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  1. Article ; Online: Quantum tunneling in ultra-near-integrable systems.

    Iijima, Riku / Koda, Ryonosuke / Hanada, Yasutaka / Shudo, Akira

    Physical review. E

    2023  Volume 106, Issue 6-1, Page(s) 64205

    Abstract: We study the tunneling tail of eigenfunctions of the quantum map using arbitrary precision arithmetic and find that nonmonotonic decaying tails accompanied by step structures appear even when the corresponding classical system is extremely close to the ... ...

    Abstract We study the tunneling tail of eigenfunctions of the quantum map using arbitrary precision arithmetic and find that nonmonotonic decaying tails accompanied by step structures appear even when the corresponding classical system is extremely close to the integrable limit. Using the integrable basis constructed with the Baker-Campbell-Hausdorff (BCH) formula, we clarify that the observed structure emerges due to the coupling with excited states via the quantum resonance mechanism. Further calculations reveal that the step structure gives stretched exponential decay as a function of the inverse Planck constant, which is not expected to appear in normal tunneling processes.
    MeSH term(s) Vibration ; Quantum Theory
    Language English
    Publishing date 2023-01-20
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2844562-4
    ISSN 2470-0053 ; 2470-0045
    ISSN (online) 2470-0053
    ISSN 2470-0045
    DOI 10.1103/PhysRevE.106.064205
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  2. Article ; Online: Fast-track preparation of lung specimens for electron microscope observations of the pulmonary endothelial glycocalyx.

    Wakatsuki, Mone / Takaki, Takashi / Ushiyama, Akira / Honda, Kazuho / Iijima, Takehiko

    Medical molecular morphology

    2023  Volume 56, Issue 4, Page(s) 239–249

    Abstract: The glycocalyx (GCX) covers the luminal surface of blood vessels and regulates vascular permeability. As GCX degradation predicts various types of vasculopathy, confirming the presence of this structure is useful for diagnosis. Since the GCX layer is ... ...

    Abstract The glycocalyx (GCX) covers the luminal surface of blood vessels and regulates vascular permeability. As GCX degradation predicts various types of vasculopathy, confirming the presence of this structure is useful for diagnosis. Since the GCX layer is very fragile, careful fixation is necessary to preserve its structure. We explored appropriate and feasible methodologies for visualizing the GCX layer using lung tissue specimens excised from anesthetized mice. Each specimen was degassed and immersed in Alcian blue (ALB) fixative solution, and then observed using electron microscopy. Specimens from septic mice were prepared as negative GCX controls. Using these immersion-fixed specimens, the GCX layer was successfully observed using both transmission and scanning electron microscopy; these observations were similar to those obtained using the conventional method of lanthanum perfusion fixation. Spherical aggregates of GCX were observed in the septic mouse specimens, and the GCX density was lower in the septic specimens than in the non-septic specimens. Of note, the presently reported methodology reduced the specimen preparation time from 6 to 2 days. We, therefore, concluded that our novel method could be applied to human lung specimens and could potentially contribute to the further elucidation of vasculopathies.
    MeSH term(s) Mice ; Humans ; Animals ; Glycocalyx ; Electrons ; Endothelium, Vascular ; Microscopy, Electron, Scanning ; Lung
    Language English
    Publishing date 2023-07-05
    Publishing country Japan
    Document type Journal Article
    ZDB-ID 2190059-0
    ISSN 1860-1499 ; 1860-1480
    ISSN (online) 1860-1499
    ISSN 1860-1480
    DOI 10.1007/s00795-023-00360-1
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 4019: Show issues Location:
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  3. Article ; Online: Natural course of acute COVID-19 among healthy children in a tertiary hospital.

    Kondo, Ryota / Iijima, Hiroyuki / Funaki, Takanori / Ishiguro, Akira / Ogimi, Chikara

    Pediatrics international : official journal of the Japan Pediatric Society

    2023  Volume 65, Issue 1, Page(s) e15647

    Abstract: Background: Previous studies have reported the clinical and epidemiological characteristics of children with coronavirus disease 2019 (COVID-19) in a cross-sectional fashion; however, the natural course of each symptom based on a daily basis during the ... ...

    Abstract Background: Previous studies have reported the clinical and epidemiological characteristics of children with coronavirus disease 2019 (COVID-19) in a cross-sectional fashion; however, the natural course of each symptom based on a daily basis during the acute phase has not yet been clarified. This retrospective study aimed to describe the natural course of COVID-19 in children according to dominant variants.
    Methods: We conducted our study on symptomatic children with COVID-19 who were hospitalized at the National Center for Child Health and Development, in Japan. We excluded patients who were observed for less than 9 days and those with underlying disease, COVID-19 vaccination, coinfection, complications, or therapeutic intervention. We collected the data on each participant's age at admission, sex, medical history, observation period, hospitalization period, SARS-CoV-2 test results, and 10 daily symptoms in the first 9 days from the illness onset.
    Results: Eventually, 115 children were included in this study. The prevalence of fever during the omicron era declined more rapidly over time than that during the pre-omicron era. The prevalence of cough and rhinorrhea did not decline during the observation period, and these clinical manifestations were more common during the pre-omicron era at any point. The prevalence of dysgeusia and/or dysosmia steadily increased over time in the pre-omicron era. This study demonstrated that the prevalence of some symptoms differed not only at the onset but also over time during the acute phase.
    Conclusion: Details of the natural clinical course of children with COVID-19 help primary care physicians to manage these patients.
    MeSH term(s) Humans ; Child ; COVID-19/epidemiology ; Tertiary Care Centers ; SARS-CoV-2 ; COVID-19 Vaccines ; Cross-Sectional Studies ; Retrospective Studies
    Chemical Substances COVID-19 Vaccines
    Language English
    Publishing date 2023-10-04
    Publishing country Australia
    Document type Journal Article
    ZDB-ID 1470376-2
    ISSN 1442-200X ; 1328-8067
    ISSN (online) 1442-200X
    ISSN 1328-8067
    DOI 10.1111/ped.15647
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 848: Show issues Location:
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  4. Article: Bacterial meningitis due to the

    Fukayama, Haruka / Shoji, Kensuke / Yoshida, Michiko / Iijima, Hiroyuki / Maekawa, Takanobu / Ishiguro, Akira / Miyairi, Isao

    IDCases

    2022  Volume 27, Page(s) e01406

    Abstract: ... ...

    Abstract The
    Language English
    Publishing date 2022-01-13
    Publishing country Netherlands
    Document type Case Reports
    ZDB-ID 2745454-X
    ISSN 2214-2509
    ISSN 2214-2509
    DOI 10.1016/j.idcr.2022.e01406
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  5. Article: Case of atrial septal defect closure relieving refractory migraine.

    Hoshina, Yuta / Iijima, Hiroyuki / Kubota, Mitsuru / Murakami, Tsutomu / Nagai, Akira

    Clinical case reports

    2022  Volume 10, Issue 11, Page(s) e6484

    Abstract: The effectiveness of patent foramen ovale closure for migraine has been previously discussed. By contrast, very few studies have reported the association between migraine and atrial septal defect closure. Here, we report a case in which atrial septal ... ...

    Abstract The effectiveness of patent foramen ovale closure for migraine has been previously discussed. By contrast, very few studies have reported the association between migraine and atrial septal defect closure. Here, we report a case in which atrial septal defect closure effectively relieved migraine headaches.
    Language English
    Publishing date 2022-11-06
    Publishing country England
    Document type Case Reports
    ZDB-ID 2740234-4
    ISSN 2050-0904
    ISSN 2050-0904
    DOI 10.1002/ccr3.6484
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  6. Article: Time-Dependent Dynamics Required for the Degradation and Restoration of the Vascular Endothelial Glycocalyx Layer in Lipopolysaccharide-Treated Septic Mice.

    Shinohara, Akane / Ushiyama, Akira / Iijima, Takehiko

    Frontiers in cardiovascular medicine

    2021  Volume 8, Page(s) 730298

    Abstract: The endothelial glycocalyx (GCX) plays a key role in the development of organ failure following sepsis. Researchers have investigated GCX degradation caused by pathological conditions. Nonetheless, the GCX restoration process remains poorly understood. ... ...

    Abstract The endothelial glycocalyx (GCX) plays a key role in the development of organ failure following sepsis. Researchers have investigated GCX degradation caused by pathological conditions. Nonetheless, the GCX restoration process remains poorly understood. Herein, we developed a model in which GCX restoration could be reproduced in mice using
    Language English
    Publishing date 2021-09-14
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2781496-8
    ISSN 2297-055X
    ISSN 2297-055X
    DOI 10.3389/fcvm.2021.730298
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  7. Article ; Online: Single-polyp metabolomics for coral health assessment.

    Iguchi, Akira / Iijima, Mariko / Mizusawa, Nanami / Ohno, Yoshikazu / Yasumoto, Ko / Suzuki, Atsushi / Suga, Shunichi / Tanaka, Ken / Zaitsu, Kei

    Scientific reports

    2024  Volume 14, Issue 1, Page(s) 3369

    Abstract: Coral reef ecosystems supported by environmentally sensitive reef-building corals face serious threats from human activities. Our understanding of these reef threats is hampered by the lack of sufficiently sensitive coral environmental impact assessment ... ...

    Abstract Coral reef ecosystems supported by environmentally sensitive reef-building corals face serious threats from human activities. Our understanding of these reef threats is hampered by the lack of sufficiently sensitive coral environmental impact assessment systems. In this study, we established a platform for metabolomic analysis at the single-coral-polyp level using state-of-the-art mass spectrometry (probe electrospray ionization/tandem mass spectrometry; PESI/MS/MS) capable of fine-scale analysis. We analyzed the impact of the organic UV filter, benzophenone (BP), which has a negative impact on corals. We also analyzed ammonium and nitrate samples, which affect the environmental sensitivity of coral-zooxanthella (Symbiodiniaceae) holobionts, to provide new insights into coral biology with a focus on metabolites. The method established in this study breaks new ground by combining PESI/MS/MS with a technique for coral polyps that can control the presence or absence of zooxanthellae in corals, enabling functions of zooxanthellae to be assessed on a polyp-by-polyp basis for the first time. This system will clarify biological mechanisms of corals and will become an important model system for environmental impact assessment using marine organisms.
    MeSH term(s) Humans ; Animals ; Anthozoa ; Ecosystem ; Tandem Mass Spectrometry ; Coral Reefs ; Dinoflagellida ; Polyps
    Language English
    Publishing date 2024-03-05
    Publishing country England
    Document type Journal Article
    ZDB-ID 2615211-3
    ISSN 2045-2322 ; 2045-2322
    ISSN (online) 2045-2322
    ISSN 2045-2322
    DOI 10.1038/s41598-024-53294-8
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  8. Article ; Online: Accuracy of transcutaneous bilirubin level measured by a JM-105 bilirubinometer.

    Ohishi, Akira / Kondo, Miyuki / Fujita, Tomoka / Baba, Toru / Iijima, Shigeo

    Pediatrics and neonatology

    2022  Volume 64, Issue 1, Page(s) 32–37

    Abstract: Background: Transcutaneous bilirubin (TcB) measurement is useful, but dissociation with total serum bilirubin (TSB) is a clinical problem in measurement. We verified the accuracy of the latest version of the JM-105 jaundice meter.: Methods: The TcB, ... ...

    Abstract Background: Transcutaneous bilirubin (TcB) measurement is useful, but dissociation with total serum bilirubin (TSB) is a clinical problem in measurement. We verified the accuracy of the latest version of the JM-105 jaundice meter.
    Methods: The TcB, TSB, and hematocrit (Hct) measurements obtained in the first 4 days of life in 2788 term neonates were analyzed.
    Results: When divided into 2-mg/dL classes, the difference between the TcB and TSB measurements did not change as TcB increased, but both overestimation and underestimation of TcB increased as TcB increased. At TcB greater than 11 mg/dL, inaccurate measurements with dissociation greater than 2 mg/dL exceeded 10% of the TcB measurements. The Hct value was associated with overestimation and underestimation.
    Conclusion: To evaluate neonatal jaundice accurately, it is desirable to measure TSB by blood sampling before discharge from obstetrics or in the case of worsening jaundice on day 4 or 5 of life.
    MeSH term(s) Infant, Newborn ; Humans ; Bilirubin ; Neonatal Screening ; Sensitivity and Specificity ; Jaundice, Neonatal/diagnosis ; Jaundice
    Chemical Substances Bilirubin (RFM9X3LJ49)
    Language English
    Publishing date 2022-08-24
    Publishing country Singapore
    Document type Journal Article
    ZDB-ID 2441816-X
    ISSN 2212-1692 ; 1875-9572
    ISSN (online) 2212-1692
    ISSN 1875-9572
    DOI 10.1016/j.pedneo.2022.05.012
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    In stock of ZB MED Cologne/Königswinter

    Zs.B 1083: Show issues Location:
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  9. Article ; Online: Walking capacity of Japanese patients with colorectal cancer relates to early postoperative health-related quality of life: a multi-center cohort study.

    Hara, Tsuyoshi / Kogure, Eisuke / Iijima, Shinno / Fukawa, Yasuhisa / Kubo, Akira / Kakuda, Wataru

    Physiotherapy theory and practice

    2023  , Page(s) 1–9

    Abstract: Purpose: This study investigated the impact of surgical treatment on the health-related quality of life (HRQOL) of Japanese patients with colorectal cancer (CRC).: Methods: This three-institution cohort study included 106 Japanese patients with CRC ( ... ...

    Abstract Purpose: This study investigated the impact of surgical treatment on the health-related quality of life (HRQOL) of Japanese patients with colorectal cancer (CRC).
    Methods: This three-institution cohort study included 106 Japanese patients with CRC (69 men; mean age: 62.6 ± 12.4 years; age range = 30-85 years). HRQOL was evaluated using the Short-Form 36-Item Health Survey version 2 one to two days prior to surgery (baseline) and four weeks after surgery. Clinical characteristics, social characteristics, and HRQOL at baseline were investigated.
    Results: Physical functioning, role-physical, bodily pain, and social functioning decreased significantly at four weeks after surgery compared with baseline, whereas mental health significantly improved. Physical functioning and general health perception showed an especially strong relation with the six-minute walk test (6MWT) at four weeks after surgery and HRQOL scores at baseline. The cutoff value for the 6MWT for clinically relevant improvement was 552.5 meters for physical functioning (area under curve [AUC] = 0.780, 95% confidence interval [CI] = 0.692-0.867) and 480.3 meters for general health perception (AUC = 0.721, 95% CI = 0.626-0.817).
    Conclusion: Patients with CRC could potentially improve their postoperative HRQOL by increasing their walking capacity post-surgery, and they may need follow-up interventions after discharge such as physical rehabilitation to do so. The results provide a potential pathway for improving HRQOL of Japanese patients with CRC.
    Language English
    Publishing date 2023-04-21
    Publishing country England
    Document type Journal Article
    ZDB-ID 1045333-7
    ISSN 1532-5040 ; 0959-3985
    ISSN (online) 1532-5040
    ISSN 0959-3985
    DOI 10.1080/09593985.2023.2204481
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    Zs.A 2190: Show issues Location:
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  10. Article: Addition of the nutrition factor enhances the cancer prehabilitation program design for colorectal cancer patients: a multi-center cohort study.

    Hara, Tsuyoshi / Kogure, Eisuke / Iijima, Shinno / Fukawa, Yasuhisa / Kubo, Akira / Kakuda, Wataru

    Journal of physical therapy science

    2023  Volume 35, Issue 12, Page(s) 817–824

    Abstract: Purpose] The purpose of this study was to investigate the interrelationship between different baseline functional capacity items, and their relationship with postoperative course in colorectal cancer patients. [Participants and Methods] This was a three- ...

    Abstract [Purpose] The purpose of this study was to investigate the interrelationship between different baseline functional capacity items, and their relationship with postoperative course in colorectal cancer patients. [Participants and Methods] This was a three-institution cohort study that included 127 patients scheduled for elective colorectal cancer surgery. Baseline functional capacity was evaluated using skeletal muscle index (SMI), six-minute walk test (6MWT), serum-albumin (Alb), vitality, and mental health before surgery. Postoperative findings, including C-reactive protein (CRP) levels 3 days post-operation, frequency of postoperative complications, and length of hospital stay (LOS), were evaluated based on the medical records. [Results] CRP was positively related to SMI, but negatively related to Alb level. LOS was negatively related to vitality. The 6MWT results and mental health-related findings were not significantly related to the postoperative course, but were directly and indirectly related to vitality, respectively. Alb level was also indirectly related to vitality through the 6MWT and mental health-related findings. The final constructed model demonstrated an acceptable fit to the data (goodness-of-fit index=0.958, adjusted goodness-of-fit index=0.930, comparative fit index=1.000, root mean square error of approximation=0.000). [Conclusion] Nutrition status, as measured by Alb level before surgery, may positively affect both the postoperative course and other functional capacity parameters.
    Language English
    Publishing date 2023-12-01
    Publishing country Japan
    Document type Journal Article
    ZDB-ID 2038898-6
    ISSN 0915-5287
    ISSN 0915-5287
    DOI 10.1589/jpts.35.817
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