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  1. Article ; Online: Volker K. H. Sonntag, M.D.: pioneer in spinal neurosurgery and consummate educator, colleague, and family man.

    Abla, Adib A / Uschold, Timothy / Kick, Shelley A / Link, Timothy E / Spetzler, Robert F

    World neurosurgery

    2012  Volume 78, Issue 1-2, Page(s) 24–30

    MeSH term(s) Arizona ; Faculty, Medical/history ; Germany, East ; History, 20th Century ; Neurosurgery/history ; Spine/surgery
    Language English
    Publishing date 2012-07
    Publishing country United States
    Document type Biography ; Historical Article ; Journal Article ; Portraits
    ZDB-ID 2534351-8
    ISSN 1878-8769 ; 1878-8750
    ISSN (online) 1878-8769
    ISSN 1878-8750
    DOI 10.1016/j.wneu.2011.05.061
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Microangiopathy in multiple myeloma: a case of carfilzomib-induced secondary thrombotic microangiopathy successfully treated with plasma exchange and complement inhibition.

    Catanese, Lorenzo / Link, Katharina / Rupprecht, Harald

    BMC nephrology

    2023  Volume 24, Issue 1, Page(s) 179

    Abstract: Background: Thrombotic microangiopathy (TMA) is a potentially organ and life-threatening condition affecting patients with multiple myeloma (MM). Cases of proteasome inhibitor-induced TMA and specifically carfilzomib-induced TMA have been rarely ... ...

    Abstract Background: Thrombotic microangiopathy (TMA) is a potentially organ and life-threatening condition affecting patients with multiple myeloma (MM). Cases of proteasome inhibitor-induced TMA and specifically carfilzomib-induced TMA have been rarely reported and standards for diagnostic workup and treatment are not available.
    Case presentation: We describe a case of a male MM patient under salvage therapy including proteasome inhibitor carfilzomib following chemotherapy and autologous stem cell transplantation. The patient then developed acute kidney injury with clinical and laboratory signs of TMA. Hemodialysis became necessary and treatment with plasma exchange was initiated followed by therapy with C5 complement inhibitor eculizumab which led to amelioration of kidney function and hemolysis parameters.
    Conclusion: We report a patient with suspected proteasome inhibitor-induced secondary thrombotic microangiopathy that has been successfully treated with plasma exchange and eculizumab, a monoclonal antibody targeting complement factor C5.
    MeSH term(s) Humans ; Male ; Multiple Myeloma/complications ; Multiple Myeloma/drug therapy ; Plasma Exchange ; Proteasome Inhibitors/adverse effects ; Hematopoietic Stem Cell Transplantation/adverse effects ; Transplantation, Autologous ; Thrombotic Microangiopathies/chemically induced ; Thrombotic Microangiopathies/diagnosis
    Chemical Substances carfilzomib (72X6E3J5AR) ; Proteasome Inhibitors
    Language English
    Publishing date 2023-06-19
    Publishing country England
    Document type Case Reports ; Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2041348-8
    ISSN 1471-2369 ; 1471-2369
    ISSN (online) 1471-2369
    ISSN 1471-2369
    DOI 10.1186/s12882-023-03228-9
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article: Leserbrief zur Arbeit: Erste Ergebnisse der lumbalen Zweienergie-Röntgenabsorptiometrie (DEXA) im Vergleich mit der Doppel-Energie-quantitativen Computertomographie. Von Link, J. M., M. Zwaan, H.-D. Weiss, K. J. Borgis, B. Bätge in: Fortschr. Röntgen

    Schneider, P / Laßmann, M / Börner, W / Link, Johann

    RöFo

    1994  Volume 160, Issue 2, Page(s) 186–187

    Language German
    Document type Article
    ZDB-ID 554830-5
    ISSN 1438-9010 ; 0340-1618 ; 0936-6652 ; 1433-5972 ; 1438-9029
    ISSN (online) 1438-9010
    ISSN 0340-1618 ; 0936-6652 ; 1433-5972 ; 1438-9029
    DOI 10.1055/s-2008-1032403
    Database bibnet.org

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  4. Article: The Global Influence of Sodium on Cyanobacteria in Resuscitation from Nitrogen Starvation.

    Burkhardt, Markus / Rapp, Johanna / Menzel, Claudia / Link, Hannes / Forchhammer, Karl

    Biology

    2023  Volume 12, Issue 2

    Abstract: Dormancy and resuscitation are key to bacterial survival under fluctuating environmental conditions. In the absence of combined nitrogen sources, the non-diazotrophic model ... ...

    Abstract Dormancy and resuscitation are key to bacterial survival under fluctuating environmental conditions. In the absence of combined nitrogen sources, the non-diazotrophic model cyanobacterium
    Language English
    Publishing date 2023-01-19
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2661517-4
    ISSN 2079-7737
    ISSN 2079-7737
    DOI 10.3390/biology12020159
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  5. Article: Leserbrief zur Arbeit: Erste Ergebnisse der lumbalen Zweienergie-Röntgenabsorptiometrie (DEXA) im Vergleich mit der Doppel-Energie-quantitativen Computertomographie. Von Link, J. M., M. Zwaan, H.-D. Weiss, K. J. Borgis, B. Bätge in: Fortschr. Röntgenstr. 158 (1993) 475-478

    Schneider, P. / Laßmann, M. / Börner, W. / Link, Johann

    RöFo - Fortschritte auf dem Gebiet der Röntgenstrahlen und der bildgebenden Verfahren

    1994  Volume 160, Issue 02, Page(s) 186–187

    Language German
    Publishing date 1994-01-01
    Publishing place Stuttgart ; New York
    Document type Article
    ZDB-ID 554830-5
    ISSN 1438-9010 ; 1438-9029 ; 0340-1618 ; 0936-6652 ; 1433-5972
    ISSN (online) 1438-9010
    ISSN 1438-9029 ; 0340-1618 ; 0936-6652 ; 1433-5972
    DOI 10.1055/s-2008-1032403
    Database Thieme publisher's database

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  6. Article ; Online: Comparison of diffusion-weighted MRI and [

    Morakote, Wipawee / Baratto, Lucia / Ramasamy, Shakthi K / Adams, Lisa C / Liang, Tie / Sarrami, Amir H / Daldrup-Link, Heike E

    European radiology

    2023  Volume 34, Issue 1, Page(s) 643–653

    Abstract: Objective: To compare tumor therapy response assessments with whole-body diffusion-weighted imaging (WB-DWI) and 18F-fluorodeoxyglucose ([: Materials and methods: In a retrospective, non-randomized single-center study, we reviewed serial simultaneous ...

    Abstract Objective: To compare tumor therapy response assessments with whole-body diffusion-weighted imaging (WB-DWI) and 18F-fluorodeoxyglucose ([
    Materials and methods: In a retrospective, non-randomized single-center study, we reviewed serial simultaneous WB-DWI and [
    Results: After induction chemotherapy, 95% (19 of 20) of patients with Hodgkin lymphoma and 72% (18 of 25) of patients with non-Hodgkin lymphoma showed concordant response in tumor metabolism and proton diffusion. We found a high agreement between treatment response assessments on WB-DWI and [
    Conclusion: Therapy response of Hodgkin lymphoma can be evaluated with either [
    Clinical relevance statement: Hodgkin lymphoma and non-Hodgkin lymphoma exhibit different patterns of tumor response to induction chemotherapy on diffusion-weighted MRI and PET/MRI.
    Key points: • Diffusion-weighted imaging has been proposed as an alternative imaging to assess tumor response without ionizing radiation. • After induction therapy, whole-body diffusion-weighted imaging and PET/MRI revealed a higher agreement in patients with Hodgkin lymphoma than in those with non-Hodgkin lymphoma. • At the end of therapy, whole-body diffusion-weighted imaging and PET/MRI revealed an excellent agreement for overall tumor therapy responses for all lymphoma types.
    MeSH term(s) Male ; Young Adult ; Humans ; Child ; Infant ; Child, Preschool ; Adolescent ; Adult ; Fluorodeoxyglucose F18 ; Hodgkin Disease/diagnostic imaging ; Hodgkin Disease/therapy ; Hodgkin Disease/pathology ; Retrospective Studies ; Radiopharmaceuticals ; Magnetic Resonance Imaging/methods ; Diffusion Magnetic Resonance Imaging/methods ; Lymphoma, Non-Hodgkin/diagnostic imaging ; Lymphoma, Non-Hodgkin/therapy ; Lymphoma, Non-Hodgkin/pathology ; Positron-Emission Tomography/methods ; Whole Body Imaging/methods
    Chemical Substances Fluorodeoxyglucose F18 (0Z5B2CJX4D) ; Radiopharmaceuticals
    Language English
    Publishing date 2023-08-05
    Publishing country Germany
    Document type Review ; Journal Article
    ZDB-ID 1085366-2
    ISSN 1432-1084 ; 0938-7994 ; 1613-3749
    ISSN (online) 1432-1084
    ISSN 0938-7994 ; 1613-3749
    DOI 10.1007/s00330-023-10015-5
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  7. Article ; Online: Predictors of Engagement Barriers for Adolescent ADHD Treatment.

    Johansson, Margaret / Greenwood, Lydia / Torres Antunez, Gissell / Link, Kara / Sibley, Margaret H

    Journal of attention disorders

    2023  Volume 27, Issue 5, Page(s) 499–509

    Abstract: Objective: The purpose of this study was to understand patient characteristics that predict engagement barriers during behavior therapy for ADHD.: Method: Participants were 121 adolescents with ADHD and parents who received evidence-based behavior ... ...

    Abstract Objective: The purpose of this study was to understand patient characteristics that predict engagement barriers during behavior therapy for ADHD.
    Method: Participants were 121 adolescents with ADHD and parents who received evidence-based behavior therapy for ADHD. Multiple regression examined relationships between six independent variables and frequency of barriers.
    Results: ODD comorbidity and parental ADHD predicted higher frequency of overall barriers. With respect to barriers subtypes, these variables also predicted higher frequencies of cognitive, teen, early-treatment and mid-treatment barriers. Late-treatment, ODD predicted higher frequency of barriers, while minority status predicted lower barriers.
    Conclusions: Adolescents diagnosed with ADHD and comorbid ODD, or who have parents that are also diagnosed with ADHD, are at greatest risk for engagement barriers during behavior therapy. During all phases of treatment, this patient subgroup would benefit from enhancements to standard behavior therapy that focus on therapeutic engagement-particularly targeting teen beliefs about treatment.
    MeSH term(s) Humans ; Adolescent ; Attention Deficit Disorder with Hyperactivity/epidemiology ; Attention Deficit Disorder with Hyperactivity/therapy ; Attention Deficit Disorder with Hyperactivity/diagnosis ; Attention Deficit and Disruptive Behavior Disorders ; Parents ; Comorbidity ; Behavior Therapy
    Language English
    Publishing date 2023-02-17
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't ; Research Support, N.I.H., Extramural
    ZDB-ID 2004350-8
    ISSN 1557-1246 ; 1087-0547
    ISSN (online) 1557-1246
    ISSN 1087-0547
    DOI 10.1177/10870547231153876
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  8. Article ; Online: Engagement Barriers to Behavior Therapy for Adolescent ADHD.

    Sibley, Margaret H / Link, Kara / Torres Antunez, Gissell / Greenwood, Lydia

    Journal of clinical child and adolescent psychology : the official journal for the Society of Clinical Child and Adolescent Psychology, American Psychological Association, Division 53

    2022  Volume 52, Issue 6, Page(s) 834–849

    Abstract: Objective: To identify barriers to behavior therapy for adolescent ADHD (Supporting Teens' Autonomy Daily; STAND) and understand the relationship between barriers and treatment engagement.: Method: A mixed-method design with qualitative coding of 822 ...

    Abstract Objective: To identify barriers to behavior therapy for adolescent ADHD (Supporting Teens' Autonomy Daily; STAND) and understand the relationship between barriers and treatment engagement.
    Method: A mixed-method design with qualitative coding of 822 audio-recorded therapy sessions attended by 121 adolescents with ADHD (ages 11-16; 72.7% male, 77.7% Latinx, 7.4% African-American, 11.6% White, non-Latinx) and parents. Grounded theory methodology identified barriers articulated by parents and adolescents in session. Barriers were sorted by subtype (cognitive/attitudinal, behavioral, logistical) and subject (parent, teen, dyad). Frequency and variety of barriers were calculated by treatment phase (engagement, skills, planning). Generalized linear models and generalized estimating equations examined between-phase differences in frequency of each barrier and relationships between barriers frequency, subtype, subject, and phase on engagement (attendance and homework completion).
    Results: Coding revealed twenty-five engagement barriers (ten cognitive/attitudinal, eleven behavioral, four logistical). Common barriers were: low adolescent desire (72.5%), parent failure to monitor skill application (69.4%), adolescent forgetfulness (60.3%), and adolescent belief that no change is needed (56.2%). Barriers were most commonly cognitive/attitudinal, teen-related, and occurring in STAND's planning phase. Poorer engagement was associated with cognitive/attitudinal, engagement phase, and dyadic barriers. Higher engagement in treatment was predicted by more frequent behavioral, logistical, parent, and skills/planning phase barriers.
    Conclusions: Baseline assessment of barriers may promote individualized engagement strategies for adolescent ADHD treatment. Cognitive/attitudinal barriers should be targeted at treatment outset using evidence-based engagement strategies (e.g., Motivational Interviewing). Behavioral and logistical barriers should be addressed when planning and reviewing application of skills.
    MeSH term(s) Humans ; Male ; Adolescent ; Female ; Attention Deficit Disorder with Hyperactivity/therapy ; Attention Deficit Disorder with Hyperactivity/psychology ; Behavior Therapy ; Motivational Interviewing ; Adolescent Behavior/psychology ; Parents/psychology
    Language English
    Publishing date 2022-01-27
    Publishing country England
    Document type Journal Article
    ZDB-ID 2073310-0
    ISSN 1537-4424 ; 1537-4416
    ISSN (online) 1537-4424
    ISSN 1537-4416
    DOI 10.1080/15374416.2022.2025597
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  9. Article ; Conference proceedings: Physicians’ attitudes towards use of digital media in clinic and practice: a national NOGGO-AIO intergroup survey

    Kolbe, C / Grimm, D / Kranawetter, M / Pietzner, K / Link, H / Sehouli, J

    Geburtshilfe und Frauenheilkunde

    2022  Volume 82, Issue 10

    Event/congress 64. Kongress der Deutschen Gesellschaft für Gynäkologie und Geburtshilfe e. V., München, 2022-10-12
    Language German
    Publishing date 2022-10-01
    Publisher Georg Thieme Verlag
    Publishing place Stuttgart ; New York
    Document type Article ; Conference proceedings
    ZDB-ID 80111-2
    ISSN 1438-8804 ; 0016-5751 ; 1615-3359
    ISSN (online) 1438-8804
    ISSN 0016-5751 ; 1615-3359
    DOI 10.1055/s-0042-1756903
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  10. Article: Salvage Radiosurgery for Optic Nerve Sheath Meningioma.

    Vakharia, Kunal / Hasegawa, Hirotaka / Stafford, Scott L / Link, Michael J

    Cureus

    2021  Volume 13, Issue 7, Page(s) e16450

    Abstract: Optic nerve sheath meningiomas (ONSMs) are rare and benign tumors that affect the optic nerve. Although surgical decompression may be used for large tumors that cause mass effect on the surrounding structures, the mainstay of treatment is radiotherapy. ... ...

    Abstract Optic nerve sheath meningiomas (ONSMs) are rare and benign tumors that affect the optic nerve. Although surgical decompression may be used for large tumors that cause mass effect on the surrounding structures, the mainstay of treatment is radiotherapy. We report the case of a 54-year-old female patient who presented with progressive vision loss due to a recurrent right ONSM despite fractionated radiotherapy eight years prior and the subsequent interval regression of the tumor. The optical coherence tomography at the time of recurrence revealed thinning of the right retinal nerve fiber layer. She underwent salvage stereotactic radiosurgery using a marginal dose of 15 Gy. At six months post-radiosurgery, the patient had a dramatic improvement in visual acuity and visual fields despite persistent thinning of the retinal nerve fiber layer. This case illustrates how salvage radiosurgery can be a useful treatment modality in these challenging situations. This tumor's exophytic growth and the steep dose fall-off of Gamma Knife radiosurgery might favorably affect visual recovery. However, the outcomes of single-session radiosurgery for ONSMs should be further evaluated.
    Language English
    Publishing date 2021-07-18
    Publishing country United States
    Document type Case Reports
    ZDB-ID 2747273-5
    ISSN 2168-8184
    ISSN 2168-8184
    DOI 10.7759/cureus.16450
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