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Article ; Online: Improving radiology workflow using ChatGPT and artificial intelligence.

Mese, Ismail / Taslicay, Ceylan Altintas / Sivrioglu, Ali Kemal

2023 Volume 103, Page(s) 109993

Abstract: Artificial Intelligence is a branch of computer science that aims to create intelligent machines capable of performing tasks that typically require human intelligence. One of the branches of artificial intelligence is natural language processing, which ... ...

Abstract	Artificial Intelligence is a branch of computer science that aims to create intelligent machines capable of performing tasks that typically require human intelligence. One of the branches of artificial intelligence is natural language processing, which is dedicated to studying the interaction between computers and human language. ChatGPT is a sophisticated natural language processing tool that can understand and respond to complex questions and commands in natural language. Radiology is a vital aspect of modern medicine that involves the use of imaging technologies to diagnose and treat medical conditions artificial intelligence, including ChatGPT, can be integrated into radiology workflows to improve efficiency, accuracy, and patient care. ChatGPT can streamline various radiology workflow steps, including patient registration, scheduling, patient check-in, image acquisition, interpretation, and reporting. While ChatGPT has the potential to transform radiology workflows, there are limitations to the technology that must be addressed, such as the potential for bias in artificial intelligence algorithms and ethical concerns. As technology continues to advance, ChatGPT is likely to become an increasingly important tool in the field of radiology, and in healthcare more broadly.
MeSH term(s)	Humans ; Artificial Intelligence ; Workflow ; Radiography ; Radiology ; Algorithms
Language	English
Publishing date	2023-10-06
Publishing country	United States
Document type	Journal Article ; Review
ZDB-ID	1028123-x
ISSN	1873-4499 ; 0899-7071
ISSN (online)	1873-4499
ISSN	0899-7071
DOI	10.1016/j.clinimag.2023.109993
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Article ; Online: Synergizing photon-counting CT with deep learning: potential enhancements in medical imaging.

Mese, Ismail / Altintas Taslicay, Ceylan / Sivrioglu, Ali Kemal

Acta radiologica (Stockholm, Sweden : 1987)

2023 Volume 65, Issue 2, Page(s) 159–166

Abstract: This review article highlights the potential of integrating photon-counting computed tomography (CT) and deep learning algorithms in medical imaging to enhance diagnostic accuracy, improve image quality, and reduce radiation exposure. The use of photon- ... ...

Abstract	This review article highlights the potential of integrating photon-counting computed tomography (CT) and deep learning algorithms in medical imaging to enhance diagnostic accuracy, improve image quality, and reduce radiation exposure. The use of photon-counting CT provides superior image quality, reduced radiation dose, and material decomposition capabilities, while deep learning algorithms excel in automating image analysis and improving diagnostic accuracy. The integration of these technologies can lead to enhanced material decomposition and classification, spectral image analysis, predictive modeling for individualized medicine, workflow optimization, and radiation dose management. However, data requirements, computational resources, and regulatory and ethical concerns remain challenges that need to be addressed to fully realize the potential of this technology. The fusion of photon-counting CT and deep learning algorithms is poised to revolutionize medical imaging and transform patient care.
MeSH term(s)	Humans ; Deep Learning ; Tomography, X-Ray Computed/methods ; Image Processing, Computer-Assisted/methods ; Algorithms ; Photons ; Phantoms, Imaging
Language	English
Publishing date	2023-12-25
Publishing country	England
Document type	Journal Article ; Review
ZDB-ID	105-3
ISSN	1600-0455 ; 0284-1851 ; 0349-652X
ISSN (online)	1600-0455
ISSN	0284-1851 ; 0349-652X
DOI	10.1177/02841851231217995
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Article ; Online: Educating the next generation of radiologists: a comparative report of ChatGPT and e-learning resources.

Meşe, İsmail / Altıntaş Taşlıçay, Ceylan / Kuzan, Beyza Nur / Kuzan, Taha Yusuf / Sivrioğlu, Ali Kemal

Diagnostic and interventional radiology (Ankara, Turkey)

2023

Abstract: Rapid technological advances have transformed medical education, particularly in radiology, which depends on advanced imaging and visual data. Traditional electronic learning (e-learning) platforms have long served as a cornerstone in radiology education, ...

Abstract	Rapid technological advances have transformed medical education, particularly in radiology, which depends on advanced imaging and visual data. Traditional electronic learning (e-learning) platforms have long served as a cornerstone in radiology education, offering rich visual content, interactive sessions, and peer-reviewed materials. They excel in teaching intricate concepts and techniques that necessitate visual aids, such as image interpretation and procedural demonstrations. However, Chat Generative Pre-Trained Transformer (ChatGPT), an artificial intelligence (AI)-powered language model, has made its mark in radiology education. It can generate learning assessments, create lesson plans, act as a round-the-clock virtual tutor, enhance critical thinking, translate materials for broader accessibility, summarize vast amounts of information, and provide real-time feedback for any subject, including radiology. Concerns have arisen regarding ChatGPT's data accuracy, currency, and potential biases, especially in specialized fields such as radiology. However, the quality, accessibility, and currency of e-learning content can also be imperfect. To enhance the educational journey for radiology residents, the integration of ChatGPT with expert-curated e-learning resources is imperative for ensuring accuracy and reliability and addressing ethical concerns. While AI is unlikely to entirely supplant traditional radiology study methods, the synergistic combination of AI with traditional e-learning can create a holistic educational experience.
Language	English
Publishing date	2023-12-25
Publishing country	Turkey
Document type	Journal Article
ZDB-ID	2184145-7
ISSN	1305-3612 ; 1305-3612
ISSN (online)	1305-3612
ISSN	1305-3612
DOI	10.4274/dir.2023.232496
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Article ; Online: Olfactory Neuroepithelium in Olfactory Cleft Polyps: Do They Have Any Effect on Olfaction Results After Endoscopic Sinus Surgery?

Özcan, Cengiz / İsmi, Onur / Meşe, Feyzi / Gürses, İclal / Vayisoğlu, Yusuf / Görür, Kemal

Turkish archives of otorhinolaryngology

2022 Volume 60, Issue 2, Page(s) 65–71

Abstract: Objective: How the presence of olfactory structures in olfactory cleft polyps (OCPs) affect olfaction function outcomes after surgical removal has not yet been investigated. In this study we aimed to assess the presence of olfactory structures in OCPs ... ...

Abstract	Objective: How the presence of olfactory structures in olfactory cleft polyps (OCPs) affect olfaction function outcomes after surgical removal has not yet been investigated. In this study we aimed to assess the presence of olfactory structures in OCPs and correlate these findings with olfactory outcomes after endoscopic sinus surgery (ESS). Methods: Twenty seven patients with OCP underwent preoperative topical and systemic steroid treatment and ESS. Biopsies from the middle meatal polyps (MMPs) and OCPs were immunohistochemically analyzed for olfactory marker protein (OMP). The smell diskettes olfaction test was applied to patients at baseline, after steroid treatment (AST) and after ESS. Results: OCPs exhibited OMP staining more commonly and intensely compared to MMPs (p=0.008), however, there were no correlations between OMP staining scores and any of the olfaction scores (p>0.05). Steroid treatment increased smell function significantly (p<0.001), however, there were no significant differences between AST and after ESS smell scores (p=0.17). There were significant correlations between smell gains AST and final smell gains after ESS (r=0.665, p<0.001). Conclusion: OCPs contain olfactory neuroepithelium more commonly and intensely than MMPs in nasal polyp patients. However, surgical importance of this finding is controversial because removal of these polyps did not decrease smell function postoperatively in our study. Nasal polyp patients who will take steroid treatment pre-operatively must be informed that the success of ESS on olfaction depends on the response of the steroid treatment and ESS AST might not have additional favorable effect on smell function.
Language	English
Publishing date	2022-08-31
Publishing country	Turkey
Document type	Journal Article
ISSN	2667-7474
ISSN (online)	2667-7474
DOI	10.4274/tao.2022.2022-4-5
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Article ; Online: MicroRNA Changes in Gastric Carcinogenesis: Differential Dysregulation during

Prinz, Christian / Mese, Kemal / Weber, David

Genes

2021 Volume 12, Issue 4

Abstract: Despite medical advances, gastric-cancer (GC) mortality remains high in Europe. Bacterial infection ... ...

Abstract	Despite medical advances, gastric-cancer (GC) mortality remains high in Europe. Bacterial infection with
MeSH term(s)	Carcinogenesis/genetics ; Carcinogenesis/pathology ; Epstein-Barr Virus Infections/complications ; Epstein-Barr Virus Infections/virology ; Gene Expression Profiling ; Gene Expression Regulation, Neoplastic ; Helicobacter Infections/complications ; Helicobacter Infections/virology ; Helicobacter pylori/isolation & purification ; Herpesvirus 4, Human/isolation & purification ; Humans ; MicroRNAs/genetics ; Stomach Neoplasms/genetics ; Stomach Neoplasms/pathology ; Stomach Neoplasms/virology
Chemical Substances	MicroRNAs
Language	English
Publishing date	2021-04-19
Publishing country	Switzerland
Document type	Journal Article ; Review
ZDB-ID	2527218-4
ISSN	2073-4425 ; 2073-4425
ISSN (online)	2073-4425
ISSN	2073-4425
DOI	10.3390/genes12040597
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Article ; Online: Olfactory neuroepithelium in the middle turbinate: is there any impact on olfaction function after lateral marsupialization for concha bullosa surgery?

İsmi, Onur / Meşe, Feyzi / Gür, Harun / Gürses, İclal / Vayısoğlu, Yusuf / Görür, Kemal / Özcan, Cengiz

Brazilian journal of otorhinolaryngology

2021

Abstract: Introduction: The effect of the quantity of olfactory neuroepithelium in the middle turbinate on the postoperative olfactory function for middle turbinate concha bullosa patients has not yet been evaluated.: Objective: The primary aim of this study ... ...

Abstract	Introduction: The effect of the quantity of olfactory neuroepithelium in the middle turbinate on the postoperative olfactory function for middle turbinate concha bullosa patients has not yet been evaluated. Objective: The primary aim of this study was to investigate the olfactory structures in the middle turbinate by immunohistochemical analysis of the olfactory marker protein and to correlate the immunostaining results with the olfaction test results for patients with middle turbinate concha bullosa. Methods: Surgical materials of 18 middle turbinate concha bullosa patients who had undergone lateral marsupialization surgery were immunostained with olfactory marker protein antibodies. Smell diskettes olfaction test was applied to all of the study group patients both preoperatively and three months postoperatively. A visual analog scale was used to quantify the sense of nasal obstruction. Results: It was observed that the postoperative smell scores and the nasal obstruction visual analog scale values were significantly improved as compared to the preoperative values (p < 0.05). In addition, there was a significant correlation between the smell score gain and the visual analog scale gain values (r = 0.682). Results also indicated no significant correlation between the olfactory marker protein staining scores and the smell scores (p > 0.05). Conclusion: This first paper demonstrated that the quantity of the olfactory mucosa in the middle turbinate was not a determining factor for the postoperative smell function degree for middle turbinate concha bullosa patients. The underlying cause of the olfactory deficit for middle turbinate concha bullosa patients seems to be obstruction related rather than the middle turbinate's olfactory mucosa containing status.
Language	English
Publishing date	2021-07-20
Publishing country	Brazil
Document type	Journal Article
ZDB-ID	2428110-4
ISSN	1808-8686 ; 1808-8694
ISSN (online)	1808-8686
ISSN	1808-8694
DOI	10.1016/j.bjorl.2021.06.005
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Article ; Online: Case Report: Cytomegalovirus Reactivation and Pericarditis Following ChAdOx1 nCoV-19 Vaccination Against SARS-CoV-2.

Plüß, Marlene / Mese, Kemal / Kowallick, Johannes T / Schuster, Andreas / Tampe, Désirée / Tampe, Björn

Frontiers in immunology

2022 Volume 12, Page(s) 784145

Abstract: As the coronavirus disease 2019 (COVID-19) pandemic is ongoing and new variants of severe acute respiratory syndrome coronavirus type 2 (SARS-CoV-2) are emerging, there is an urgent need for vaccines to protect individuals at high risk for complications ... ...

Abstract	As the coronavirus disease 2019 (COVID-19) pandemic is ongoing and new variants of severe acute respiratory syndrome coronavirus type 2 (SARS-CoV-2) are emerging, there is an urgent need for vaccines to protect individuals at high risk for complications and to potentially control disease outbreaks by herd immunity. Surveillance of rare safety issues related to these vaccines is progressing, since more granular data emerge about adverse events of SARS-CoV-2 vaccines during post-marketing surveillance. Varicella zoster virus (VZV), Epstein-Barr virus (EBV) and cytomegalovirus (CMV) reactivation has already been reported in COVID-19 patients. In addition, adverse events after SARS-CoV-2 mRNA vaccination have also been in the context of varicella zoster virus (VZV) reactivation and directly associated with the mRNA vaccine. We present the first case of CMV reactivation and pericarditis in temporal association with SARS-CoV-2 vaccination, particularly adenovirus-based DNA vector vaccine ChAdOx1 nCoV-19 against SARS-CoV-2. After initiation of antiviral therapy with oral valganciclovir, CMV viremia disappeared and clinical symptoms rapidly improved. Since huge vaccination programs are ongoing worldwide, post-marketing surveillance systems must be in place to assess vaccine safety that is important for the detection of any events. In the context of the hundreds of millions of individuals to be vaccinated against SARS-CoV-2, a potential causal association with CMV reactivation may result in a considerable number of cases with potentially severe complications.
MeSH term(s)	Aged ; Antiviral Agents/therapeutic use ; COVID-19/prevention & control ; ChAdOx1 nCoV-19/adverse effects ; Cytomegalovirus/drug effects ; Cytomegalovirus/physiology ; Cytomegalovirus Infections/chemically induced ; Cytomegalovirus Infections/drug therapy ; Cytomegalovirus Infections/virology ; Female ; Humans ; Pericarditis/chemically induced ; Pericarditis/drug therapy ; Pericarditis/virology ; SARS-CoV-2/immunology ; Treatment Outcome ; Valganciclovir/therapeutic use ; Viremia/chemically induced ; Viremia/drug therapy ; Viremia/virology ; Virus Activation/drug effects
Chemical Substances	Antiviral Agents ; ChAdOx1 nCoV-19 (B5S3K2V0G8) ; Valganciclovir (GCU97FKN3R)
Language	English
Publishing date	2022-01-18
Publishing country	Switzerland
Document type	Case Reports
ZDB-ID	2606827-8
ISSN	1664-3224 ; 1664-3224
ISSN (online)	1664-3224
ISSN	1664-3224
DOI	10.3389/fimmu.2021.784145
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Article: MicroRNA Changes in Gastric Carcinogenesis: Differential Dysregulation during Helicobacter pylori and EBV Infection

Prinz, Christian / Mese, Kemal / Weber, David

Genes. 2021 Apr. 19, v. 12, no. 4

2021

Abstract: Despite medical advances, gastric-cancer (GC) mortality remains high in Europe. Bacterial infection with Helicobacter pylori (H. pylori) and viral infection with the Epstein–Barr virus (EBV) are associated with the development of both distal and proximal ...

Abstract	Despite medical advances, gastric-cancer (GC) mortality remains high in Europe. Bacterial infection with Helicobacter pylori (H. pylori) and viral infection with the Epstein–Barr virus (EBV) are associated with the development of both distal and proximal gastric cancer. Therefore, the detection of these infections and the prediction of further cancer development could be clinically significant. To this end, microRNAs (miRNAs) could serve as promising new tools. MiRNAs are highly conserved noncoding RNAs that play an important role in gene silencing, mainly acting via translational repression and the degradation of mRNA targets. Recent reports demonstrate the downregulation of numerous miRNAs in GC, especially miR-22, miR-145, miR-206, miR-375, and miR-490, and these changes seem to promote cancer-cell invasion and tumor spreading. The dysregulation of miR-106b, miR-146a, miR-155, and the Let-7b/c complex seems to be of particular importance during H. pylori infection or gastric carcinogenesis. In contrast, many reports describe changes in host miRNA expression and outline the effects of bamHI-A region rightward transcript (BART) miRNA in EBV-infected tissue. The differential regulation of these miRNA, acting alone or in close interaction when both infections coexist, may therefore enable us to detect cancer earlier. In this review, we focus on the two different etiologies of gastric cancer and outline the molecular pathways through which H. pylori- or EBV-induced changes might synergistically act via miR-155 dysregulation to potentiate cancer risk. The three markers, namely, H. pylori presence, EBV infection, and miR-155 expression, may be checked in routine biopsies to evaluate the risk of developing gastric cancer.
Keywords	Helicobacter pylori ; Human gammaherpesvirus 4 ; bacterial infections ; carcinogenesis ; genes ; microRNA ; mortality ; neoplasm cells ; prediction ; risk ; risk assessment ; stomach neoplasms ; Europe
Language	English
Dates of publication	2021-0419
Publishing place	Multidisciplinary Digital Publishing Institute
Document type	Article
Note	NAL-AP-2-clean
ZDB-ID	2527218-4
ISSN	2073-4425
ISSN	2073-4425
DOI	10.3390/genes12040597
Database	NAL-Catalogue (AGRICOLA)

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Article ; Online: State-of-the-art human adenovirus vectorology for therapeutic approaches.

Gao, Jian / Mese, Kemal / Bunz, Oskar / Ehrhardt, Anja

FEBS letters

2019 Volume 593, Issue 24, Page(s) 3609–3622

Abstract: Human adenoviruses (Ads) have long been studied in the basic virology field and are exploited as vectors for gene therapy, vaccination, and oncolytic therapy. Ads are usually mild pathogens, but they can cause severe infections and symptoms in ... ...

Abstract	Human adenoviruses (Ads) have long been studied in the basic virology field and are exploited as vectors for gene therapy, vaccination, and oncolytic therapy. Ads are usually mild pathogens, but they can cause severe infections and symptoms in immunocompromised individuals. Ads show a large natural diversity and a broad spectrum of hosts. However, replication-competent and replication-deficient Ad vectors with therapeutic applications have been built mainly starting from human Ad type 5, because generating vectors from other human and animal Ads has proven challenging. This review provides an updated overview of vectors that are not derived from human Ad type 5. We discuss genetic engineering techniques for getting access to the natural diversity of human Ads and for vectorization of alternative Ad types. A catalogue of currently available vectorized human Ads and translational applications thereof is also compiled. We conclude with a perspective on Ad vectorology that looks into the future of Ad vectors in translational medicine.
MeSH term(s)	Adenoviruses, Human/genetics ; Adenoviruses, Human/physiology ; Genetic Engineering/methods ; Genetic Therapy ; Genetic Vectors/administration & dosage ; Humans ; Oncolytic Viruses ; Vaccination ; Virus Replication
Language	English
Publishing date	2019-12-09
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't ; Review
ZDB-ID	212746-5
ISSN	1873-3468 ; 0014-5793
ISSN (online)	1873-3468
ISSN	0014-5793
DOI	10.1002/1873-3468.13691
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Article ; Online: Targeting Oncolytic Adenoviruses to Cancer Cells Using a Designed Ankyrin Repeat Protein Lipocalin-2 Fusion Protein.

Schellhorn, Sebastian / Brücher, Dominik / Wolff, Natascha A / Schröer, Katrin / Sallard, Erwan / Mese, Kemal / Zhang, Wenli / Ehrke-Schulz, Eric / Thévenod, Frank / Plückthun, Andreas / Ehrhardt, Anja

Human gene therapy

2023 Volume 34, Issue 5-6, Page(s) 203–216

Abstract: Oncolytic viruses are a promising technology to attack cancer cells and to recruit immune cells to the tumor site. Since the Lipocalin-2 receptor (LCN2R) is expressed on most cancer cells, we used its ligand LCN2 to target oncolytic adenoviruses (Ads) to ...

Abstract	Oncolytic viruses are a promising technology to attack cancer cells and to recruit immune cells to the tumor site. Since the Lipocalin-2 receptor (LCN2R) is expressed on most cancer cells, we used its ligand LCN2 to target oncolytic adenoviruses (Ads) to cancer cells. Therefore, we fused a Designed Ankyrin Repeat Protein (DARPin) adapter binding the knob of Ad type 5 (knob5) to LCN2 to retarget the virus toward LCN2R with the aim of analyzing the basic characteristics of this novel targeting approach. The adapter was tested
MeSH term(s)	Animals ; Cricetinae ; Adenoviridae/genetics ; Lipocalin-2/genetics ; Ankyrin Repeat/genetics ; CHO Cells ; Designed Ankyrin Repeat Proteins ; Cricetulus ; Ligands ; Cell Line, Tumor ; Oncolytic Viruses/genetics ; Oncolytic Virotherapy/methods ; Luciferases ; Virus Replication ; Neoplasms/genetics ; Neoplasms/therapy
Chemical Substances	Lipocalin-2 ; Designed Ankyrin Repeat Proteins ; Ligands ; Luciferases (EC 1.13.12.-)
Language	English
Publishing date	2023-02-21
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	1028152-6
ISSN	1557-7422 ; 1043-0342
ISSN (online)	1557-7422
ISSN	1043-0342
DOI	10.1089/hum.2022.215
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