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Article: Mechanical Properties Analysis of Explosive Welded Sheet of AA2519-Ti6Al4V with Interlayer of AA1050 Subjected to Heat-Treatment.

Szachogłuchowicz, Ireneusz / Śnieżek, Lucjan / Ślęzak, Tomasz

2022 Volume 15, Issue 11

Abstract: The paper presents results of investigations of welding sheets of AA2519-Ti6Al4V, a difficult-to-joint components materials, produced by explosive welding with a thin technological interlayer of AA1050. The joining process leads to the formation of ... ...

Abstract	The paper presents results of investigations of welding sheets of AA2519-Ti6Al4V, a difficult-to-joint components materials, produced by explosive welding with a thin technological interlayer of AA1050. The joining process leads to the formation of intermetalics in the vicinity of joint and generates significant residual stresses. In the next step the laminate was subjected to a heat treatment process in order to improve the mechanical properties by precipitation hardening. This treatment should not be carried out before welding because of negative influence on a ductility of the aluminum alloy. Material in this state was subjected to the tests of chemical composition, microstructure, and microhardness. A tensile test was carried out with accompanying strain analysis by the digital image correlation (DIC) method. Moreover, the residual stresses were determined which were measured by using two methods, the X-ray diffraction and the hole drilling. This approach made it possible to measure the residual stresses both in the plane parallel to the surface and in the cross section of the laminate.
Language	English
Publishing date	2022-06-06
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2487261-1
ISSN	1996-1944
ISSN	1996-1944
DOI	10.3390/ma15114023
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Article: Effect of Shot Peening on the Low-Cycle Fatigue Behavior of an AA2519-T62 Friction-Stir-Welded Butt Joint.

Kosturek, Robert / Ślęzak, Tomasz / Torzewski, Janusz / Bucior, Magdalena / Zielecki, Władysław / Śnieżek, Lucjan / Sęp, Jarosław

Materials (Basel, Switzerland)

2023 Volume 16, Issue 22

Abstract: In this investigation, an AA2519-T62 FSW butt joint was subjected to shot peening with an air pressure of p = 0.6 MPa, a processing time of t = 10 min (per side), and a steel ball diameter of ... ...

Abstract	In this investigation, an AA2519-T62 FSW butt joint was subjected to shot peening with an air pressure of p = 0.6 MPa, a processing time of t = 10 min (per side), and a steel ball diameter of d
Language	English
Publishing date	2023-11-11
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2487261-1
ISSN	1996-1944
ISSN	1996-1944
DOI	10.3390/ma16227131
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Article ; Online: Engineered Ultra-High Affinity Synthetic Antibodies for SARS-CoV-2 Neutralization and Detection.

Slezak, Tomasz / Kossiakoff, Anthony A

Journal of molecular biology

2021 Volume 433, Issue 10, Page(s) 166956

Abstract: The Covid-19 pandemic is a centenarial global catastrophe. Similar events are likely to be recurring with more frequency in the future. The inability to control the virus' impact is caused by many factors, but the lack of a technology infrastructure to ... ...

Abstract	The Covid-19 pandemic is a centenarial global catastrophe. Similar events are likely to be recurring with more frequency in the future. The inability to control the virus' impact is caused by many factors, but the lack of a technology infrastructure to detect and impede the virus at an early stage are principal shortcomings. Using phage display mutagenesis, we have generated a cohort of high performance antibody fragments (Fabs) that can be used in a sensitive point of care (POC) assay and are potent inhibitors (IC
MeSH term(s)	Amino Acid Sequence ; Animals ; Antibodies, Neutralizing/chemistry ; Antibodies, Neutralizing/immunology ; Antibody Affinity ; Chlorocebus aethiops ; Epitopes, B-Lymphocyte/chemistry ; Epitopes, B-Lymphocyte/immunology ; Freeze Drying ; Genetic Complementation Test ; Immunoglobulin Fab Fragments/chemistry ; Immunoglobulin Fab Fragments/immunology ; Neutralization Tests ; Peptide Library ; Point-of-Care Systems ; SARS-CoV-2/immunology ; SARS-CoV-2/isolation & purification ; Spike Glycoprotein, Coronavirus/chemistry ; Spike Glycoprotein, Coronavirus/immunology ; Vero Cells ; Virus Internalization ; beta-Lactamases/metabolism
Chemical Substances	Antibodies, Neutralizing ; Epitopes, B-Lymphocyte ; Immunoglobulin Fab Fragments ; Peptide Library ; Spike Glycoprotein, Coronavirus ; spike protein, SARS-CoV-2 ; beta-Lactamases (EC 3.5.2.6)
Language	English
Publishing date	2021-03-26
Publishing country	England
Document type	Journal Article
ZDB-ID	80229-3
ISSN	1089-8638 ; 0022-2836
ISSN (online)	1089-8638
ISSN	0022-2836
DOI	10.1016/j.jmb.2021.166956
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Article: Engineered Ultra-High Affinity Synthetic Antibodies for SARS-CoV-2 Neutralization and Detection

Slezak, Tomasz / Kossiakoff, Anthony A

Journal of molecular biology. 2021 May 14, v. 433, no. 10

2021

Abstract: The Covid-19 pandemic is a centenarial global catastrophe. Similar events are likely to be recurring with more frequency in the future. The inability to control the virus’ impact is caused by many factors, but the lack of a technology infrastructure to ... ...

Abstract	The Covid-19 pandemic is a centenarial global catastrophe. Similar events are likely to be recurring with more frequency in the future. The inability to control the virus’ impact is caused by many factors, but the lack of a technology infrastructure to detect and impede the virus at an early stage are principal shortcomings. Using phage display mutagenesis, we have generated a cohort of high performance antibody fragments (Fabs) that can be used in a sensitive point of care (POC) assay and are potent inhibitors (IC₅₀-0.5 nM) to viral entry into cells. The POC assay is based on a split-enzyme (β-lactamase) complementation strategy that detects virus particles at low nM levels. We have shown that this assay is equally effective for detecting other viruses like Ebola and Zika. Importantly, its components can be freeze dried and stored, but becomes fully active when rehydrated.
Keywords	COVID-19 infection ; Severe acute respiratory syndrome coronavirus 2 ; antibodies ; bacteriophages ; infrastructure ; molecular biology ; mutagenesis ; neutralization ; point-of-care systems
Language	English
Dates of publication	2021-0514
Publishing place	Elsevier Ltd
Document type	Article
Note	NAL-AP-2-clean
ZDB-ID	80229-3
ISSN	1089-8638 ; 0022-2836
ISSN (online)	1089-8638
ISSN	0022-2836
DOI	10.1016/j.jmb.2021.166956
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Article ; Online: Ultrafast Laser-Induced Dynamics of Non-Equilibrium Electron Spill-Out in Nanoplasmonic Bilayers.

Avdizhiyan, Artur / Janus, Weronika / Szpytma, Marcin / Ślezak, Tomasz / Przybylski, Marek / Chrobak, Maciej / Roddatis, Vladimir / Stupakiewicz, Andrzej / Razdolski, Ilya

Nano letters

2023 Volume 24, Issue 1, Page(s) 466–471

Abstract: Contemporary quantum plasmonics capture subtle corrections to the properties of plasmonic nano-objects in equilibrium. Here, we demonstrate non-equilibrium spill-out redistribution of the electronic density at the ultrafast time scale. As revealed by ... ...

Abstract	Contemporary quantum plasmonics capture subtle corrections to the properties of plasmonic nano-objects in equilibrium. Here, we demonstrate non-equilibrium spill-out redistribution of the electronic density at the ultrafast time scale. As revealed by time-resolved 2D spectroscopy of nanoplasmonic Fe/Au bilayers, an injection of the laser-excited non-thermal electrons induces transient electron spill-out thus changing the plasma frequency. The response of the local electronic density switches the electronic density behavior from spill-in to strong (an order of magnitude larger) spill-out at the femtosecond time scale. The superdiffusive transport of hot electrons and the lack of a direct laser heating indicate significantly non-thermal origin of the underlying physics. Our results demonstrate an ultrafast and non-thermal way to control surface plasmon dispersion through transient variations of the spatial electron distribution at the nanoscale. These findings expand quantum plasmonics into previously unexplored directions by introducing ultrashort time scales in the non-equilibrium electronic systems.
Language	English
Publishing date	2023-12-27
Publishing country	United States
Document type	Journal Article
ISSN	1530-6992
ISSN (online)	1530-6992
DOI	10.1021/acs.nanolett.3c04318
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Article: A Comprehensive Study of a Novel Explosively Hardened Pure Titanium Alloy for Medical Applications.

Gloc, Michał / Przybysz, Sylwia / Dulnik, Judyta / Kołbuk, Dorota / Wachowski, Marcin / Kosturek, Robert / Ślęzak, Tomasz / Krawczyńska, Agnieszka / Ciupiński, Łukasz

Materials (Basel, Switzerland)

2023 Volume 16, Issue 22

Abstract: Pure titanium is gaining increasing interest due to its potential use in dental and orthopedic applications. Due to its relatively weak mechanical parameters, a limited number of components manufactured from pure titanium are available on the market. In ... ...

Abstract	Pure titanium is gaining increasing interest due to its potential use in dental and orthopedic applications. Due to its relatively weak mechanical parameters, a limited number of components manufactured from pure titanium are available on the market. In order to improve the mechanical parameters of pure titanium, manufacturers use alloys containing cytotoxic vanadium and aluminum. This paper presents unique explosive hardening technology that can be used to strengthen pure titanium parameters. The analysis confirms that explosive induced α-ω martensitic transformation and crystallographic anisotropy occurred due to the explosive pressure. The mechanical properties related to residual stresses are very nonuniform. The corrosion properties of the explosive hardened pure titanium test do not change significantly compared to nonhardened titanium. The biocompatibility of all the analyzed samples was confirmed in several tests. The morphology of bone cells does not depend on the titanium surface phase composition and crystallographic orientation.
Language	English
Publishing date	2023-11-16
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2487261-1
ISSN	1996-1944
ISSN	1996-1944
DOI	10.3390/ma16227188
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Article ; Online: Using expert-reviewed CSAM to train CNNs and its anthropological analysis.

Oronowicz-Jaśkowiak, Wojciech / Kozłowski, Tomasz / Polańska, Marta / Wojciechowski, Jerzy / Wasilewski, Piotr / Ślęzak, Dominik / Kowaluk, Mirosław

Journal of forensic and legal medicine

2023 Volume 101, Page(s) 102619

Abstract: Machine learning methods for the identification of child sexual abuse materials (CSAM) have been previously studied, however, they have serious limitations. Firstly, the training sets used to train the appropriate machine learning algorithms were not ... ...

Abstract	Machine learning methods for the identification of child sexual abuse materials (CSAM) have been previously studied, however, they have serious limitations. Firstly, the training sets used to train the appropriate machine learning algorithms were not previously annotated by a forensic expert in anthropology. Secondly, previously presented solutions have rarely used models trained using real pornographic content involving children. Thirdly, previous studies have not presented a detailed justification for the classification decisions made, which is important due to the recent guidelines of the European Commission (Artificial Intelligence Act). The aim of the study was to train convolution neural networks (CNNs) using expert-labelled CSAM images and thereby identify the elements of the body and/or the environment that are critical for classifications by the neural network. To train and evaluate machine learning models, we used 60,000 images equally divided into four classes (CSAM images, images displaying sexual activity involving adults, images of people without sexual activity, and images not containing people). We used four neural network architectures: MobileNet, ResNet152, xResNet152 and its modification ResNet-s, designed for the purpose of research. The trained models provided high accuracy of classifying CSAM images: xResNet152 (F1 = 0.93, 92,8%), xResNet-s (F1 = 0.93, 93,1%), ResNet152 (F1 = 0.90, 91,39%), MobileNet (F1 ranged from 0.85 to 0.87, accuracy ranged from 86% to 87%). The results of the conducted research suggest that using expert knowledge (in sexology and anthropology) significantly improved the accuracy of the models. In regard to further anthropological analysis, the results indicate that the breasts, face and torso are crucial areas for the classification of pornographic content with children's participation. Results suggests that the ResNet-s neural network may be a reliable tool for clinical work and to support the work of experts witnesses in the field of anthropology. The study design received a positive opinion of the Ethics Committee of the Faculty of Mathematics, Informatics and Mechanics of the University of Warsaw. The clinical material was used for research purposes with the consent of the relevant prosecutor's offices. Authors provided free version of Windows application to classify CSAM for forensic experts, policemen and prosecutors at the OSF repository (DOI: 10.17605/OSF.IO/RU7JX).
MeSH term(s)	Child ; Humans ; Artificial Intelligence ; Child Abuse, Sexual ; Neural Networks, Computer ; Algorithms ; Machine Learning
Language	English
Publishing date	2023-11-17
Publishing country	England
Document type	Journal Article
ZDB-ID	2268721-X
ISSN	1878-7487 ; 1752-928X
ISSN (online)	1878-7487
ISSN	1752-928X
DOI	10.1016/j.jflm.2023.102619
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Article ; Online: Engineering of a synthetic antibody fragment for structural and functional studies of K+ channels.

Rohaim, Ahmed / Slezak, Tomasz / Koh, Young Hoon / Blachowicz, Lydia / Kossiakoff, Anthony A / Roux, Benoît

The Journal of general physiology

2022 Volume 154, Issue 4

Abstract: Engineered antibody fragments (Fabs) have made major impacts on structural biology research, particularly to aid structural determination of membrane proteins. Nonetheless, Fabs generated by traditional monoclonal technology suffer from challenges of ... ...

Abstract	Engineered antibody fragments (Fabs) have made major impacts on structural biology research, particularly to aid structural determination of membrane proteins. Nonetheless, Fabs generated by traditional monoclonal technology suffer from challenges of routine production and storage. Starting from the known IgG paratopes of an antibody that binds to the "turret loop" of the KcsA K+ channel, we engineered a synthetic Fab (sFab) based upon the highly stable Herceptin Fab scaffold, which can be recombinantly expressed in Escherichia coli and purified with single-step affinity chromatography. This synthetic Fab was used as a crystallization chaperone to obtain crystals of the KcsA channel that diffracted to a resolution comparable to that from the parent Fab. Furthermore, we show that the turret loop can be grafted into the unrelated voltage-gated Kv1.2-Kv2.1 channel and still strongly bind the engineered sFab, in support of the loop grafting strategy. Macroscopic electrophysiology recordings show that the sFab affects the activation and conductance of the chimeric voltage-gated channel. These results suggest that straightforward engineering of antibodies using recombinant formats can facilitate the rapid and scalable production of Fabs as structural biology tools and functional probes. The impact of this approach is expanded significantly based on the potential portability of the turret loop to a myriad of other K+ channels.
MeSH term(s)	Amino Acid Sequence ; Immunoglobulin Fragments/metabolism ; Potassium Channels/metabolism ; Potassium Channels, Voltage-Gated/metabolism
Chemical Substances	Immunoglobulin Fragments ; Potassium Channels ; Potassium Channels, Voltage-Gated
Language	English
Publishing date	2022-03-02
Publishing country	United States
Document type	Journal Article ; Research Support, N.I.H., Extramural ; Research Support, U.S. Gov't, Non-P.H.S.
ZDB-ID	3118-5
ISSN	1540-7748 ; 0022-1295
ISSN (online)	1540-7748
ISSN	0022-1295
DOI	10.1085/jgp.202112965
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Article ; Online: Bioactive Lavandula angustifolia essential oil-loaded nanoemulsion dressing for burn wound healing. In vitro and in vivo studies.

Miastkowska, Małgorzata / Sikora, Elżbieta / Kulawik-Pióro, Agnieszka / Kantyka, Tomasz / Bielecka, Ewa / Kałucka, Urszula / Kamińska, Marta / Szulc, Joanna / Piasecka-Zelga, Joanna / Zelga, Piotr / Staniszewska-Ślęzak, Emilia

Biomaterials advances

2023 Volume 148, Page(s) 213362

Abstract: The aim of this study was to develop a dressing with bioactive lavender in a new form of nanoemulsion, and to verify its biosafety and effectiveness in burn wound healing. As part of this research, the composition of the bioactive carrier of lavender oil ...

Abstract	The aim of this study was to develop a dressing with bioactive lavender in a new form of nanoemulsion, and to verify its biosafety and effectiveness in burn wound healing. As part of this research, the composition of the bioactive carrier of lavender oil in the form of a nanoemulsion obtained using ultrasound was optimised. The mean particle size of the internal phase and polydispersity were determined using the dynamic light scattering method using a Zestasizer NanoZS by Malvern and using cryo-transmission electron microscopy (TEM). These studies confirmed that the selected formulation had a particle size of approximately 180 nm and remained stable over time. The preparation was also subjected to rheological analysis (viscosity approximately 480 mPa·s) and a pH test (approximately 6). A macroemulsion (ME) with the same qualitative composition was developed as a reference. Nanoformulations and MEs were tested for skin penetration using Raman spectroscopy in an in vitro model. Research has shown that both formulations deliver oil to living layers of the skin. Subsequently, studies were conducted to confirm the effect of lavender oil in emulsion systems on the mitigation of the inflammatory reaction and its pro-regenerative effect on the wound healing process in an in vitro cell culture model. The safe concentration of the oil in the emulsion preparation was also determined based on preliminary in vivo tests of skin sensitisation and irritation as well as an hemocompatibility test of the preparation.
MeSH term(s)	Lavandula ; Emulsions ; Wound Healing ; Oils, Volatile/pharmacology ; Oils, Volatile/therapeutic use ; Bandages
Chemical Substances	Emulsions ; Oils, Volatile
Language	English
Publishing date	2023-03-03
Publishing country	Netherlands
Document type	Journal Article
ISSN	2772-9508
ISSN (online)	2772-9508
DOI	10.1016/j.bioadv.2023.213362
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Article: Research on the Properties and Low Cycle Fatigue of Sc-Modified AA2519-T62 FSW Joint.

Kosturek, Robert / Śnieżek, Lucjan / Torzewski, Janusz / Ślęzak, Tomasz / Wachowski, Marcin / Szachogłuchowicz, Ireneusz

Materials (Basel, Switzerland)

2020 Volume 13, Issue 22

Abstract: The aim of this research was to examine the mechanical and fatigue properties of friction stir welded Sc-modified 5 mm thick AA2519-T62 extrusion. The joint was obtained using the following parameters: 800 rpm tool rotation speed, 100 mm/min tool ... ...

Abstract	The aim of this research was to examine the mechanical and fatigue properties of friction stir welded Sc-modified 5 mm thick AA2519-T62 extrusion. The joint was obtained using the following parameters: 800 rpm tool rotation speed, 100 mm/min tool traverse speed, 17 kN axial, and MX Triflute as a tool. The investigation has involved microstructure observations, microhardness distribution analysis, tensile test with digital image correlation technique, observations of the fracture surface, measurements of residual stresses, low cycle fatigue testing, and fractography. It was stated that the obtained weld is defect-free and has joint efficiency of 83%. The failure in the tensile test occurred at the boundary of the thermo-mechanically affected zone and stir zone on the advancing side of the weld. The residual stress measurements have revealed that the highest values of longitudinal stress are localized at the distance of 10 mm from the joint line with their values of 124 MPa (the retreating side) and 159 MPa (the advancing side). The results of low cycle fatigue testing have allowed establishing of the values of the cyclic strength coefficient (k' = 504.37 MPa) and cyclic strain hardening exponent (n' = 0.0068) as well as the factors of the Manson-Coffin-Basquin equation: the fatigue strength coefficient σ'
Language	English
Publishing date	2020-11-19
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2487261-1
ISSN	1996-1944
ISSN	1996-1944
DOI	10.3390/ma13225226
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