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Article ; Online: Recovering struvite from livestock wastewater by fluidized-bed homogeneous crystallization as a pre-treatment process to sludge co-digestion.

Hsiao, Chen-Tsung / Huang, Tsan-Huai / Lacson, Carl Francis Z / Vilando, Anabella C / Lu, Ming-Chun

2023 Volume 235, Page(s) 116639

Abstract: Livestock wastewater can contain high levels of phosphates and trace amounts of various ionic species harming the environment and human health. These ions can be successfully removed from livestock effluent and recovered in a non-toxic crystal form via ... ...

Abstract	Livestock wastewater can contain high levels of phosphates and trace amounts of various ionic species harming the environment and human health. These ions can be successfully removed from livestock effluent and recovered in a non-toxic crystal form via crystallization. The fluidized bed homogeneous crystallization (FBHC) technology is a cutting-edge pretreatment method that removes phosphate and ammonium by crystallizing struvite. The findings demonstrated a 37% removal for ammonium solutions alone, 38% with copper, 35% with zinc, and 33% when copper and zinc were present, while the crystallization efficiency was achieved at 35%, 33% with copper, 28% with zinc, and 26% with copper and zinc. For phosphate-containing solutions, 95% was removed, 81% with copper, 96% with zinc, and 88% with copper and zinc. Similarly, crystallization efficiency was attained at 87%, 60% with copper, 94% with zinc, and 81% when copper and zinc were combined with phosphates. For ammonium solutions, copper and zinc reduced the removal and crystallization efficiency at constant pH and increased at increasing pH. For phosphate solutions, the removal and crystallization efficiencies increased at increasing pH. However, zinc ions resulted in the highest removal, and crystallization efficiency for phosphate solutions was attained. Based on SEM, EDS, XRD, and XPS analyses, the peaks revealed the presence of struvite in the form of magnesium ammonium phosphate.
MeSH term(s)	Animals ; Humans ; Struvite ; Wastewater ; Sewage ; Livestock ; Magnesium Compounds/chemistry ; Crystallization ; Copper ; Phosphates/chemistry ; Ammonium Compounds ; Digestion ; Phosphorus ; Waste Disposal, Fluid/methods
Chemical Substances	Struvite (AW3EJL1462) ; Wastewater ; Sewage ; Magnesium Compounds ; Copper (789U1901C5) ; Phosphates ; Ammonium Compounds ; Phosphorus (27YLU75U4W)
Language	English
Publishing date	2023-07-13
Publishing country	Netherlands
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	205699-9
ISSN	1096-0953 ; 0013-9351
ISSN (online)	1096-0953
ISSN	0013-9351
DOI	10.1016/j.envres.2023.116639
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Article ; Online: Recovering struvite from livestock wastewater by fluidized-bed homogeneous crystallization as a pre-treatment process to sludge co-digestion

Hsiao, Chen-Tsung / Huang, Tsan-Huai / Lacson, Carl Francis Z. / Vilando, Anabella C. / Lü, Mingjun

Environmental Research. 2023 Oct., v. 235 p.116639-

2023

Abstract	Livestock wastewater can contain high levels of phosphates and trace amounts of various ionic species harming the environment and human health. These ions can be successfully removed from livestock effluent and recovered in a non-toxic crystal form via crystallization. The fluidized bed homogeneous crystallization (FBHC) technology is a cutting-edge pretreatment method that removes phosphate and ammonium by crystallizing struvite. The findings demonstrated a 37% removal for ammonium solutions alone, 38% with copper, 35% with zinc, and 33% when copper and zinc were present, while the crystallization efficiency was achieved at 35%, 33% with copper, 28% with zinc, and 26% with copper and zinc. For phosphate-containing solutions, 95% was removed, 81% with copper, 96% with zinc, and 88% with copper and zinc. Similarly, crystallization efficiency was attained at 87%, 60% with copper, 94% with zinc, and 81% when copper and zinc were combined with phosphates. For ammonium solutions, copper and zinc reduced the removal and crystallization efficiency at constant pH and increased at increasing pH. For phosphate solutions, the removal and crystallization efficiencies increased at increasing pH. However, zinc ions resulted in the highest removal, and crystallization efficiency for phosphate solutions was attained. Based on SEM, EDS, XRD, and XPS analyses, the peaks revealed the presence of struvite in the form of magnesium ammonium phosphate.
Keywords	ammonium ; anaerobic digestion ; copper ; crystallization ; fluidized beds ; human health ; livestock ; magnesium ammonium phosphate ; pH ; research ; sludge ; wastewater ; zinc ; Struvite ; Phosphate
Language	English
Dates of publication	2023-10
Publishing place	Elsevier Inc.
Document type	Article ; Online
ZDB-ID	205699-9
ISSN	1096-0953 ; 0013-9351
ISSN (online)	1096-0953
ISSN	0013-9351
DOI	10.1016/j.envres.2023.116639
Database	NAL-Catalogue (AGRICOLA)

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Article ; Online: Using artificial intelligence algorithms to predict the overall survival of hemodialysis patients during the COVID-19 pandemic: A prospective cohort study.

Tang, Shao-Yu / Chen, Tz-Heng / Kuo, Ko-Lin / Huang, Jue-Ni / Kuo, Chen-Tsung / Chu, Yuan-Chia

Journal of the Chinese Medical Association : JCMA

2023 Volume 86, Issue 11, Page(s) 1020–1027

Abstract: Background: Hemodialysis (HD) patients are a vulnerable population at high risk for severe complications from COVID-19. The impact of partial COVID-19 vaccination on the survival of HD patients remains uncertain. This prospective cohort study was ... ...

Abstract	Background: Hemodialysis (HD) patients are a vulnerable population at high risk for severe complications from COVID-19. The impact of partial COVID-19 vaccination on the survival of HD patients remains uncertain. This prospective cohort study was designed to use artificial intelligence algorithms to predict the survival impact of partial COVID-19 vaccination in HD patients. Methods: A cohort of 433 HD patients was used to develop machine-learning models based on a subset of clinical features assessed between July 1, 2021, and April 29, 2022. The patient cohort was randomly split into training (80%) and testing (20%) sets for model development and evaluation. Machine-learning models, including categorical boosting (CatBoost), light gradient boosting machines (LightGBM), RandomForest, and extreme gradient boosting models (XGBoost), were applied to evaluate their discriminative performance using the patient cohorts. Results: Among these models, LightGBM achieved the highest F1 score of 0.95, followed by CatBoost, RandomForest, and XGBoost, with area under the receiver operating characteristic curve values of 0.94 on the testing dataset. The SHapley Additive explanation summary plot derived from the XGBoost model indicated that key features such as age, albumin, and vaccination details had a significant impact on survival. Furthermore, the fully vaccinated group exhibited higher levels of anti-spike (S) receptor-binding domain antibodies. Conclusion: This prospective cohort study involved using artificial intelligence algorithms to predict overall survival in HD patients during the COVID-19 pandemic. These predictive models assisted in identifying high-risk individuals and guiding vaccination strategies for HD patients, ultimately improving overall prognosis. Further research is warranted to validate and refine these predictive models in larger and more diverse populations of HD patients.
MeSH term(s)	Humans ; Artificial Intelligence ; COVID-19 Vaccines ; Pandemics ; Prospective Studies ; COVID-19 ; Algorithms ; Renal Dialysis
Chemical Substances	COVID-19 Vaccines
Language	English
Publishing date	2023-09-15
Publishing country	Netherlands
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2107283-8
ISSN	1728-7731 ; 1726-4901
ISSN (online)	1728-7731
ISSN	1726-4901
DOI	10.1097/JCMA.0000000000000994
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Article ; Online: Efficient FPGA Implementation of a Dual-Frequency GNSS Receiver with Robust Inter-Frequency Aiding.

Huang, Kuan-Ying / Juang, Jyh-Ching / Tsai, Yung-Fu / Lin, Chen-Tsung

Sensors (Basel, Switzerland)

2021 Volume 21, Issue 14

Abstract: Multiple frequency global navigation satellite system (GNSS) has become more complex due to the existence of extra channels. Typically, auxiliary methods are used to synchronize the second signals at other bands by aiding the acquired channel parameters. ...

Abstract	Multiple frequency global navigation satellite system (GNSS) has become more complex due to the existence of extra channels. Typically, auxiliary methods are used to synchronize the second signals at other bands by aiding the acquired channel parameters. However, there are critical limitations because the reception of GNSS signals is subject to uncertainties due to noise carrier injection or circuit interference. The relationship between the two Doppler frequencies can be affected by uncertainties. Therefore, we aimed to implement an efficient dual-frequency field-programmable gate array (FPGA), performing a direct aid tracking method for the secondary channel to achieve resource efficiency and inner aid robustness. A robust estimator that directly links two loops in the two bands is proposed. In this scheme, (1) a robust estimator able to cope with uncertainty; (2) a primary tracking scheme to obtain the error boundary, and (3) a tracked bit-boundary for the initial code phase of the second channel are used. Based on experiments on the FPGA, the robust channel link can achieve direct aid tracking, and 31.02% of the original hardware resources from the aided acquisition module were released satisfactorily.
Language	English
Publishing date	2021-07-06
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2052857-7
ISSN	1424-8220 ; 1424-8220
ISSN (online)	1424-8220
ISSN	1424-8220
DOI	10.3390/s21144634
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Article ; Online: Homoharringtonine as a PHGDH inhibitor: Unraveling metabolic dependencies and developing a potent therapeutic strategy for high-risk neuroblastoma.

Hsieh, Chiao-Hui / Huang, Chen-Tsung / Cheng, Yi-Sheng / Hsu, Chun-Hua / Hsu, Wen-Ming / Chung, Yun-Hsien / Liu, Yen-Lin / Yang, Tsai-Shan / Chien, Chia-Yu / Lee, Yu-Hsuan / Huang, Hsuan-Cheng / Juan, Hsueh-Fen

Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie

2023 Volume 166, Page(s) 115429

Abstract: Neuroblastoma, a childhood cancer affecting the sympathetic nervous system, continues to challenge the development of potent treatments due to the limited availability of druggable targets for this aggressive illness. Recent investigations have uncovered ...

Abstract	Neuroblastoma, a childhood cancer affecting the sympathetic nervous system, continues to challenge the development of potent treatments due to the limited availability of druggable targets for this aggressive illness. Recent investigations have uncovered that phosphoglycerate dehydrogenase (PHGDH), an essential enzyme for de novo serine synthesis, serves as a non-oncogene dependency in high-risk neuroblastoma. In this study, we show that homoharringtonine (HHT) acts as a PHGDH inhibitor, inducing intricate alterations in cellular metabolism, and thus providing an efficient treatment for neuroblastoma. We have experimentally verified the reliance of neuroblastoma on PHGDH and employed molecular docking, thermodynamic evaluations, and X-ray crystallography techniques to determine the bond interactions between HHT and PHGDH. Administering HHT to treat neuroblastoma resulted in effective cell elimination in vitro and tumor reduction in vivo. Metabolite and functional assessments additionally disclosed that HHT treatment suppressed de novo serine synthesis, initiating intricate metabolic reconfiguration and oxidative stress in neuroblastoma. Collectively, these discoveries highlight the potential of targeting PHGDH using HHT as a potent approach for managing high-risk neuroblastoma.
MeSH term(s)	Humans ; Child ; Phosphoglycerate Dehydrogenase ; Homoharringtonine ; Molecular Docking Simulation ; Enzyme Inhibitors ; Neuroblastoma/drug therapy ; Serine
Chemical Substances	Phosphoglycerate Dehydrogenase (EC 1.1.1.95) ; Homoharringtonine (6FG8041S5B) ; Enzyme Inhibitors ; Serine (452VLY9402)
Language	English
Publishing date	2023-09-04
Publishing country	France
Document type	Journal Article
ZDB-ID	392415-4
ISSN	1950-6007 ; 0753-3322 ; 0300-0893
ISSN (online)	1950-6007
ISSN	0753-3322 ; 0300-0893
DOI	10.1016/j.biopha.2023.115429
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Article ; Online: Oral microbiota in xerostomia patients - A preliminary study.

Weng, Chen-Tsung / Huang, Shir-Ly / Yang, Hui-Wen / Kao, Chih-Chin / Wei, Cheng-Chung / Huang, Yu-Feng

Journal of dental sciences

2021 Volume 17, Issue 1, Page(s) 324–330

Abstract: Background/purpose: The estimated prevalence of xerostomia (lack of saliva) ranges from 10% to 50% of the general population. The oral cavity provides a multivariant environmental habitat to over 700 species of bacteria and fungi. We hypothesized that ... ...

Abstract	Background/purpose: The estimated prevalence of xerostomia (lack of saliva) ranges from 10% to 50% of the general population. The oral cavity provides a multivariant environmental habitat to over 700 species of bacteria and fungi. We hypothesized that xerostomia will alter the composition of oral microbiota. Material and methods: Nineteen xerostomia patients and 10 healthy normal volunteers were studied for the oral microbiota. Gingival plaques were collected and microbiota were detected using bacterial 16S ribosomal RNA and analyzed based on the levels of phylum and class. Results: In all cases, phyla of Actinobacteria, Bacteroidetes, Firmicutes, Fusobacteria, and Proteobacteria make up to 100% of oral microbiota at phylum level. Analyzing individual phylum, presence of Bacteroidetes in xerostomia patients and normal subjects were 23.12 ± 2.56% and 23.23 ± 2.58%, respectively. Mean percentage presence of Firmicutes phylum in xerostomia patients and normal subjects were 18.94 ± 1.83% and 14.06 ± 0.98%, respectively. Statistically significant difference was not observed between xerostomia patients and normal subjects in this study. Conclusion: These observations revealed obvious but not statistically significant changes in oral major microorganism phylum between xerostomia patients and normal subjects in this study. More samples are needed to verify the current results and to use oral microbiota as a tool in the diagnosis of xerostomia.
Language	English
Publishing date	2021-08-28
Publishing country	Netherlands
Document type	Journal Article
ISSN	2213-8862
ISSN (online)	2213-8862
DOI	10.1016/j.jds.2021.08.007
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Article: BI-2536 Promotes Neuroblastoma Cell Death via Minichromosome Maintenance Complex Components 2 and 10.

Hsieh, Chiao-Hui / Yeh, Hsiang-Ning / Huang, Chen-Tsung / Wang, Wei-Hsuan / Hsu, Wen-Ming / Huang, Hsuan-Cheng / Juan, Hsueh-Fen

Pharmaceuticals (Basel, Switzerland)

2021 Volume 15, Issue 1

Abstract: DNA replication is initiated with the recognition of the starting point of multiple replication forks by the origin recognition complex and activation of the minichromosome maintenance complex 10 (MCM10). Subsequently, DNA helicase, consisting of the MCM ...

Abstract	DNA replication is initiated with the recognition of the starting point of multiple replication forks by the origin recognition complex and activation of the minichromosome maintenance complex 10 (MCM10). Subsequently, DNA helicase, consisting of the MCM protein subunits MCM2-7, unwinds double-stranded DNA and DNA synthesis begins. In previous studies, replication factors have been used as clinical targets in cancer therapy. The results showed that MCM2 could be a proliferation marker for numerous types of malignant cancer. We analyzed samples obtained from patients with neuroblastoma, revealing that higher levels of MCM2 and MCM10 mRNA were associated with poor survival rate. Furthermore, we combined the results of the perturbation-induced reversal effects on the expression levels of MCM2 and MCM10 and the sensitivity correlation between perturbations and MCM2 and MCM10 from the Cancer Therapeutics Response Portal database. Small molecule BI-2536, a polo-like kinase 1 (PLK-1) inhibitor, is a candidate for the inhibition of MCM2 and MCM10 expression. To test this hypothesis, we treated neuroblastoma cells with BI-2536. The results showed that the drug decreased cell viability and reduced the expression levels of MCM2 and MCM10. Functional analysis further revealed enrichments of gene sets involved in mitochondria, cell cycle, and DNA replication for BI-2536-perturbed transcriptome. We used cellular assays to demonstrate that BI-2536 promoted mitochondria fusion, G2/M arrest, and apoptosis. In summary, our findings provide a new strategy for neuroblastoma therapy with BI-2536.
Language	English
Publishing date	2021-12-28
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2193542-7
ISSN	1424-8247
ISSN	1424-8247
DOI	10.3390/ph15010037
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Article ; Online: BI-2536 Promotes Neuroblastoma Cell Death via Minichromosome Maintenance Complex Components 2 and 10

Chiao-Hui Hsieh / Hsiang-Ning Yeh / Chen-Tsung Huang / Wei-Hsuan Wang / Wen-Ming Hsu / Hsuan-Cheng Huang / Hsueh-Fen Juan

Pharmaceuticals, Vol 15, Iss 37, p

2022 Volume 37

Abstract	DNA replication is initiated with the recognition of the starting point of multiple replication forks by the origin recognition complex and activation of the minichromosome maintenance complex 10 (MCM10). Subsequently, DNA helicase, consisting of the MCM protein subunits MCM2-7, unwinds double-stranded DNA and DNA synthesis begins. In previous studies, replication factors have been used as clinical targets in cancer therapy. The results showed that MCM2 could be a proliferation marker for numerous types of malignant cancer. We analyzed samples obtained from patients with neuroblastoma, revealing that higher levels of MCM2 and MCM10 mRNA were associated with poor survival rate. Furthermore, we combined the results of the perturbation-induced reversal effects on the expression levels of MCM2 and MCM10 and the sensitivity correlation between perturbations and MCM2 and MCM10 from the Cancer Therapeutics Response Portal database. Small molecule BI-2536, a polo-like kinase 1 (PLK-1) inhibitor, is a candidate for the inhibition of MCM2 and MCM10 expression. To test this hypothesis, we treated neuroblastoma cells with BI-2536. The results showed that the drug decreased cell viability and reduced the expression levels of MCM2 and MCM10. Functional analysis further revealed enrichments of gene sets involved in mitochondria, cell cycle, and DNA replication for BI-2536-perturbed transcriptome. We used cellular assays to demonstrate that BI-2536 promoted mitochondria fusion, G2/M arrest, and apoptosis. In summary, our findings provide a new strategy for neuroblastoma therapy with BI-2536.
Keywords	minichromosome maintenance complex 2 and 10 ; BI-2536 ; neuroblastoma ; mitochondria fusion ; cell death ; Medicine ; R ; Pharmacy and materia medica ; RS1-441
Language	English
Publishing date	2022-12-01T00:00:00Z
Publisher	MDPI AG
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Does Overhead Squat Performance Affect the Swing Kinematics and Lumbar Spine Loads during the Golf Downswing?

Chen, Zi-Han / Pandy, Marcus / Huang, Tsung-Yu / Tang, Wen-Tzu

Sensors (Basel, Switzerland)

2024 Volume 24, Issue 4

Abstract: The performance of the overhead squat may affect the golf swing mechanics associated with golf-related low back pain. This study investigates the difference in lumbar kinematics and joint loads during the golf downswing between golfers with different ... ...

Abstract	The performance of the overhead squat may affect the golf swing mechanics associated with golf-related low back pain. This study investigates the difference in lumbar kinematics and joint loads during the golf downswing between golfers with different overhead squat abilities. Based on the performance of the overhead squat test, 21 golfers aged 18 to 30 years were divided into the highest-scoring group (HS, N = 10, 1.61 ± 0.05 cm, and 68.06 ± 13.67 kg) and lowest-scoring group (LS, N = 11, 1.68 ± 0.10 cm, and 75.00 ± 14.37 kg). For data collection, a motion analysis system, two force plates, and TrackMan were used. OpenSim 4.3 software was used to simulate the joint loads for each lumbar joint. An independent
MeSH term(s)	Biomechanical Phenomena ; Golf ; Lumbar Vertebrae ; Posture ; Mechanical Phenomena ; Movement
Language	English
Publishing date	2024-02-15
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2052857-7
ISSN	1424-8220 ; 1424-8220
ISSN (online)	1424-8220
ISSN	1424-8220
DOI	10.3390/s24041252
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Article ; Online: The IFSD Score-A Practical Prognostic Model for Invasive Fungal Spondylodiscitis.

Yang, Chao-Chun / Lee, Ming-Hsueh / Liu, Chia-Yen / Lin, Meng-Hung / Yang, Yao-Hsu / Chen, Kuo-Tai / Huang, Tsung-Yu

Journal of fungi (Basel, Switzerland)

2024 Volume 10, Issue 1

Abstract: Objectives: ...

Abstract	Objectives:
Language	English
Publishing date	2024-01-12
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2784229-0
ISSN	2309-608X ; 2309-608X
ISSN (online)	2309-608X
ISSN	2309-608X
DOI	10.3390/jof10010061
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