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Article ; Online: An ethical framework for human embryology with embryo models.

Rivron, Nicolas C / Martinez Arias, Alfonso / Pera, Martin F / Moris, Naomi / M'hamdi, Hafez Ismaili

2023 Volume 186, Issue 17, Page(s) 3548–3557

Abstract: A human embryo's legal definition and its entitlement to protection vary greatly worldwide. Recently, human pluripotent stem cells have been used to form in vitro models of early embryos that have challenged legal definitions and raised questions ... ...

Abstract	A human embryo's legal definition and its entitlement to protection vary greatly worldwide. Recently, human pluripotent stem cells have been used to form in vitro models of early embryos that have challenged legal definitions and raised questions regarding their usage. In this light, we propose a refined legal definition of an embryo, suggest "tipping points" for when human embryo models could eventually be afforded similar protection to that of embryos, and then revisit basic ethical principles that might help to draft a roadmap for the gradual, justified usage of embryo models in a manner that aims to maximize benefits to society.
MeSH term(s)	Humans ; Embryo, Mammalian ; Pluripotent Stem Cells ; Embryo Research/ethics
Language	English
Publishing date	2023-08-16
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't ; Review
ZDB-ID	187009-9
ISSN	1097-4172 ; 0092-8674
ISSN (online)	1097-4172
ISSN	0092-8674
DOI	10.1016/j.cell.2023.07.028
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Article ; Online: Micro-aggregates do not influence bone marrow stromal cell chondrogenesis.

Potier, E / Rivron, N C / Van Blitterswijk, C A / Ito, K

Journal of tissue engineering and regenerative medicine

2016 Volume 10, Issue 12, Page(s) 1021–1032

Abstract: Although bone marrow stromal cells (BMSCs) appear promising for cartilage repair, current clinical results are suboptimal and the success of BMSC-based therapies relies on a number of methodological improvements, among which is better understanding and ... ...

Abstract	Although bone marrow stromal cells (BMSCs) appear promising for cartilage repair, current clinical results are suboptimal and the success of BMSC-based therapies relies on a number of methodological improvements, among which is better understanding and control of their differentiation pathways. We investigated here the role of the cellular environment (paracrine vs juxtacrine signalling) in the chondrogenic differentiation of BMSCs. Bovine BMSCs were encapsulated in alginate beads, as dispersed cells or as small micro-aggregates, to create different paracrine and juxtacrine signalling conditions. BMSCs were then cultured for 21 days with TGFβ
Language	English
Publishing date	2016-12
Publishing country	England
Document type	Journal Article
ISSN	1932-7005
ISSN (online)	1932-7005
DOI	10.1002/term.1887
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Article ; Online: Changing the public perception of human embryology.

Rivron, Nicolas C / Martinez-Arias, Alfonso / Sermon, Karen / Mummery, Christine / Schöler, Hans R / Wells, James / Nichols, Jenny / Hadjantonakis, Anna-Katerina / Lancaster, Madeline A / Moris, Naomi / Fu, Jianping / Sturmey, Roger G / Niakan, Kathy / Rossant, Janet / Kato, Kazuto

Nature cell biology

2023 Volume 25, Issue 12, Page(s) 1717–1719

Language	English
Publishing date	2023-11-20
Publishing country	England
Document type	Journal Article
ZDB-ID	1474722-4
ISSN	1476-4679 ; 1465-7392
ISSN (online)	1476-4679
ISSN	1465-7392
DOI	10.1038/s41556-023-01289-4
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Zs.A 5169: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular Jg. 1995 - 2021: Lesesall (2.OG) ab Jg. 2022: Lesesaal (EG)
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Article ; Online: Author Correction: Changing the public perception of human embryology.

Nature cell biology

2023 Volume 25, Issue 12, Page(s) 1884

Language	English
Publishing date	2023-11-27
Publishing country	England
Document type	Published Erratum
ZDB-ID	1474722-4
ISSN	1476-4679 ; 1465-7392
ISSN (online)	1476-4679
ISSN	1465-7392
DOI	10.1038/s41556-023-01319-1
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Zs.A 5169: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular Jg. 1995 - 2021: Lesesall (2.OG) ab Jg. 2022: Lesesaal (EG)
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Article ; Online: Disruption of the circadian clock component BMAL1 elicits an endocrine adaption impacting on insulin sensitivity and liver disease.

Jouffe, Céline / Weger, Benjamin D / Martin, Eva / Atger, Florian / Weger, Meltem / Gobet, Cédric / Ramnath, Divya / Charpagne, Aline / Morin-Rivron, Delphine / Powell, Elizabeth E / Sweet, Matthew J / Masoodi, Mojgan / Uhlenhaut, N Henriette / Gachon, Frédéric

Proceedings of the National Academy of Sciences of the United States of America

2022 Volume 119, Issue 10, Page(s) e2200083119

Abstract: SignificanceWhile increasing evidence associates the disruption of circadian rhythms with pathologic conditions, including obesity, type 2 diabetes, and nonalcoholic fatty liver diseases (NAFLD), the involved mechanisms are still poorly described. Here, ... ...

Abstract	SignificanceWhile increasing evidence associates the disruption of circadian rhythms with pathologic conditions, including obesity, type 2 diabetes, and nonalcoholic fatty liver diseases (NAFLD), the involved mechanisms are still poorly described. Here, we show that, in both humans and mice, the pathogenesis of NAFLD is associated with the disruption of the circadian clock combined with perturbations of the growth hormone and sex hormone pathways. However, while this condition protects mice from the development of fibrosis and insulin resistance, it correlates with increased fibrosis in humans. This suggests that the perturbation of the circadian clock and its associated disruption of the growth hormone and sex hormone pathways are critical for the pathogenesis of metabolic and liver diseases.
MeSH term(s)	ARNTL Transcription Factors/genetics ; ARNTL Transcription Factors/physiology ; Animals ; Circadian Clocks ; Diet, High-Fat ; Gene Deletion ; Gene Expression Regulation ; Humans ; Insulin Resistance ; Leptin/genetics ; Lipid Metabolism/genetics ; Male ; Mice ; Mice, Knockout ; Non-alcoholic Fatty Liver Disease/etiology ; Non-alcoholic Fatty Liver Disease/genetics ; Obesity/genetics
Chemical Substances	ARNTL Transcription Factors ; BMAL1 protein, human ; Leptin
Language	English
Publishing date	2022-03-01
Publishing country	United States
Document type	Journal Article
ZDB-ID	209104-5
ISSN	1091-6490 ; 0027-8424
ISSN (online)	1091-6490
ISSN	0027-8424
DOI	10.1073/pnas.2200083119
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Article ; Online: Single-cell multi-omics of human preimplantation embryos shows susceptibility to glucocorticoids.

Zhao, Cheng / Biondic, Savana / Vandal, Katherine / Björklund, Åsa K / Hagemann-Jensen, Michael / Sommer, Theresa Maria / Canizo, Jesica / Clark, Stephen / Raymond, Pascal / Zenklusen, Daniel R / Rivron, Nicolas / Reik, Wolf / Petropoulos, Sophie

Genome research

2022

Abstract: The preconceptual, intrauterine, and early life environments can have a profound and long-lasting impact on the developmental trajectories and health outcomes of the offspring. Given the relatively low success rates of assisted reproductive technologies ( ...

Abstract	The preconceptual, intrauterine, and early life environments can have a profound and long-lasting impact on the developmental trajectories and health outcomes of the offspring. Given the relatively low success rates of assisted reproductive technologies (ART; ∼25%), additives and adjuvants, such as glucocorticoids, are used to improve the success rate. Considering the dynamic developmental events that occur during this window, these exposures may alter blastocyst formation at a molecular level, and as such, affect not only the viability of the embryo and the ability of the blastocyst to implant, but also the developmental trajectory of the first three cell lineages, ultimately influencing the physiology of the embryo. In this study, we present a comprehensive single-cell transcriptome, methylome, and small RNA atlas in the day 7 human embryo. We show that, despite no change in morphology and developmental features, preimplantation glucocorticoid exposure reprograms the molecular profile of the TE lineage, and these changes are associated with an altered metabolic and inflammatory response. Our data also suggest that glucocorticoids can precociously mature the TE sublineages, supported by the presence of extravillous trophoblast markers in the polar sublineage and presence of X Chromosome dosage compensation. Further, we have elucidated that epigenetic regulation-DNA methylation and microRNAs (miRNAs)-likely underlies the transcriptional changes observed. This study suggests that exposures to exogenous compounds during preimplantation may unintentionally reprogram the human embryo, possibly leading to suboptimal development and longer-term health outcomes.
Language	English
Publishing date	2022-08-10
Publishing country	United States
Document type	Journal Article
ZDB-ID	1284872-4
ISSN	1549-5469 ; 1088-9051 ; 1054-9803
ISSN (online)	1549-5469
ISSN	1088-9051 ; 1054-9803
DOI	10.1101/gr.276665.122
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Zs.A 3729: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular Jg. 1995 - 2021: Lesesall (2.OG) ab Jg. 2022: Lesesaal (EG)
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Article ; Online: 20 years of Developmental Cell: Looking forward.

Hiiragi, Takashi / Gladfelter, Amy S / Miguel-Aliaga, Irene / Coller, Hilary A / Lau, On Sun / McBride, Heidi M / Aoki, Kazuhiro / Linkermann, Andreas / Santaguida, Stefano / Wasteneys, Geoffrey / Rivron, Nicolas C / Shahbazi, Marta N / Ebisuya, Miki / Lancaster, Madeline A

Developmental cell

2022 Volume 56, Issue 23, Page(s) 3185–3191

Abstract: In our 20th anniversary year, we reflect on how fields have changed since our first issue and here look to the future. In this collection of Voices, our writers speculate on the future: in terms of philosophy, cell states, cell processes, and then how to ...

Abstract	In our 20th anniversary year, we reflect on how fields have changed since our first issue and here look to the future. In this collection of Voices, our writers speculate on the future: in terms of philosophy, cell states, cell processes, and then how to model cell systems.
MeSH term(s)	Cell Biology ; Developmental Biology ; Humans ; Periodicals as Topic/statistics & numerical data ; Time Factors
Language	English
Publishing date	2022-02-11
Publishing country	United States
Document type	Journal Article
ZDB-ID	2054967-2
ISSN	1878-1551 ; 1534-5807
ISSN (online)	1878-1551
ISSN	1534-5807
DOI	10.1016/j.devcel.2021.11.017
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Zs.A 5742: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular Jg. 1995 - 2021: Lesesall (2.OG) ab Jg. 2022: Lesesaal (EG)
Zs.MG 76: Show issues

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Article ; Online: Directed Assembly and Development of Material-Free Tissues with Complex Architectures.

Vrij, Erik / Rouwkema, Jeroen / LaPointe, Vanessa / van Blitterswijk, Clemens / Truckenmüller, Roman / Rivron, Nicolas

Advanced materials (Deerfield Beach, Fla.)

2016 Volume 28, Issue 21, Page(s) 4032–4039

Abstract: Material-free tissues are assembled using solely cells. Microstructured hydrogel templates and high content screening allow the formation of centimeter-scale tissues with precise architectures. Similar to developing tissues, these contract autonomously, ... ...

Abstract	Material-free tissues are assembled using solely cells. Microstructured hydrogel templates and high content screening allow the formation of centimeter-scale tissues with precise architectures. Similar to developing tissues, these contract autonomously, controllably shift shape, self-scaffold by secreting extracellular matrix, and undergo morphogenesis.
MeSH term(s)	Extracellular Matrix ; Hydrogels ; Tissue Engineering
Chemical Substances	Hydrogels
Language	English
Publishing date	2016-03-22
Publishing country	Germany
Document type	Journal Article
ZDB-ID	1474949-X
ISSN	1521-4095 ; 0935-9648
ISSN (online)	1521-4095
ISSN	0935-9648
DOI	10.1002/adma.201505723
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Article ; Online: Sonoprinting liposomes on tumor spheroids by microbubbles and ultrasound.

Roovers, S / Deprez, J / Priwitaningrum, D / Lajoinie, G / Rivron, N / Declercq, H / De Wever, O / Stride, E / Le Gac, S / Versluis, M / Prakash, J / De Smedt, S C / Lentacker, I

Journal of controlled release : official journal of the Controlled Release Society

2019 Volume 316, Page(s) 79–92

Abstract: Ultrasound-triggered drug-loaded microbubbles have great potential for drug delivery due to their ability to locally release drugs and simultaneously enhance their delivery into the target tissue. We have recently shown that upon applying ultrasound, ... ...

Abstract	Ultrasound-triggered drug-loaded microbubbles have great potential for drug delivery due to their ability to locally release drugs and simultaneously enhance their delivery into the target tissue. We have recently shown that upon applying ultrasound, nanoparticle-loaded microbubbles can deposit nanoparticles onto cells grown in 2D monolayers, through a process that we termed "sonoprinting". However, the rigid surfaces on which cell monolayers are typically growing might be a source of acoustic reflections and aspherical microbubble oscillations, which can influence microbubble-cell interactions. In the present study, we aim to reveal whether sonoprinting can also occur in more complex and physiologically relevant tissues, by using free-floating 3D tumor spheroids as a tissue model. We show that both monospheroids (consisting of tumor cells alone) and cospheroids (consisting of tumor cells and fibroblasts, which produce an extracellular matrix) can be sonoprinted. Using doxorubicin-liposome-loaded microbubbles, we show that sonoprinting allows to deposit large amounts of doxorubicin-containing liposomes to the outer cell layers of the spheroids, followed by doxorubicin release into the deeper layers of the spheroids, resulting in a significant reduction in cell viability. Sonoprinting may become an attractive approach to deposit drug patches at the surface of tissues, thereby promoting the delivery of drugs into target tissues.
MeSH term(s)	Animals ; Antibiotics, Antineoplastic/administration & dosage ; Antibiotics, Antineoplastic/pharmacology ; Cell Line, Tumor ; Cell Survival/drug effects ; Doxorubicin/administration & dosage ; Doxorubicin/pharmacology ; Drug Delivery Systems ; Drug Liberation ; Extracellular Matrix/metabolism ; Fibroblasts/metabolism ; Liposomes ; Mice ; Microbubbles ; Nanoparticles ; Neoplasms/drug therapy ; Neoplasms/pathology ; Spheroids, Cellular/drug effects ; Ultrasonics
Chemical Substances	Antibiotics, Antineoplastic ; Liposomes ; Doxorubicin (80168379AG)
Language	English
Publishing date	2019-10-29
Publishing country	Netherlands
Document type	Comparative Study ; Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	632533-6
ISSN	1873-4995 ; 0168-3659
ISSN (online)	1873-4995
ISSN	0168-3659
DOI	10.1016/j.jconrel.2019.10.051
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Article ; Online: Limitations of currently available

Fussell, Karma C / Marin-Kuan, Maricel / Debon, Emma / Gentili, Bastien / Morin-Rivron, Delphine / Poquet, Laure / Serrant, Patrick / Badoud, Flavia / Bessaire, Thomas / Christinat, Nicolas / Ernest, Marion / Félix, Alexandre / Latado, Hélia / Montoya Parra, Gina / Scholz, Gabriele / Stroheker, Thomas / Schilter, Benoit

Food additives & contaminants. Part A, Chemistry, analysis, control, exposure & risk assessment

2021 Volume 38, Issue 11, Page(s) 1817–1839

Abstract: The idea that previously unknown hazards can be readily revealed in complex mixtures such as foods is a seductive one, giving rise to the hope that data from effect-based assays of food products collected in market surveys is of suitable quality to be ... ...

Abstract	The idea that previously unknown hazards can be readily revealed in complex mixtures such as foods is a seductive one, giving rise to the hope that data from effect-based assays of food products collected in market surveys is of suitable quality to be the basis for data-driven decision-making. To study this, we undertook a comparative study of the oestrogenicity of blinded cereal samples, both in a number of external testing laboratories and in our own facility. The results clearly showed little variance in the activities of 9 samples when using a single method, but great differences between the activities from each method. Further exploration of these findings suggest that the oestrogenic activity is likely an inherent part of the natural food matrix which the varying sample preparation methods are able to release and extract to differing degrees. These issues indicate the current poor suitability of these types of datasets to be used as the basis for consumer advice or food decision-making. Data quality must be improved before such testing is used in practice.
MeSH term(s)	Biological Assay/methods ; Estrogens/chemistry ; Food Analysis/methods ; Humans ; In Vitro Techniques ; Laboratories/standards ; Receptors, Estrogen/metabolism ; Risk Assessment ; Toxicity Tests/methods ; Whole Grains/chemistry
Chemical Substances	Estrogens ; Receptors, Estrogen
Language	English
Publishing date	2021-07-06
Publishing country	England
Document type	Journal Article
ZDB-ID	2462951-0
ISSN	1944-0057 ; 1944-0049
ISSN (online)	1944-0057
ISSN	1944-0049
DOI	10.1080/19440049.2021.1923823
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