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Article: Evolving types of pudendal neuromodulation for lower urinary tract dysfunction.

Parodi, Stefano / Kendall, Harry J / Terrone, Carlo / Heesakkers, John Pfa

2024 Volume 77, Issue 1, Page(s) 82–88

Abstract: Introduction: Sacral neuromodulation and posterior tibial nerve stimulation for lower urinary tract dysfunction (LUTD) and overactive bladder yield good and reliable results. However, neuromodulation research is continuously evolving because there is ... ...

Abstract	Introduction: Sacral neuromodulation and posterior tibial nerve stimulation for lower urinary tract dysfunction (LUTD) and overactive bladder yield good and reliable results. However, neuromodulation research is continuously evolving because there is still need for more patient-friendly treatment options in the therapeutic management of LUTD. Pudendal neuromodulation (PNM) has been emerging as a promising alternative treatment option for the last few decades. The aim of this study is to review the current state of the art of PNM. Material and methods: A wide literature search was conducted in the field of PNM using Medline through the PubMed database and Elsevier using the Scopus database; a critical review of the results was then carried out. PNM has been studied in its various possible aspects: percutaneous PNM, transrectal/transvaginal PNM, and both percutaneous and transcutaneous dorsal genital nerve stimulation. Results: Each technique was found to result in promising improvements in different clinical outcomes, with some trials reporting even better results than sacral neuromodulation. Conclusions: As a result of a comparison between the various PNM techniques with both sacral neuromodulation and posterior tibial nerve stimulation, we think that PNM should be seen as seriously promising, and we believe it will expand the treatment options for overactive bladder. Even though several studies accordingly showed PNM to be safe and effective, a systematic review and meta-analysis were not feasible. PNM in its various techniques is a promising treatment for LUTD. Nevertheless, further research is needed to include it in treatment algorithms.
Language	English
Publishing date	2024-01-06
Publishing country	Poland
Document type	Journal Article ; Review
ZDB-ID	2672528-9
ISSN	2080-4873 ; 2080-4806
ISSN (online)	2080-4873
ISSN	2080-4806
DOI	10.5173/ceju.2023.86
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Article ; Online: What Is in the Pipeline on Investigational Neuromodulation Techniques for Lower Urinary Tract Dysfunction: A Narrative Review.

Parodi, Stefano / Kendall, Harry J / Terrone, Carlo / Heesakkers, John P F A

Neuromodulation : journal of the International Neuromodulation Society

2023 Volume 27, Issue 2, Page(s) 267–272

Abstract: Objectives: Overactive bladder (OAB) affects millions of patients worldwide. Its treatment is challenging but improves the patient's quality of life. Besides standard techniques for neuromodulation (sacral and pudendal neuromodulation and posterior ... ...

Abstract	Objectives: Overactive bladder (OAB) affects millions of patients worldwide. Its treatment is challenging but improves the patient's quality of life. Besides standard techniques for neuromodulation (sacral and pudendal neuromodulation and posterior tibial nerve stimulation), several new techniques have been investigated to treat symptoms of refractory OAB. The purpose of the present review is to outline the state of the art of new neuromodulation techniques for lower urinary tract dysfunction (LUTD). Materials and methods: In March 2023, a comprehensive MEDLINE, EMBASE, and Scopus search was carried out (keywords: LUTD, new technologies, neuromodulation, LUTS, OAB, painful bladder syndromes, etc). Articles were included according to inclusion (randomized controlled trials, prospective trials, large retrospective studies) and exclusion (case reports, outcomes not clearly expressed in full text, animal studies) criteria. The reference lists of the included studies also were scanned. Both adult and pediatric populations were included, in addition to both neurogenic and nonneurogenic OAB. A narrative review was then performed. Results: Peroneal neuromodulation, transcutaneous electrical nerve stimulation, magnetic nerve stimulation, and parasacral transcutaneous neuromodulation are the most studied investigative techniques and were shown to yield promising results in treating OAB symptoms. Most studies showed promising results even in the complex scenarios of patients with OAB refractory to standard treatments. Comparing investigational techniques with standard of care and their respective clinical outcomes and safety profiles, and confronting their pros and cons, we reasonably believe that once such treatment modalities are further developed, they could play a role in the OAB treatment algorithm. Conclusions: Although the described neuromodulation techniques are being intensely studied, the available results are not yet sufficient for any guidelines to recommend their use.
MeSH term(s)	Humans ; Child ; Adult ; Urinary Bladder ; Prospective Studies ; Retrospective Studies ; Quality of Life ; Urinary Bladder, Overactive/therapy ; Transcutaneous Electric Nerve Stimulation/methods ; Tibial Nerve ; Treatment Outcome
Language	English
Publishing date	2023-10-21
Publishing country	United States
Document type	Journal Article ; Review
ZDB-ID	1500372-3
ISSN	1525-1403 ; 1094-7159
ISSN (online)	1525-1403
ISSN	1094-7159
DOI	10.1016/j.neurom.2023.09.002
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Article ; Online: Deep Gluteal Pain Syndrome: Endoscopic Technique and Medium-Term Functional Outcomes.

Parodi, Dante / Villegas, Diego / Escobar, Gonzalo / Bravo, José / Tobar, Carlos

The Journal of bone and joint surgery. American volume

2023 Volume 105, Issue 10, Page(s) 762–770

Abstract: Background: Sciatic nerve entrapment is an entity that generates disabling pain, mainly when the patient is sitting on the involved side. According to some studies, the presence of fibrovascular bands has been described as the main cause of this ... ...

Abstract	Background: Sciatic nerve entrapment is an entity that generates disabling pain, mainly when the patient is sitting on the involved side. According to some studies, the presence of fibrovascular bands has been described as the main cause of this pathology, and the sciatic nerve's decompression by endoscopic release has been described as an effective treatment generally associated with a piriformis tenotomy. The aim of this study was to present the medium-term functional results of endoscopic release of the sciatic nerve without resection of the piriformis tendon. Methods: This prospective, observational study included 57 patients who underwent an endoscopic operation for sciatic nerve entrapment between January 2014 and January 2019. In all cases, a detailed medical history was obtained and a physical examination and a functional evaluation were performed using the modified Harris hip score (mHHS), the 12-item International Hip Outcome Tool (iHOT-12), and the visual analog scale (VAS) for pain. All patients had pelvic radiographs and magnetic resonance imaging (MRI) scans of the hip on the involved side and underwent a prior evaluation by a spine surgeon. Results: This study included 20 male and 37 female patients with a mean age of 43.6 years (range, 24 to 88 years) and a mean follow-up of 22.7 months. The median mHHS improved from 59 to 85 points. The median iHOT-12 improved from 60 to 85 points. The median VAS decreased from 7 to 2. Postoperative complications occurred in 12% of patients: 1 patient with extensive symptomatic hematoma, 3 patients with hypoesthesia, and 3 patients with dysesthesia. Conclusions: Endoscopic release of the sciatic nerve by resection of fibrovascular bands without piriformis tenotomy is a technique with good to excellent functional results comparable with those of techniques in the literature incorporating piriformis tenotomy. Level of evidence: Therapeutic Level IV . See Instructions for Authors for a complete description of levels of evidence.
MeSH term(s)	Humans ; Male ; Female ; Adult ; Piriformis Muscle Syndrome/diagnosis ; Piriformis Muscle Syndrome/etiology ; Piriformis Muscle Syndrome/therapy ; Prospective Studies ; Sciatic Nerve/surgery ; Endoscopy/methods ; Treatment Outcome ; Nerve Compression Syndromes/surgery ; Retrospective Studies
Language	English
Publishing date	2023-03-21
Publishing country	United States
Document type	Observational Study ; Journal Article
ZDB-ID	220625-0
ISSN	1535-1386 ; 0021-9355
ISSN (online)	1535-1386
ISSN	0021-9355
DOI	10.2106/JBJS.22.00394
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Article ; Online: Influence of microphytobenthos on the sedimentary organic matter composition in two contrasting estuarine microhabitats.

Fernández, Carolina / Lara, Rubén J / Parodi, Elisa R

Environmental monitoring and assessment

2021 Volume 193, Issue 4, Page(s) 201

Abstract: The influence of microphytobenthic community on the composition of sedimentary organic matter was evaluated in two Bahía Blanca estuary microhabitats contrasting in vegetation and hydrodynamic conditions; namely, S1 located in a Sarcocornia perennis ... ...

Abstract	The influence of microphytobenthic community on the composition of sedimentary organic matter was evaluated in two Bahía Blanca estuary microhabitats contrasting in vegetation and hydrodynamic conditions; namely, S1 located in a Sarcocornia perennis saltmarsh with macroscopic microbial mats and S2 in a mudflat without macroscopic microbial mats or vegetation. Moisture, organic matter, chlorophyll a, phaeopigments, carbohydrates (CH), proteins (PRT), and abundance and structure of microphytobenthic community were evaluated in surface sediments. Higher moisture was observed at S2 and was related to the proximity of this site to the subtidal zone and the effect of the environmental variables temperature and rain. No significant differences were found in organic matter content between sites; however, at S1, a higher concentration was registered during winter and early spring associated to the period of higher microphytobenthic biomass. Chlorophyll a and phaeopigments were higher at S1, attributed to the higher microphytobenthos abundance at this site. Differences in microphytobenthos were observed not only in quantity but also in community structure since at S1 filamentous cyanobacteria dominated the community, whereas at S2, higher abundance of centric diatoms and the absence of cyanobacteria were observed during most of the study. S1 showed higher concentration of proteins and carbohydrates which could be attributed to the higher production of fresh organic matter by microphytobenthos. The total protein and carbohydrate concentrations allowed us to classify both microhabitats into the meso-oligotrophic category, contrasting with the classification made by other authors using water column proxies.
MeSH term(s)	Chlorophyll A ; Cyanobacteria ; Diatoms ; Environmental Monitoring ; Estuaries ; Geologic Sediments
Chemical Substances	Chlorophyll A (YF5Q9EJC8Y)
Language	English
Publishing date	2021-03-20
Publishing country	Netherlands
Document type	Journal Article
ZDB-ID	782621-7
ISSN	1573-2959 ; 0167-6369
ISSN (online)	1573-2959
ISSN	0167-6369
DOI	10.1007/s10661-021-08888-4
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Article ; Online: 5-year Outcomes of Fenestrated and Branched Endovascular Repair of Complex Aortic Aneurysms Based on Aneurysm Extent.

Raulli, Stephen J / Gomes, Vivian Carla / Parodi, F Ezequiel / Vasan, Priya / Sun, Dichen / Marston, William A / Pascarella, Luigi / McGinigle, Katharine L / Wood, Jacob C / Farber, Mark A

Journal of vascular surgery

2024

Abstract: Objectives: To evaluate the 5-year outcomes of fenestrated/branched endovascular aortic repair (F/BEVAR) for the treatment of complex aortic aneurysms stratified by the aneurysm extent.: Methods: Patients with the diagnosis of complex aortic aneurysm, ...

Abstract	Objectives: To evaluate the 5-year outcomes of fenestrated/branched endovascular aortic repair (F/BEVAR) for the treatment of complex aortic aneurysms stratified by the aneurysm extent. Methods: Patients with the diagnosis of complex aortic aneurysm, who underwent F/BEVAR at a single center were included in this study and retrospectively analyzed. The cohort was divided according to the aneurysm extent, comparing group 1 (types I-III thoracoabdominal aneurysms-TAAA), group 2 (type IV TAAA), and group 3 (juxtarenal, pararenal, or paravisceral aortic aneurysms - JRAA, PRAA, PVAA). The primary endpoints were 30-day and 5-year survival. The secondary endpoints were technical success, occurrence of spinal cord ischemia, primary patency of the visceral arteries, freedom from target vessel instability, and secondary interventions. Results: Of 436 patients who underwent F/BEVAR between July 2012 and May 2023, 131 presented with types I-III TAAA, 69 with type IV TAAA, and 236 with JRAA, PRAA, or PVAA. All cases were treated under a physician-sponsored IDE protocol with a patient-specific company-manufactured or off-the-shelf device. Group 1 had significantly younger patients than group 2 or 3 respectively (69.6 ± 8.7 vs 72.4 ± 7.1 vs 73.2 ± 7.3, P < .001) and had a higher percentage of females (50.4% vs 21.7% vs 17.8%, P < .001). Prior history of aortic dissection was significantly more common among patients in group 1 (26% vs 1.4% vs 0.9%, P < .001), and mean aneurysm diameter was larger in group 1 (64.5 vs 60.7 vs 63.2 mm, P = .033). Comorbidities were similar between groups, except for coronary artery disease (P < .001) and tobacco use (P = .003), which were less prevalent in group 1. Technical success was similar in the three groups (98.5% vs 98.6% vs 98.7%, P > .99). The 30-day mortality was 4.5%, 1.4%, and 0.4%, in groups 1, 2, and 3, respectively, and was significantly higher in group 1 when compared to group 3 (P = .01). The incidence of spinal cord ischemia was significantly higher in group 1 compared to group 3 (5.3 vs 4.3% vs .4%, P = .004). The 5-year survival was significantly higher in group 3 when compared to group 1 (P = .01). Freedom from secondary intervention was significantly higher in group 3 when compared to group 1 (P = .003). At 5 years, there was no significant difference in freedom from target vessel instability between groups or primary patency in the 1652 target vessels examined. Conclusions: Larger aneurysm extent was associated with lower 5-year survival, higher 30-day mortality, incidence of secondary interventions, and spinal cord ischemia. The prevalence of secondary interventions in all groups make meticulous follow-up paramount in complex aortic aneurysm patients treated with F/BEVAR.
Language	English
Publishing date	2024-04-10
Publishing country	United States
Document type	Journal Article
ZDB-ID	605700-7
ISSN	1097-6809 ; 0741-5214
ISSN (online)	1097-6809
ISSN	0741-5214
DOI	10.1016/j.jvs.2024.04.017
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Article ; Online: Characteristics of Hospitalized Adults With COVID-19 in an Integrated Health Care System in California.

Myers, Laura C / Parodi, Stephen M / Escobar, Gabriel J / Liu, Vincent X

JAMA

2020 Volume 323, Issue 21, Page(s) 2195–2198

MeSH term(s)	Aged ; Betacoronavirus ; COVID-19 ; COVID-19 Testing ; California/epidemiology ; Clinical Laboratory Techniques/statistics & numerical data ; Coronavirus Infections/diagnosis ; Coronavirus Infections/epidemiology ; Coronavirus Infections/mortality ; Coronavirus Infections/therapy ; Delivery of Health Care, Integrated ; Female ; Health Maintenance Organizations/statistics & numerical data ; Hospital Mortality ; Hospitalization/statistics & numerical data ; Humans ; Intensive Care Units/statistics & numerical data ; Male ; Middle Aged ; Oxygen Inhalation Therapy/statistics & numerical data ; Pandemics ; Pneumonia, Viral/diagnosis ; Pneumonia, Viral/epidemiology ; Pneumonia, Viral/mortality ; Pneumonia, Viral/therapy ; Retrospective Studies ; SARS-CoV-2
Keywords	covid19
Language	English
Publishing date	2020-04-09
Publishing country	United States
Document type	Journal Article
ZDB-ID	2958-0
ISSN	1538-3598 ; 0254-9077 ; 0002-9955 ; 0098-7484
ISSN (online)	1538-3598
ISSN	0254-9077 ; 0002-9955 ; 0098-7484
DOI	10.1001/jama.2020.7202
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Article ; Online: Heteroternary cucurbit[8]uril complexes as supramolecular scaffolds for self-assembled bifunctional photoredoxcatalysts.

Lutz, Fabian / Lorenzo-Parodi, Nerea / Schmidt, Torsten C / Niemeyer, Jochen

Chemical communications (Cambridge, England)

2021 Volume 57, Issue 23, Page(s) 2887–2890

Abstract: The self-assembly of bifunctional photoredoxcatalysts is reported. A series of photosensitizers and water-reducing catalysts were functionalized with viologen- and naphthol-units, respectively. Subsequent formation of the heteroternary cucurbit[8]uril- ... ...

Abstract	The self-assembly of bifunctional photoredoxcatalysts is reported. A series of photosensitizers and water-reducing catalysts were functionalized with viologen- and naphthol-units, respectively. Subsequent formation of the heteroternary cucurbit[8]uril-viologen-naphthol complexes was used for the constitution of bifunctional photoredoxcatalysts for hydrogen generation.
Language	English
Publishing date	2021-02-19
Publishing country	England
Document type	Journal Article
ZDB-ID	1472881-3
ISSN	1364-548X ; 1359-7345 ; 0009-241X
ISSN (online)	1364-548X
ISSN	1359-7345 ; 0009-241X
DOI	10.1039/d0cc08025j
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Article ; Online: Analysis of Lipid-linked Oligosaccharides Synthesized

Valko, Ayelen / Gallo, Giovanna L / Weisz, Ariel D / Parodi, Armando J / D'Alessio, Cecilia

Bio-protocol

2022 Volume 12, Issue 18

Abstract: Dolichol diphosphate-linked oligosaccharides (LLO) are the sugar donors ... ...

Abstract	Dolichol diphosphate-linked oligosaccharides (LLO) are the sugar donors in
Language	English
Publishing date	2022-09-20
Publishing country	United States
Document type	Journal Article
ZDB-ID	2833269-6
ISSN	2331-8325 ; 2331-8325
ISSN (online)	2331-8325
ISSN	2331-8325
DOI	10.21769/BioProtoc.4508
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Article ; Online: Hiperferritinemia: Experiencia de un Centro Universitario en Chile.

Huenur F, Julieth / Parodi C, María / Aravena G, Carmen / Eymin L, Gonzalo / Triantafilo C, Nicolás / Walkowiak N, Stefan / Valenzuela S, Andrés / Corsi S, Óscar

Revista medica de Chile

2024 Volume 151, Issue 4, Page(s) 412–419

Abstract: Introduction: The distribution of causes of hyperferritinemia in international series is heterogeneous. Also, the association between ferritin and prognosis is controversial. This study aims to describe the diagnosis associated with hyperferritinemia in ...

Title translation	Hyperferritinemia in a Chilean Academic Healthcare Network: A Retrospective Study.
Abstract	Introduction: The distribution of causes of hyperferritinemia in international series is heterogeneous. Also, the association between ferritin and prognosis is controversial. This study aims to describe the diagnosis associated with hyperferritinemia in a retrospective cohort at an academic healthcare network in Chile. Methods: A retrospective review of adult patients admitted to our academic medical center from June 2014 to February 2017 with ferritin ≥3,000 ng/mL. All patients were classified into nine diagnostic categories. Then, the association between ferritin level and disease category, as well as mortality, was evaluated. Results: Ninety-nine patients were identified. The mean age was 50.8 ± 19.9 years, 54.5% were men. The most frequent categories were "inflammatory and autoimmune diseases" (21.2%) and "hematological malignancies" (19.2%). The average ferritin was 10,539 ± 13,016.9 ng/mL, while the higher mean was 16,707 ng/mL in the "inflammatory and autoimmune diseases" category. There was a statistically significant association between the ferritin value and age but not between ferritin and diagnostic categories. In the group over 50, hematologic neoplasms (19%) and infections (19%) were more frequent. In those under 50, inflammatory and autoimmune diseases were more frequent (26.8%). There was no association between the ferritin level and mortality at 1, 3, and 12 months. Conclusions: The most frequent categories were "inflammatory and autoimmune diseases" and "hematological malignancies", but ferritin level was similar in both. Further research could validate a prognostic role.
MeSH term(s)	Humans ; Retrospective Studies ; Male ; Chile/epidemiology ; Middle Aged ; Female ; Adult ; Ferritins/blood ; Aged ; Hyperferritinemia/blood ; Prognosis ; Academic Medical Centers/statistics & numerical data ; Autoimmune Diseases/blood ; Young Adult
Chemical Substances	Ferritins (9007-73-2)
Language	Spanish
Publishing date	2024-03-19
Publishing country	Chile
Document type	English Abstract ; Journal Article
ZDB-ID	732136-3
ISSN	0717-6163 ; 0034-9887
ISSN (online)	0717-6163
ISSN	0034-9887
DOI	10.4067/s0034-98872023000400412
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Article: Leveraging Julia's automated differentiation and symbolic computation to increase spectral DCM flexibility and speed.

Hofmann, David / Chesebro, Anthony G / Rackauckas, Chris / Mujica-Parodi, Lilianne R / Friston, Karl J / Edelman, Alan / Strey, Helmut H

bioRxiv : the preprint server for biology

2023

Abstract: Using neuroimaging and electrophysiological data to infer neural parameter estimations from theoretical circuits requires solving the inverse problem. Here, we provide a new Julia language package designed to i) compose complex dynamical models in a ... ...

Abstract	Using neuroimaging and electrophysiological data to infer neural parameter estimations from theoretical circuits requires solving the inverse problem. Here, we provide a new Julia language package designed to i) compose complex dynamical models in a simple and modular way with ModelingToolkit.jl, ii) implement parameter fitting based on spectral dynamic causal modeling (sDCM) using the Laplace approximation, analogous to MATLAB implementation in SPM12, and iii) leverage Julia's unique strengths to increase accuracy and speed by employing Automatic Differentiation during the fitting procedure. To illustrate the utility of our flexible modular approach, we provide a method to improve correction for fMRI scanner field strengths (1.5T, 3T, 7T) when fitting models to real data.
Language	English
Publishing date	2023-11-01
Publishing country	United States
Document type	Preprint
DOI	10.1101/2023.10.27.564407
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