LIVIVO - The Search Portal for Life Sciences

zur deutschen Oberfläche wechseln
Advanced search

Search results

Result 1 - 10 of total 68

Search options

  1. Article ; Online: Delivering specialised care to people ageing with HIV in the UK: experience and evolution of services from 2009 to 2019.

    Milinkovic, Ana / Pereira, Branca / Mazziteli, Maria / Girometti, Nicolo / Asboe, David / Pozniak, Anton / Boffito, Marta

    The lancet. HIV

    2022  Volume 9 Suppl 1, Page(s) S1

    Abstract: Background: The introduction of antiretrovirals has resulted in a demographic shift with an increasing proportion of people living with HIV older than 50 years and a change in the spectrum of diseases affecting this population. A specialised clinical ... ...

    Abstract Background: The introduction of antiretrovirals has resulted in a demographic shift with an increasing proportion of people living with HIV older than 50 years and a change in the spectrum of diseases affecting this population. A specialised clinical service dedicated to older people living with HIV was implemented at Chelsea and Westminster Hospital, London, UK in 2009, following training of health-care providers in HIV, ageing, comorbidity, and polypharmacy management. We report the results of a service evaluation reviewing 10 years of activity of this specialised clinic, including lessons to be applied in routine practice.
    Methods: We estimated the prevalence of multimorbidity and polypharmacy and described algorithms devised for use across our HIV outpatient services following implementation of the specialised clinical pathway. The service evaluation was approved by our local clinical governance system and data relative to the period 2009-19 were collected on a secured trust database.
    Findings: Dedicated time was created for senior and junior doctors, a nurse, and a pharmacy to create clinical appointments for older people living with HIV referred by all service care providers. The team would review different clinical scenarios, book follow-up appointments to review results, refer to different specialists or to complex multidisciplinary teams when necessary. 744 people with HIV aged 50 years and older attended our services (93% [691] male, 7·1% [53] female; mean age 56·5 years [SD 5·5]; 84·2% [622] White, 7·5% [56] Black, 0·9% [7] Asian, 7·5% [56] other race or ethnicity). The prevalence of multimorbidity was 69·3% and of polypharmacy was 46·6%. The most common comorbidities were vitamin D deficiency (428 of 690, 62%), dyslipidaemia (373, 50·1%), hypertension (157, 21·5%), depressive or anxious disorders (117, 15·8%), osteoporosis (91, 12·2%), obesity (98, 13·2%), chronic kidney disease (56, 7·5%), and diabetes (43, 5·7%). Patients with dyslipidaemia, osteoporosis, and metabolic disorders were referred to a live well pathway clinic focusing on targeted lifestyle interventions, including diet and physical exercise, under the supervision of a dietician and a physiotherapist.
    Interpretation: We have described how our HIV over-50 clinic was organised and implemented, and we reported data showing high rates of comorbidities and polypharmacy, which led to the establishment of a specialised care pathway for all HIV care providers and to the implementation of further joint HIV and specialty clinics (cardiology, metabolic, menopause, nephrology, neurology, and geriatric).
    Funding: None.
    MeSH term(s) Aged ; Aging ; Comorbidity ; Dyslipidemias ; Female ; HIV Infections/drug therapy ; HIV Infections/epidemiology ; Humans ; Male ; Middle Aged ; Osteoporosis/epidemiology ; United Kingdom/epidemiology
    Language English
    Publishing date 2022-03-18
    Publishing country Netherlands
    Document type Journal Article
    ISSN 2352-3018
    ISSN (online) 2352-3018
    DOI 10.1016/S2352-3018(22)00066-2
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

  2. Article ; Online: COVID-19 in patients with HIV.

    Jones, Rachael / Nelson, Mark / Bracchi, Margherita / Asboe, David / Boffito, Marta

    The lancet. HIV

    2020  Volume 7, Issue 6, Page(s) e383

    MeSH term(s) Betacoronavirus ; COVID-19 ; Coronavirus Infections ; HIV Infections ; Humans ; Pandemics ; Pneumonia, Viral ; SARS-CoV-2
    Keywords covid19
    Language English
    Publishing date 2020-05-14
    Publishing country Netherlands
    Document type Letter ; Comment
    ISSN 2352-3018
    ISSN (online) 2352-3018
    DOI 10.1016/S2352-3018(20)30139-9
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

  3. Article ; Online: Covid-19 First Wave Impact National Survey for HIV Clinicians by Public Health England (PHE), the British HIV Association (BHIVA) and the Children's HIV Association (CHIVA).

    Shanks, Gabriella / Shah, Ammi / Williams, Amanda / Asboe, David / Anderson, Jane / Delpech, Valerie / Ely, Amanda / Waters, Laura

    HIV medicine

    2022  Volume 23, Issue 10, Page(s) 1098–1102

    Abstract: Introduction: This short report describes the results of a survey that was developed by Public Health England (PHE), the British HIV Association (BHIVA) and the Children's HIV Association (CHIVA) and circulated to all UK national health service HIV ... ...

    Abstract Introduction: This short report describes the results of a survey that was developed by Public Health England (PHE), the British HIV Association (BHIVA) and the Children's HIV Association (CHIVA) and circulated to all UK national health service HIV providers in the UK following the first wave of the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2; coronavirus disease 2019 [COVID-19]) pandemic to assess the impact of the pandemic on HIV clinics.
    Methods: The survey was created by BHIVA/CHIVA and PHE and was piloted prior to circulation to all HIV clinics within the UK on 3 July 2020. The survey questions were designed to assess the impact of the first wave of COVID-19 on HIV clinics and lead/senior HIV clinicians. Clinicians' responses were collected between 3 July 2020 and 17 September 2020. The survey responses were collated, and non-statistical analysis was performed.
    Results: The results of the survey confirmed that services had undergone substantial changes, including a shift from face-to-face consults to predominantly virtual consultations. Some clinicians' responses suggested that the first wave had many negative effects on people living with HIV, including their ability to access mental health services.
    Conclusion: The first wave of COVID-19 caused significant changes to HIV services within the UK. There was a shift toward the use of technology in healthcare, and results from subsequent clinician surveys carried out since the first wave of COVID-19 will reflect the ongoing transformation of care towards a more virtual service.
    MeSH term(s) COVID-19/epidemiology ; Child ; England/epidemiology ; HIV Infections/epidemiology ; Humans ; Public Health ; SARS-CoV-2 ; State Medicine
    Language English
    Publishing date 2022-03-28
    Publishing country England
    Document type Journal Article
    ZDB-ID 2001932-4
    ISSN 1468-1293 ; 1464-2662
    ISSN (online) 1468-1293
    ISSN 1464-2662
    DOI 10.1111/hiv.13307
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

  4. Article ; Online: COVID-19 in patients with HIV

    Jones, Rachael / Nelson, Mark / Bracchi, Margherita / Asboe, David / Boffito, Marta

    The Lancet HIV

    2020  Volume 7, Issue 6, Page(s) e383

    Keywords covid19
    Language English
    Publisher Elsevier BV
    Publishing country us
    Document type Article ; Online
    ISSN 2352-3018
    DOI 10.1016/s2352-3018(20)30139-9
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

    More links

    Kategorien

  5. Article ; Online: Factors associated with overweight/obesity in a cohort of people living with HIV over 50 years of age.

    Mazzitelli, Maria / Isabel Pereira, Branca / Moyle, Graeme / Asboe, David / Pozniak, Anton / Boffito, Marta / Milinkovic, Ana

    AIDS care

    2021  Volume 34, Issue 4, Page(s) 542–544

    Abstract: Changes in body weight in people living with HIV vary by regimen components, timing of therapy introduction (naive, switch) and demographic factors. Our objective was to evaluate weight change and factors associated in an ageing cohort of treated ... ...

    Abstract Changes in body weight in people living with HIV vary by regimen components, timing of therapy introduction (naive, switch) and demographic factors. Our objective was to evaluate weight change and factors associated in an ageing cohort of treated subjects with HIV at Chelsea and Westminster Hospital. We found that the prevalence of obesity was similar to general population and was associated with a number of health conditions, which increase metabolic risk.
    MeSH term(s) Cohort Studies ; HIV Infections/complications ; HIV Infections/epidemiology ; Humans ; Middle Aged ; Obesity/complications ; Obesity/epidemiology ; Overweight/complications ; Overweight/epidemiology ; Risk Factors
    Language English
    Publishing date 2021-06-04
    Publishing country England
    Document type Journal Article
    ZDB-ID 1012651-x
    ISSN 1360-0451 ; 0954-0121
    ISSN (online) 1360-0451
    ISSN 0954-0121
    DOI 10.1080/09540121.2021.1935438
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

  6. Article: Enfuvirtide: antiretroviral class 4, drug 1.

    Asboe, David

    HIV clinical trials

    2004  Volume 5, Issue 1, Page(s) 1–6

    Abstract: With the licensing of enfuvirtide, physicians prescribing antiretroviral medications now have available the first of a new class of drugs, the fusion inhibitors. In this article, enfuvirtide is discussed with particular emphasis on the clinical trials ... ...

    Abstract With the licensing of enfuvirtide, physicians prescribing antiretroviral medications now have available the first of a new class of drugs, the fusion inhibitors. In this article, enfuvirtide is discussed with particular emphasis on the clinical trials that led to the drug's licensing. The possible placement of enfuvirtide in the sequence of treatment is also discussed.
    MeSH term(s) Drug Administration Schedule ; Drug Resistance, Viral ; HIV Envelope Protein gp41/drug effects ; HIV Envelope Protein gp41/pharmacology ; HIV Fusion Inhibitors/administration & dosage ; HIV Fusion Inhibitors/pharmacology ; HIV Fusion Inhibitors/therapeutic use ; HIV Infections/drug therapy ; HIV-1/drug effects ; Humans ; Peptide Fragments/pharmacology ; Randomized Controlled Trials as Topic ; Receptors, CCR5/drug effects ; Receptors, CXCR4/drug effects ; Viral Fusion Proteins/antagonists & inhibitors
    Chemical Substances HIV Envelope Protein gp41 ; HIV Fusion Inhibitors ; Peptide Fragments ; Receptors, CCR5 ; Receptors, CXCR4 ; Viral Fusion Proteins ; enfuvirtide (19OWO1T3ZE)
    Language English
    Publishing date 2004-01
    Publishing country England
    Document type Journal Article ; Review
    ZDB-ID 2060516-X
    ISSN 1528-4336
    ISSN 1528-4336
    DOI 10.1310/RCE8-HADB-EFH8-563X
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

  7. Article ; Online: Evaluation of a Clinic Dedicated to People Aging with HIV at Chelsea and Westminster Hospital: Results of a 10-Year Experience.

    Pereira, Branca / Mazzitelli, Maria / Milinkovic, Ana / Casley, Christina / Rubio, Javier / Channa, Rachel / Girometti, Nicolo / Asboe, David / Pozniak, Anton / Boffito, Marta

    AIDS research and human retroviruses

    2021  Volume 38, Issue 3, Page(s) 188–197

    Abstract: Successful management of HIV infection as a chronic condition has resulted in a demographic shift where the proportion of people living with HIV (PLWH) older than 50 years is steadily increasing. A dedicated clinic to PLWH older than 50 years was ... ...

    Abstract Successful management of HIV infection as a chronic condition has resulted in a demographic shift where the proportion of people living with HIV (PLWH) older than 50 years is steadily increasing. A dedicated clinic to PLWH older than 50 years was established at Chelsea and Westminster Hospital in January 2009 and then extended to HIV services across the directorate. We report the results of a service evaluation reviewing 10 years of activities of this clinic between January 2009 and 2019. We aimed to estimate the prevalence of major noninfectious comorbidities, polypharmacy (≥5 medications), and multimorbidity (≥2 non-HIV-related comorbidities) and describe algorithms devised for use in HIV outpatient clinics across the directorate. A cohort of 744 PLWH older than 50 years attending this service were analyzed (93% male; mean age of 56 ± 5.5 years; 84% white ethnicity); 97.7% were on antiretroviral treatment and 95.9% had undetectable HIV-RNA at the time of evaluation. The most common comorbidities diagnosed were dyslipidemia (50.1%), hypertension (21.5%), mental health disorders (depression and/or anxiety disorders, 15.7%), osteoporosis (12.2%), obesity (11.9%), chronic kidney disease (7.5%), and diabetes (5.8%). Low vitamin D levels were found in 62% of patients [43% with vitamin D deficiency (<40 mmol/liter) and 57% with vitamin D insufficiency (40-70 mmol/liter)]. The overall prevalence of polypharmacy and multimorbidity was 46.6% and 69.3%, respectively. This study showed significant rates of non-HIV-related comorbidities and polypharmacy in PLWH older than 50 years, leading on to the implementation of clinical care pathways and new joint HIV/specialty clinics (cardiology, nephrology, neurology, metabolic, menopause, and geriatric) to improve prevention, diagnosis, and management of major comorbidities in people aging with HIV.
    MeSH term(s) Aged ; Aging ; Ambulatory Care Facilities ; Comorbidity ; Cross-Sectional Studies ; Female ; HIV Infections/complications ; HIV Infections/drug therapy ; HIV Infections/epidemiology ; Hospitals ; Humans ; Male ; Middle Aged
    Language English
    Publishing date 2021-08-13
    Publishing country United States
    Document type Journal Article
    ZDB-ID 639130-8
    ISSN 1931-8405 ; 0889-2229
    ISSN (online) 1931-8405
    ISSN 0889-2229
    DOI 10.1089/AID.2021.0083
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

  8. Article ; Online: Polypharmacy and evaluation of anticholinergic risk in a cohort of elderly people living with HIV.

    Mazzitelli, Maria / Milinkovic, Ana / Pereira, Branca / Palmer, James / Tong, Timothy / Asboe, David / Boffito, Marta

    AIDS (London, England)

    2019  Volume 33, Issue 15, Page(s) 2439–2441

    Abstract: As a consequence of ageing, the number of prescribed medications for people living with HIV is increasing. Concomitant use of different drugs and their potential interactions may increase anticholinergic exposure and escalate the risk for side effects. ...

    Abstract : As a consequence of ageing, the number of prescribed medications for people living with HIV is increasing. Concomitant use of different drugs and their potential interactions may increase anticholinergic exposure and escalate the risk for side effects. We conducted an analysis in our cohort of people living with HIV over 50 years of age to evaluate the overall anticholinergic risk, as it is useful to identify, prevent, and manage increased side effect risks.
    MeSH term(s) Antiretroviral Therapy, Highly Active ; Cholinergic Antagonists/adverse effects ; Codeine/adverse effects ; Cohort Studies ; Female ; HIV Infections/drug therapy ; Humans ; London ; Male ; Middle Aged ; Pain/drug therapy ; Polypharmacy
    Chemical Substances Cholinergic Antagonists ; Codeine (Q830PW7520)
    Language English
    Publishing date 2019-11-25
    Publishing country England
    Document type Letter ; Multicenter Study
    ZDB-ID 639076-6
    ISSN 1473-5571 ; 0269-9370 ; 1350-2840
    ISSN (online) 1473-5571
    ISSN 0269-9370 ; 1350-2840
    DOI 10.1097/QAD.0000000000002403
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

  9. Article ; Online: Switching to High Genetic Barrier Integrase Inhibitors Reduces Drug-Drug Interactions in People Living With HIV.

    Askari, Ara / Nashier, Chhavi / Ghelani, Rahul / Vargas Zhang, Adrian / Ng, Megan / Karagozlu, Zekiye / Bracchi, Margherita / Moyle, Graeme / Asboe, David / Boffito, Marta

    Journal of acquired immune deficiency syndromes (1999)

    2022  Volume 92, Issue 4, Page(s) e19–e20

    MeSH term(s) Humans ; HIV Infections/drug therapy ; HIV Integrase Inhibitors/therapeutic use ; Anti-HIV Agents/therapeutic use ; Drug Interactions ; HIV Integrase/genetics ; Drug Resistance, Viral/genetics
    Chemical Substances HIV Integrase Inhibitors ; Anti-HIV Agents ; HIV Integrase (EC 2.7.7.-)
    Language English
    Publishing date 2022-09-16
    Publishing country United States
    Document type Journal Article
    ZDB-ID 645053-2
    ISSN 1944-7884 ; 1077-9450 ; 0897-5965 ; 0894-9255 ; 1525-4135
    ISSN (online) 1944-7884 ; 1077-9450
    ISSN 0897-5965 ; 0894-9255 ; 1525-4135
    DOI 10.1097/QAI.0000000000003151
    Database MEDical Literature Analysis and Retrieval System OnLINE

    More links

    Kategorien

To top