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  1. Article ; Online: Guglielmi detachable coils.

    Guglielmi, Guido

    Journal of neurointerventional surgery

    2014  Volume 10, Issue 4, Page(s) e5

    MeSH term(s) Embolization, Therapeutic ; Humans ; Intracranial Aneurysm
    Language English
    Publishing date 2014-05-09
    Publishing country England
    Document type Letter ; Comment
    ZDB-ID 2514982-9
    ISSN 1759-8486 ; 1759-8478
    ISSN (online) 1759-8486
    ISSN 1759-8478
    DOI 10.1136/neurintsurg-2014-011257
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Cerebral flow variation at different intra-aortic balloon settings in cardiogenic shock.

    Colombo, Costanza Natalia Julia / Guglielmi, Angelo / Mojoli, Francesco / Tavazzi, Guido

    European heart journal. Cardiovascular Imaging

    2022  Volume 23, Issue 6, Page(s) e270

    MeSH term(s) Aorta ; Humans ; Intra-Aortic Balloon Pumping ; Myocardial Infarction ; Shock, Cardiogenic/diagnostic imaging ; Shock, Cardiogenic/therapy
    Language English
    Publishing date 2022-03-13
    Publishing country England
    Document type Journal Article
    ZDB-ID 2638345-7
    ISSN 2047-2412 ; 2047-2404
    ISSN (online) 2047-2412
    ISSN 2047-2404
    DOI 10.1093/ehjci/jeac054
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  3. Article ; Online: History of detachable coils: the backdrop.

    Guglielmi, Guido

    Journal of neurosurgery

    2010  Volume 112, Issue 1, Page(s) 217–218

    MeSH term(s) Embolization, Therapeutic/history ; Embolization, Therapeutic/instrumentation ; Equipment Design ; History, 20th Century ; Humans
    Language English
    Publishing date 2010-01
    Publishing country United States
    Document type Comment ; Historical Article ; Letter
    ZDB-ID 3089-2
    ISSN 1933-0693 ; 0022-3085
    ISSN (online) 1933-0693
    ISSN 0022-3085
    DOI 10.3171/2009.10.JNS091557
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article: Coil over clip.

    Guglielmi, Guido

    Journal of neurosurgery

    2009  Volume 111, Issue 2, Page(s) 410–1; author reply 411–2

    MeSH term(s) Brain Damage, Chronic/prevention & control ; Embolization, Therapeutic/methods ; Humans ; Intracranial Aneurysm/surgery
    Language English
    Publishing date 2009-08
    Publishing country United States
    Document type Comment ; Letter
    ZDB-ID 3089-2
    ISSN 1933-0693 ; 0022-3085
    ISSN (online) 1933-0693
    ISSN 0022-3085
    DOI 10.3171/2009.2.JNS0951
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  5. Article: History of the genesis of detachable coils. A review.

    Guglielmi, Guido

    Journal of neurosurgery

    2009  Volume 111, Issue 1, Page(s) 1–8

    Abstract: The genesis of detachable coils and the background of this genesis are described in this article. To frame the beginning developmental stages of the discovery of detachable coils, the previous extravascular-intravascular and endovascular techniques are ... ...

    Abstract The genesis of detachable coils and the background of this genesis are described in this article. To frame the beginning developmental stages of the discovery of detachable coils, the previous extravascular-intravascular and endovascular techniques are presented, as well as the development of the various delivery systems. The experimental studies, initial clinical application, and crucial moment of the conception of detachable coils are also reported.
    MeSH term(s) Embolization, Therapeutic/history ; Embolization, Therapeutic/instrumentation ; History, 20th Century ; Humans ; Intracranial Aneurysm/history ; Intracranial Aneurysm/therapy
    Language English
    Publishing date 2009-03-11
    Publishing country United States
    Document type Historical Article ; Journal Article
    ZDB-ID 3089-2
    ISSN 1933-0693 ; 0022-3085
    ISSN (online) 1933-0693
    ISSN 0022-3085
    DOI 10.3171/2009.2.JNS081039
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  6. Article ; Online: History of endovascular surgery: personal accounts of the evolution.

    Guglielmi, Guido

    Neurosurgery

    2007  Volume 61, Issue 6, Page(s) E1340; author reply E1340

    MeSH term(s) History, 20th Century ; History, 21st Century ; Humans ; Vascular Surgical Procedures/history
    Language English
    Publishing date 2007-12
    Publishing country United States
    Document type Comment ; Historical Article ; Letter
    ZDB-ID 135446-2
    ISSN 1524-4040 ; 0148-396X
    ISSN (online) 1524-4040
    ISSN 0148-396X
    DOI 10.1227/01.neu.0000306122.23787.c5
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article ; Online: Minimally invasive treatment of colorectal liver metastases: does robotic surgery provide any technical advantages over laparoscopy? A multicenter analysis from the IGoMILS (Italian Group of Minimally Invasive Liver Surgery) registry.

    Masetti, Michele / Fallani, Guido / Ratti, Francesca / Ferrero, Alessandro / Giuliante, Felice / Cillo, Umberto / Guglielmi, Alfredo / Ettorre, Giuseppe Maria / Torzilli, Guido / Vincenti, Leonardo / Ercolani, Giorgio / Cipressi, Chiara / Lombardi, Raffaele / Aldrighetti, Luca / Jovine, Elio

    Updates in surgery

    2022  Volume 74, Issue 2, Page(s) 535–545

    Abstract: Surgery has been the mainstay treatment for colorectal liver metastases (CRLM). Although the benefits of a laparoscopic approach have been evidenced by several comparative studies, the comparison between robotic and laparoscopic liver surgery has not ... ...

    Abstract Surgery has been the mainstay treatment for colorectal liver metastases (CRLM). Although the benefits of a laparoscopic approach have been evidenced by several comparative studies, the comparison between robotic and laparoscopic liver surgery has not been elucidated. Thus, in this study, we aim to analyze the short-term outcomes of a multicenter population that underwent robotic versus laparoscopic liver resection for CRLM. Consecutive patients with CRLM who were enrolled in the IGoMILS registry between November 2014 and June 2019 were retrospectively evaluated to compare robot-assisted procedures with laparoscopic procedures. Primary outcomes were postoperative morbidity and mortality, while secondary outcomes were length of hospital stay, operative time, and histological features of the surgical specimen. The effect size of surgical technique on resection margins was quantified using Hedges' g. In total, 1030 patients underwent minimally invasive liver surgery (MILS) for CRLM; of these, 77 (7.5%) underwent a robot-assisted approach (R-MILS), whereas 953 (92.5%) underwent a laparoscopic approach (L-MILS). Laparoscopy and robot-assisted surgery were comparable in terms of postoperative outcomes: specifically, complication rates, Comprehensive Complication Index (CCI
    MeSH term(s) Colorectal Neoplasms/surgery ; Humans ; Laparoscopy ; Length of Stay ; Liver Neoplasms/secondary ; Liver Neoplasms/surgery ; Margins of Excision ; Minimally Invasive Surgical Procedures ; Postoperative Complications/epidemiology ; Postoperative Complications/surgery ; Registries ; Retrospective Studies ; Robotic Surgical Procedures ; Treatment Outcome
    Language English
    Publishing date 2022-01-31
    Publishing country Italy
    Document type Journal Article ; Multicenter Study
    ZDB-ID 2572692-4
    ISSN 2038-3312 ; 2038-131X
    ISSN (online) 2038-3312
    ISSN 2038-131X
    DOI 10.1007/s13304-022-01245-1
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  8. Article ; Online: Analysis of the hemodynamic characteristics of brain arteriovenous malformations using electrical models: baseline settings, surgical extirpation, endovascular embolization, and surgical bypass.

    Guglielmi, Guido

    Neurosurgery

    2008  Volume 63, Issue 1, Page(s) 1–10; discussion 11

    Abstract: Objective: The goal of this report is to analyze the hemodynamic characteristics of low- and high-flow arteriovenous malformations (AVM) using computerized electrical models.: Methods: Two electrical models of brain AVMs were created. These models ... ...

    Abstract Objective: The goal of this report is to analyze the hemodynamic characteristics of low- and high-flow arteriovenous malformations (AVM) using computerized electrical models.
    Methods: Two electrical models of brain AVMs were created. These models consist of electrical resistors that simulate AVM vessels. In both models, a low-flow AVM and a high-flow AVM, the flow of electrons simulates the flow of blood.
    Results: Using the models, it was possible to analyze the pressure and flow patterns in the nidus of the small, low-flow AVM and in the nidus of the large, high-flow AVM. Baseline hemodynamic "physiological" conditions of the two AVMs were studied. With the models, it was also possible to assess the AVM hemodynamic changes (in the feeding arteries, in the various parts of the nidus, and in the draining veins) after surgery, after embolization, and after surgical bypass of the malformation. The role of autoregulation in the three treatment modalities was also assessed.
    Conclusion: These electrical models seem to be useful in simulating and studying the behavior of flow and pressure in the different parts of the AVM nidus (arterial, arteriolar, arteriolar-venular, venular, venous) before and after treatment. The models can also be used to devise and simulate new treatment strategies that might lead to improved treatment of these highly complex vascular malformations of the brain.
    MeSH term(s) Cerebral Revascularization/methods ; Electric Impedance ; Embolization, Therapeutic/methods ; Hemodynamics/physiology ; Humans ; Intracranial Arteriovenous Malformations/physiopathology ; Intracranial Arteriovenous Malformations/surgery ; Models, Biological
    Language English
    Publishing date 2008-07
    Publishing country United States
    Document type Journal Article
    ZDB-ID 135446-2
    ISSN 1524-4040 ; 0148-396X
    ISSN (online) 1524-4040
    ISSN 0148-396X
    DOI 10.1227/01.NEU.0000335065.07448.8A
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  9. Article ; Online: Neuropsychological predictors of conversion from mild cognitive impairment to dementia at different timepoints.

    Quaranta, Davide / Caraglia, Naike / L'Abbate, Federica / Giuffrè, Guido Maria / Guglielmi, Valeria / Iacobucci, Giovanna Masone / Rossini, Paolo Maria / Calabresi, Paolo / Marra, Camillo

    Brain and behavior

    2023  Volume 13, Issue 9, Page(s) e3098

    Abstract: Introduction: Impairment of episodic memory is largely considered the main cognitive marker of prodromic Alzheimer's disease (AD). Nevertheless, the neuropathological process in AD starts several years before and, apart from biomarkers well defined in ... ...

    Abstract Introduction: Impairment of episodic memory is largely considered the main cognitive marker of prodromic Alzheimer's disease (AD). Nevertheless, the neuropathological process in AD starts several years before and, apart from biomarkers well defined in the Amyloid (A), Tauopathy (T), Neurodegeneration (N) framework, early clinical and neuropsychological markers able to detect mild cognitive impairment (MCI) due to AD before the appearance of memory disorders are lacking in clinical practice. Investigations on semantic memory have shown promising results in providing an earlier marker of dementia in MCI patients.
    Methods: A total of 253 MCI subjects were followed up every 6 months for 6 years-186 converted to dementia and 67 remained stable at the sixth year of follow-up. Twenty-seven patients progressed in the first 2 years (fast converters), 107 in the third to fourth year (intermediate converters), and 51 after the fourth year of follow-up (slow converters).
    Results: Stable MCI subjects performed better than fast decliners in Mini-Mental State Examination (MMSE), several long-term memory scores, and category verbal fluency test (CFT); stable and intermediate converters differ only in MMSE and CFT tests; and stable and slow converters differ only in MMSE and phonological/semantic discrepancy score.
    Conclusion: Early impairment of semantic memory could predict the evolution to AD before the onset of episodic memory disorders, and the discrepancy between phonological and semantic verbal fluency could be able to detect this impairment in advance in respect of simple CFT tests. The assessment of different aspects of semantic memory and its degradation could represent an early cognitive marker to intercept MCI due to AD in clinical practice.
    MeSH term(s) Humans ; Follow-Up Studies ; Disease Progression ; Neuropsychological Tests ; Cognitive Dysfunction/pathology ; Alzheimer Disease/pathology ; Memory Disorders/diagnosis
    Language English
    Publishing date 2023-08-07
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2623587-0
    ISSN 2162-3279 ; 2162-3279
    ISSN (online) 2162-3279
    ISSN 2162-3279
    DOI 10.1002/brb3.3098
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  10. Article ; Online: Cerebrospinal fluid neurofilament light chain and total-tau as biomarkers of neurodegeneration in Alzheimer's disease and frontotemporal dementia.

    Giuffrè, Guido Maria / Quaranta, Davide / Costantini, Emanuele Maria / Citro, Salvatore / Martellacci, Noemi / De Ninno, Grazia / Vita, Maria Gabriella / Guglielmi, Valeria / Rossini, Paolo Maria / Calabresi, Paolo / Marra, Camillo

    Neurobiology of disease

    2023  Volume 186, Page(s) 106267

    Abstract: Introduction: CSF Neurofilament light chain(NfL) is a promising biomarker of neurodegeneration, but its utility in discriminating between Alzheimer's disease(AD) and frontotemporal dementia(FTD) is limited.: Methods: 105 patients with clinical- ... ...

    Abstract Introduction: CSF Neurofilament light chain(NfL) is a promising biomarker of neurodegeneration, but its utility in discriminating between Alzheimer's disease(AD) and frontotemporal dementia(FTD) is limited.
    Methods: 105 patients with clinical-biological diagnosis of mild cognitive impairment(MCI) due to AD (N = 72) or clinical diagnosis of FTD (N = 33) underwent neuropsychological assessment and CSF Aβ42/40, p-tau181, total-tau and NfL quantification. Group comparisons, correlations between continuous variables and ROC curve analysis were carried out to assess NfL role in discriminating between MCI due to AD and FTD, exploring the associations between NfL, ATN biomarkers and neuropsychological measures.
    Results: NfL levels were significantly lower in the AD group, while levels of total-tau were higher. In the FTD group, significant correlations were found between NfL, p-tau181 and total-tau, and between NfL and cognitive performances. In the AD group, NfL levels were directly correlated with total-tau and p-tau181; Aβ42/40 ratio was inversely correlated with total-tau and p-tau181, but not with NfL. Moreover, p-tau181 and t-tau levels were found to be associated with episodic memory and lexical-semantic impairment. Total-tau/NfL ratio differentiated prodromal-AD from FTD with an AUC of 0.951, higher than the individual measures.
    Discussion & conclusions: The results support that NfL and total-tau levels reflect distinct pathophysiological neurodegeneration mechanisms, independent and dependent of Aβ pathology, respectively, Combining them may enhance both markers reliability, their ratio showing high accuracy in distinguishing MCI due to AD from FTD. Moreover, our results revealed associations between NfL and disease severity in FTD and between tauopathy and episodic memory and lexical-semantic impairment in prodromal-AD.
    MeSH term(s) Humans ; Frontotemporal Dementia/diagnosis ; Alzheimer Disease/diagnosis ; Intermediate Filaments ; Reproducibility of Results ; Pick Disease of the Brain ; Biomarkers
    Chemical Substances Biomarkers
    Language English
    Publishing date 2023-08-29
    Publishing country United States
    Document type Journal Article
    ZDB-ID 1211786-9
    ISSN 1095-953X ; 0969-9961
    ISSN (online) 1095-953X
    ISSN 0969-9961
    DOI 10.1016/j.nbd.2023.106267
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