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  1. AU=Thumann Gabriele
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  1. Book ; Thesis: Transplantation of iris pigment epithelial cells to substitute for retinal pigment epithelial cells in age related macular degeneration

    Thumann, Gabriele

    2001  

    Author's details vorgelegt von Gabriele Thumann
    Language English
    Size 104 S. : Ill.
    Publishing country Germany
    Document type Book ; Thesis
    Thesis / German Habilitation thesis Köln, Univ., Habil.-Schr., 2001
    HBZ-ID HT013313738
    Database Catalogue ZB MED Medicine, Health

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    In stock of ZB MED Cologne/Königswinter

    Shelf markLoan statusLocation
    2002 E 811 order for loan Magazin

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  2. Article ; Online: Bilateral Spontaneous Suprachoroidal Haemorrhage Induced by the Valsalva Manoeuvre: A Challenging Diagnosis.

    Bravetti, Giorgio Enrico / Van Delden, Sébastien / Magnin, Simon / Thumann, Gabriele / Malclès, Ariane

    Klinische Monatsblatter fur Augenheilkunde

    2024  Volume 241, Issue 4, Page(s) 449–452

    Title translation Bilaterale spontane suprachoroidale Blutung, hervorgerufen durch das Valsalva-Manöver: eine herausfordernde Diagnose.
    MeSH term(s) Female ; Humans ; Choroid Hemorrhage/etiology ; Choroid Hemorrhage/diagnosis ; Diagnosis, Differential ; Valsalva Maneuver ; Aged
    Language English
    Publishing date 2024-04-23
    Publishing country Germany
    Document type Case Reports ; Journal Article
    ZDB-ID 80175-6
    ISSN 1439-3999 ; 0344-6360 ; 0344-6387 ; 0023-2165
    ISSN (online) 1439-3999
    ISSN 0344-6360 ; 0344-6387 ; 0023-2165
    DOI 10.1055/a-2219-0330
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Rapid diurnal variation of serous retinal detachment during BRAF and MEK inhibitor treatment: A case series.

    Bravetti, Giorgio Enrico / Muggler, Kevin / Ben Aissa, Assma / Thumann, Gabriele / Malclès, Ariane

    Acta ophthalmologica

    2024  Volume 102, Issue 4, Page(s) e651–e656

    MeSH term(s) Humans ; Retinal Detachment/diagnosis ; Proto-Oncogene Proteins B-raf/antagonists & inhibitors ; Male ; Protein Kinase Inhibitors/adverse effects ; Female ; Middle Aged ; Melanoma/drug therapy ; Circadian Rhythm/physiology ; Aged ; Tomography, Optical Coherence/methods ; MAP Kinase Kinase 1/antagonists & inhibitors
    Chemical Substances Proto-Oncogene Proteins B-raf (EC 2.7.11.1) ; Protein Kinase Inhibitors ; BRAF protein, human (EC 2.7.11.1) ; MAP Kinase Kinase 1 (EC 2.7.12.2)
    Language English
    Publishing date 2024-01-18
    Publishing country England
    Document type Letter ; Case Reports ; Journal Article
    ZDB-ID 2408333-1
    ISSN 1755-3768 ; 1755-375X
    ISSN (online) 1755-3768
    ISSN 1755-375X
    DOI 10.1111/aos.16639
    Database MEDical Literature Analysis and Retrieval System OnLINE

    Full text online

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  4. Article: Bilateral Spontaneous Suprachoroidal Haemorrhage Induced by the Valsalva Manoeuvre: A Challenging Diagnosis

    Bravetti, Giorgio Enrico / Van Delden, Sébastien / Magnin, Simon / Thumann, Gabriele / Malclès, Ariane

    Klinische Monatsblätter für Augenheilkunde

    2024  Volume 241, Issue 04, Page(s) 449–452

    Language English
    Publishing date 2024-04-01
    Publisher Georg Thieme Verlag KG
    Publishing place Stuttgart ; New York
    Document type Article
    ZDB-ID 80175-6
    ISSN 1439-3999 ; 0023-2165 ; 0344-6360 ; 0344-6387
    ISSN (online) 1439-3999
    ISSN 0023-2165 ; 0344-6360 ; 0344-6387
    DOI 10.1055/a-2219-0330
    Database Thieme publisher's database

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  5. Book ; Thesis: Leberchirurgie im Wachstumsalter

    Thumann, Gabriele

    1994  

    Author's details vorgelegt von Gabriele Thumann
    Keywords Liver / surgery ; Liver / injuries ; Liver Neoplasms / surgery ; Liver Neoplasms / in infancy & childhood ; Wounds and Injuries / in infancy & childhood
    Language German
    Size 91 S. : Ill., graph. Darst.
    Document type Book ; Thesis
    Thesis / German Habilitation thesis Köln, Univ., Diss., 1994
    HBZ-ID HT006310640
    Database Catalogue ZB MED Medicine, Health

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  6. Article: Predictability of Astigmatism Correction by Arcuate Incisions with a Femtosecond Laser Using the Gaussian Approximation Calculation.

    Sanmillan, Isabel Llopis / Thumann, Gabriele / Kropp, Martina / Cvejic, Zeljka / Pajic, Bojan

    Micromachines

    2023  Volume 14, Issue 5

    Abstract: Planning astigmatic correction is a complex task. Biomechanical simulation models are useful for predicting the effects of the physical procedure on the cornea. Algorithms based on these models allow preoperative planning and simulate the outcome of ... ...

    Abstract Planning astigmatic correction is a complex task. Biomechanical simulation models are useful for predicting the effects of the physical procedure on the cornea. Algorithms based on these models allow preoperative planning and simulate the outcome of patient-specific treatment. The objective of this study was to develop a customised optimisation algorithm and determine the predictability of astigmatism correction by femtosecond laser arcuate incisions. In this study, biomechanical models and Gaussian approximation curve calculations were used for surgical planning. Thirty-four eyes with mild astigmatism were included, and corneal topographies were evaluated before and after femtosecond laser-assisted cataract surgery with arcuate incisions. The follow-up time was up to 6 weeks. Retrospective data showed a significant reduction in postoperative astigmatism. A total of 79.4% showed a postoperative astigmatic value less than 1 D. Clinical refraction was significantly reduced from -1.39 ± 0.79 D preoperatively to -0.86 ± 0.67 D postoperatively (
    Language English
    Publishing date 2023-05-07
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2620864-7
    ISSN 2072-666X
    ISSN 2072-666X
    DOI 10.3390/mi14051009
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article: Prospectives for gene therapy of retinal degenerations.

    Thumann, Gabriele

    Current genomics

    2013  Volume 13, Issue 5, Page(s) 350–362

    Abstract: Retinal degenerations encompass a large number of diseases in which the retina and associated retinal pigment epithelial (RPE) cells progressively degenerate leading to severe visual disorders or blindness. Retinal degenerations can be divided into two ... ...

    Abstract Retinal degenerations encompass a large number of diseases in which the retina and associated retinal pigment epithelial (RPE) cells progressively degenerate leading to severe visual disorders or blindness. Retinal degenerations can be divided into two groups, a group in which the defect has been linked to a specific gene and a second group that has a complex etiology that includes environmental and genetic influences. The first group encompasses a number of relatively rare diseases with the most prevalent being Retinitis pigmentosa that affects approximately 1 million individuals worldwide. Attempts have been made to correct the defective gene by transfecting the appropriate cells with the wild-type gene and while these attempts have been successful in animal models, human gene therapy for these inherited retinal degenerations has only begun recently and the results are promising. To the second group belong glaucoma, age-related macular degeneration (AMD) and diabetic retinopathy (DR). These retinal degenerations have a genetic component since they occur more often in families with affected probands but they are also linked to environmental factors, specifically elevated intraocular pressure, age and high blood sugar levels respectively. The economic and medical impact of these three diseases can be assessed by the number of individuals affected; AMD affects over 30 million, DR over 40 million and glaucoma over 65 million individuals worldwide. The basic defect in these diseases appears to be the relative lack of a neurogenic environment; the neovascularization that often accompanies these diseases has suggested that a decrease in pigment epithelium-derived factor (PEDF), at least in part, may be responsible for the neurodegeneration since PEDF is not only an effective neurogenic and neuroprotective agent but also a potent inhibitor of neovascularization. In the last few years inhibitors of vascularization, especially antibodies against vascular endothelial cell growth factors (VEGF), have been used to prevent the neovascularization that accompanies AMD and DR resulting in the amelioration of vision in a significant number of patients. In animal models it has been shown that transfection of RPE cells with the gene for PEDF and other growth factors can prevent or slow degeneration. A limited number of studies in humans have also shown that transfection of RPE cells in vivo with the gene for PEDF is effective in preventing degeneration and restore vision. Most of these studies have used virally mediated gene delivery with all its accompanying side effects and have not been widely used. New techniques using non-viral protocols that allow efficient delivery and permanent integration of the transgene into the host cell genome offer novel opportunities for effective treatment of retinal degenerations.
    Language English
    Publishing date 2013-01-23
    Publishing country United Arab Emirates
    Document type Journal Article
    ZDB-ID 2033677-9
    ISSN 1875-5488 ; 1389-2029
    ISSN (online) 1875-5488
    ISSN 1389-2029
    DOI 10.2174/138920212801619214
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article ; Online: Meibomian Gland Dysfunction: Intense Pulsed Light Therapy in Combination with Low-Level Light Therapy as Rescue Treatment.

    Solomos, Leonidas / Bouthour, Walid / Malclès, Ariane / Thumann, Gabriele / Massa, Horace

    Medicina (Kaunas, Lithuania)

    2021  Volume 57, Issue 6

    Abstract: Background and Objectives: ...

    Abstract Background and Objectives:
    MeSH term(s) Humans ; Intense Pulsed Light Therapy ; Low-Level Light Therapy ; Meibomian Gland Dysfunction ; Meibomian Glands ; Quality of Life ; Retrospective Studies ; Tears
    Language English
    Publishing date 2021-06-14
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2188113-3
    ISSN 1648-9144 ; 1010-660X
    ISSN (online) 1648-9144
    ISSN 1010-660X
    DOI 10.3390/medicina57060619
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article ; Online: Comparison of Conventional and Femtosecond Laser-Assisted Cataract Surgery Regarding Macula Behavior and Thickness.

    Slezak, Filip / Thumann, Gabriele / Kropp, Martina / Cvejic, Zeljka / De Clerck, Eline Elodie Barbara / Bravetti, Giorgio Enrico / Guber, Ivo / Pajic, Bojan

    Medicina (Kaunas, Lithuania)

    2023  Volume 59, Issue 4

    Abstract: ... ...

    Abstract Background
    MeSH term(s) Humans ; Laser Therapy/methods ; Cataract Extraction ; Phacoemulsification/methods ; Lasers ; Cataract
    Language English
    Publishing date 2023-03-23
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2188113-3
    ISSN 1648-9144 ; 1010-660X
    ISSN (online) 1648-9144
    ISSN 1010-660X
    DOI 10.3390/medicina59040639
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  10. Article ; Online: Bilateral Loss of Vision a Few Hours After a Motor Vehicle Crash.

    Villard, Frédéric / Thumann, Gabriele / Malclès, Ariane

    JAMA ophthalmology

    2019  Volume 137, Issue 9, Page(s) 1080–1081

    Language English
    Publishing date 2019-07-21
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2701705-9
    ISSN 2168-6173 ; 2168-6165
    ISSN (online) 2168-6173
    ISSN 2168-6165
    DOI 10.1001/jamaophthalmol.2019.2674
    Database MEDical Literature Analysis and Retrieval System OnLINE

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