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  1. Book: RNA interference and CRISPR technologies

    Sioud, Mouldy

    technical advances and new therapeutic opportunities

    (Methods in molecular biology ; 2115)

    2020  

    Author's details edited by Mouldy Sioud
    Series title Methods in molecular biology ; 2115
    Collection
    Language English
    Size xvi, 486 Seiten, Illustrationen
    Publisher Humana Press
    Publishing place New York, NY
    Publishing country United States
    Document type Book
    HBZ-ID HT020374915
    ISBN 978-1-0716-0289-8 ; 9781071602904 ; 1-0716-0289-6 ; 107160290X
    Database Catalogue ZB MED Medicine, Health

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    In stock of ZB MED Cologne/Königswinter

    Shelf markLoan statusLocation
    Zs A 7042 -2115- verfügbar in Königswinter Königswinter

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  2. Book: RNA interference

    Sioud, Mouldy

    challenges and therapeutic opportunities

    (Methods in molecular biology ; 1218 ; Springer protocols)

    2015  

    Author's details ed. by Mouldy Sioud
    Series title Methods in molecular biology ; 1218
    Springer protocols
    Collection
    Language English
    Size XVI, 495 S. : Ill., graph. Darst.
    Publisher Humana Press
    Publishing place New York u.a.
    Publishing country United States
    Document type Book
    HBZ-ID HT018453092
    ISBN 978-1-4939-1537-8 ; 9781493915385 ; 1-4939-1537-1 ; 149391538X
    Database Catalogue ZB MED Medicine, Health

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    In stock of ZB MED Cologne/Königswinter

    Shelf markLoan statusLocation
    Zs A 7042 -1218- verfügbar in Königswinter Königswinter

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  3. Book: RNA therapeutics

    Sioud, Mouldy

    function, design, and delivery

    (Methods in molecular biology ; 629 ; Springer protocols)

    2010  

    Author's details ed. by Mouldy Sioud
    Series title Methods in molecular biology ; 629
    Springer protocols
    Collection
    Language English
    Size XVI, 526 S. : Ill., graph. Darst.
    Publisher Humana Press
    Publishing place New York u.a.
    Publishing country United States
    Document type Book
    HBZ-ID HT016181685
    ISBN 978-1-60761-656-6 ; 9781607616573 ; 1-60761-656-4 ; 1607616572
    Database Catalogue ZB MED Medicine, Health

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    In stock of ZB MED Cologne/Königswinter

    Shelf markLoan statusLocation
    2010 A 5192 order for loan Magazin

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  4. Book: SiRNA and miRNA gene silencing

    Sioud, Mouldy

    from bench to bedside

    (Methods in molecular biology ; 487)

    2009  

    Author's details ed. by Mouldy Sioud
    Series title Methods in molecular biology ; 487
    Collection
    Keywords Small interfering RNA ; Gene silencing
    Subject code 572.88
    Language English
    Size XIV, 472 S. : zahlr. Ill., graph. Darst., 26cm
    Publisher Humana Press
    Publishing place Totowa, NJ
    Publishing country United States
    Document type Book
    HBZ-ID HT015820040
    ISBN 1-60327-546-0 ; 978-1-60327-546-0 ; 9781603275477 ; 1603275479
    Database Catalogue ZB MED Medicine, Health

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    In stock of ZB MED Cologne/Königswinter

    Shelf markLoan statusLocation
    2009 A 567 order for loan Magazin

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  5. Article ; Online: How the initial discovery of modified RNA enabled evasion of innate immune responses and facilitated the development of RNA therapeutics.

    Sioud, Mouldy

    Scandinavian journal of immunology

    2023  Volume 98, Issue 1, Page(s) e13282

    Abstract: Besides being the physical link between DNA and proteins, RNAs play several other key roles, including RNA catalysis and gene regulation. Recent advances in the design of lipid nanoparticles have facilitated the development of RNA-based therapeutics. ... ...

    Abstract Besides being the physical link between DNA and proteins, RNAs play several other key roles, including RNA catalysis and gene regulation. Recent advances in the design of lipid nanoparticles have facilitated the development of RNA-based therapeutics. However, chemically and in vitro transcribed RNAs can activate innate immunity, leading to the production of proinflammatory cytokines and interferons, a response similar to the one induced by viral infections. Since these responses are undesirable for certain therapeutic applications, it is important to develop ways to block the sensing of exogenous RNAs by immune cells, such as monocytes, macrophages and dendritic cells. Fortunately, RNA sensing can be blocked by chemical modifications of certain nucleotides, particularly uridine, a finding that has facilitated the development of RNA-based therapeutics such as small interfering RNAs and mRNA vaccines. Here, I provide a backstory on how improved understanding of RNA sensing by innate immunity can be applied to develop more effective RNA therapeutics.
    MeSH term(s) RNA, Small Interfering/genetics ; Immunity, Innate ; Gene Expression Regulation ; Monocytes ; Immune Evasion
    Chemical Substances RNA, Small Interfering
    Language English
    Publishing date 2023-05-14
    Publishing country England
    Document type Journal Article ; Review
    ZDB-ID 120476-2
    ISSN 1365-3083 ; 0300-9475
    ISSN (online) 1365-3083
    ISSN 0300-9475
    DOI 10.1111/sji.13282
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 806: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

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  6. Book: Target discovery and validation / 1

    Sioud, Mouldy

    reviews and prolocols

    (Methods in molecular biology ; 360)

    2007  

    Series title Methods in molecular biology ; 360
    Target discovery and validation
    Collection Target discovery and validation
    Language English
    Size XII, 354 S. : Ill., grap. Darst.
    Publisher Humana Press
    Publishing place Totowa, NJ
    Publishing country United States
    Document type Book
    HBZ-ID HT014731167
    ISBN 1-58829-656-3 ; 978-1-58829-656-6
    Database Catalogue ZB MED Medicine, Health

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    In stock of ZB MED Cologne/Königswinter

    Shelf markLoan statusLocation
    2007 A 1704 order for loan Magazin

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  7. Book: Target discovery and validation / 2

    Sioud, Mouldy

    reviews and prolocols

    (Methods in molecular biology ; 361)

    2007  

    Series title Methods in molecular biology ; 361
    Target discovery and validation
    Collection Target discovery and validation
    Language English
    Size XIV, 345 S. : Ill.
    Publisher Humana Press
    Publishing place Totowa, NJ
    Publishing country United States
    Document type Book
    HBZ-ID HT014731174
    ISBN 1-58829-890-6 ; 978-1-58829-890-4
    Database Catalogue ZB MED Medicine, Health

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    In stock of ZB MED Cologne/Königswinter

    Shelf markLoan statusLocation
    2007 A 3039 order for loan Magazin

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    This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

  8. Book ; Collection: Target discovery and validation

    Sioud, Mouldy

    reviews and prolocols

    (Methods in molecular biology ; ...)

    2007  

    Series title Methods in molecular biology
    ...
    Keywords Antineoplastic Agents ; Drug Design ; Tumor Markers, Biological
    Language English
    Dates of publication 2007-9999
    Publisher Humana Press
    Publishing place Totowa, NJ
    Publishing country United States
    Document type Book ; Collection (display volumes)
    HBZ-ID HT014731152
    Database Catalogue ZB MED Medicine, Health

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  9. Book: RNA interference

    Sioud, Mouldy

    (Journal of biomedicine and biotechnology ; 2006, Special issue)

    2006  

    Author's details guest ed.: Mouldy Sioud
    Series title Journal of biomedicine and biotechnology ; 2006, Special issue
    Journal of biomedicine & biotechnology
    Collection Journal of biomedicine & biotechnology
    Language English
    Size Getr. Zählung : Ill., graph. Darst.
    Publisher Hindawi
    Publishing place Akron, Ohio
    Publishing country United States
    Document type Book
    HBZ-ID HT015275549
    ISBN 977-5945-63-1 ; 978-977-5945-63-1
    Database Catalogue ZB MED Medicine, Health

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    In stock of ZB MED Cologne/Königswinter

    Shelf markLoan statusLocation
    Zs A 5540 -2006,Spec.Issue- not available for loan Zeitschriften-Lesesaal

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  10. Article ; Online: Reducing the immunosuppressive tumor microenvironment enhances photoimmunotherapy efficacy

    Mouldy Sioud

    EBioMedicine, Vol 67, Iss , Pp 103351- (2021)

    2021  

    Keywords Medicine ; R ; Medicine (General) ; R5-920
    Language English
    Publishing date 2021-05-01T00:00:00Z
    Publisher Elsevier
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

    Full text online

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