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  1. Article ; Online: The

    Zhang, Meiqi / Wu, Xiaoyu / Chen, Luhan / Yang, Lin / Cui, Xiaoshuang / Cao, Yunyun

    International journal of molecular sciences

    2024  Volume 25, Issue 6

    Abstract: Guanine nucleotide-exchange ... ...

    Abstract Guanine nucleotide-exchange factors
    MeSH term(s) Brassica rapa/metabolism ; Stress, Physiological/genetics ; Salt Stress ; Multigene Family ; Gene Expression Profiling ; Phylogeny ; Gene Expression Regulation, Plant ; Plant Proteins/genetics ; Plant Proteins/metabolism
    Chemical Substances Plant Proteins
    Language English
    Publishing date 2024-03-21
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2019364-6
    ISSN 1422-0067 ; 1422-0067 ; 1661-6596
    ISSN (online) 1422-0067
    ISSN 1422-0067 ; 1661-6596
    DOI 10.3390/ijms25063541
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Fast cycling of lithium metal in solid-state batteries by constriction-susceptible anode materials.

    Ye, Luhan / Lu, Yang / Wang, Yichao / Li, Jianyuan / Li, Xin

    Nature materials

    2024  Volume 23, Issue 2, Page(s) 244–251

    Abstract: Interface reaction between lithium (Li) and materials at the anode is not well understood in an all-solid environment. This paper unveils a new phenomenon of constriction susceptibility for materials at such an interface, the utilization of which helps ... ...

    Abstract Interface reaction between lithium (Li) and materials at the anode is not well understood in an all-solid environment. This paper unveils a new phenomenon of constriction susceptibility for materials at such an interface, the utilization of which helps facilitate the design of an active three-dimensional scaffold to host rapid plating and stripping of a significant amount of a thick Li metal layer. Here we focus on the well-known anode material silicon (Si) to demonstrate that, rather than strong Li-Si alloying at the conventional solid-liquid interface, the lithiation reaction of micrometre-sized Si can be significantly constricted at the solid-solid interface so that it occurs only at thin surface sites of Si particles due to a reaction-induced, diffusion-limiting process. The dynamic interaction between surface lithiation and Li plating of a family of anode materials, as predicted by our constrained ensemble computational approach and represented by Si, silver (Ag) and alloys of magnesium (Mg), can thus more homogeneously distribute current densities for the rapid cycling of Li metal at high areal capacity, which is important in regard to solid-state battery application.
    Language English
    Publishing date 2024-01-08
    Publishing country England
    Document type Journal Article
    ZDB-ID 2088679-2
    ISSN 1476-4660 ; 1476-1122
    ISSN (online) 1476-4660
    ISSN 1476-1122
    DOI 10.1038/s41563-023-01722-x
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article: Genome-Wide Identification of

    Chen, Luhan / Wu, Xiaoyu / Zhang, Meiqi / Yang, Lin / Ji, Zhaojing / Chen, Rui / Cao, Yunyun / Huang, Jiabao / Duan, Qiaohong

    Plants (Basel, Switzerland)

    2024  Volume 13, Issue 8

    Abstract: CCT MOTIF ... ...

    Abstract CCT MOTIF FAMILY
    Language English
    Publishing date 2024-04-17
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2704341-1
    ISSN 2223-7747
    ISSN 2223-7747
    DOI 10.3390/plants13081118
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  4. Article ; Online: Understanding heavy metal distribution in timberline vegetations: A case from the Gongga Mountain, eastern Tibetan Plateau.

    Zeng, Shufang / Li, Xianming / Yang, Luhan / Wang, Dingyong

    The Science of the total environment

    2023  Volume 874, Page(s) 162523

    Abstract: To quantify impacts of vegetation and topographic factors on heavy metal accumulation in montane forests, we assessed the spatial distribution and determined the sources of mercury (Hg), cadmium (Cd), lead (Pb), chromium (Cr), copper (Cu) and zinc (Zn) ... ...

    Abstract To quantify impacts of vegetation and topographic factors on heavy metal accumulation in montane forests, we assessed the spatial distribution and determined the sources of mercury (Hg), cadmium (Cd), lead (Pb), chromium (Cr), copper (Cu) and zinc (Zn) in timberline forests of Gongga Mountain. Our results show that vegetation type has little impact on the soil Hg, Cd and Pb concentrations. The soil concentrations of Cr, Cu and Zn are controlled by litter return, moss and lichen biomass, and canopy interception, with the highest concentrations in shrub forest. In contrast to other forests, the soil Hg pool in coniferous forest is significantly high due to the elevated Hg concentration and greater biomass production in litter. However, the soil pool sizes of Cd, Cr, Cu and Zn show a distinct increase along the elevation, which are attributed to the elevated heavy metal inputs from litter and moss, as well as the greater cloud water-induced atmospheric heavy metal depositions. The highest Hg concentrations of the aboveground parts of plant are in the foliage and bark, while the concentrations of Cd, Pb, Cr, Cu and Zn in the branch and bark are the highest. The decreased biomass density leads to a downward trend in the total vegetation pool sizes of Hg, Cd, Pb, Cr, Cu and Zn by 0.4-4.4 times with increasing elevation. The statistical analysis finally suggests that Hg, Cd and Pb mainly originate from anthropogenic atmospheric deposition, whereas Cr, Cu and Zn are mainly from natural sources. Our results highlight the importance of vegetation types and terrain conditions on distribution patterns of heavy metal in alpine forests.
    MeSH term(s) Cadmium/analysis ; Tibet ; Lead/analysis ; Soil Pollutants/analysis ; Metals, Heavy/analysis ; Mercury/analysis ; Chromium/analysis ; Soil ; Bryophyta ; Environmental Monitoring/methods ; China ; Risk Assessment
    Chemical Substances Cadmium (00BH33GNGH) ; Lead (2P299V784P) ; Soil Pollutants ; Metals, Heavy ; Mercury (FXS1BY2PGL) ; Chromium (0R0008Q3JB) ; Soil
    Language English
    Publishing date 2023-03-02
    Publishing country Netherlands
    Document type Journal Article
    ZDB-ID 121506-1
    ISSN 1879-1026 ; 0048-9697
    ISSN (online) 1879-1026
    ISSN 0048-9697
    DOI 10.1016/j.scitotenv.2023.162523
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 949: Show issues Location:
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    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
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  5. Article ; Online: Mercury Accumulation and Sequestration in a Deglaciated Forest Chronosequence: Insights from Particulate and Mineral-Associated Forms of Organic Matter.

    Wu, Fei / Yang, Luhan / Wang, Xun / Yuan, Wei / Lin, Che-Jen / Feng, Xinbin

    Environmental science & technology

    2023  Volume 57, Issue 43, Page(s) 16512–16521

    Abstract: Understanding mercury (Hg) complexation with soil organic matter is important in assessing atmospheric Hg accumulation and sequestration processes in forest ecosystems. Separating soil organic matter into particulate organic matter (POM) and mineral- ... ...

    Abstract Understanding mercury (Hg) complexation with soil organic matter is important in assessing atmospheric Hg accumulation and sequestration processes in forest ecosystems. Separating soil organic matter into particulate organic matter (POM) and mineral-associated organic matter (MAOM) can help in the understanding of Hg dynamics and cycling due to their very different chemical constituents and associated formation and functioning mechanisms. The concentration of Hg, carbon, and nitrogen contents and isotopic signatures of POM and MAOM in a deglaciated forest chronosequence were determined to construct the processes of Hg accumulation and sequestration. The results show that Hg in POM and MAOM are mainly derived from atmospheric Hg
    MeSH term(s) Mercury/analysis ; Ecosystem ; Forests ; Minerals ; Soil/chemistry ; Dust ; Particulate Matter ; Environmental Monitoring/methods
    Chemical Substances Mercury (FXS1BY2PGL) ; Minerals ; Soil ; Dust ; Particulate Matter
    Language English
    Publishing date 2023-10-19
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ISSN 1520-5851
    ISSN (online) 1520-5851
    DOI 10.1021/acs.est.3c03107
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  6. Article ; Online: Quantitative identification of the co-exposure effects of e-waste pollutants on human oxidative stress by explainable machine learning.

    Yang, Luhan / Zhang, Tao / Gao, Yanxia / Li, Dairui / Cui, Rui / Gu, Cheng / Wang, Lei / Sun, Hongwen

    Journal of hazardous materials

    2024  Volume 466, Page(s) 133560

    Abstract: Global electronic waste (e-waste) generation continues to grow. The various pollutants released during precarious e-waste disposal activities can contribute to human oxidative stress. This study encompassed 129 individuals residing near e-waste ... ...

    Abstract Global electronic waste (e-waste) generation continues to grow. The various pollutants released during precarious e-waste disposal activities can contribute to human oxidative stress. This study encompassed 129 individuals residing near e-waste dismantling sites in China, with elevated urinary concentrations of e-waste-related pollutants including heavy metals, polycyclic aromatic hydrocarbons (PAHs), organophosphorus flame retardants (OPFRs), bisphenols (BPs), and phthalate esters (PAEs). Utilizing an explainable machine learning framework, the study quantified the co-exposure effects of these pollutants, finding that approximately 23% and 18% of the variance in oxidative DNA damage and lipid peroxidation, respectively, was attributable to these substances. Heavy metals emerged as the most critical factor in inducing oxidative stress, followed by PAHs and PAEs for oxidative DNA damage, and BPs, OPFRs, and PAEs for lipid peroxidation. The interactions between different pollutant classes were found to be weak, attributable to their disparate biological pathways. In contrast, the interactions among congeneric pollutants were strong, stemming from their shared pathways and resultant synergistic or additive effects on oxidative stress. An intelligent analysis system for e-waste pollutants was also developed, which enables more efficient processing of large-scale and dynamic datasets in evolving environments. This study offered an enticing peek into the intricacies of co-exposure effect of e-waste pollutants.
    MeSH term(s) Humans ; Environmental Pollutants/toxicity ; Environmental Pollutants/analysis ; Electronic Waste/analysis ; Metals, Heavy/analysis ; Refuse Disposal ; Oxidative Stress ; Polycyclic Aromatic Hydrocarbons/analysis ; China ; Flame Retardants
    Chemical Substances Environmental Pollutants ; Metals, Heavy ; Polycyclic Aromatic Hydrocarbons ; Flame Retardants
    Language English
    Publishing date 2024-01-19
    Publishing country Netherlands
    Document type Journal Article
    ZDB-ID 1491302-1
    ISSN 1873-3336 ; 0304-3894
    ISSN (online) 1873-3336
    ISSN 0304-3894
    DOI 10.1016/j.jhazmat.2024.133560
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  7. Article: Emerging technologies for engineering of extracellular vesicles.

    Zhou, Xin / Huang, Qing / Jiang, Yang / Tang, Huijing / Zhang, Luhan / Li, Danyang / Xu, Yunsheng

    Frontiers in bioengineering and biotechnology

    2023  Volume 11, Page(s) 1298746

    Abstract: Extracellular vesicles (EVs) are lipid-bilayer membrane-enclosed vesicles that are secreted by all cell types. Natural EVs contain biological information such as proteins, nucleic acids, and lipids from their parent cells. Therefore, EVs have been ... ...

    Abstract Extracellular vesicles (EVs) are lipid-bilayer membrane-enclosed vesicles that are secreted by all cell types. Natural EVs contain biological information such as proteins, nucleic acids, and lipids from their parent cells. Therefore, EVs have been extensively studied as diagnostic biomarkers and therapeutic tools under normal and pathological conditions. However, some drawbacks, including low yield, poor therapeutic effects, lack of imaging, and targeting capacity of natural EVs, still need to be improved. Emerging engineering technologies have rendered EVs new properties or functionalities that broadened their applications in the biomedical field. Herein, in this review, we gave a brief overview of advanced strategies for EV engineering. We focused on pre-treatment of parent cells to regulate their released EVs. Meanwhile, we summarized and discussed the direct modification of EVs to achieve drug loading, imaging, and targeting functionalities for downstream applications.
    Language English
    Publishing date 2023-11-09
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2719493-0
    ISSN 2296-4185
    ISSN 2296-4185
    DOI 10.3389/fbioe.2023.1298746
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  8. Article ; Online: Advances on the Role of Ferroptosis in Ionizing Radiation Response.

    Wang, Fang / Dai, QingHui / Xu, Luhan / Gan, Lu / Shi, Yidi / Yang, Mingjun / Yang, Shuhong

    Current pharmaceutical biotechnology

    2023  Volume 25, Issue 4, Page(s) 396–410

    Abstract: Ferroptosis is an iron-dependent programmed cell death mode that is distinct from other cell death modes, and radiation is able to stimulate cellular oxidative stress and induce the production of large amounts of reactive oxygen radicals, which in turn ... ...

    Abstract Ferroptosis is an iron-dependent programmed cell death mode that is distinct from other cell death modes, and radiation is able to stimulate cellular oxidative stress and induce the production of large amounts of reactive oxygen radicals, which in turn leads to the accumulation of lipid peroxide and the onset of ferroptosis. In this review, from the perspective of the role of ferroptosis in generating a radiation response following cellular irradiation, the relationship between ferroptosis induced by ionizing radiation stress and the response to ionizing radiation is reviewed, including the roles of MAPK and Nrf2 signaling pathways in ferroptosis, resulting from the oxidative stress response to ionizing radiation, the metabolic regulatory role of the p53 gene in ferroptosis, and regulatory modes of action of iron metabolism and iron metabolism-related regulatory proteins in promoting and inhibiting ferroptosis. It provides some ideas for the follow-up research to explore the specific mechanism and regulatory network of ferroptosis in response to ionizing radiation.
    MeSH term(s) Ferroptosis ; Cell Death ; Lipid Peroxides ; Radiation, Ionizing ; Reactive Oxygen Species ; Iron
    Chemical Substances Lipid Peroxides ; Reactive Oxygen Species ; Iron (E1UOL152H7)
    Language English
    Publishing date 2023-08-22
    Publishing country Netherlands
    Document type Review ; Journal Article
    ZDB-ID 2132197-8
    ISSN 1873-4316 ; 1389-2010
    ISSN (online) 1873-4316
    ISSN 1389-2010
    DOI 10.2174/1389201024666230823091144
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 6212: Show issues Location:
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  9. Article ; Online: Transmission-Blocking Strategies Against Malaria Parasites During Their Mosquito Stages.

    Yu, Shasha / Wang, Jing / Luo, Xue / Zheng, Hong / Wang, Luhan / Yang, Xuesen / Wang, Ying

    Frontiers in cellular and infection microbiology

    2022  Volume 12, Page(s) 820650

    Abstract: Malaria is still the most widespread parasitic disease and causes the most infections globally. Owing to improvements in sanitary conditions and various intervention measures, including the use of antimalarial drugs, the malaria epidemic in many regions ... ...

    Abstract Malaria is still the most widespread parasitic disease and causes the most infections globally. Owing to improvements in sanitary conditions and various intervention measures, including the use of antimalarial drugs, the malaria epidemic in many regions of the world has improved significantly in the past 10 years. However, people living in certain underdeveloped areas are still under threat. Even in some well-controlled areas, the decline in malaria infection rates has stagnated or the rates have rebounded because of the emergence and spread of drug-resistant malaria parasites. Thus, new malaria control methods must be developed. As the spread of the
    MeSH term(s) Animals ; Culicidae ; Humans ; Malaria/prevention & control ; Malaria, Falciparum/parasitology ; Parasites ; Plasmodium falciparum
    Language English
    Publishing date 2022-02-16
    Publishing country Switzerland
    Document type Journal Article ; Research Support, Non-U.S. Gov't ; Review
    ZDB-ID 2619676-1
    ISSN 2235-2988 ; 2235-2988
    ISSN (online) 2235-2988
    ISSN 2235-2988
    DOI 10.3389/fcimb.2022.820650
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article ; Online: Testing multiplexed anti-ASFV CRISPR-Cas9 in reducing African swine fever virus.

    Zheng, Zezhong / Xu, Lei / Dou, Hongwei / Zhou, Yixuan / Feng, Xu / He, Xiangjun / Tian, Zhen / Song, Lingling / Gao, Yangbin / Mo, Guolong / Hu, Jiapan / Zhao, Hongye / Wei, Hongjiang / Church, George M / Yang, Luhan

    Microbiology spectrum

    2024  , Page(s) e0216423

    Abstract: African swine fever (ASF) is a highly fatal viral disease that poses a significant threat to domestic pigs and wild boars globally. In our study, we aimed to explore the potential of a multiplexed CRISPR-Cas system in suppressing ASFV replication and ... ...

    Abstract African swine fever (ASF) is a highly fatal viral disease that poses a significant threat to domestic pigs and wild boars globally. In our study, we aimed to explore the potential of a multiplexed CRISPR-Cas system in suppressing ASFV replication and infection. By engineering CRISPR-Cas systems to target nine specific loci within the ASFV genome, we observed a substantial reduction in viral replication
    Importance: ASFV is currently a devastating disease with no effective vaccine or treatment available. Our study introduces a multiplexed CRISPR-Cas system targeting nine specific loci in the ASFV genome. This innovative approach successfully inhibits ASFV replication
    Language English
    Publishing date 2024-04-02
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2807133-5
    ISSN 2165-0497 ; 2165-0497
    ISSN (online) 2165-0497
    ISSN 2165-0497
    DOI 10.1128/spectrum.02164-23
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