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Article: Biodistribution and radiation dosimetry of

Moraitis, Alexandros / Jentzen, Walter / Reiter, Gloria / Schmitz, Jochen / Pöppel, Thorsten Dirk / Weber, Manuel / Herrmann, Ken / Fendler, Wolfgang Peter / Fragoso Costa, Pedro / Bockisch, Andreas / Kersting, David

EJNMMI physics

2024 Volume 11, Issue 1, Page(s) 3

Abstract: Aim: Positron emission tomography (PET) using : Methods: Adult patients with neural crest tumours who underwent sequential : Results: Twenty-one patients (11 females, 10 males) were evaluated. For adults, the organs exposed to the highest dose per ...

Abstract	Aim: Positron emission tomography (PET) using Methods: Adult patients with neural crest tumours who underwent sequential Results: Twenty-one patients (11 females, 10 males) were evaluated. For adults, the organs exposed to the highest dose per unit administered activity were urinary bladder (1.54 ± 0.40 mGy/MBq), salivary glands (0.77 ± 0.28 mGy/MBq) and liver (0.65 ± 0.22 mGy/MBq). Mean effective dose coefficient for adults was 0.25 ± 0.04 mSv/MBq (male: 0.24 ± 0.03 mSv/MBq, female: 0.26 ± 0.06 mSv/MBq), and increased gradually to 0.29, 0.44, 0.69, 1.21, and 2.94 mSv/MBq for the 15-, 10-, 5-, 1-years-old, and newborn paediatric reference patients. Projected mean effective dose coefficients for Conclusion: PET-based derived radiation dosimetry data for
Language	English
Publishing date	2024-01-03
Publishing country	Germany
Document type	Journal Article
ZDB-ID	2768912-8
ISSN	2197-7364
ISSN	2197-7364
DOI	10.1186/s40658-023-00604-0
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Article ; Online: Biodistribution and radiation dosimetry of 124I-mIBG in adult patients with neural crest tumours and extrapolation to paediatric models

Alexandros Moraitis / Walter Jentzen / Gloria Reiter / Jochen Schmitz / Thorsten Dirk Pöppel / Manuel Weber / Ken Herrmann / Wolfgang Peter Fendler / Pedro Fragoso Costa / Andreas Bockisch / David Kersting

EJNMMI Physics, Vol 11, Iss 1, Pp 1-

2024 Volume 14

Abstract: Abstract Aim Positron emission tomography (PET) using 124I-mIBG has been established for imaging and pretherapeutic dosimetry. Here, we report the first systematic analysis of the biodistribution and radiation dosimetry of 124I-mIBG in patients with ... ...

Abstract	Abstract Aim Positron emission tomography (PET) using 124I-mIBG has been established for imaging and pretherapeutic dosimetry. Here, we report the first systematic analysis of the biodistribution and radiation dosimetry of 124I-mIBG in patients with neural crest tumours and project the results to paediatric patient models. Methods Adult patients with neural crest tumours who underwent sequential 124I-mIBG PET were included in this retrospective single-center analysis. PET data were acquired 4, 24, 48, and/or 120 h after administration of a mean of 43 MBq 124I-mIBG. Whole-body counting and blood sampling were performed at 2, 4, 24, 48 and 120 h after administration. Absorbed organ dose and effective dose coefficients were estimated in OLINDA/EXM 2.2 according to the MIRD formalism. Extrapolation to paediatric models was performed based on mass-fraction scaling of the organ-specific residence times. Biodistribution data for adults were also projected to 123I-mIBG and 131I-mIBG. Results Twenty-one patients (11 females, 10 males) were evaluated. For adults, the organs exposed to the highest dose per unit administered activity were urinary bladder (1.54 ± 0.40 mGy/MBq), salivary glands (0.77 ± 0.28 mGy/MBq) and liver (0.65 ± 0.22 mGy/MBq). Mean effective dose coefficient for adults was 0.25 ± 0.04 mSv/MBq (male: 0.24 ± 0.03 mSv/MBq, female: 0.26 ± 0.06 mSv/MBq), and increased gradually to 0.29, 0.44, 0.69, 1.21, and 2.94 mSv/MBq for the 15-, 10-, 5-, 1-years-old, and newborn paediatric reference patients. Projected mean effective dose coefficients for 123I-mIBG and 131I-mIBG for adults were 0.014 ± 0.002 mSv/MBq and 0.18 ± 0.04 mSv/MBq, respectively. Conclusion PET-based derived radiation dosimetry data for 124I-mIBG from this study agreed well with historical projected data from ICRP 53. The effective dose coefficients presented here may aid in guidance for establishing weight-based activity administration protocols.
Keywords	Dosimetry ; 124I-mIBG ; PET ; Effective dose ; Neural crest tumour ; Medical physics. Medical radiology. Nuclear medicine ; R895-920
Subject code	616
Language	English
Publishing date	2024-01-01T00:00:00Z
Publisher	SpringerOpen
Document type	Article ; Online
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Article ; Online: Biomimetic Mineralization Promotes Viability and Differentiation of Human Mesenchymal Stem Cells in a Perfusion Bioreactor.

Ramírez-Rodríguez, Gloria Belén / Pereira, Ana Rita / Herrmann, Marietta / Hansmann, Jan / Delgado-López, José Manuel / Sprio, Simone / Tampieri, Anna / Sandri, Monica

International journal of molecular sciences

2021 Volume 22, Issue 3

Abstract: In bone tissue engineering, the design of 3D systems capable of recreating composition, architecture and micromechanical environment of the native extracellular matrix (ECM) is still a challenge. While perfusion bioreactors have been proposed as ... ...

Abstract	In bone tissue engineering, the design of 3D systems capable of recreating composition, architecture and micromechanical environment of the native extracellular matrix (ECM) is still a challenge. While perfusion bioreactors have been proposed as potential tool to apply biomechanical stimuli, its use has been limited to a low number of biomaterials. In this work, we propose the culture of human mesenchymal stem cells (hMSC) in biomimetic mineralized recombinant collagen scaffolds with a perfusion bioreactor to simultaneously provide biochemical and biophysical cues guiding stem cell fate. The scaffolds were fabricated by mineralization of recombinant collagen in the presence of magnesium (RCP.MgAp). The organic matrix was homogeneously mineralized with apatite nanocrystals, similar in composition to those found in bone. X-Ray microtomography images revealed isotropic porous structure with optimum porosity for cell ingrowth. In fact, an optimal cell repopulation through the entire scaffolds was obtained after 1 day of dynamic seeding in the bioreactor. Remarkably, RCP.MgAp scaffolds exhibited higher cell viability and a clear trend of up-regulation of osteogenic genes than control (non-mineralized) scaffolds. Results demonstrate the potential of the combination of biomimetic mineralization of recombinant collagen in presence of magnesium and dynamic culture of hMSC as a promising strategy to closely mimic bone ECM.
MeSH term(s)	Apatites/chemistry ; Biocompatible Materials/chemistry ; Biomimetics ; Bioreactors ; Bone Marrow Cells/cytology ; Cell Culture Techniques/instrumentation ; Cell Culture Techniques/methods ; Cell Differentiation/drug effects ; Cell Lineage ; Cell Survival/drug effects ; Collagen/chemistry ; Culture Media ; Extracellular Matrix/metabolism ; Humans ; Magnesium/chemistry ; Mesenchymal Stem Cells/cytology ; Nanoparticles/chemistry ; Osteogenesis ; Perfusion ; Porosity ; Spectroscopy, Fourier Transform Infrared ; Thermogravimetry ; Tissue Engineering/methods ; Tissue Scaffolds ; X-Ray Microtomography
Chemical Substances	Apatites ; Biocompatible Materials ; Culture Media ; Collagen (9007-34-5) ; Magnesium (I38ZP9992A)
Language	English
Publishing date	2021-02-01
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2019364-6
ISSN	1422-0067 ; 1422-0067 ; 1661-6596
ISSN (online)	1422-0067
ISSN	1422-0067 ; 1661-6596
DOI	10.3390/ijms22031447
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Article ; Online: Evaluation of knowledge and confidence following opioid overdose prevention training: A comparison of types of training participants and naloxone administration methods.

Ashrafioun, Lisham / Gamble, Stephanie / Herrmann, Michele / Baciewicz, Gloria

Substance abuse

2016 Volume 37, Issue 1, Page(s) 76–81

Abstract: Background: The purpose of the current study was to assess the effect of opioid overdose prevention training on participants' knowledge about opioid overdose and confidence to recognize and respond to opioid overdose situations as a function of naloxone ...

Abstract	Background: The purpose of the current study was to assess the effect of opioid overdose prevention training on participants' knowledge about opioid overdose and confidence to recognize and respond to opioid overdose situations as a function of naloxone administration (i.e., injection vs. intranasal spray) and participant type (friend/family, provider, "other"). Methods: Opioid overdose prevention trainings were offered throughout a mid-sized metropolitan area in the northeast. Participants (n = 428) were trained to administer naloxone via intramuscular injection (n = 154) or intranasal spray (n = 274). All training participants were given pre-post assessments of knowledge about opioid overdose and confidence to recognize and respond to opioid overdose situations. Results: Participants' overall knowledge and confidence increased significantly from pre- to post-training (ps < .001). There was no significant association between knowledge and route of administration or participant type. Knowledge significantly increased from pre- to post-training in all participant types (ps < .001). Confidence improved significantly from pre- to post-training across both routes of administration (ps < .001). However, confidence was higher among those who were trained using the intranasal naloxone compared to those who were trained using the intramuscular injection naloxone at pre- (p = .011) and post-training (p < .001). Confidence increased from pre- to post-training in each of the participant types (ps < .001). Post-hoc tests revealed that confidence was higher among providers and friends/family members compared to "other" participants, such as first responders, only at post-training (p < .05). Conclusions: Opioid overdose trainings are effective in increasing knowledge and confidence related to opioid overdose situations. Findings suggest that trainees are more confident administering naloxone via intranasal spray compared to injection. Future research should attempt to identify other factors that may increase the likelihood of trainees' effectively intervening in opioid overdose situations.
MeSH term(s)	Administration, Intranasal ; Analgesics, Opioid/adverse effects ; Drug Overdose/drug therapy ; Drug Overdose/prevention & control ; Health Knowledge, Attitudes, Practice ; Health Personnel/education ; Health Personnel/psychology ; Humans ; Injections, Intramuscular ; Naloxone/administration & dosage ; Naloxone/therapeutic use ; Narcotic Antagonists/therapeutic use ; Program Evaluation
Chemical Substances	Analgesics, Opioid ; Narcotic Antagonists ; Naloxone (36B82AMQ7N)
Language	English
Publishing date	2016
Publishing country	United States
Document type	Comparative Study ; Evaluation Studies ; Journal Article ; Research Support, U.S. Gov't, Non-P.H.S.
ZDB-ID	1458030-5
ISSN	1547-0164 ; 0889-7077
ISSN (online)	1547-0164
ISSN	0889-7077
DOI	10.1080/08897077.2015.1110550
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Article ; Online: Teaching patient-centred communication skills during clinical procedural skill training - a preliminary pre-post study comparing international and local medical students.

Nagy, Ede / Luta, Gloria Matondo Miguel / Huhn, Daniel / Cranz, Anna / Schultz, Jobst-Hendrik / Herrmann-Werner, Anne / Bugaj, Till Johannes / Friederich, Hans-Christoph / Nikendei, Christoph

BMC medical education

2021 Volume 21, Issue 1, Page(s) 469

Abstract: Background: International medical students are frequently confronted with intercultural, psychosocial, and language barriers and often receive lower marks in written, oral, and clinical-practical examinations than fellow local students. Training ... ...

Abstract	Background: International medical students are frequently confronted with intercultural, psychosocial, and language barriers and often receive lower marks in written, oral, and clinical-practical examinations than fellow local students. Training communication competence in procedural skills, such as blood sampling, is further challenge in this particular group of medical students. This pre-post comparative intervention study aimed to investigate the effects of training communication skills during the performance of procedural skills (taking blood samples from a silicone model) in international and local students as part of their clinical practical medical training. Methods: Study participants performed blood sampling on an arm prosthesis model (part-task trainer) before and after the communication skills training, focusing on accompanying communication with a simulation patient sitting next to the arm model. The pre- and post-evaluation video was assessed by two independent evaluators using a binary checklist, the Integrated Procedural Performance Instrument (IPPI) and global assessments of clinical professionalism in terms of procedural and communication performance. Linear models with mixed effects were used. Group differences regarding global competence levels were analysed with χ Results: International medical students did not perform as well as their local counterparts in the pre- and post-examinations. Both groups improved their performance significantly, whereby the international students improved more than their local counterparts in terms of their communication performance, assessed via binary checklist. Clinical professionalism evaluated via global assessments of procedural and communication performance highlights the intervention's impact insofar as no international student was assessed as clinically not competent after the training. Conclusions: Our results suggest that already a low-dose intervention can lead to improved communication skills in medical students performing procedural tasks and significantly increase their confidence in patient interaction.
MeSH term(s)	Clinical Competence ; Communication ; Education, Medical, Undergraduate ; Humans ; Physical Examination ; Students, Medical
Language	English
Publishing date	2021-09-03
Publishing country	England
Document type	Journal Article
ZDB-ID	2044473-4
ISSN	1472-6920 ; 1472-6920
ISSN (online)	1472-6920
ISSN	1472-6920
DOI	10.1186/s12909-021-02901-7
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Article ; Online: Genetic Obesity in Children: Overview of Possible Diagnoses with a Focus on SH2B1 Deletion.

Giannopoulou, Eleni Z / Zorn, Stefanie / Schirmer, Melanie / Herrmann, Gloria / Heger, Sabine / Reinehr, Thomas / Denzer, Christian / Rabenstein, Hannah / Hillmer, Morten / Sowada, Nadine / Siebert, Reiner / von Schnurbein, Julia / Wabitsch, Martin

Hormone research in paediatrics

2021 Volume 95, Issue 2, Page(s) 137–148

Abstract: Introduction: Genetic obesity is rare and quite challenging for pediatricians in terms of early identification. Src-homology-2 (SH2) B adapter protein 1 (SH2B1) is an important component in the leptin-melanocortin pathway and is found to play an ... ...

Abstract	Introduction: Genetic obesity is rare and quite challenging for pediatricians in terms of early identification. Src-homology-2 (SH2) B adapter protein 1 (SH2B1) is an important component in the leptin-melanocortin pathway and is found to play an important role in leptin and insulin signaling and therefore in the pathogenesis of obesity and diabetes. Microdeletions in chromosome 16p11.2, encompassing the SH2B1 gene, are known to be associated with obesity, insulin resistance, hyperphagia, and developmental delay. The aim of our study is to report on a case series of young individuals with 16p11.2 microdeletions, including the SH2B1 gene, and provide detailed information on body mass index (BMI) development and obesity-associated comorbidities. In this way, we want to raise awareness of this syndromic form of obesity as a differential diagnosis of genetic obesity. Methods: We describe the phenotype of 7 children (3 male; age range: 2.8-18.0 years) with 16p11.2 microdeletions, encompassing the SH2B1 gene, and present their BMI trajectories from birth onward. Screening for obesity-associated comorbidities was performed at the time of genetic diagnosis. Results: All children presented with severe, early-onset obesity already at the age of 5 years combined with variable developmental delay. Five patients presented with elevated fasting insulin levels, 1 patient developed diabetes mellitus type 2, 4 patients had dyslipidemia, and 4 developed nonalcoholic fatty-liver disease. Discussion/conclusion: Chromosomal microdeletions in 16p11.2, including the SH2B1 gene, in children are associated with severe, early-onset obesity and comorbidities associated with insulin resistance. Early genetic testing in suspicious patients and early screening for comorbidities are recommended.
MeSH term(s)	Adaptor Proteins, Signal Transducing/genetics ; Adolescent ; Body Mass Index ; Child ; Child, Preschool ; Female ; Gene Deletion ; Humans ; Insulin/metabolism ; Insulin Resistance/genetics ; Leptin/metabolism ; Male ; Pediatric Obesity/diagnosis ; Pediatric Obesity/genetics
Chemical Substances	Adaptor Proteins, Signal Transducing ; Insulin ; Leptin ; SH2B1 protein, human
Language	English
Publishing date	2021-10-22
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2537278-6
ISSN	1663-2826 ; 1663-2818
ISSN (online)	1663-2826
ISSN	1663-2818
DOI	10.1159/000520402
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Article ; Online: Propensity matched comparison of TAVI and SAVR in intermediate-risk patients with severe aortic stenosis and moderate-to-severe chronic kidney disease: a subgroup analysis from the German Aortic Valve Registry.

Mas-Peiro, Silvia / Faerber, Gloria / Bon, Dimitra / Herrmann, Eva / Bauer, Timm / Bleiziffer, Sabine / Bekeredjian, Raffi / Böning, Andreas / Frerker, Christian / Beckmann, Andreas / Möllmann, Helge / Ensminger, Stephan / Hamm, Christian W / Beyersdorf, Friedhelm / Fichtlscherer, Stephan / Walther, Thomas

Clinical research in cardiology : official journal of the German Cardiac Society

2022 Volume 111, Issue 12, Page(s) 1387–1395

Abstract: Objective: We compared TAVI vs. SAVR in patients with moderate-to-severe chronic kidney disease (eGFR 15-60 ml/min/1.73 m: Background: According to both ACC/AHA and ESC/EACTS recent guidelines, aortic stenosis may be treated with either transcatheter ...

Abstract	Objective: We compared TAVI vs. SAVR in patients with moderate-to-severe chronic kidney disease (eGFR 15-60 ml/min/1.73 m Background: According to both ACC/AHA and ESC/EACTS recent guidelines, aortic stenosis may be treated with either transcatheter (TAVI) or surgical (SAVR) aortic valve replacement in a subgroup of patients. A shared therapeutic decision is made by a heart team based on individual factors, including chronic kidney disease (CKD). Methods: Data from the large nationwide German Aortic Valve Registry were used. A propensity score method was used to select 704 TAVI and 374 SAVR matched patients. Primary endpoint was 1-year survival. Secondary endpoints were clinical complications, including pacemaker implantation, vascular complications, myocardial infarction, bleeding, and the need for new-onset dialysis. Results: One-year survival was similar (HR [95% CI] for TAVI 1.271 [0.795, 2.031], p = 0.316), with no divergence in Kaplan-Meier curves. In spite of post-procedural short-term survival being numerically higher for TAVI patients and 1-year survival being numerically higher for SAVR patients, such differences did not reach statistical significance (96.4% vs. 94.2%, p = 0.199, and 86.2% vs. 81.2%, p = 0.316, respectively). In weighted analyses, pacemaker implantation, vascular complications, and were significantly more common with TAVI; whereas myocardial infarction, bleeding requiring transfusion, and longer ICU-stay and overall hospitalization were higher with SAVR. Temporary dialysis was more common with SAVR (p < 0.0001); however, a probable need for chronic dialysis was rare and similar in both groups. Conclusion: Both TAVI and SAVR led to comparable and excellent results in patients with moderate-to-severe CKD in an intermediate-risk population of patients with symptomatic severe aortic stenosis for whom both therapies could possibly be considered.
MeSH term(s)	Humans ; Aged, 80 and over ; Aortic Valve/surgery ; Heart Valve Prosthesis Implantation/methods ; Aortic Valve Stenosis/diagnosis ; Aortic Valve Stenosis/surgery ; Transcatheter Aortic Valve Replacement/adverse effects ; Transcatheter Aortic Valve Replacement/methods ; Risk Factors ; Registries ; Renal Insufficiency, Chronic/complications ; Renal Insufficiency, Chronic/diagnosis ; Renal Insufficiency, Chronic/epidemiology ; Myocardial Infarction/etiology ; Treatment Outcome
Language	English
Publishing date	2022-09-08
Publishing country	Germany
Document type	Journal Article
ZDB-ID	2213295-8
ISSN	1861-0692 ; 1861-0684
ISSN (online)	1861-0692
ISSN	1861-0684
DOI	10.1007/s00392-022-02083-2
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Article ; Online: Biomimetic Mineralization Promotes Viability and Differentiation of Human Mesenchymal Stem Cells in a Perfusion Bioreactor

Gloria Belén Ramírez-Rodríguez / Ana Rita Pereira / Marietta Herrmann / Jan Hansmann / José Manuel Delgado-López / Simone Sprio / Anna Tampieri / Monica Sandri

International Journal of Molecular Sciences, Vol 22, Iss 3, p

2021 Volume 1447

Abstract	In bone tissue engineering, the design of 3D systems capable of recreating composition, architecture and micromechanical environment of the native extracellular matrix (ECM) is still a challenge. While perfusion bioreactors have been proposed as potential tool to apply biomechanical stimuli, its use has been limited to a low number of biomaterials. In this work, we propose the culture of human mesenchymal stem cells (hMSC) in biomimetic mineralized recombinant collagen scaffolds with a perfusion bioreactor to simultaneously provide biochemical and biophysical cues guiding stem cell fate. The scaffolds were fabricated by mineralization of recombinant collagen in the presence of magnesium (RCP.MgAp). The organic matrix was homogeneously mineralized with apatite nanocrystals, similar in composition to those found in bone. X-Ray microtomography images revealed isotropic porous structure with optimum porosity for cell ingrowth. In fact, an optimal cell repopulation through the entire scaffolds was obtained after 1 day of dynamic seeding in the bioreactor. Remarkably, RCP.MgAp scaffolds exhibited higher cell viability and a clear trend of up-regulation of osteogenic genes than control (non-mineralized) scaffolds. Results demonstrate the potential of the combination of biomimetic mineralization of recombinant collagen in presence of magnesium and dynamic culture of hMSC as a promising strategy to closely mimic bone ECM.
Keywords	scaffold ; perfusion bioreactor ; collagen ; apatite nanoparticles ; magnesium ; human mesenchymal stem cell ; Biology (General) ; QH301-705.5 ; Chemistry ; QD1-999
Subject code	571
Language	English
Publishing date	2021-02-01T00:00:00Z
Publisher	MDPI AG
Document type	Article ; Online
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Article ; Online: Teaching patient-centred communication skills during clinical procedural skill training - a preliminary pre-post study comparing international and local medical students

Ede Nagy / Gloria Matondo Miguel Luta / Daniel Huhn / Anna Cranz / Jobst-Hendrik Schultz / Anne Herrmann-Werner / Till Johannes Bugaj / Hans-Christoph Friederich / Christoph Nikendei

BMC Medical Education, Vol 21, Iss 1, Pp 1-

2021 Volume 11

Abstract: Abstract Background International medical students are frequently confronted with intercultural, psychosocial, and language barriers and often receive lower marks in written, oral, and clinical-practical examinations than fellow local students. Training ... ...

Abstract	Abstract Background International medical students are frequently confronted with intercultural, psychosocial, and language barriers and often receive lower marks in written, oral, and clinical-practical examinations than fellow local students. Training communication competence in procedural skills, such as blood sampling, is further challenge in this particular group of medical students. This pre-post comparative intervention study aimed to investigate the effects of training communication skills during the performance of procedural skills (taking blood samples from a silicone model) in international and local students as part of their clinical practical medical training. Methods Study participants performed blood sampling on an arm prosthesis model (part-task trainer) before and after the communication skills training, focusing on accompanying communication with a simulation patient sitting next to the arm model. The pre- and post-evaluation video was assessed by two independent evaluators using a binary checklist, the Integrated Procedural Performance Instrument (IPPI) and global assessments of clinical professionalism in terms of procedural and communication performance. Linear models with mixed effects were used. Group differences regarding global competence levels were analysed with χ2-tests. Results International medical students did not perform as well as their local counterparts in the pre- and post-examinations. Both groups improved their performance significantly, whereby the international students improved more than their local counterparts in terms of their communication performance, assessed via binary checklist. Clinical professionalism evaluated via global assessments of procedural and communication performance highlights the intervention’s impact insofar as no international student was assessed as clinically not competent after the training. Conclusions Our results suggest that already a low-dose intervention can lead to improved communication skills in medical students performing procedural tasks and significantly increase their confidence in patient interaction.
Keywords	International medical students ; Skills-lab training ; Communication skills ; IPPI ; Binary checklist ; Special aspects of education ; LC8-6691 ; Medicine ; R
Subject code	796
Language	English
Publishing date	2021-09-01T00:00:00Z
Publisher	BMC
Document type	Article ; Online
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Article ; Online: Predictors of surgical complications in boys with hypospadias: data from an internationa registry.

Scougall, Kathryn / Bryce, Jillian / Baronio, Federico / Boal, Rachel L / Castera, Jose Roberto / Castro, Sebastián / Cheetham, Tim / Costa, Eduardo Corrêa / Darendeliler, Feyza / Davies, Justin H / Dirlewanger, Mirjam / Gazdagh, Gabriella / Globa, Evgenia / Guerra-Junior, Gil / Guran, Tulay / Herrmann, Gloria / Holterhus, Paul-Martin / Akgül, Ahsen Karagözlü / Markosyan, Renata /

McElreavey, Kenneth / Miranda, Marcio Lopes / Nordenstrom, Anna / O'Toole, Stuart / Poyrazoglu, Sukran / Russo, Gianni / Schwitzgebel, Valerie / Stancampiano, Marianna / Steigert, Michael / Ahmed, S Faisal / Lucas-Herald, Angela K

World journal of pediatric surgery

2023 Volume 6, Issue 4, Page(s) e000599

Abstract: Background: Complications are frequently reported after hypospadias repair and there is a need to understand the factors that influence their occurrence.: Methods: Data from boys with hypospadias born between 2000 and 2020 were obtained from the ... ...

Abstract	Background: Complications are frequently reported after hypospadias repair and there is a need to understand the factors that influence their occurrence. Methods: Data from boys with hypospadias born between 2000 and 2020 were obtained from the International Disorders of Sex Development (I-DSD) Registry. Logistic regressions, fisher's exact tests and spearman's correlation tests were performed on the data to assess associations between clinical factors and complication rates. Results: Of the 551 eligible boys, data were available on 160 (29%). Within the cohort, the median (range) External Masculinization Score (EMS) was 6 (2, 9). All presented with one or more additional genital malformation and 61 (38%) presented with additional extragenital malformations. Disorders of androgen action, androgen synthesis and gonadal development were diagnosed in 28 (18%), 22 (14%) and 9 (6%) boys, respectively. The remaining 101 (62%) patients were diagnosed as having non-specific 46,XY Disorders of Sex Development. Eighty (50%) boys had evidence of abnormal biochemistry, and gene variants were identified in 42 (26%). Median age at first hypospadias surgery was 2 years (0, 9), and median length of follow-up was 5 years (0, 17). Postsurgical complications were noted in 102 (64%) boys. There were no significant associations with postsurgical complications. Conclusions: Boys with proximal hypospadias in the I-DSD Registry have high rates of additional comorbidities and a high risk of postoperative complications. No clinical factors were significantly associated with complication rates. High complication rates with no observable cause suggest the involvement of other factors which need investigation.
Language	English
Publishing date	2023-10-11
Publishing country	England
Document type	Journal Article
ISSN	2516-5410
ISSN (online)	2516-5410
DOI	10.1136/wjps-2023-000599
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