatum/drug effects ; Corpus Striatum/metabolism ; Dopamine Agonists/pharmacology ; Dose-Response Relationship, Drug ; Dyskinesia, Drug-Induced/metabolism ; Functional Laterality ; Levodopa/adverse effects ; Levodopa/pharmacology ; Male ; Mitogen-Activated Protein Kinase 1/metabolism ; Mitogen-Activated Protein Kinase 3/metabolism ; Motor Activity/drug effects ; Motor Activity/physiology ; Oxazines/pharmacology ; Oxidopamine ; Parkinsonian Disorders/drug therapy ; Parkinsonian Disorders/metabolism ; Rats, Sprague-Dawley ; Receptors, Dopamine D1/agonists ; Receptors, Dopamine D1/metabolism ; Receptors, Dopamine D3/agonists ; Receptors, Dopamine D3/metabolism
Chemical Substances	Antiparkinson Agents ; Benzopyrans ; Dopamine Agonists ; Drd3 protein, rat ; Oxazines ; Receptors, Dopamine D1 ; Receptors, Dopamine D3 ; 3,4,4a,10b-tetrahydro-4-propyl-2H,5H-(1)benzopyrano(4,3-b)-1,4-oxazin-9-ol (123594-64-9) ; Levodopa (46627O600J) ; 2,3,4,5-Tetrahydro-7,8-dihydroxy-1-phenyl-1H-3-benzazepine (67287-49-4) ; Oxidopamine (8HW4YBZ748) ; Mapk1 protein, rat (EC 2.7.11.24) ; Mitogen-Activated Protein Kinase 1 (EC 2.7.11.24) ; Mitogen-Activated Protein Kinase 3 (EC 2.7.11.24)
Language	English
Publishing date	2018-06-21
Publishing country	England
Document type	Journal Article ; Research Support, N.I.H., Intramural ; Research Support, Non-U.S. Gov't
ZDB-ID	218272-5
ISSN	1873-7064 ; 0028-3908
ISSN (online)	1873-7064
ISSN	0028-3908
DOI	10.1016/j.neuropharm.2018.06.024
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Article ; Online: Comment on Huțanu et al. Low Serum Vitamin D in COVID-19 Patients Is Not Related to Inflammatory Markers and Patients' Outcomes-A Single-Center Experience and a Brief Review of the Literature.

Chambers, Patrick

Nutrients

2022 Volume 14, Issue 16

Abstract: The article by Huțanu et al. [ ... ]. ...

Abstract	The article by Huțanu et al. [...].
MeSH term(s)	Biomarkers ; COVID-19 ; Humans ; Nutrients ; Vitamin D
Chemical Substances	Biomarkers ; Vitamin D (1406-16-2)
Language	English
Publishing date	2022-08-18
Publishing country	Switzerland
Document type	Journal Article ; Review
ZDB-ID	2518386-2
ISSN	2072-6643 ; 2072-6643
ISSN (online)	2072-6643
ISSN	2072-6643
DOI	10.3390/nu14163387
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Article ; Online: Vitamin D and Streptococci: The Interface of Nutrition, Host Immune Response, and Antimicrobial Activity in Response to Infection.

Guevara, Miriam A / Lu, Jacky / Moore, Rebecca E / Chambers, Schuyler A / Eastman, Alison J / Francis, Jamisha D / Noble, Kristen N / Doster, Ryan S / Osteen, Kevin G / Damo, Steven M / Manning, Shannon D / Aronoff, David M / Halasa, Natasha B / Townsend, Steven D / Gaddy, Jennifer A

ACS infectious diseases

2020 Volume 6, Issue 12, Page(s) 3131–3140

Abstract: ... ...

Abstract	Streptococcus
MeSH term(s)	Anti-Infective Agents ; Female ; Humans ; Immunity ; Pregnancy ; Streptococcal Infections ; Streptococcus ; Vitamin D ; Vitamin D Deficiency
Chemical Substances	Anti-Infective Agents ; Vitamin D (1406-16-2)
Language	English
Publishing date	2020-11-10
Publishing country	United States
Document type	Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't ; Research Support, U.S. Gov't, Non-P.H.S. ; Research Support, U.S. Gov't, P.H.S. ; Review
ISSN	2373-8227
ISSN (online)	2373-8227
DOI	10.1021/acsinfecdis.0c00666
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