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Article ; Online: Can we think psychoanalytically about transgenderism? An expanded live Zoom debate with David Bell and Avgi Saketopoulou, moderated by Rachel Blass.

Blass, Rachel B / Bell, David / Saketopoulou, Avgi

The International journal of psycho-analysis

2021 Volume 102, Issue 5, Page(s) 968–1000

MeSH term(s)	Humans ; Psychoanalytic Therapy ; Transsexualism
Language	English
Publishing date	2021-07-30
Publishing country	England
Document type	Journal Article
ZDB-ID	220636-5
ISSN	1745-8315 ; 0020-7578
ISSN (online)	1745-8315
ISSN	0020-7578
DOI	10.1080/00207578.2021.1939940
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Article ; Online: Impact of skin cancer screening on melanoma thickness and stage.

Morr, Claudia / Prechtel, Taylor Jade / Hardacker, Rachel / Bell, Maria / Slaven, James E / Que, Syril Keena T

Journal of the American Academy of Dermatology

2024

Language	English
Publishing date	2024-02-14
Publishing country	United States
Document type	Journal Article
ZDB-ID	603641-7
ISSN	1097-6787 ; 0190-9622
ISSN (online)	1097-6787
ISSN	0190-9622
DOI	10.1016/j.jaad.2023.12.075
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Article ; Online: Point Sensor Networks Struggle to Detect and Quantify Short Controlled Releases at Oil and Gas Sites.

Day, Rachel Elizabeth / Emerson, Ethan / Bell, Clay / Zimmerle, Daniel

Sensors (Basel, Switzerland)

2024 Volume 24, Issue 8

Abstract: ... with the site average relative error ranging from -100% to 24% for solution D, -100% to -43% for solution E, -25 ...

Abstract	This study evaluated multiple commercially available continuous monitoring (CM) point sensor network (PSN) solutions under single-blind controlled release testing conducted at operational upstream and midstream oil and natural gas (O&G) sites. During releases, PSNs reported site-level emission rate estimates of 0 kg/h between 38 and 86% of the time. When non-zero site-level emission rate estimates were provided, no linear correlation between the release rate and the reported emission rate estimate was observed. The average, aggregated across all PSN solutions during releases, shows 5% of the mixing ratio readings at downwind sensors were greater than the site's baseline plus two standard deviations. Four of seven total PSN solutions tested during this field campaign provided site-level emission rate estimates with the site average relative error ranging from -100% to 24% for solution D, -100% to -43% for solution E, -25% for solution F (solution F was only at one site), and -99% to 430% for solution G, with an overall average of -29% across all sites and solutions. Of all the individual site-level emission rate estimates, only 11% were within ±2.5 kg/h of the study team's best estimate of site-level emissions at the time of the releases.
Language	English
Publishing date	2024-04-10
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2052857-7
ISSN	1424-8220 ; 1424-8220
ISSN (online)	1424-8220
ISSN	1424-8220
DOI	10.3390/s24082419
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Article ; Online: Public Health Policy Actions to Address Health Issues Associated with Drought in a Changing Climate.

Lookadoo, Rachel E / Bell, Jesse E

The Journal of law, medicine & ethics : a journal of the American Society of Law, Medicine & Ethics

2021 Volume 48, Issue 4, Page(s) 653–663

Abstract: Over the last century, droughts have caused more deaths internationally than any other weather- or climate-related disaster. Like other natural disasters, droughts cause significant changes in the environment that can lead to negative health outcomes. As ...

Abstract	Over the last century, droughts have caused more deaths internationally than any other weather- or climate-related disaster. Like other natural disasters, droughts cause significant changes in the environment that can lead to negative health outcomes. As droughts are becoming more frequent and intense with climate change, public health systems need to address impacts associated with these events. Partnering with federal and local entities, we evaluated the state of knowledge of drought and health in the United States through a National Drought and Public Health Summit and a series of subsequent regional workshops. The intended outcome was to develop public health strategies for implementing activities to better support and prepare public health systems for future droughts. The information gathered from this work identified multiple policy and law options to address the public health issues associated with drought. These policy recommendations include the use of public health emergency declarations for drought events, increased usage of preparedness evaluations for drought emergencies, and engagement of drought and climate experts in state and local risk assessments. As drought events are projected to increase in frequency and magnitude with climate change, taking policy action now will help decrease the health impacts of drought and save lives.
MeSH term(s)	Climate Change ; Disaster Planning ; Droughts ; Emergencies ; Humans ; Public Health ; Public Policy ; Risk Assessment ; Stakeholder Participation ; United States
Language	English
Publishing date	2021-01-28
Publishing country	England
Document type	Journal Article ; Research Support, U.S. Gov't, Non-P.H.S.
ZDB-ID	1168812-9
ISSN	1748-720X ; 1073-1105 ; 0277-8459
ISSN (online)	1748-720X
ISSN	1073-1105 ; 0277-8459
DOI	10.1177/1073110520979372
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Article ; Online: Nontuberculous Mycobacteria in Cystic Fibrosis in the Era of Cystic Fibrosis Transmembrane Regulator Modulators.

Burke, Andrew / Thomson, Rachel M / Wainwright, Claire E / Bell, Scott C

Seminars in respiratory and critical care medicine

2023 Volume 44, Issue 2, Page(s) 287–296

Abstract: Nontuberculous mycobacteria (NTM) are a group of mycobacteria which represent opportunistic pathogens that are of increasing concern in people with cystic fibrosis (pwCF). The acquisition has been traditionally though to be from environmental sources, ... ...

Abstract	Nontuberculous mycobacteria (NTM) are a group of mycobacteria which represent opportunistic pathogens that are of increasing concern in people with cystic fibrosis (pwCF). The acquisition has been traditionally though to be from environmental sources, though recent work has suggested clustered clonal infections do occur and transmission potential demonstrated among pwCF attending CF specialist centers. Guidelines for the screening, diagnosis, and identification of NTM and management of pwCF have been published. The emergence of CF-specific therapies, in particular cystic fibrosis transmembrane regulator (CFTR) modulator drugs, have led to significant improvement in the health and well-being of pwCF and may lead to challenges in sampling the lower respiratory tract including to screen for NTM. This review highlights the epidemiology, modes of acquisition, screening and diagnosis, therapeutic approaches in the context of improved clinical status for pwCF, and the clinical application of CFTR modulator therapies.
MeSH term(s)	Humans ; Cystic Fibrosis/drug therapy ; Nontuberculous Mycobacteria ; Cystic Fibrosis Transmembrane Conductance Regulator/genetics ; Mycobacterium Infections, Nontuberculous/diagnosis ; Mycobacterium Infections, Nontuberculous/drug therapy ; Mycobacterium Infections, Nontuberculous/epidemiology
Chemical Substances	Cystic Fibrosis Transmembrane Conductance Regulator (126880-72-6)
Language	English
Publishing date	2023-01-17
Publishing country	United States
Document type	Review ; Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	1183617-9
ISSN	1098-9048 ; 1069-3424
ISSN (online)	1098-9048
ISSN	1069-3424
DOI	10.1055/s-0042-1759883
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Zs.A 1555: Show issues

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Article ; Online: Behaviour and sun exposure in holidaymakers alters skin microbiota composition and diversity.

Willmott, Thomas / Campbell, Paul M / Griffiths, Christopher E M / O'Connor, Clare / Bell, Michael / Watson, Rachel E B / McBain, Andrew J / Langton, Abigail K

Frontiers in aging

2023 Volume 4, Page(s) 1217635

Abstract: Introduction: ...

Abstract	Introduction:
Language	English
Publishing date	2023-08-08
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	3076785-4
ISSN	2673-6217 ; 2673-6217
ISSN (online)	2673-6217
ISSN	2673-6217
DOI	10.3389/fragi.2023.1217635
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Article: Nontuberculous Mycobacteria in Cystic Fibrosis in the Era of Cystic Fibrosis Transmembrane Regulator Modulators

Burke, Andrew / Thomson, Rachel M. / Wainwright, Claire E. / Bell, Scott C.

Seminars in Respiratory and Critical Care Medicine

(Cystic Fibrosis)

2023 Volume 44, Issue 02, Page(s) 287–296

Series title	Cystic Fibrosis
Abstract	Nontuberculous mycobacteria (NTM) are a group of mycobacteria which represent opportunistic pathogens that are of increasing concern in people with cystic fibrosis (pwCF). The acquisition has been traditionally though to be from environmental sources, though recent work has suggested clustered clonal infections do occur and transmission potential demonstrated among pwCF attending CF specialist centers. Guidelines for the screening, diagnosis, and identification of NTM and management of pwCF have been published. The emergence of CF-specific therapies, in particular cystic fibrosis transmembrane regulator (CFTR) modulator drugs, have led to significant improvement in the health and well-being of pwCF and may lead to challenges in sampling the lower respiratory tract including to screen for NTM. This review highlights the epidemiology, modes of acquisition, screening and diagnosis, therapeutic approaches in the context of improved clinical status for pwCF, and the clinical application of CFTR modulator therapies.
Keywords	cystic fibrosis ; nontuberculous mycobacteria ; complex ; CFTR modulator ; epidemiology ; environmental exposure
Language	English
Publishing date	2023-01-17
Publisher	Thieme Medical Publishers, Inc.
Publishing place	Stuttgart ; New York
Document type	Article
ZDB-ID	1183617-9
ISSN	1098-9048 ; 1069-3424
ISSN (online)	1098-9048
ISSN	1069-3424
DOI	10.1055/s-0042-1759883
Database	Thieme publisher's database

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Article ; Online: A systematic review of the clinical impact of small colony variants in patients with cystic fibrosis.

Ryan, Harrigan / Ballard, Emma / Stockwell, Rebecca E / Duplancic, Christine / Thomson, Rachel M / Smith, Kimberley / Bell, Scott C

BMC pulmonary medicine

2023 Volume 23, Issue 1, Page(s) 323

Abstract: Background: Cystic fibrosis (CF) is a life-limiting disorder that is characterised by respiratory tract inflammation that is mediated by a range of microbial pathogens. Small colony variants (SCVs) of common respiratory pathogens are being increasingly ... ...

Abstract	Background: Cystic fibrosis (CF) is a life-limiting disorder that is characterised by respiratory tract inflammation that is mediated by a range of microbial pathogens. Small colony variants (SCVs) of common respiratory pathogens are being increasingly recognised in CF. The aim of this systematic review is to investigate the prevalence of SCVs, clinical characteristics and health outcomes for patients with CF, and laboratory diagnostic features of SCVs compared to non-small colony variants (NCVs) for a range of Gram-positive and Gram-negative respiratory pathogens. Methods: A literature search was conducted (PubMed, Web of Science, Embase and Scopus) in April 2020 to identify articles of interest. Data pertaining to demographic characteristics of participants, diagnostic criteria of SCVs, SCV prevalence and impact on lung function were extracted from included studies for analysis. Results: Twenty-five of 673 studies were included in the systematic review. Individuals infected with SCVs of Staphylococcus aureus (S. aureus) were more likely to have had prior use of the broad-spectrum antibiotic trimethoprim sulfamethoxazole (p < 0.001), and the prevalence of SCVs in patients infected with S. aureus was estimated to be 19.3% (95% CI: 13.5% to 25.9%). Additionally, patients infected with SCVs of Gram-negative and Gram-positive pathogens were identified to have a lower forced expiratory volume in one second percentage predicted (-16.8, 95% CI: -23.2 to -10.4) than those infected by NCVs. Gram-positive SCVs were commonly described as small and non-haemolytic, grown on Mannitol salt or blood agar for 24 h at 35°C and confirmed using tube coagulase testing. Conclusion: The findings of this systematic review demonstrate that SCVs of S. aureus have a high prevalence in the CF community, and that the occurrence of SCVs in Gram-positive and Gram-negative pathogens is linked to poorer respiratory function. Further investigation is necessary to determine the effect of infection by SCVs on the CF population.
MeSH term(s)	Humans ; Cystic Fibrosis ; Staphylococcus aureus ; Patients ; Anti-Bacterial Agents/therapeutic use ; Culture Media
Chemical Substances	Anti-Bacterial Agents ; Culture Media
Language	English
Publishing date	2023-09-01
Publishing country	England
Document type	Systematic Review ; Journal Article
ZDB-ID	2059871-3
ISSN	1471-2466 ; 1471-2466
ISSN (online)	1471-2466
ISSN	1471-2466
DOI	10.1186/s12890-023-02611-4
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Article ; Online: Kidney shape statistical analysis: associations with disease and anthropometric factors.

Thanaj, Marjola / Basty, Nicolas / Cule, Madeleine / Sorokin, Elena P / Whitcher, Brandon / Srinivasan, Ramprakash / Lennon, Rachel / Bell, Jimmy D / Thomas, E Louise

BMC nephrology

2023 Volume 24, Issue 1, Page(s) 362

Abstract: Background: Organ measurements derived from magnetic resonance imaging (MRI) have the potential to enhance our understanding of the precise phenotypic variations underlying many clinical conditions.: Methods: We applied morphometric methods to study ... ...

Abstract	Background: Organ measurements derived from magnetic resonance imaging (MRI) have the potential to enhance our understanding of the precise phenotypic variations underlying many clinical conditions. Methods: We applied morphometric methods to study the kidneys by constructing surface meshes from kidney segmentations from abdominal MRI data in 38,868 participants in the UK Biobank. Using mesh-based analysis techniques based on statistical parametric maps (SPMs), we were able to detect variations in specific regions of the kidney and associate those with anthropometric traits as well as disease states including chronic kidney disease (CKD), type-2 diabetes (T2D), and hypertension. Statistical shape analysis (SSA) based on principal component analysis was also used within the disease population and the principal component scores were used to assess the risk of disease events. Results: We show that CKD, T2D and hypertension were associated with kidney shape. Age was associated with kidney shape consistently across disease groups. Body mass index (BMI) and waist-to-hip ratio (WHR) were also associated with kidney shape for the participants with T2D. Using SSA, we were able to capture kidney shape variations, relative to size, angle, straightness, width, length, and thickness of the kidneys, within disease populations. We identified significant associations between both left and right kidney length and width and incidence of CKD (hazard ratio (HR): 0.74, 95% CI: 0.61-0.90, p < 0.05, in the left kidney; HR: 0.76, 95% CI: 0.63-0.92, p < 0.05, in the right kidney) and hypertension (HR: 1.16, 95% CI: 1.03-1.29, p < 0.05, in the left kidney; HR: 0.87, 95% CI: 0.79-0.96, p < 0.05, in the right kidney). Conclusions: The results suggest that shape-based analysis of the kidneys can augment studies aiming at the better categorisation of pathologies associated with chronic kidney conditions.
MeSH term(s)	Humans ; Kidney/diagnostic imaging ; Anthropometry ; Renal Insufficiency, Chronic/diagnostic imaging ; Renal Insufficiency, Chronic/epidemiology ; Body Mass Index ; Hypertension/diagnostic imaging ; Hypertension/epidemiology ; Diabetes Mellitus, Type 2/diagnostic imaging ; Diabetes Mellitus, Type 2/epidemiology ; Risk Factors
Language	English
Publishing date	2023-12-06
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2041348-8
ISSN	1471-2369 ; 1471-2369
ISSN (online)	1471-2369
ISSN	1471-2369
DOI	10.1186/s12882-023-03407-8
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Article ; Online: Evaluation of hydroxocobalamin use for the treatment of suspected cyanide toxicity secondary to smoke inhalation.

Kamta, Jeff / Maynard, Kaylee / Schult, Rachel F / Bell, Derek E / Jones, Courtney M C / Acquisto, Nicole M

Burns : journal of the International Society for Burn Injuries

2023 Volume 50, Issue 1, Page(s) 157–166

Abstract: Hydroxocobalamin is used for cyanide toxicity after smoke inhalation, but diagnosis is challenging. Retrospective studies have associated hydroxocobalamin with acute kidney injury (AKI). This is a retrospective analysis of patients receiving ... ...

Abstract	Hydroxocobalamin is used for cyanide toxicity after smoke inhalation, but diagnosis is challenging. Retrospective studies have associated hydroxocobalamin with acute kidney injury (AKI). This is a retrospective analysis of patients receiving hydroxocobalamin for suspected cyanide toxicity. The primary outcome was the proportion of patients meeting predefined appropriate use criteria defined as ≥1 of the following: serum lactate ≥8 mmol/L, systolic blood pressure (SBP) <90 mmHg, new-onset seizure, cardiac arrest, or respiratory arrest. Secondary outcomes included incidence of AKI, pneumonia, resolution of initial neurologic symptoms, and in-hospital mortality. Forty-six patients were included; 35 (76%) met the primary outcome. All met appropriate use criteria due to respiratory arrest, 15 (43%) for lactate, 14 (40%) for SBP, 12 (34%) for cardiac arrest. AKI, pneumonia, and resolution of neurologic symptoms occurred in 30%, 21%, and 49% of patients, respectively. In-hospital mortality was higher in patients meeting criteria, 49% vs. 9% (95% CI 0.16, 0.64). When appropriate use criteria were modified to exclude respiratory arrest in a post-hoc analysis, differences were maintained, suggesting respiratory arrest alone is not a critical component to determine hydroxocobalamin administration. Predefined appropriate use criteria identify severely ill smoke inhalation victims and provides hydroxocobalamin treatment guidance.
MeSH term(s)	Humans ; Hydroxocobalamin/therapeutic use ; Cyanides ; Antidotes/therapeutic use ; Retrospective Studies ; Burns ; Smoke Inhalation Injury/drug therapy ; Heart Arrest/chemically induced ; Heart Arrest/drug therapy ; Lactic Acid ; Acute Kidney Injury/chemically induced ; Acute Kidney Injury/drug therapy ; Pneumonia ; Smoking
Chemical Substances	Hydroxocobalamin (Q40X8H422O) ; Cyanides ; Antidotes ; Lactic Acid (33X04XA5AT)
Language	English
Publishing date	2023-09-04
Publishing country	Netherlands
Document type	Journal Article
ZDB-ID	197308-3
ISSN	1879-1409 ; 0305-4179
ISSN (online)	1879-1409
ISSN	0305-4179
DOI	10.1016/j.burns.2023.08.020
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