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  1. Article ; Online: Brachyterapy: The radiation oncologist opinion.

    Tagliaferri, Luca / Valentini, Vincenzo

    Urologia

    2024  Volume 91, Issue 1, Page(s) 8–10

    Abstract: The role of the radiation oncologist in the management of patients affected by prostate cancer is increasingly considered thanks to important technological innovations that have marked the radiotherapeutic approach in its three main fields: external beam ...

    Abstract The role of the radiation oncologist in the management of patients affected by prostate cancer is increasingly considered thanks to important technological innovations that have marked the radiotherapeutic approach in its three main fields: external beam radiotherapy (EB-RT), brachytherapy (interventional radiotherapy, I-RT), and metabolic radiotherapy (M-RT) through the use of new radiopharmaceuticals. Regarding the modern brachytherapy, the introduction of intensity-modulated techniques (IM-IRT), thanks to the implementation of HDR remote-after loading machines, and image-guided techniques (IG-IRT), has led to advantages in optimizing dose distribution after implantation with the possibility of modulating the dose according to the intraprostatic dominant lesions, limiting the dose to the surrounding tissues with improvement in local control and a significant reduction in side effects. I-RT today represents a safe, scientifically established, effective and well-tolerated treatment for patients affected by prostate cancer. Like most special techniques, in order to obtain the best results, it must be performed in centers with a high volume of activity and consolidated experience with an interdisciplinary approach.
    MeSH term(s) Male ; Humans ; Radiation Oncologists ; Brachytherapy/adverse effects ; Brachytherapy/methods ; Prostatic Neoplasms/pathology ; Radiotherapy Dosage
    Language English
    Publishing date 2024-03-11
    Publishing country United States
    Document type Journal Article
    ZDB-ID 204043-8
    ISSN 1724-6075 ; 0376-0057 ; 0391-5603
    ISSN (online) 1724-6075
    ISSN 0376-0057 ; 0391-5603
    DOI 10.1177/03915603241231732
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Modeling Dissolution-Precipitation Kinetics of Alkali-Activated Metakaolin.

    Valentini, Luca

    ACS omega

    2018  Volume 3, Issue 12, Page(s) 18100–18108

    Abstract: The numerical model HydratiCA was used to simulate the reaction kinetics of alkali-activated metakaolin, a material belonging to a class of sustainable binders alternative to Portland cement. The full chemistry of the system, including solid phases and ... ...

    Abstract The numerical model HydratiCA was used to simulate the reaction kinetics of alkali-activated metakaolin, a material belonging to a class of sustainable binders alternative to Portland cement. The full chemistry of the system, including solid phases and aqueous species, is taken into account in these simulations. Specifically, metakaolin dissolution, reaction product nucleation and growth, and ion speciation, and diffusion in solution are simulated. The sodium aluminosilicate (N-A-S-H), formed by the reaction of metakaolin in alkaline solution, is implemented in the model as a combination of co-precipitating pseudo-zeolitic phases, with variable stoichiometry. The results show how variations of the reaction pathways, occurring when alkaline activators of different composition and concentration are used, can be associated with different macroscopic behaviors in terms of mechanical performance and durability. Reconciling these macroscopic properties with the basic chemical processes will be a fundamental technological challenge for the deployment of sustainable technologies in the construction industry.
    Language English
    Publishing date 2018-12-24
    Publishing country United States
    Document type Journal Article
    ISSN 2470-1343
    ISSN (online) 2470-1343
    DOI 10.1021/acsomega.8b02380
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  3. Article ; Online: Modeling Dissolution–Precipitation Kinetics of Alkali-Activated Metakaolin

    Luca Valentini

    ACS Omega, Vol 3, Iss 12, Pp 18100-

    2018  Volume 18108

    Keywords Chemistry ; QD1-999
    Language English
    Publishing date 2018-12-01T00:00:00Z
    Publisher American Chemical Society
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  4. Article ; Online: A Special Section on

    Baia, Monica / Baibarac, Mihaela A / Valentini, Luca / Baia, Lucian

    Journal of nanoscience and nanotechnology

    2021  Volume 21, Issue 4, Page(s) 2265–2268

    Language English
    Publishing date 2021-01-26
    Publishing country United States
    Document type Journal Article
    ISSN 1533-4899
    ISSN (online) 1533-4899
    DOI 10.1166/jnn.2021.18977
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  5. Article ; Online: “A Woman Clothed with the Sun”

    Claudia Colantonio / Luca Lanteri / Ramona Bocci / Valeria Valentini / Claudia Pelosi

    Applied Sciences, Vol 13, Iss 23, p

    The Diagnostic Study and Testing of Enzyme-Based Green Products for the Restoration of an Early 17th Century Wall Painting in the Palazzo Gallo in Bagnaia (Italy)

    2023  Volume 12884

    Abstract: A 17th century wall painting, representing the Virgin between two Saints, in a noble Italian renaissance palace, the Palazzo Gallo in Bagnaia (Viterbo, Italy), was restored in 2021 in the context of a wider restoration campaign involving the main room of ...

    Abstract A 17th century wall painting, representing the Virgin between two Saints, in a noble Italian renaissance palace, the Palazzo Gallo in Bagnaia (Viterbo, Italy), was restored in 2021 in the context of a wider restoration campaign involving the main room of the palace built by cardinal Sansoni Riario. Diagnostic analyses performed using traditional characterization techniques (optical microscopy on micro-stratigraphic sections, X-ray fluorescence spectroscopy and Fourier transform infrared spectroscopy) provided the identification of both the original painting and its restoration materials, while imaging investigations using the ultraviolet fluorescence photography, false color images and multispectral mapping provided by the hypercolorimetric multispectral imaging (HMI) technique enabled the evaluation of the state of conservation, the location of restoration interventions and supported the monitoring of the cleaning procedure. An altered protective Paraloid ® -based coating dating from the early 2000s had to be removed due to the unpleasant glossy finishing it had given to the painted surface, making the scene barely readable. To pursue a restoration protocol based on environmental sustainability and green chemistry, enzyme-based gels marketed by the Nasier-Brenta© and CTS© companies were tested in different protocols for the cleaning of the mixture (known as beverone ) covering the painting. Although some interesting results were observed, the enzymatic cleaning had limited effectiveness, and was more timing-consuming than was reasonable. Traditional chemical solvents such as Dowanol PM (methoxy propanol) and benzyl alcohol were necessary to complete the cleaning of the painting surface.
    Keywords wall painting ; restoration ; enzymatic cleaning ; non-invasive diagnostics ; Technology ; T ; Engineering (General). Civil engineering (General) ; TA1-2040 ; Biology (General) ; QH301-705.5 ; Physics ; QC1-999 ; Chemistry ; QD1-999
    Subject code 700
    Language English
    Publishing date 2023-11-01T00:00:00Z
    Publisher MDPI AG
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  6. Article ; Online: Bionicomposites.

    Pugno, Nicola M / Valentini, Luca

    Nanoscale

    2019  Volume 11, Issue 7, Page(s) 3102–3111

    Abstract: Incorporating nanomaterials in living systems could force the latter to produce "bionicomposites". We report a review of the first attempts with such bionicomposites, e.g. showing how the control of the eating and dormant states of microorganisms can ... ...

    Abstract Incorporating nanomaterials in living systems could force the latter to produce "bionicomposites". We report a review of the first attempts with such bionicomposites, e.g. showing how the control of the eating and dormant states of microorganisms can provide nano-architectures with novel mechanical and functional properties, and how introducing nanomaterials in the diets of animals producing silks (spiders or silkworms) leads to intrinsically reinforced fibers with strengths higher than those of their natural counterparts, as well as those of synthetic polymer fibers or carbon fiber-reinforced polymeric composites.
    MeSH term(s) Biomimetic Materials/chemistry ; Nanostructures/chemistry ; Silk/chemistry
    Chemical Substances Silk
    Language English
    Publishing date 2019-02-07
    Publishing country England
    Document type Journal Article
    ZDB-ID 2515664-0
    ISSN 2040-3372 ; 2040-3364
    ISSN (online) 2040-3372
    ISSN 2040-3364
    DOI 10.1039/c8nr08569b
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article ; Online: A Proposal for a Forest Digital Twin Framework and Its Perspectives

    Luca Buonocore / Jim Yates / Riccardo Valentini

    Forests, Vol 13, Iss 498, p

    2022  Volume 498

    Abstract: The increasing importance of forest ecosystems for human society and planetary health is widely recognized, and the advancement of data collection technologies enables new and integrated ways for forest ecosystems monitoring. Therefore, the target of ... ...

    Abstract The increasing importance of forest ecosystems for human society and planetary health is widely recognized, and the advancement of data collection technologies enables new and integrated ways for forest ecosystems monitoring. Therefore, the target of this paper is to propose a framework to design a forest digital twin (FDT) that, by integrating different state variables at both tree and forest levels, creates a virtual copy of the forest. The integration of these data sets could be used for scientific purposes, for reporting the health status of forests, and ultimately for implementing sustainable forest management practices on the basis of the use cases that a specific implementation of the framework would underpin. Achieving such outcomes requires the twinning of single trees as a core element of the FDT by recording the physical and biotic state variables of the tree and of the near environment via real–virtual digital sockets. Following a nested approach, the twinned trees and the related physical and physiological processes are then part of a broader twinning of the entire forest realized by capturing data at forest scale from sources such as remote sensing technologies and flux towers. Ultimately, to unlock the economic value of forest ecosystem services, the FDT should implement a distributed ledger-based on blockchain and smart contracts to ensure the highest transparency, reliability, and thoroughness of the data and the related transactions and to sharpen forest risk management with the final goal to improve the capital flow towards sustainable practices of forest management.
    Keywords forest digital twin ; ecosystem services ; blockchain ; IoT ; Earth’s digital models ; Plant ecology ; QK900-989
    Subject code 333
    Language English
    Publishing date 2022-03-01T00:00:00Z
    Publisher MDPI AG
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  8. Article ; Online: Vernal keratoconjunctivitis in Down syndrome: a case report.

    Artesani, Maria Cristina / Esposito, Mariacristina / Valentini, Diletta / Villani, Alberto / Fiocchi, Alessandro Giovanni / Buzzonetti, Luca

    BMC ophthalmology

    2023  Volume 23, Issue 1, Page(s) 106

    Abstract: Background: Down syndrome (DS) or Trisomy 21 is the most common chromosomal disease and is characterized by possible heart defects, cognitive impairment and visual disorders.: Case presentation: We describe for the first time a 17-year-old Caucasian ... ...

    Abstract Background: Down syndrome (DS) or Trisomy 21 is the most common chromosomal disease and is characterized by possible heart defects, cognitive impairment and visual disorders.
    Case presentation: We describe for the first time a 17-year-old Caucasian girl suffering from Down syndrome associated with vernal keratoconjunctivitis (VKC), a rare disorder of the anterior segment of the eye, characterized by intense photophobia, redness, watering eyes and itching due to an inflammatory-allergic reaction of the cornea and conjunctiva. On slit-lamp examination, the girl showed conjunctival hyperemia, papillary hypertrophy, giant papillae and corneal leukoma in right eye as a result of a previous corneal ulcer. A successful topical immunosuppressant therapy with cyclosporin 1% was started.
    Conclusion: So far, to our knowledge, this is the first description of VKC in a patient with DS. Finding an inflammatory-allergic disease such as VKC in DS is unusual but it must be taken into account because keratoconus, one of the most frequent eye pathologies in DS, can be secondary to an unrecognized VKC.
    MeSH term(s) Female ; Humans ; Adolescent ; Conjunctivitis, Allergic/complications ; Conjunctivitis, Allergic/diagnosis ; Down Syndrome/complications ; Down Syndrome/pathology ; Conjunctiva/pathology ; Cyclosporine/therapeutic use ; Cornea/pathology ; Inflammation
    Chemical Substances Cyclosporine (83HN0GTJ6D)
    Language English
    Publishing date 2023-03-17
    Publishing country England
    Document type Case Reports ; Journal Article
    ZDB-ID 2050436-6
    ISSN 1471-2415 ; 1471-2415
    ISSN (online) 1471-2415
    ISSN 1471-2415
    DOI 10.1186/s12886-023-02855-y
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  9. Article ; Online: Correction to "Electrospun Nanofibrous UV Filters with Bidirectional Actuation Properties Based on Salmon Sperm DNA/Silk Fibroin for Biomedical Applications".

    Ceccarini, Maria Rachele / Chiesa, Irene / Ripanti, Francesca / Cardinali, Martina Alunni / Micalizzi, Simone / Scattini, Gabriele / De Maria, Carmelo / Paciaroni, Alessandro / Petrillo, Caterina / Comez, Lucia / Bertelli, Matteo / Sassi, Paola / Pascucci, Luisa / Beccari, Tommaso / Valentini, Luca

    ACS omega

    2024  Volume 9, Issue 5, Page(s) 6025

    Abstract: This corrects the article DOI: 10.1021/acsomega.3c04563.]. ...

    Abstract [This corrects the article DOI: 10.1021/acsomega.3c04563.].
    Language English
    Publishing date 2024-01-25
    Publishing country United States
    Document type Published Erratum
    ISSN 2470-1343
    ISSN (online) 2470-1343
    DOI 10.1021/acsomega.4c00072
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article ; Online: Comparison between clinical evaluations and laboratory findings and the impact of biofilm on antimicrobial susceptibility in vitro in canine otitis externa.

    Luciani, Luca / Stefanetti, Valentina / Rampacci, Elisa / Gobbi, Pietro / Valentini, Laura / Capuozzo, Raffaella / Passamonti, Fabrizio

    Veterinary dermatology

    2023  Volume 34, Issue 6, Page(s) 586–596

    Abstract: Background: In canine otitis externa (OE), biofilm-producing bacteria are frequently present but biofilm may be underdiagnosed clinically.: Hypothesis/objectives: The study aimed to investigate an association between clinical and cytological findings ...

    Abstract Background: In canine otitis externa (OE), biofilm-producing bacteria are frequently present but biofilm may be underdiagnosed clinically.
    Hypothesis/objectives: The study aimed to investigate an association between clinical and cytological findings with bacteriological data from dogs with OE, to establish, through Environmental Scanning Electron Microscope (ESEM) examination, whether the presence of biofilm in vivo can be predicted and to evaluate the impact of biofilm on antimicrobial susceptibility tests.
    Materials and methods: Fifty-six dogs showing clinical signs of OE were enrolled. One cotton swab each was collected for ESEM, bacterial culture and susceptibility testing and for cytology. Staphylococcus pseudintermedius (n = 42, 48.8%) and Pseudomonas aeruginosa (n = 26, 30.2%) were tested for their ability to form biofilm. Minimum Inhibitory Concentrations (MIC), Minimal Biofilm Inhibitory Concentrations (MBIC) and Minimal Biofilm Eradication Concentrations (MBEC) towards enrofloxacin, gentamicin, polymyxin B and rifampicin were determined.
    Results: Pseudomonas aeruginosa was positively associated with the biofilm clinical evaluation (p < 0.01) and neutrophils (p < 0.05), nuclear streaks (p < 0.01) and rods bacteria (p < 0.01) on cytology. S. pseudintermedius was associated with a low presence of neutrophils. There was a statistical correlation between clinical and cytological biofilm presence (p ≤ 0.01), but none with the biofilm production assay nor ESEM biofilm detection. No differences were found comparing the results of MIC and MBIC. MBEC results showed higher values than MIC and MBIC for all antimicrobials tested (p ≤ 0.001).
    Conclusions and clinical relevance: Biofilm presence in OE was often underdiagnosed. Even if there is no specific clinical or cytological pattern related to biofilm, its presence should always be suspected.
    MeSH term(s) Dogs ; Animals ; Otitis Externa/drug therapy ; Otitis Externa/veterinary ; Otitis Externa/microbiology ; Anti-Bacterial Agents/pharmacology ; Anti-Bacterial Agents/therapeutic use ; Anti-Infective Agents/pharmacology ; Biofilms ; Microbial Sensitivity Tests/veterinary ; Dog Diseases/drug therapy ; Dog Diseases/microbiology
    Chemical Substances Anti-Bacterial Agents ; methyl 2-(-5-fluoro-2-hydroxyphenyl)-1 H-benzo(d)imidazole-5-carboxylate ; Anti-Infective Agents
    Language English
    Publishing date 2023-08-14
    Publishing country England
    Document type Journal Article
    ZDB-ID 2011122-8
    ISSN 1365-3164 ; 0959-4493
    ISSN (online) 1365-3164
    ISSN 0959-4493
    DOI 10.1111/vde.13197
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