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Article ; Online: Willingness to receive COVID-19 vaccination in people living with HIV/AIDS from Latin America.

Ortiz-Martínez, Yeimer / López-López, Miguel Ángel / Ruiz-González, Carlos E / Turbay-Caballero, Valentina / Sacoto, Daniel H / Caldera-Caballero, Marcela / Bravo, Heyman / Sarmiento, Jheinner / Rodriguez-Morales, Alfonso J

International journal of STD & AIDS

2022 Volume 33, Issue 7, Page(s) 652–659

Abstract: Background: Prior research has established some risk factors for an increased risk of severe disease and mortality from coronavirus disease 2019 (COVID-19). However, the impact of HIV infection on SARS-CoV-2 susceptibility and severity is a significant ... ...

Abstract	Background: Prior research has established some risk factors for an increased risk of severe disease and mortality from coronavirus disease 2019 (COVID-19). However, the impact of HIV infection on SARS-CoV-2 susceptibility and severity is a significant gap in the literature. In the same way, not many studies across the globe have analyzed the degree of vaccination willingness among people living with HIV/AIDS (PLWHA) and considerations regarding prioritizing this population during vaccination plans, particularly in developing countries. Methods: A descriptive-analytical cross-sectional study was conducted. Self-completed electronic surveys directed to PLWHA were performed via Twitter in February 2021, using accounts of HIV activists. Results: 460 (87.1%) participants were willing to be vaccinated with any COVID-19 vaccine. The reasons for that were listed as 1) the belief that vaccination prevents both the COVID-19 infection (81.3%) as well as being a spreader (52.2%); 2) having a high occupational risk of becoming infected with COVID-19 (22%); and 3) the belief that they would be at high risk of death because of COVID-19 (21.3%). Only 56 (10.6%) participants expressed hesitancy toward vaccination, and 12 (2.2%) stated they did not want to get vaccinated. Conclusions: Our results may support the prioritization of people living with HIV during the implementation of vaccination plans in developing countries. New strategies should be adopted to overcome the hesitancy and unwillingness toward the COVID-19 vaccination, especially in populations with risk factors for severe disease.
MeSH term(s)	COVID-19/epidemiology ; COVID-19/prevention & control ; COVID-19 Vaccines ; Cross-Sectional Studies ; HIV Infections/epidemiology ; Health Knowledge, Attitudes, Practice ; Humans ; Latin America/epidemiology ; SARS-CoV-2 ; Vaccination
Chemical Substances	COVID-19 Vaccines
Language	English
Publishing date	2022-04-29
Publishing country	England
Document type	Journal Article
ZDB-ID	1018089-8
ISSN	1758-1052 ; 0956-4624
ISSN (online)	1758-1052
ISSN	0956-4624
DOI	10.1177/09564624221091752
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Article: Spontaneous coronary artery dissection with left ventricular thrombus.

Joo, Joseph H / Caldera, Angel E / Divakaran, Vijay G

Proceedings (Baylor University. Medical Center)

2018 Volume 32, Issue 1, Page(s) 99–100

Abstract: Spontaneous coronary artery dissection (SCAD) is a rare, nonatherosclerotic cause of acute coronary syndrome. The etiology is unclear, and optimal treatment for SCAD remains undefined. We describe a patient with significant cardiovascular risk factors ... ...

Abstract	Spontaneous coronary artery dissection (SCAD) is a rare, nonatherosclerotic cause of acute coronary syndrome. The etiology is unclear, and optimal treatment for SCAD remains undefined. We describe a patient with significant cardiovascular risk factors who presented with SCAD resulting in anterior wall acute myocardial infarction with left ventricular thrombus. The patient was managed conservatively with anticoagulant and antiplatelet therapy.
Language	English
Publishing date	2018-12-20
Publishing country	United States
Document type	Case Reports
ZDB-ID	2703932-8
ISSN	1525-3252 ; 0899-8280
ISSN (online)	1525-3252
ISSN	0899-8280
DOI	10.1080/08998280.2018.1507974
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Zs.A 6987: Show issues

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Article ; Online: Case records of the Massachusetts General Hospital. Case 36-2011. A 93-year-old woman with shortness of breath and chest pain.

Senecal, Emily L / Rosenfield, Kenneth / Caldera, Angel E / Passeri, Jonathan J

The New England journal of medicine

2011 Volume 365, Issue 21, Page(s) 2021–2028

MeSH term(s)	Aged, 80 and over ; Chest Pain/etiology ; Coronary Angiography ; Diagnosis, Differential ; Dyspnea/etiology ; Echocardiography ; Electrocardiography ; Female ; Heart Diseases/diagnosis ; Humans ; Hypertension/complications ; Takotsubo Cardiomyopathy/complications ; Takotsubo Cardiomyopathy/diagnosis
Language	English
Publishing date	2011-11-24
Publishing country	United States
Document type	Case Reports ; Clinical Conference ; Journal Article
ZDB-ID	207154-x
ISSN	1533-4406 ; 0028-4793
ISSN (online)	1533-4406
ISSN	0028-4793
DOI	10.1056/NEJMcpc1103565
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Article ; Online: Prevalence and Clinical Impact of Systemic Autoimmune Rheumatic Disease in Patients with Silicosis.

Blanco Pérez, José Jesús / Arnalich Montiel, Victoria / Salgado-Barreira, Ángel / Alvarez Moure, María Angel / Caldera Díaz, Adriana Carolina / Melero Gonzalez, Rafael / Pallarés Sanmartín, Abel / Fernandez Villar, Alberto / González Barcala, Francisco Javier

Archivos de bronconeumologia

2020

Abstract: Background: Silicosis is associated with an increased risk of developing systemic autoimmune rheumatic disease (SARD). The prognostic implications of this association are poorly characterized. The aim of this study was to determine the prevalence of ... ...

Title translation	Prevalencia e impacto clínico de las enfermedades reumatológicas autoinmunitarias sistémicas en pacientes con silicosis.
Abstract	Background: Silicosis is associated with an increased risk of developing systemic autoimmune rheumatic disease (SARD). The prognostic implications of this association are poorly characterized. The aim of this study was to determine the prevalence of SARD and autoimmune markers in a cohort of patients with exposure to silica and assess their impact on prognosis. Method: We performed a prospective observational study of all patients attending the dedicated silicosis clinic of our pulmonology unit between 2009 and December 2017. Diagnosis was confirmed by a rheumatologist according to Spanish Rheumatology Society criteria. Autoimmune markers, pulmonary function tests, radiological progression, visits to the emergency department and primary care center, and hospital admissions for respiratory causes, and mortality were analyzed. Results: Overall, 489 cases of silicosis and 95 cases of exposure were studied. In total, 54 (11.0%) patients with silicosis had SARD: 12 (2.4%) rheumatoid arthritis, 10 (2.0%) systemic lupus erythematosus, 10 (2.0%) systemic sclerosis, 3 (0.6%) Sjögren syndrome, 2 (0.4%) vasculitis associated with anti-neutrophil cytoplasmic antibodies (ANCA +), 6 (1.2%) psoriatic arthritis, 3 (0.6%) ankylosing spondylitis, and 8 (1.6%) other autoimmune diseases with no special features. The patients with SARD visited the emergency room more often (63.0 vs. 42.5%; p = 0.004), and progressed more rapidly (22.2 vs. 11.7%; p = 0.030). Conclusions: The presence of systemic rheumatic autoimmune diseases involves radiological progression and a higher clinical impact.
Language	Spanish
Publishing date	2020-05-31
Publishing country	Spain
Document type	Journal Article
ZDB-ID	2591346-3
ISSN	2173-5751 ; 2173-5751
ISSN (online)	2173-5751
ISSN	2173-5751
DOI	10.1016/j.arbres.2020.04.012
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Article: Angiographic significance of a discordant ST-segment elevation of > or =5 millimeters in patients with ventricular-paced rhythm and acute myocardial infarction.

Caldera, Angel E / Bryce, Miguel / Kotler, Morris / Braitman, Leonard E / Spielman, Scott

The American journal of cardiology

2002 Volume 90, Issue 11, Page(s) 1240–1243

MeSH term(s)	Aged ; Aged, 80 and over ; Cardiac Pacing, Artificial ; Coronary Angiography ; Coronary Artery Disease/complications ; Electrocardiography ; Female ; Humans ; Male ; Middle Aged ; Myocardial Infarction/diagnosis ; Myocardial Infarction/etiology ; Severity of Illness Index
Language	English
Publishing date	2002-12-01
Publishing country	United States
Document type	Journal Article
ZDB-ID	80014-4
ISSN	1879-1913 ; 0002-9149
ISSN (online)	1879-1913
ISSN	0002-9149
DOI	10.1016/s0002-9149(02)02842-4
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Ui IV Zs.73: Show issues

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Article: Electrocardiogram in Pneumocystis carinii pneumonia: can it be used as a prognostic variable?

Caldera, Angel E / Crespo, Guillermo J / Maraj, Suraj / Kotler, Morris / Braitman, Leonard E / Eiger, Glenn

Critical care medicine

2002 Volume 30, Issue 7, Page(s) 1425–1428

Abstract: Objective: Many prognostic variables have been studied in patients with Pneumocystis carinii pneumonia and acquired immunodeficiency syndrome (AIDS). The role of the electrocardiogram in this setting has not been previously evaluated. We analyzed the ... ...

Abstract	Objective: Many prognostic variables have been studied in patients with Pneumocystis carinii pneumonia and acquired immunodeficiency syndrome (AIDS). The role of the electrocardiogram in this setting has not been previously evaluated. We analyzed the admission electrocardiogram in patients with Pneumocystis carinii pneumonia and AIDS in an attempt to identify electrocardiogram findings that could be associated with adverse clinical outcomes and worse prognostic variables. Design: A retrospective medical chart review. Setting: All confirmed cases of Pneumocystis carinii pneumonia in patients positive for human immunodeficiency virus admitted to Albert Einstein Medical Center from 1994 to 2000. Methods: Patients were assigned increasing severity ranks based on the findings on the admission electrocardiogram (normal sinus rhythm, sinus tachycardia, and right ventricular strain pattern). Data were extracted regarding study outcomes (admission to intensive care unit, mechanical ventilation, and hospital mortality) and prognostic variables. Main results: Of the 40 study patients, 14 (35%) had normal sinus rhythm, 15 (37.5%) had sinus tachycardia, and 11 (27.5%) presented with signs of right ventricular strain. The number of admissions to the intensive care unit, use of mechanical ventilation, and hospital mortality rate all increased with the severity of the electrocardiogram findings (p < or =.03). The serum lactate dehydrogenase concentrations and the alveolar-arterial oxygen gradient both increased with the severity of the electrocardiogram findings (p < or =.02). Conclusion: Electrocardiogram findings of sinus tachycardia and right heart strain are common in Pneumocystis carinii pneumonia. These findings are associated with adverse clinical outcomes as well as worsening of prognostic variables. The electrocardiogram may be useful in predicting outcome in patients with Pneumocystis carinii pneumonia.
MeSH term(s)	Adult ; Electrocardiography ; Female ; HIV Infections/complications ; Humans ; Male ; Middle Aged ; Pneumonia, Pneumocystis/complications ; Pneumonia, Pneumocystis/physiopathology ; Prognosis ; Retrospective Studies
Language	English
Publishing date	2002-07
Publishing country	United States
Document type	Journal Article
ZDB-ID	197890-1
ISSN	1530-0293 ; 0090-3493
ISSN (online)	1530-0293
ISSN	0090-3493
DOI	10.1097/00003246-200207000-00004
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Zs.A 1261: Show issues

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Article: Evolución de los pacientes en diferentes estadios de insuficiencia hepática sometidos a erradicación de várices esofágicas con ligaduras endoscópicas.

Estela Caldera, Elisa / Reyes Dorantes, Angel Andrés / González Ortiz, Julio Alberto

Revista de gastroenterologia de Mexico

2005 Volume 70, Issue 1, Page(s) 33–37

Abstract: Objective: To know the patients' progress with distinct stages of hepatic failure, according to the Child Pugh classification, who underwent esophageal varices eradication with the use of endoscopic band ligation.: Design: Descriptive, longitudinal, ... ...

Title translation	Patient evolution in different stages of hepatic failure submitted to eradication of esophageal varices with endoscopic ligation.
Abstract	Objective: To know the patients' progress with distinct stages of hepatic failure, according to the Child Pugh classification, who underwent esophageal varices eradication with the use of endoscopic band ligation. Design: Descriptive, longitudinal, prospective and comparative study. CENTRE: Endoscopy Department of the Central Military Hospital, Mexico, D.F. Methods: One-hundred twenty-four patients with esophageal varices and a history of bleeding, were submitted to various band ligation sessions every 4 weeks until the varices were eradicated and control sessions every 3 months. Results: A total of 425 endoscopy sessions were performed of which 239 were ligature applications and 187 control sessions. Eradication of varices was achieved in 100% of the patients. Of the Child A, 2/3 of them were eradicated in one session and the other 1/3 with 2 sessions. The patients of the Child B class, 66% of varices were effaced in one session, 22% in two and 12% in three sessions. In the Child C group, 50% were obliterated in two sessions, 47% with three, 2% needed 4 sessions. The follow-up period was from 4 months being the minimum and 13 months the maximum (mean of 7 months). In 15% of the patients varices recurred. None were from the Child A group. Those pertaining to the Child B group varices reappeared in 7.3% of which 2/3 required another ligation session to eradicate them once again and the other 1/3 were removed in two sessions. In the Child C group the incidence of recidivation was 28%, 43% of these needing one session to eliminate them once again, 50% two sessions and 7% three sessions for complete eradication. Rebleeding appeared in 7.7% of the sample, all of them were from the Child C class. The occurrence of congestive gastropathy before ligature was 42%, and 73% at the conclusion of the follow-up period. Congestive gastropathy developed in 11% of the Child A patients after eradication, 34% of the Child B group and 38.5% of the Child C group. The incidence of gastric varices was 21% before ligature and at the end of the follow-up period 17% more developed gastric varices. None of the Child A patients developed gastric varices, 12% of group B and 24% of group C. From the (n = 124) 22.5% presented dysphagia as a complication which lasted less than one week and in 0.8% mucosal ulcer Conclusion: It is possible to eradicate esophageal varices by band ligation independently of the hepatic function reserve. A greater number of sessions is required to eradicate varices in the poor hepatic function group and the incidence of recidivation, rebleeding, and complications that developed such as gastric varices and gastropathy are more frequent in patients with poor hepatic function reserve.
MeSH term(s)	Adolescent ; Adult ; Aged ; Aged, 80 and over ; Endoscopy ; Esophageal and Gastric Varices/complications ; Esophageal and Gastric Varices/surgery ; Female ; Humans ; Ligation ; Liver Failure/complications ; Male ; Middle Aged ; Prospective Studies ; Treatment Outcome
Language	Spanish
Publishing date	2005-01
Publishing country	Mexico
Document type	English Abstract ; Journal Article
ZDB-ID	732082-6
ISSN	0375-0906
ISSN	0375-0906
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Article: Synthesis of 1-amino-6,7,8,8a-tetrahydroacenaphthene and its effect on the inhibition of the MAO-enzyme at the brain cortex and liver level.

Charris, J / Pérez, J / Duerto de Pérez, Z / Companogne, R / Ayala, C / Stern, A I / Migliore de Angel, B / de Báez, E M / Caldera, J / Avila, D / Angel, J

Die Pharmazie

2000 Volume 55, Issue 1, Page(s) 62–64

Abstract: 1-Amino-6,7,8,8a-tetrahydroacenaphthene was synthesized and evaluated as a novel drug acting on the dopaminergic system. It was shown that the new compound displays activity as MAO inhibitor. ...

Abstract	(+/-)-1-Amino-6,7,8,8a-tetrahydroacenaphthene was synthesized and evaluated as a novel drug acting on the dopaminergic system. It was shown that the new compound displays activity as MAO inhibitor.
MeSH term(s)	Acenaphthenes/chemical synthesis ; Acenaphthenes/pharmacology ; Animals ; Cerebral Cortex/drug effects ; Cerebral Cortex/enzymology ; Dopamine/physiology ; Liver/drug effects ; Liver/enzymology ; Male ; Monoamine Oxidase Inhibitors/chemical synthesis ; Monoamine Oxidase Inhibitors/pharmacology ; Rats ; Rats, Sprague-Dawley ; Spectrophotometry, Infrared ; Stereoisomerism
Chemical Substances	1-amino-6,7,8,8a-tetrahydroacenaphthene ; Acenaphthenes ; Monoamine Oxidase Inhibitors ; Dopamine (VTD58H1Z2X)
Language	English
Publishing date	2000-01
Publishing country	Germany
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	208793-5
ISSN	0031-7144
ISSN	0031-7144
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Article: Synthesis and theoretical study of 2-amino-2,3,3a,4,5,6-hexahydro-1H-phenalene and its biological evaluation on central dopaminergic system.

Angel-Guío, J E / Charris, J E / Pérez, J / Duerto de Pérez, Z D / Compagnone, R / Israel, A / Orfila, L / Migliore de Angel, B / López, S E / Rodríguez, L / Caldera, J / Michelena de Báez, E / Arrieta, F

Farmaco (Societa chimica italiana : 1989)

2000 Volume 55, Issue 9-10, Page(s) 575–582

Abstract: Compound 2 considered as a rigid non-hydroxylated 2-amino tetralin was synthesized and biologically evaluated. Central administration of compound 2 (50 microg or 100 microg/10 microl) induced a reduction in urinary sodium and potassium excretion at 3 and ...

Abstract	Compound 2 considered as a rigid non-hydroxylated 2-amino tetralin was synthesized and biologically evaluated. Central administration of compound 2 (50 microg or 100 microg/10 microl) induced a reduction in urinary sodium and potassium excretion at 3 and 6 h of urine collection. We speculate that compound 2 may be acting as a dopamine receptor antagonist.
MeSH term(s)	Amines/chemical synthesis ; Amines/chemistry ; Amines/pharmacology ; Animals ; Diuresis/drug effects ; Dopamine Antagonists/chemical synthesis ; Dopamine Antagonists/chemistry ; Dopamine Antagonists/pharmacology ; Dopamine D2 Receptor Antagonists ; Heterocyclic Compounds/chemical synthesis ; Heterocyclic Compounds/chemistry ; Heterocyclic Compounds/pharmacology ; Male ; Molecular Structure ; Natriuresis/drug effects ; Phenalenes ; Polycyclic Compounds/chemical synthesis ; Polycyclic Compounds/chemistry ; Polycyclic Compounds/pharmacology ; Potassium/urine ; Rats ; Rats, Sprague-Dawley ; Receptors, Dopamine D1/antagonists & inhibitors ; Sodium/urine
Chemical Substances	2-amino-2,3,3a,4,5,6-hexahydro-1H-phenalene ; Amines ; Dopamine Antagonists ; Dopamine D2 Receptor Antagonists ; Heterocyclic Compounds ; Phenalenes ; Polycyclic Compounds ; Receptors, Dopamine D1 ; Sodium (9NEZ333N27) ; Potassium (RWP5GA015D)
Language	English
Publishing date	2000-09
Publishing country	France
Document type	Evaluation Studies ; Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	130072-6
ISSN	1879-0569 ; 0014-827X
ISSN (online)	1879-0569
ISSN	0014-827X
DOI	10.1016/s0014-827x(00)00081-1
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Article ; Online: Primary dissociated midbrain dopamine cell cultures from rodent neonates.

Frank, Lauren E / Caldera-Siu, Angela D / Pothos, Emmanuel N

Journal of visualized experiments : JoVE

2008 , Issue 21

Abstract: ... video microscopy (i.e., of real-time vesicular fusion with the plasma membrane), cell viability assays and ...

Abstract	The ability to create primary cell cultures of dopamine neurons allows for the study of the presynaptic characteristics of dopamine neurons in isolation from systemic input from elsewhere in the brain. In our lab, we use these neurons to assess dopamine release kinetics using carbon fiber amperometry, as well as expression levels of dopamine related genes and proteins using quantitative PCR and immunocytochemistry. In this video, we show you how we generate these cultures from rodent neonates. The process involves several steps, including the plating of cortical glial astrocytes, the conditioning of neuronal cell culture media by the glial substrate, the dissection of the midbrain in neonates, the digestion, extraction and plating of dopamine neurons and the addition of neurotrophic factors to ensure cell survival. The applications suitable for such a preparation include electrophysiology, immunocytochemistry, quantitative PCR, video microscopy (i.e., of real-time vesicular fusion with the plasma membrane), cell viability assays and other toxicological screens.
MeSH term(s)	Animals ; Animals, Newborn ; Cell Culture Techniques/methods ; Dopamine/metabolism ; Electrophysiology/methods ; Immunohistochemistry/methods ; Mesencephalon/cytology ; Mesencephalon/metabolism ; Neurons/cytology ; Neurons/metabolism ; Rodentia
Chemical Substances	Dopamine (VTD58H1Z2X)
Language	English
Publishing date	2008-11-05
Publishing country	United States
Document type	Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't ; Video-Audio Media
ZDB-ID	2259946-0
ISSN	1940-087X ; 1940-087X
ISSN (online)	1940-087X
ISSN	1940-087X
DOI	10.3791/820
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