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  1. Article ; Online: SIR model of the pandemic trend of COVID-19 in Peru.

    Huarachi Olivera, Ronald Eleazar / Lazarte RIvera, Antonio Mateo

    Revista de la Facultad de Ciencias Medicas (Cordoba, Argentina)

    2021  Volume 78, Issue 3, Page(s) 236–242

    Abstract: The SARS-CoV-2 virus from Europe has reached Peru on March 5 and since March 16 a state of national emergency has been declared, leading to the confinement of the entire population. The objective of this study is to characterize the epidemic evolution of ...

    Title translation [Modelo SIR de la tendencia pandémica de COVID-19 en Perú.]
    Abstract The SARS-CoV-2 virus from Europe has reached Peru on March 5 and since March 16 a state of national emergency has been declared, leading to the confinement of the entire population. The objective of this study is to characterize the epidemic evolution of coronavirus disease (COVID-19) applying the SIR model (Susceptible-Infectious-recovered or deceased) during a period of 200 days. The time series data of COVID-19 from March 06 to May 14, 2020 of the Peruvian Ministry of Health was used, presenting estimated cases by varying the basic reproduction number R0. According to the SIR model, the peak of those infected occurs shortly after May 30 from the beginning of the epidemic (day 86) where the total number of infected cases decreases to R0 = 1.5. The results suggest that Peru's current stringent measures can effectively prevent the spread of COVID-19 and should be maintained even with efficient results.
    MeSH term(s) COVID-19 ; Humans ; Pandemics ; Peru ; SARS-CoV-2
    Language Spanish
    Publishing date 2021-08-23
    Publishing country Argentina
    Document type Journal Article
    ZDB-ID 390127-0
    ISSN 1853-0605 ; 0014-6722 ; 0301-7281
    ISSN (online) 1853-0605
    ISSN 0014-6722 ; 0301-7281
    DOI 10.31053/1853.0605.v78.n3.31142
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Modelo SIR de la tendencia pandémica de COVID-19 en Perú

    Ronald Eleazar Huarachi Olivera / Antonio Mateo Lazarte RIvera

    Revista de la Facultad de Ciencias Médicas de Córdoba, Vol 78, Iss

    2021  Volume 3

    Abstract: El virus SARS-CoV-2 procedente de Europa ha llegado a Perú el 5 Marzo y desde el 16 de marzo se ha declarado el estado de emergencia nacional llevando al confinamiento a toda la población. El objetivo de este estudio es caracterizar la evolución ... ...

    Abstract El virus SARS-CoV-2 procedente de Europa ha llegado a Perú el 5 Marzo y desde el 16 de marzo se ha declarado el estado de emergencia nacional llevando al confinamiento a toda la población. El objetivo de este estudio es caracterizar la evolución epidémica de la enfermedad de coronavirus (COVID-19) aplicando el modelo SIR (Susceptibles-Infecciosos-recuperados o fallecidos) durante un periodo de 200 días. Se utilizó los datos de series temporales de COVID-19 del 06 de marzo al 14 de mayo de 2020 del ministerio de salud peruano planteando casos estimados variando el número básico de reproducción R0. Según el modelo SIR, el pico de infectados se produce poco después del 30 de Mayo desde el inicio de la epidemia (día 86) donde disminuye el número total de casos infectados a R0=1,5. Los resultados sugieren que las estrictas medidas actuales de Perú pueden prevenir eficazmente la propagación de COVID-19 y deben mantenerse aun obteniendo resultados eficientes.
    Keywords coronavirus ; epidemia ; número básico de reproducción ; Medicine ; R ; Medicine (General) ; R5-920
    Language English
    Publishing date 2021-08-01T00:00:00Z
    Publisher Universidad Nacional de Córdoba
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  3. Article ; Online: Enfermedad del coronavirus (covid-19) y las sirtuinas.

    Huarachi Olivera, Ronald Eleazar / Lazarte Rivera, Antonio

    Revista de la Facultad de Ciencias Medicas (Cordoba, Argentina)

    2020  Volume 77, Issue 2, Page(s) 117–125

    Abstract: Introduction: The NAD+dependent proteins deacetylases are called Sirtuins (SIRT).: Objectives: Objectives: this review is to study the sirtuins involved in cancer, as well as SIRT1 inhibition studies in patients with coronavirus disease COVID-19.: ... ...

    Title translation Coronavirus disease (COVID-19) and sirtuins.
    Abstract Introduction: The NAD+dependent proteins deacetylases are called Sirtuins (SIRT).
    Objectives: Objectives: this review is to study the sirtuins involved in cancer, as well as SIRT1 inhibition studies in patients with coronavirus disease COVID-19.
    Data source and selection: For this, a search was made in Medline, Scopus and WOS, where descriptive studies of each of the functions of sirtuins were included, adjusted to recent scientific research. SIRT1 inhibition reduces CD8 T cell cytotoxicity in patients with systemic erythematosus lupus, being susceptible to SARS Cov-2 infections. SIRT2 is regulated by the secretion of IL-4 by eosinophils and the increase in SIRT2 increases hyperplasia, in contrast, SIRT3 promotes angiogenesis, inducing cardiac remodeling. SIRT4 is a tumor suppressor, in contrastto SIRT5 that promotes cell proliferation causing colorectal cancer; SIRT6 attenuates herpes virus associated with Kaposi's Sarcoma (KSHV) in immune compromised patients. Suppression of SIRT7 inhibits the growth of endometrial cancer cells.
    Conclusions: It is concluded that SIRT1, SIRT2 and SIRT4 are involved in the development of cancer, the suppression of SIRT5 and SIRT7 promotes the apoptosis of cancer cells and SIRT6 attenuates the replication of KSHV, in addition to the molecular pathology pathway of COVID-19 is associated with the inhibition of SIRT1 activity that may be related to inflammatory processes.
    MeSH term(s) Betacoronavirus ; Biomarkers, Tumor/metabolism ; COVID-19 ; Coronavirus Infections/metabolism ; Histone Deacetylases/metabolism ; Humans ; Immunohistochemistry ; Neoplasms/metabolism ; Pandemics ; Pneumonia, Viral/metabolism ; SARS-CoV-2 ; Sirtuin 1/antagonists & inhibitors
    Chemical Substances Biomarkers, Tumor ; SIRT1 protein, human (EC 3.5.1.-) ; Sirtuin 1 (EC 3.5.1.-) ; Histone Deacetylases (EC 3.5.1.98)
    Language Spanish
    Publishing date 2020-06-16
    Publishing country Argentina
    Document type Journal Article ; Review
    ZDB-ID 390127-0
    ISSN 1853-0605 ; 0014-6722 ; 0301-7281
    ISSN (online) 1853-0605
    ISSN 0014-6722 ; 0301-7281
    DOI 10.31053/1853.0605.v77.n2.28196
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.B 2644: Show issues Location:
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  4. Article ; Online: Enfermedad del coronavirus (covid-19) y las sirtuinas

    Ronald Eleazar Huarachi Olivera / Antonio Lazarte Rivera

    Revista de la Facultad de Ciencias Médicas de Córdoba, Vol 77, Iss 2, Pp 117-

    2020  Volume 125

    Abstract: Las proteínas desacetilasas dependientes del NAD+, se denominan Sirtuinas (SIRT). Objetivos: estudiar las sirtuinas involucradas en el cáncer, así como los estudios de inhibición de SIRT1 en pacientes con la enfermedad del coronavirus COVID-19. Fuente y ... ...

    Abstract Las proteínas desacetilasas dependientes del NAD+, se denominan Sirtuinas (SIRT). Objetivos: estudiar las sirtuinas involucradas en el cáncer, así como los estudios de inhibición de SIRT1 en pacientes con la enfermedad del coronavirus COVID-19. Fuente y selección de datos: Para ello se realizó una búsqueda en Medline, Scopus y WOS, donde se incluyeron estudios descriptivos de cada una de las funciones de las sirtuinas ajustado a las recientes investigaciones científicas. La inhibición de SIRT1 disminuye la citotoxicidad de las células T CD8 en pacientes con lupus eritematoso sistémico, siendo susceptibles a infecciones por SARS CoV-2. La SIRT2 se regula por la secreción de IL-4 por los eosinófilos y el aumento de SIRT2 incrementa la hiperplasia, en contraste la SIRT3 promueve la angiogénesis, induciendo la remodelación cardiaca. La SIRT4 es un supresor de tumores, en contraste con la SIRT5 que promueve la proliferación celular provocando el cáncer colorrectal; la SIRT6 atenúa al herpes virus asociado al Sarcoma de Kaposi (KSHV) en pacientes inmuno comprometidos. La supresión de SIRT7 inhibe el crecimiento de las células cancerígenas endometriales. Conclusiones: Se concluye que las SIRT1, SIRT2 y SIRT4 están involucradas en el desarrollo del cáncer, la supresión de SIRT5 y SIRT7 promueve la apoptosis de células cancerígenas y la SIRT6 atenúa la replicación de KSHV, además la vía de patología molecular de la COVID-19 está asociada a la inhibición de la actividad de SIRT1 que puede estar relacionada a procesos inflamatorios.
    Keywords infecciones por coronavirus ; neoplasias ; inhibidores de histona ; desacetilasas ; nad ; sirtuinas ; Medicine ; R ; Medicine (General) ; R5-920 ; covid19
    Language English
    Publishing date 2020-06-01T00:00:00Z
    Publisher Universidad Nacional de Córdoba
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  5. Article: Enfermedad del coronavirus (covid-19) y las sirtuinas./ [Coronavirus disease (COVID-19) and sirtuins]

    Huarachi Olivera, Ronald Eleazar / Lazarte Rivera, Antonio

    Rev Fac Cien Med Univ Nac Cordoba

    Abstract: Introduction: The NAD+dependent proteins deacetylases are called Sirtuins (SIRT). Objectives: Objectives: this review is to study the sirtuins involved in cancer, as well as SIRT1 inhibition studies in patients with coronavirus disease COVID-19. Data ... ...

    Abstract Introduction: The NAD+dependent proteins deacetylases are called Sirtuins (SIRT). Objectives: Objectives: this review is to study the sirtuins involved in cancer, as well as SIRT1 inhibition studies in patients with coronavirus disease COVID-19. Data source and selection: For this, a search was made in Medline, Scopus and WOS, where descriptive studies of each of the functions of sirtuins were included, adjusted to recent scientific research. SIRT1 inhibition reduces CD8 T cell cytotoxicity in patients with systemic erythematosus lupus, being susceptible to SARS Cov-2 infections. SIRT2 is regulated by the secretion of IL-4 by eosinophils and the increase in SIRT2 increases hyperplasia, in contrast, SIRT3 promotes angiogenesis, inducing cardiac remodeling. SIRT4 is a tumor suppressor, in contrastto SIRT5 that promotes cell proliferation causing colorectal cancer; SIRT6 attenuates herpes virus associated with Kaposi's Sarcoma (KSHV) in immune compromised patients. Suppression of SIRT7 inhibits the growth of endometrial cancer cells. Conclusions: It is concluded that SIRT1, SIRT2 and SIRT4 are involved in the development of cancer, the suppression of SIRT5 and SIRT7 promotes the apoptosis of cancer cells and SIRT6 attenuates the replication of KSHV, in addition to the molecular pathology pathway of COVID-19 is associated with the inhibition of SIRT1 activity that may be related to inflammatory processes.
    Keywords covid19
    Publisher WHO
    Document type Article
    Note WHO #Covidence: #32558516
    Database COVID19

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  6. Article ; Online: Coronavirus disease (COVID-19) and sirtuins ; Enfermedad del coronavirus (covid-19) y las sirtuinas ; Doença de coronavírus (COVID-19) e sirtuínas

    Huarachi Olivera, Ronald Eleazar / Lazarte Rivera, Antonio

    Revista de la Facultad de Ciencias Médicas de Córdoba; Vol. 77 Núm.; 117-125 ; Revista da Faculdade de Ciências Médicas de Córdoba; v. 77 n. 2 (2020); 117-125 ; 1853-0605 ; 0014-6722 ; 10.31053/1853.0605.v77.n2

    2020  Volume 2

    Abstract: The NAD+dependent proteins deacetylases are called Sirtuins (SIRT). Objectives: this review is to study the sirtuins involved in cancer, as well as SIRT1 inhibition studies in patients with coronavirus disease COVID-19. Data source and selection: For ... ...

    Abstract The NAD+dependent proteins deacetylases are called Sirtuins (SIRT). Objectives: this review is to study the sirtuins involved in cancer, as well as SIRT1 inhibition studies in patients with coronavirus disease COVID-19. Data source and selection: For this, a search was made in Medline, Scopus and WOS, where descriptive studies of each of the functions of sirtuins were included, adjusted to recent scientific research. SIRT1 inhibition reduces CD8 T cell cytotoxicity in patients with systemic erythematosus lupus, being susceptible to SARS Cov-2 infections. SIRT2 is regulated by the secretion of IL-4 by eosinophils and the increase in SIRT2 increases hyperplasia, in contrast, SIRT3 promotes angiogenesis, inducing cardiac remodeling. SIRT4 is a tumor suppressor, in contrastto SIRT5 that promotes cell proliferation causing colorectal cancer; SIRT6 attenuates herpes virus associated with Kaposi's Sarcoma (KSHV) in immune compromised patients. Suppression of SIRT7 inhibits the growth of endometrial cancer cells. Conclusions: It is concluded that SIRT1, SIRT2 and SIRT4 are involved in the development of cancer, the suppression of SIRT5 and SIRT7 promotes the apoptosis of cancer cells and SIRT6 attenuates the replication of KSHV, in addition to the molecular pathology pathway of COVID-19 is associated with the inhibition of SIRT1 activity that may be related to inflammatory processes.

    Las proteínas desacetilasas dependientes del NAD+, se denominan Sirtuinas (SIRT). Objetivos: estudiar las sirtuinas involucradas en el cáncer, así como los estudios de inhibición de SIRT1 en pacientes con la enfermedad del coronavirus COVID-19. Fuente y selección de datos: Para ello se realizó una búsqueda en Medline, Scopus y WOS, donde se incluyeron estudios descriptivos de cada una de las funciones de las sirtuinas ajustado a las recientes investigaciones científicas. La inhibición de SIRT1 disminuye la citotoxicidad de las células T CD8 en pacientes con lupus eritematoso sistémico, siendo susceptibles a infecciones por SARS CoV-2. La SIRT2 se regula por la secreción de IL-4 por los eosinófilos y el aumento de SIRT2 incrementa la hiperplasia, en contraste la SIRT3 promueve la angiogénesis, induciendo la remodelación cardiaca. La SIRT4 es un supresor de tumores, en contraste con la SIRT5 que promueve la proliferación celular provocando el cáncer colorrectal; la SIRT6 atenúa al herpes virus asociado al Sarcoma de Kaposi (KSHV) en pacientes inmuno comprometidos. La supresión de SIRT7 inhibe el crecimiento de las células cancerígenas endometriales. Conclusiones: Se concluye que las SIRT1, SIRT2 y SIRT4 están involucradas en el desarrollo del cáncer, la supresión de SIRT5 y SIRT7 promueve la apoptosis de células cancerígenas y la SIRT6 atenúa la replicación de KSHV, además la vía de patología molecular de la COVID-19 está asociada a la inhibición de la actividad de SIRT1 que puede estar relacionada a procesos inflamatorios.

    As proteínas desacetilases dependentes de NAD + são chamadas Sirtuins (SIRT). Objetivos: destarevisão é estudar as sirtuínas envolvidas no câncer, bem como estudos de inibição da SIRT1 em pacientes com doença de coronavírus COVID-19. Fonte e seleção dos dados: Para isso, foi realizada uma pesquisa no Medline, Scopus e WOS, onde foram incluídos estudos descritivos de cada uma das funções das sirtuínas, ajustados às pesquisas científicas recentes. À inibição da SIRT1 diminui a citotoxicidade das células T CD8 em pacientes com Lúpus Eritematoso Sistêmico sendo suscetível a infecções por SARS Cov-2. O SIRT2 é regulado pela secreção de IL-4 pelos eosinófilos e o aumento do SIRT2 aumenta a hiperplasia, enquanto o SIRT3 promove a angiogênese, induzindo a remodelação cardíaca. SIRT4 é um supressor de tumor, em contraste com o SIRT5, que promove a proliferação celular causando cáncer colorretal; O SIRT6 atenua o vírus do herpes associadoao Sarcoma de Kaposi (KSHV) em pacientes imunocomprometidos. A supressão de SIRT7 inibe o crescimento de células cancerígenas endometriais. Conclusões: Conclui-se que SIRT1, SIRT2 e SIRT4 estão envolvidos no desenvolvimento do câncer, a supressão de SIRT5 e SIRT7 promove a apoptose das células cancerígenas e o SIRT6 atenua a replicação do KSHV, alémdisso, a via da patologia molecular do COVID-19 é associado à inibição da atividade da SIRT1 que pode estar relacionada a procesos inflamatórios.
    Keywords Coronavirus infections ; Neoplasms ; Histone deacetylases ; NAD ; Sirtuins ; Infecciones por coronavirus ; neoplasias ; Inhibidores de Histona ; Desacetilasas ; Sirtuinas ; Infecções por Coronavirus ; Inibidores de Histona ; Desacetilases ; covid19
    Language Spanish
    Publishing date 2020-06-16
    Publisher Universidad Nacional Cba. Facultad de Ciencias Médicas. Secretaria de Ciencia y Tecnología
    Publishing country ar
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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