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Article: Editorial: Cerebrovascular imaging-From micro- to macroscopic scales.

Zhu, Chengcheng / Tanter, Mickael / Fan, Zhaoyang / Hu, Song / Sadat, Umar / Wang, Danny J J

2022 Volume 16, Page(s) 1086022

Language	English
Publishing date	2022-11-22
Publishing country	Switzerland
Document type	Editorial
ZDB-ID	2411902-7
ISSN	1662-453X ; 1662-4548
ISSN (online)	1662-453X
ISSN	1662-4548
DOI	10.3389/fnins.2022.1086022
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Article ; Online: N-acetylcysteine in contrast-induced acute kidney injury: clinical use against principles of evidence-based clinical medicine!

Sadat, Umar

Expert review of cardiovascular therapy

2014 Volume 12, Issue 1, Page(s) 1–3

Abstract: Contrast-induced acute kidney injury (CI-AKI) is one of the most widely discussed and debated topic in cardiovascular medicine and N-acetylcysteine (NAC) is the most widely used pharmacological agent assessed in clinical trials for offering renal ... ...

Abstract	Contrast-induced acute kidney injury (CI-AKI) is one of the most widely discussed and debated topic in cardiovascular medicine and N-acetylcysteine (NAC) is the most widely used pharmacological agent assessed in clinical trials for offering renal protection against CI-AKI. Results of these clinical trials are though split between those that favor its use and vice versa. In this brief communication we discuss the latest research advances regarding the use of NAC against CI-AKI. Recent clinical evidence and overview of in-depth statistical analyses of relevant clinical trials and their meta-analyses do not support the use of NAC in prophylaxis against CI-AKI. Adequate hydration before and after contrast media exposure, along with avoidance of nephrotoxic drugs, remains the recommended prophylaxis against CI-AKI.
MeSH term(s)	Acetylcysteine/pharmacology ; Acute Kidney Injury/chemically induced ; Acute Kidney Injury/diagnosis ; Acute Kidney Injury/drug therapy ; Contrast Media/adverse effects ; Evidence-Based Medicine ; Humans ; Kidney/drug effects ; Treatment Outcome
Chemical Substances	Contrast Media ; Acetylcysteine (WYQ7N0BPYC)
Language	English
Publishing date	2014-01
Publishing country	England
Document type	Editorial
ZDB-ID	2192343-7
ISSN	1744-8344 ; 1477-9072
ISSN (online)	1744-8344
ISSN	1477-9072
DOI	10.1586/14779072.2014.852066
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Article: Radiographic contrast-media-induced acute kidney injury: pathophysiology and prophylactic strategies.

Sadat, Umar

ISRN radiology

2013 Volume 2013, Page(s) 496438

Abstract: Contrast-induced acute kidney injury (CI-AKI) is one of the most widely discussed and debated topics in cardiovascular medicine. With increasing number of contrast-media- (CM-) enhanced imaging studies being performed and growing octogenarian population ... ...

Abstract	Contrast-induced acute kidney injury (CI-AKI) is one of the most widely discussed and debated topics in cardiovascular medicine. With increasing number of contrast-media- (CM-) enhanced imaging studies being performed and growing octogenarian population with significant comorbidities, incidence of CI-AKI remains high. In this review, pathophysiology of CI-AKI, its relationship with different types of CM, role of serum and urinary biomarkers for diagnosing CI-AKI, and various prophylactic strategies used for nephroprotection against CI-AKI are discussed in detail.
Language	English
Publishing date	2013-09-16
Publishing country	United States
Document type	Journal Article ; Review
ZDB-ID	2688729-0
ISSN	2314-4084
ISSN	2314-4084
DOI	10.5402/2013/496438
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Article ; Online: Clinical feasibility of diffuse speckle contrast analysis for real-time tissue perfusion monitoring.

Awopetu, Ayoola I / Gohel, Manjit S / Sadat, Umar / Hayes, Paul D

International angiology : a journal of the International Union of Angiology

2021 Volume 41, Issue 1, Page(s) 82–89

Abstract: Background: Adequate tissue perfusion is an important prognostic and diagnostic factor during the management of lower limb peripheral arterial disease. Convenient and real-time tissue perfusion monitoring remains an elusive challenge.: Methods: ... ...

Abstract	Background: Adequate tissue perfusion is an important prognostic and diagnostic factor during the management of lower limb peripheral arterial disease. Convenient and real-time tissue perfusion monitoring remains an elusive challenge. Methods: Tissue perfusion on the dorsal and plantar surfaces of both feet of 20 participants was measured during and after cuff-induced ischemia using a novel 4-channel, laser-based perfusion monitoring device based on diffuse speckle contrast analysis technology (Pedra sensors). Participants were free of significant peripheral arterial disease. Transcutaneous partial pressure of oxygen (TcPO<inf>2</inf>) measurements were recorded concurrently for comparison. Results: Pedra sensors detected perfusion changes significantly more quickly than TcPO<inf>2</inf> sensors. One minute after induced ischemia, the mean percent changes from baseline values (before ischemia) were -22.7±32.0% and -3.1±8.8% (P<0.001) for Pedra and TcPO<inf>2</inf> sensors, respectively. One minute into induced ischemia, Pedra sensors had reached 50.5% of the 5-minute ischemia reading whereas TcPO<inf>2</inf> sensors had reached only 18.6% of the 5-minute reading (P=0.046). Pedra sensors reported hyperemia immediately after cuff release with a mean percent change from baseline of 143.8±122.3%/173.4±121.8% on the dorsal/plantar surfaces while TcPO<inf>2</inf> measurements were still recording negative changes at that time (-26.7±19.4%/-18.6±24.4% dorsal/plantar). Pedra sensors exhibited markedly lower interobserver and intraobserver variability than TcPO<inf>2</inf> sensors. Conclusions: A device based on diffuse speckle contrast analysis reported tissue perfusion in real time. Cuff-induced ischemia and hyperemia following cuff release were rapidly and consistently detected on both the dorsal and plantar surfaces of the foot. Diffuse speckle contrast analysis may have value for real-time perfusion monitoring during angiography procedures.
MeSH term(s)	Blood Gas Monitoring, Transcutaneous ; Feasibility Studies ; Humans ; Ischemia/diagnosis ; Perfusion ; Peripheral Arterial Disease/diagnostic imaging
Language	English
Publishing date	2021-11-26
Publishing country	Italy
Document type	Journal Article
ZDB-ID	604910-2
ISSN	1827-1839 ; 0392-9590
ISSN (online)	1827-1839
ISSN	0392-9590
DOI	10.23736/S0392-9590.21.04740-4
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Article ; Online: Atheromatous plaque hemorrhage: early detection and its impact on the management of patients with carotid artery disease.

Sadat, Umar

Expert review of cardiovascular therapy

2009 Volume 7, Issue 1, Page(s) 25–27

Language	English
Publishing date	2009-01
Publishing country	England
Document type	Comment ; Journal Article
ZDB-ID	2192343-7
ISSN	1744-8344 ; 1477-9072
ISSN (online)	1744-8344
ISSN	1477-9072
DOI	10.1586/14779072.7.1.25
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Article ; Online: Contrast-induced nephropathy: do statins offer protection?

Sadat, Umar

Current opinion in cardiology

2011 Volume 26, Issue 4, Page(s) 334–337

Abstract: Purpose of review: Contrast-induced nephropathy (CIN) is a commonly occurring complication associated with the use of contrast media in radiological studies. Various clinical studies have been reported investigating the nephroprotective role of statins. ...

Abstract	Purpose of review: Contrast-induced nephropathy (CIN) is a commonly occurring complication associated with the use of contrast media in radiological studies. Various clinical studies have been reported investigating the nephroprotective role of statins. In this article, we review relevant clinical studies reported in 2010. Recent findings: An overview of these indicates that the evidence for the use of statins specifically for offering renal protection against CIN is conflicting and inconclusive. Summary: Pending large, well designed, adequately powered randomized controlled trials, it can be concluded that at present there is no definite evidence for their use in preventing CIN apart from their antiatherosclerotic use. However, using the analogy of beneficial effect of statin preloading with percutaneous coronary intervention, it can be speculated that high-dose statin may be beneficial in affording nephroprotection against CIN.
MeSH term(s)	Amidohydrolases/blood ; Atorvastatin Calcium ; Contrast Media/adverse effects ; Heptanoic Acids/pharmacology ; Humans ; Hydroxymethylglutaryl-CoA Reductase Inhibitors/pharmacology ; Kidney Diseases/blood ; Kidney Diseases/chemically induced ; Kidney Diseases/epidemiology ; Kidney Diseases/prevention & control ; Pyrroles/pharmacology ; Randomized Controlled Trials as Topic
Chemical Substances	Contrast Media ; Heptanoic Acids ; Hydroxymethylglutaryl-CoA Reductase Inhibitors ; Pyrroles ; Atorvastatin Calcium (48A5M73Z4Q) ; Amidohydrolases (EC 3.5.-) ; creatininase (EC 3.5.2.10)
Language	English
Publishing date	2011-07
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't ; Review
ZDB-ID	645186-x
ISSN	1531-7080 ; 0268-4705
ISSN (online)	1531-7080
ISSN	0268-4705
DOI	10.1097/HCO.0b013e3283470340
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Article ; Online: Modeling and computational framework of radiative hybrid nanofluid configured by a stretching surface subject to entropy generation

Umar Farooq / Hassan Waqas / Musaad S. Aldhabani / Nahid Fatima / Abdullah Alhushaybari / Mohamed R. Ali / R. Sadat / Taseer Muhammad

Arabian Journal of Chemistry, Vol 16, Iss 4, Pp 104628- (2023)

Using Keller box scheme

2023

Abstract: This study examines the characteristics of the velocity, thermal field and entropy profiles for hybrid nanofluid flow passing through a starching sheet with thermal radiation. The carbon nanotube (SWCNT and MWCNT) are used as a nanoparticles with ... ...

Abstract	This study examines the characteristics of the velocity, thermal field and entropy profiles for hybrid nanofluid flow passing through a starching sheet with thermal radiation. The carbon nanotube (SWCNT and MWCNT) are used as a nanoparticles with Cattaneo-Christov (CC) heat flux. Ethylene glycol is utilized as a base fluid in this case. To achieve an improved solution, the fluid flow over the geometric properties is designed using highly non-linear PDEs, and the governing equations must be converted into dimensionless non-similar equation systems using the highly efficient well-known Keller-box scheme in computational software MATLAB. The practical feasibility of these solutions is determined by the range of the controlling parameters. The velocity distribution reduces as the magnetic parameter estimate increases, however, the temperature field and entropy production increase as the magnetic parameter fluctuation esclates. As the slip parameter is increased, the velocity field diminish. The thermal field is enhanced for rising the radiation parameter, and the entropy profile is boosted for increasing Brinkman parameter values. The findings of this research might have a significant impact on industries where local cooling and heating via impingement jets are needed in electronic devices, heat sinks, drying technologies, and so on. To the best of the authors' knowledge, this is the first effort to employ a hybrid nanofluid to analyze entropy formation due to magnetohydrodynamics flow over a starching sheet.
Keywords	Hybrid nanofluid ; (Carbon nanotube ; Ferro) ; Ethylene glycol base fluid ; Thermal radiation ; Entropy generation ; Chemistry ; QD1-999
Subject code	532
Language	English
Publishing date	2023-04-01T00:00:00Z
Publisher	Elsevier
Document type	Article ; Online
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Article ; Online: Numerical treatment of Casson nanofluid Bioconvectional flow with heat transfer due to stretching cylinder/plate

Umar Farooq / Hassan Waqas / Sharifah E.Alhazmi / Abdullah Alhushaybari / Muhammad Imran / R. Sadat / Taseer Muhammad / Mohamed R. Ali

Arabian Journal of Chemistry, Vol 16, Iss 4, Pp 104589- (2023)

Variable physical properties

2023

Abstract: Purpose: The purpose of the current framework is to scrutinize the two-dimensional flow and heat transfer of Casson nanofluid over cylinder/plate along with impacts of thermophoresis and Brownian motion effects. Also, the effects of exponential thermal ... ...

Abstract	Purpose: The purpose of the current framework is to scrutinize the two-dimensional flow and heat transfer of Casson nanofluid over cylinder/plate along with impacts of thermophoresis and Brownian motion effects. Also, the effects of exponential thermal sink/source, bioconvection, and motile microorganisms are taken. Methodology/Approach: The resulting non-linear equations (PDEs) are reformed into nonlinear ODEs by using appropriate similarity variables. The resultant non-linear (ODEs) were numerically evaluated by the use of the Bvp4c package in the mathematical solver MATLAB. Findings: The numerical and graphical illustration regarding outcomes represents the performance of flow-involved physical parameters on velocity, temperature, concentration, and microorganism profiles. Additionally, the skin friction coefficient, local Nusselt number, local Sherwood number, and local microorganism density number are computed numerically for the current presented system. We noted that the velocity profile diminishes for the rising estimations of magnetic and mixed convection parameters. The Prandtl number corresponds with the declining performance of the temperature profile observed. The enhancement in the values of the Solutal Biot number and Brownian motion parameter increased in the concentration profile. Originality: In specific, this framework focuses on the rising heat transfer of Casson nanofluid with bioconvection by using a shooting mathematical model. The novel approach of the presented study is the use of motile microorganisms with exponential thermal sink/source in a Casson nano-fluid through a cylinder/plate. A presented study performed first time in the author’s opinion. Understanding the flow characteristics and behaviors of these nanofluids is crucial for the scientific community in the developing subject of nanofluids.
Keywords	Casson nanofluid ; Bioconvection ; Motile microorganisms ; Exponential heat source-sink ; Shooting approach (bvp4c) ; Cylinder/Plate ; Chemistry ; QD1-999
Subject code	532
Language	English
Publishing date	2023-04-01T00:00:00Z
Publisher	Elsevier
Document type	Article ; Online
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Article ; Online: Signaling pathways of cardioprotective ischemic preconditioning.

Sadat, Umar

International journal of surgery (London, England)

2009 Volume 7, Issue 6, Page(s) 490–498

Abstract: Background: Ischemia/reperfusion (I/R) injury is a major contributory factor to cardiac dysfunction and infarct size that determines patient prognosis after acute myocardial infarction. During the last 20 years, since the appearance of the first ... ...

Abstract	Background: Ischemia/reperfusion (I/R) injury is a major contributory factor to cardiac dysfunction and infarct size that determines patient prognosis after acute myocardial infarction. During the last 20 years, since the appearance of the first publication on ischemic preconditioning (IP), our knowledge of this phenomenon has increased exponentially. Results and conclusion: Basic scientific experiments and preliminary clinical trials in humans suggest that IP confers resistance to subsequent sustained ischemic insults not only in the regional tissue but also in distant organs (remote ischemic preconditioning), which may provide a simple, cost-effective means of reducing the risk of perioperative myocardial ischemia. The mechanism may be humoral, neural, or a combination of both, and involves adenosine, bradykinin, protein kinases and K(ATP) channels, although the precise end-effector remains unclear. This review describes different signaling pathways involved in acute ischemic preconditioning in detail.
MeSH term(s)	Acetylcholine/metabolism ; Adenosine/metabolism ; Angioplasty, Balloon, Coronary/adverse effects ; Angioplasty, Balloon, Coronary/methods ; Animals ; Bradykinin/metabolism ; Coronary Circulation/physiology ; Disease Models, Animal ; Humans ; Ischemic Preconditioning, Myocardial/methods ; Myocardial Infarction/diagnostic imaging ; Myocardial Infarction/therapy ; Myocardial Reperfusion Injury/prevention & control ; Primary Prevention/methods ; Prognosis ; Prospective Studies ; Protein Kinases/metabolism ; Radiography ; Reactive Oxygen Species/metabolism ; Risk Assessment ; Signal Transduction/physiology
Chemical Substances	Reactive Oxygen Species ; Protein Kinases (EC 2.7.-) ; Adenosine (K72T3FS567) ; Acetylcholine (N9YNS0M02X) ; Bradykinin (S8TIM42R2W)
Language	English
Publishing date	2009-12
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't ; Review
ZDB-ID	2212038-5
ISSN	1743-9159 ; 1743-9191
ISSN (online)	1743-9159
ISSN	1743-9191
DOI	10.1016/j.ijsu.2009.06.004
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Article ; Online: Thermoregulation in humid climate-adapted and Savannah breeds of goats exposed to West African cold (harmattan) season

Habibu Buhari / Umar Kausar Mohammed / Yaqub Lukman Surakat / Salifu Sadat / Makun Hussaina Joan

Agricultura Tropica et Subtropica, Vol 54, Iss 1, Pp 192-

2021 Volume 200

Abstract: The West African Dwarf (WAD) goats have hereditary dwarfism and are adapted to the humid climate. The study compared the cold tolerance of WAD and Savannah (Red Sokoto and Sahel) goats during the peak of the West African cold season in the Northern ... ...

Abstract	The West African Dwarf (WAD) goats have hereditary dwarfism and are adapted to the humid climate. The study compared the cold tolerance of WAD and Savannah (Red Sokoto and Sahel) goats during the peak of the West African cold season in the Northern Guinea Savannah of Nigeria. A total of 18 adult non-pregnant, dry does comprising equal number of each breed (six per breed) were used for the study. Thermoregulatory variables were recorded four times in the morning (07:00 h) and afternoon (13:00 h) hours at two-day intervals. Results revealed that irrespective of the hour of day, the WAD had significantly (p < 0.05) higher respiratory rate when compared with Red Sokoto and Sahel goats. The diurnal afternoon rise in respiratory rate and the magnitude of afternoon rise in rectal temperature was higher (p < 0.0001) in WAD than Sahel and Red Sokoto goats. The body surface temperature in the morning hours was significantly lower in WAD compared with Sahel breed, while in the afternoon hours, the inter-digital space temperature was significantly lower in WAD compared with Savannah breeds. However, there were no significant (p > 0.05) differences in heart rate, rectal, head and leg temperatures between the breeds in both morning and afternoon hours. Discriminant analysis revealed that the morning hours induced greater homogeneity in the thermoregulatory responses between the breeds adapted to the humid and Savannah climates as compared with the afternoon hours. It was concluded that although WAD goats employed more intense peripheral vasoconstriction to survive cold exposure and demonstrated greater diurnal amplitude in thermoregulatory variables, they maintained comparable core body temperature as the indigenous Savannah breeds. Thus, suggesting that despite the hereditary dwarfism, the WAD goats could conserve body heat during the West African cold season in the Northern Guinea Savannah zone of Nigeria.
Keywords	humid climate breed ; savannah breed ; northern guinea savannah ; thermoregulatory variables ; hereditary dwarfism ; Agriculture ; S
Subject code	630
Language	English
Publishing date	2021-01-01T00:00:00Z
Publisher	Sciendo
Document type	Article ; Online
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