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Article ; Online: Kinase Degraders, Activators, and Inhibitors: Highlights and Synthesis Routes to the Chemical Probes on opnMe.com, Part 1.

Gollner, Andreas / Heine, Claudia / Hofbauer, Karin S

2023 Volume 18, Issue 10, Page(s) e202300031

Abstract: Kinases are among the most important and successful drug targets. Chemical probe compounds have played a critical role in elucidating the role of kinases in many biological pathways. There are currently twelve well-validated chemical probes that target ... ...

Abstract	Kinases are among the most important and successful drug targets. Chemical probe compounds have played a critical role in elucidating the role of kinases in many biological pathways. There are currently twelve well-validated chemical probes that target kinases available free-of-cost via the Molecules to Order (M2O) arm of Boehringer Ingelheim's open innovation platform, opnMe.com. Here we present a summary of the key data for each of these probe compounds and the synthesis routes to all twelve compounds. We hope this will aid researchers who use or plan to use these compounds in their research.
Language	English
Publishing date	2023-03-10
Publishing country	Germany
Document type	Journal Article ; Review
ZDB-ID	2218496-X
ISSN	1860-7187 ; 1860-7179
ISSN (online)	1860-7187
ISSN	1860-7179
DOI	10.1002/cmdc.202300031
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Article ; Online: Genome Mining Reveals a Surprising Number of Sugar Reductases in

Mueller, Astrid / Xu, Li / Heine, Claudia / Flach, Tila / Mäkelä, Miia R / de Vries, Ronald P

Journal of fungi (Basel, Switzerland)

2023 Volume 9, Issue 12

Abstract: Metabolic engineering of filamentous fungi has received increasing attention in recent years, especially in the context of creating better industrial fungal cell factories to produce a wide range of valuable enzymes and metabolites from plant biomass. ... ...

Abstract	Metabolic engineering of filamentous fungi has received increasing attention in recent years, especially in the context of creating better industrial fungal cell factories to produce a wide range of valuable enzymes and metabolites from plant biomass. Recent studies into the pentose catabolic pathway (PCP) in
Language	English
Publishing date	2023-11-24
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2784229-0
ISSN	2309-608X ; 2309-608X
ISSN (online)	2309-608X
ISSN	2309-608X
DOI	10.3390/jof9121138
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Article: A 3D human co-culture to model neuron-astrocyte interactions in tauopathies.

Batenburg, Kevin L / Sestito, Claudia / Cornelissen-Steijger, Paulien / van Weering, Jan R T / Price, Leo S / Heine, Vivi M / Scheper, Wiep

Biological procedures online

2023 Volume 25, Issue 1, Page(s) 4

Abstract: Background: Intraneuronal tau aggregation is the major pathological hallmark of neurodegenerative tauopathies. It is now generally acknowledged that tau aggregation also affects astrocytes in a cell non-autonomous manner. However, mechanisms involved ... ...

Abstract	Background: Intraneuronal tau aggregation is the major pathological hallmark of neurodegenerative tauopathies. It is now generally acknowledged that tau aggregation also affects astrocytes in a cell non-autonomous manner. However, mechanisms involved are unclear, partly because of the lack of models that reflect the situation in the human tauopathy brain. To accurately model neuron-astrocyte interaction in tauopathies, there is a need for a model that contains both human neurons and human astrocytes, intraneuronal tau pathology and mimics the three-dimensional architecture of the brain. Results: Here we established a novel 100-200 µm thick 3D human neuron/astrocyte co-culture model of tau pathology, comprising homogenous populations of hiPSC-derived neurons and primary human astrocytes in microwell format. Using confocal, electron and live microscopy, we validate the procedures by showing that neurons in the 3D co-culture form pre- and postsynapses and display spontaneous calcium transients within 4 weeks. Astrocytes in the 3D co-culture display bipolar and stellate morphologies with extensive processes that ensheath neuronal somas, spatially align with axons and dendrites and can be found perisynaptically. The complex morphology of astrocytes and the interaction with neurons in the 3D co-culture mirrors that in the human brain, indicating the model's potential to study physiological and pathological neuron-astrocyte interaction in vitro. Finally, we successfully implemented a methodology to introduce seed-independent intraneuronal tau aggregation in the 3D co-culture, enabling study of neuron-astrocyte interaction in early tau pathogenesis. Conclusions: Altogether, these data provide proof-of-concept for the utility of this rapid, miniaturized, and standardized 3D model for cell type-specific manipulations, such as the intraneuronal pathology that is associated with neurodegenerative disorders.
Language	English
Publishing date	2023-02-23
Publishing country	England
Document type	Journal Article
ZDB-ID	2027823-8
ISSN	1480-9222
ISSN	1480-9222
DOI	10.1186/s12575-023-00194-2
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Article ; Online: Early-Onset Type 2 Diabetes and Tirzepatide Treatment: A Post Hoc Analysis From the SURPASS Clinical Trial Program.

Zeitler, Philip / Galindo, Rodolfo J / Davies, Melanie J / Bergman, Brandon K / Thieu, Vivian T / Nicolay, Claudia / Allen, Sheryl / Heine, Robert J / Lee, Clare J

Diabetes care

2024

Abstract: Objective: We evaluated baseline characteristics of participants with early-onset type 2 diabetes (T2D) from the SURPASS program and tirzepatide's effects on glycemic control, body weight (BW), and cardiometabolic markers.: Research design and methods! ...

Abstract	Objective: We evaluated baseline characteristics of participants with early-onset type 2 diabetes (T2D) from the SURPASS program and tirzepatide's effects on glycemic control, body weight (BW), and cardiometabolic markers. Research design and methods: This post hoc analysis compared baseline characteristics and changes in mean HbA1c, BW, waist circumference (WC), lipids, and blood pressure (BP) in 3,792 participants with early-onset versus later-onset T2D at week 40 (A Study of Tirzepatide [LY3298176] in Participants With Type 2 Diabetes Not Controlled With Diet and Exercise Alone [SURPASS-1], A Study of Tirzepatide [LY3298176] Versus Semaglutide Once Weekly as Add-on Therapy to Metformin in Participants With Type 2 Diabetes [SURPASS-2]) or week 52 (A Study of Tirzepatide [LY3298176] Versus Insulin Degludec in Participants With Type 2 Diabetes [SURPASS-3]). Analyses were performed by study on data from participants while on assigned treatment without rescue medication in case of persistent hyperglycemia. Results: At baseline in SURPASS-2, participants with early-onset versus later-onset T2D were younger with longer diabetes duration (9 vs. 7 years, P < 0.001) higher glycemic levels (8.5% vs. 8.2%, P < 0.001), higher BW (97 vs. 93 kg, P < 0.001) and BMI (35 vs. 34 kg/m2, P < 0.001), and a similarly abnormal lipid profile (e.g., triglycerides 167 vs. 156 mg/dL). At week 40, similar improvements in HbA1c (-2.6% vs. -2.4%), BW (-14 vs. -13 kg), WC (-10 vs. -10 cm), triglycerides (-26% vs. -24%), HDL (7% vs. 7%), and systolic BP (-6 vs. -7 mmHg) were observed in both subgroups with tirzepatide. Conclusions: Despite younger age, participants with early-onset T2D from the SURPASS program had higher glycemic levels and worse overall metabolic health at baseline versus those with later-onset T2D. In this post hoc analysis, similar improvements in HbA1c, BW, and cardiometabolic markers were observed with tirzepatide, irrespective of age at T2D diagnosis. Future studies are needed to determine long-term outcomes of tirzepatide in early-onset T2D.
Language	English
Publishing date	2024-04-19
Publishing country	United States
Document type	Journal Article
ZDB-ID	441231-x
ISSN	1935-5548 ; 0149-5992
ISSN (online)	1935-5548
ISSN	0149-5992
DOI	10.2337/dc23-2356
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Zs.A 1434: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular Jg. 1995 - 2021: Lesesall (1.OG) ab Jg. 2022: Lesesaal (EG)
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Article ; Online: The T1-weighted/T2-weighted ratio as a biomarker of anti-NMDA receptor encephalitis.

Hartung, Tim Julian / Cooper, Graham / Jünger, Valentin / Komnenić, Darko / Ryan, Lara / Heine, Josephine / Chien, Claudia / Paul, Friedemann / Prüss, Harald / Finke, Carsten

Journal of neurology, neurosurgery, and psychiatry

2024 Volume 95, Issue 4, Page(s) 366–373

Abstract: Background: Anti-N-methyl-D-aspartate receptor (NMDAR) encephalitis rarely causes visible lesions in conventional MRI, yet advanced imaging detects extensive white matter damage. To improve prognostic capabilities, we evaluate the T1-weighted/T2- ... ...

Abstract	Background: Anti-N-methyl-D-aspartate receptor (NMDAR) encephalitis rarely causes visible lesions in conventional MRI, yet advanced imaging detects extensive white matter damage. To improve prognostic capabilities, we evaluate the T1-weighted/T2-weighted (T1w/T2w) ratio, a measure of white matter integrity computable from clinical MRI sequences, in NMDAR encephalitis and examine its associations with cognitive impairment. Methods: T1-weighted and T2-weighted MRI were acquired cross-sectionally at 3 Tesla in 53 patients with NMDAR encephalitis (81% women, mean age 29 years) and 53 matched healthy controls. Quantitative and voxel-wise group differences in T1w/T2w ratios and associations with clinical and neuropsychological outcomes were assessed. P-values were false discovery rate (FDR) adjusted where multiple tests were conducted. Results: Patients with NMDAR encephalitis had significantly lower T1w/T2w ratios across normal appearing white matter (p=0.009, Hedges' g=-0.51), which was associated with worse verbal episodic memory performance (r=0.39, p=0.005, p(FDR)=0.026). White matter integrity loss was observed in the corticospinal tract, superior longitudinal fascicle, optic radiation and callosal body with medium to large effects (Cohen's d=[0.42-1.17]). In addition, patients showed decreased T1w/T2w ratios in the hippocampus (p=0.002, p(FDR)=0.005, Hedges' g=-0.62), amygdala (p=0.002, p(FDR)=0.005, Hedges' g=-0.63) and thalamus (p=0.010, p(FDR)=0.019, Hedges' g=-0.51). Conclusions: The T1w/T2w ratio detects microstructural changes in grey and white matter of patients with NMDAR encephalitis that correlate with cognitive performance. Computable from conventional clinical MRI sequences, this measure shows promise in bridging the clinico-radiological dissociation in NMDAR encephalitis and could serve as an imaging outcome measure in clinical trials.
MeSH term(s)	Humans ; Female ; Adult ; Male ; Anti-N-Methyl-D-Aspartate Receptor Encephalitis/diagnostic imaging ; Anti-N-Methyl-D-Aspartate Receptor Encephalitis/pathology ; Magnetic Resonance Imaging/methods ; White Matter/diagnostic imaging ; White Matter/pathology ; Hippocampus/pathology ; Biomarkers
Chemical Substances	Biomarkers
Language	English
Publishing date	2024-03-13
Publishing country	England
Document type	Journal Article
ZDB-ID	3087-9
ISSN	1468-330X ; 0022-3050
ISSN (online)	1468-330X
ISSN	0022-3050
DOI	10.1136/jnnp-2023-332069
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Article ; Online: Genome Mining Reveals a Surprising Number of Sugar Reductases in Aspergillus niger

Astrid Mueller / Li Xu / Claudia Heine / Tila Flach / Miia R. Mäkelä / Ronald P. de Vries

Journal of Fungi, Vol 9, Iss 12, p

2023 Volume 1138

Abstract	Metabolic engineering of filamentous fungi has received increasing attention in recent years, especially in the context of creating better industrial fungal cell factories to produce a wide range of valuable enzymes and metabolites from plant biomass. Recent studies into the pentose catabolic pathway (PCP) in Aspergillus niger have revealed functional redundancy in most of the pathway steps. In this study, a closer examination of the A. niger genome revealed five additional paralogs for the three original pentose reductases (LarA, XyrA, XyrB). Analysis of these genes using phylogeny, in vitro and in vivo functional analysis of the enzymes, and gene expression revealed that all can functionally replace LarA, XyrA, and XyrB. However, they are also active on several other sugars, suggesting a role for them in other pathways. This study therefore reveals the diversity of primary carbon metabolism in fungi, suggesting an intricate evolutionary process that distinguishes different species. In addition, through this study, the metabolic toolkit for synthetic biology and metabolic engineering of A. niger and other fungal cell factories has been expanded.
Keywords	sugar catabolism ; orthology-based approach ; metabolic engineering ; Aspergillus niger ; enzyme characterization ; synthetic biology ; Biology (General) ; QH301-705.5
Subject code	570
Language	English
Publishing date	2023-11-01T00:00:00Z
Publisher	MDPI AG
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Book: Mila rettet den Weihnachtsmann

Gellersen, Ruth / Heine, Claudia

eine Geschichte

(Pixi-Adventskalender ; : mit 24 Pixi-Büchern[...])

2014

Author's details	von Ruth Gellersen. Mit Bildern von Claudia Heine
Series title	Pixi-Adventskalender ; : mit 24 Pixi-Büchern[...]
Language	German
Size	[8] Bl, überw. Ill
Edition	Ausg. für Adventskalender
Publisher	Carlsen
Publishing place	Hamburg
Document type	Book
ISBN	9783551040114 ; 9783551050618 ; 3551040117 ; 3551050619
Database	Former special subject collection: coastal and deep sea fishing

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Article ; Online: Contact allergies to dental materials in patients.

Forkel, Susann / Schubert, Steffen / Corvin, Lisa / Heine, Guido / Lang, Claudia C V / Oppel, Eva / Pföhler, Claudia / Treudler, Regina / Bauer, Andrea / Sulk, Mathias / Kränke, Birger / Schäkel, Knut / Heratizadeh, Annice / Worm, Margitta / Witte, Jana / Geier, Johannes / Buhl, Timo

The British journal of dermatology

2023

Abstract: Background: Concerns regarding contact allergies and intolerance reactions to dental materials are widespread among patients. Development of novel dental materials and less frequent amalgam use may alter sensitization profiles in patients with possible ... ...

Abstract	Background: Concerns regarding contact allergies and intolerance reactions to dental materials are widespread among patients. Development of novel dental materials and less frequent amalgam use may alter sensitization profiles in patients with possible contact allergy. Objective: This study was aimed at analysing current sensitization patterns to dental materials in patients with suspected contact allergy. Methods: This retrospective, multicentre analysis from the Information Network of Departments of Dermatology (IVDK) selected patients among 169,834 patients tested in 2005-2019, and registered with (i) an affected area of 'mouth' (and 'lips'/'perioral'), (ii) with the dental material in question belonging to three groups: dental filling materials, oral implants, or dentures or equivalents, and (iii) were patch-tested in parallel with the German baseline series, (dental) metal series, and dental technician series. Results: A total of 2,730 of 169,834 tested patients met the inclusion criteria. The patients were predominantly women (81.2%) and 40 years or older (92.8%). The sensitization rates with confirmed allergic contact stomatitis in female patients (n=444) were highest for metals (nickel 28.6%, palladium 21.4%, amalgam 10.9%), (meth)acrylates (HEMA 4.8%), and the substances propolis (6.8%) and 'balsam of Peru' (11.4%). The most relevant acrylates were HEMA, HPMA, MMA, EGDMA, and PETA. Few male patients were diagnosed with allergic contact stomatitis (n=68), and their sensitization rates were highest for propolis (14.9%) and amalgam (13.6%), but not (meth)acrylates. Conclusion: Allergic contact stomatitis to dental materials is rare. Patch testing should focus on metals such as nickel, palladium, amalgam, and gold, but also (meth)acrylates and the natural substances propolis and 'balsam of Peru'.
Language	English
Publishing date	2023-12-20
Publishing country	England
Document type	Journal Article
ZDB-ID	80076-4
ISSN	1365-2133 ; 0007-0963
ISSN (online)	1365-2133
ISSN	0007-0963
DOI	10.1093/bjd/ljad525
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Article ; Conference proceedings: Immune Tolerance Induction and Immunosuppression in a 25-Year-Old Patient with Inherited Severe Factor IX Deficiency and Inhibitor: 1-Year Follow-Up

Horneff, Silvia / Goldmann, Georg / Klein, Claudia / Marquardt, Natascha / Heine, Mario / Feldmann, Georg / Brossart, Peter / Oldenburg, Johannes

Hämostaseologie

2022 Volume 42, Issue S 01

Event/congress	52. Hamburger Hämophilie Symposion, Hamburg, Germany, 2021-11-12
Language	English
Publishing date	2022-10-01
Publisher	Georg Thieme Verlag KG
Publishing place	Stuttgart ; New York
Document type	Article ; Conference proceedings
ZDB-ID	801512-0
ISSN	2567-5761 ; 0720-9355
ISSN (online)	2567-5761
ISSN	0720-9355
DOI	10.1055/s-0042-1758495
Database	Thieme publisher's database

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Article ; Online: Tapentadol prolonged release in patients with chronic low back pain: real-world data from the German Pain eRegistry.

Überall, Michael A / Elling, Christian / Eibl, Christoph / Müller-Schwefe, Gerhard Hh / Lefeber, Claudia / Heine, Myriam / Heckes, Birgit

Pain management

2021 Volume 12, Issue 2, Page(s) 211–227

Abstract: Aim: ...

Abstract	Aim:
MeSH term(s)	Analgesics, Opioid/therapeutic use ; Chronic Pain/drug therapy ; Delayed-Action Preparations ; Humans ; Low Back Pain/drug therapy ; Phenols/therapeutic use ; Retrospective Studies ; Tapentadol/therapeutic use
Chemical Substances	Analgesics, Opioid ; Delayed-Action Preparations ; Phenols ; Tapentadol (H8A007M585)
Language	English
Publishing date	2021-08-11
Publishing country	England
Document type	Journal Article
ZDB-ID	2617136-3
ISSN	1758-1877 ; 1758-1869
ISSN (online)	1758-1877
ISSN	1758-1869
DOI	10.2217/pmt-2021-0058
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