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Article ; Online: The Emerging Role of miR-200 Family in Cardiovascular Diseases.

Magenta, Alessandra / Ciarapica, Roberta / Capogrossi, Maurizio C

2017 Volume 120, Issue 9, Page(s) 1399–1402

MeSH term(s)	Animals ; Cardiovascular Diseases/genetics ; Cardiovascular Diseases/metabolism ; Cardiovascular Diseases/therapy ; Epigenesis, Genetic/physiology ; Humans ; MicroRNAs/physiology ; Oxidative Stress/physiology
Chemical Substances	MIRN200 microRNA, human ; MicroRNAs
Language	English
Publishing date	2017-04-26
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	80100-8
ISSN	1524-4571 ; 0009-7330 ; 0931-6876
ISSN (online)	1524-4571
ISSN	0009-7330 ; 0931-6876
DOI	10.1161/CIRCRESAHA.116.310274
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Ui IV Zs.70: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular ab Jg. 2022: Lesesaal (EG)
Ui IV Zs.60: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular ab Jg. 2022: Lesesaal (EG)

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Article ; Online: Chromatin methylation and cardiovascular aging.

Illi, Barbara / Ciarapica, Roberta / Capogrossi, Maurizio C

Journal of molecular and cellular cardiology

2015 Volume 83, Page(s) 21–31

Abstract: DNA and histone methylation are well characterized epigenetic marks that are altered during the aging process. In aged cells and tissues, DNA cytosine tagging by methylation undergoes the so-called "epigenetic drift", in parallel with a change in the ... ...

Abstract	DNA and histone methylation are well characterized epigenetic marks that are altered during the aging process. In aged cells and tissues, DNA cytosine tagging by methylation undergoes the so-called "epigenetic drift", in parallel with a change in the methylated histone profile. Despite the large body of knowledge regarding age-dependent epigenetic changes, there are few reports related to this topic in the cardiovascular field. This review summarizes age-dependent changes in DNA and histone methylation with a specific focus on age-related cardiovascular diseases (CVDs).
MeSH term(s)	Aging/genetics ; Aging/metabolism ; Animals ; Arrhythmias, Cardiac/genetics ; Arrhythmias, Cardiac/metabolism ; Arrhythmias, Cardiac/pathology ; Atherosclerosis/genetics ; Atherosclerosis/metabolism ; Atherosclerosis/pathology ; Chromatin/chemistry ; Chromatin/metabolism ; DNA Methylation ; Epigenesis, Genetic ; Heart Failure/genetics ; Heart Failure/metabolism ; Heart Failure/pathology ; Histones/genetics ; Histones/metabolism ; Humans ; Myocardium/metabolism ; Myocardium/pathology ; Polycomb-Group Proteins/genetics ; Polycomb-Group Proteins/metabolism ; Signal Transduction
Chemical Substances	Chromatin ; Histones ; Polycomb-Group Proteins
Language	English
Publishing date	2015-06
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't ; Review
ZDB-ID	80157-4
ISSN	1095-8584 ; 0022-2828
ISSN (online)	1095-8584
ISSN	0022-2828
DOI	10.1016/j.yjmcc.2015.02.011
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Article ; Online: Oxidative stress, microRNAs and cytosolic calcium homeostasis.

Magenta, Alessandra / Dellambra, Elena / Ciarapica, Roberta / Capogrossi, Maurizio C

Cell calcium

2016 Volume 60, Issue 3, Page(s) 207–217

Abstract: Reactive oxygen species increase cytosolic [Ca(2+)], (Cai), and also modulate the expression of some microRNAs (miRNAs), however the link among oxidative stress, miRNAs and Cai is poorly characterized. In this review we have focused on three groups of ... ...

Abstract	Reactive oxygen species increase cytosolic [Ca(2+)], (Cai), and also modulate the expression of some microRNAs (miRNAs), however the link among oxidative stress, miRNAs and Cai is poorly characterized. In this review we have focused on three groups of miRNAs: (a) miRNAs that are modulated both by ROS and Cai: miR-181a and miR-205; (b) miRNAs that are modulated by ROS and have an effect on Cai: miR-1, miR-21, miR-24, miR-25, miR-185 and miR-214; (c) miRNAs that modulate both ROS and Cai: miR-133; miR-145, miR-495, and we have analyzed their effects on cell signaling and cell function. Finally, in the last section we have examined the role of these miRNAs in the skin, under conditions associated with enhanced oxidative stress, i.e. skin aging, the response to ultraviolet light and two important skin diseases, psoriasis and atopic dermatitis. It is apparent that although some experimental evidence is already available on (a) the role of Cai in miRNAs expression and (b) on the ability of some miRNAs to modulate Cai-dependent intracellular signaling, these research lines are still largely unexplored and represent important areas of future studies.
MeSH term(s)	Animals ; Calcium/metabolism ; Cytosol/metabolism ; Homeostasis ; Humans ; MicroRNAs/genetics ; MicroRNAs/metabolism ; Oxidative Stress ; Reactive Oxygen Species/metabolism
Chemical Substances	MicroRNAs ; Reactive Oxygen Species ; Calcium (SY7Q814VUP)
Language	English
Publishing date	2016-09
Publishing country	Netherlands
Document type	Journal Article ; Review
ZDB-ID	757687-0
ISSN	1532-1991 ; 0143-4160
ISSN (online)	1532-1991
ISSN	0143-4160
DOI	10.1016/j.ceca.2016.04.002
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Article ; Online: Role of psoriasis on subclinical cardiovascular disease.

Di Vito, Luca / Abeni, Damiano / Uras, Claudia / Magenta, Alessandra / Ciarapica, Roberta / Capogrossi, Maurizio C / Melillo, Guido

Minerva medica

2018 Volume 109, Issue 3, Page(s) 255–258

MeSH term(s)	Adult ; Cardiovascular Diseases/epidemiology ; Cardiovascular Diseases/etiology ; Female ; Humans ; Hypertrophy, Left Ventricular/etiology ; Male ; Middle Aged ; Prospective Studies ; Psoriasis/complications ; Risk Assessment ; Vascular Stiffness
Language	English
Publishing date	2018-01-11
Publishing country	Italy
Document type	Letter
ZDB-ID	123586-2
ISSN	1827-1669 ; 0026-4806
ISSN (online)	1827-1669
ISSN	0026-4806
DOI	10.23736/S0026-4806.18.05448-4
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Article ; Online: Notch signaling in pediatric soft tissue sarcomas.

Rota, Rossella / Ciarapica, Roberta / Miele, Lucio / Locatelli, Franco

BMC medicine

2012 Volume 10, Page(s) 141

Abstract: Pediatric soft tissue sarcomas are rare tumors of childhood, frequently characterized by specific chromosome translocations. Despite improvements in treatment, their clinical management is often challenging due to the low responsiveness of metastatic ... ...

Abstract	Pediatric soft tissue sarcomas are rare tumors of childhood, frequently characterized by specific chromosome translocations. Despite improvements in treatment, their clinical management is often challenging due to the low responsiveness of metastatic forms and aggressive variants to conventional therapeutic approaches, which leads to poor overall survival. It is widely thought that soft tissue sarcomas derive from mesenchymal progenitor cells that, during embryonic life, have developed chromosomal aberrations with de-regulation of the main pathways governing tissue morphogenesis. The Notch signaling pathway is one of the most important molecular networks involved in differentiation processes. Emerging evidence highlights the role of Notch signaling de-regulation in the biology of these pediatric sarcomas. In this review, we present an outline of recently gathered evidence on the role of Notch signaling in soft tissue sarcomas, highlighting its importance in tumor cell biology. The potential challenges and opportunities of targeting Notch signaling in the treatment of pediatric soft tissue sarcomas are also discussed.
MeSH term(s)	Adolescent ; Child ; Child, Preschool ; Female ; Humans ; Infant ; Male ; Receptors, Notch/metabolism ; Sarcoma/pathology ; Signal Transduction ; Young Adult
Chemical Substances	Receptors, Notch
Language	English
Publishing date	2012-11-16
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't ; Review
ISSN	1741-7015
ISSN (online)	1741-7015
DOI	10.1186/1741-7015-10-141
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Article ; Online: Passive immunotherapy for N-truncated tau ameliorates the cognitive deficits in two mouse Alzheimer's disease models.

Corsetti, Veronica / Borreca, Antonella / Latina, Valentina / Giacovazzo, Giacomo / Pignataro, Annabella / Krashia, Paraskevi / Natale, Francesca / Cocco, Sara / Rinaudo, Marco / Malerba, Francesca / Florio, Rita / Ciarapica, Roberta / Coccurello, Roberto / D'Amelio, Marcello / Ammassari-Teule, Martine / Grassi, Claudio / Calissano, Pietro / Amadoro, Giuseppina

Brain communications

2020 Volume 2, Issue 1, Page(s) fcaa039

Abstract: Clinical and neuropathological studies have shown that tau pathology better correlates with the severity of dementia than amyloid plaque burden, making tau an attractive target for the cure of Alzheimer's disease. We have explored whether passive ... ...

Abstract	Clinical and neuropathological studies have shown that tau pathology better correlates with the severity of dementia than amyloid plaque burden, making tau an attractive target for the cure of Alzheimer's disease. We have explored whether passive immunization with the 12A12 monoclonal antibody (26-36aa of tau protein) could improve the Alzheimer's disease phenotype of two well-established mouse models, Tg2576 and 3xTg mice. 12A12 is a cleavage-specific monoclonal antibody which selectively binds the pathologically relevant neurotoxic NH
Language	English
Publishing date	2020-04-06
Publishing country	England
Document type	Journal Article
ISSN	2632-1297
ISSN (online)	2632-1297
DOI	10.1093/braincomms/fcaa039
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Article ; Online: Notch signaling in pediatric soft tissue sarcomas

Rota Rossella / Ciarapica Roberta / Miele Lucio / Locatelli Franco

BMC Medicine, Vol 10, Iss 1, p

2012 Volume 141

Abstract: Abstract Pediatric soft tissue sarcomas are rare tumors of childhood, frequently characterized by specific chromosome translocations. Despite improvements in treatment, their clinical management is often challenging due to the low responsiveness of ... ...

Abstract	Abstract Pediatric soft tissue sarcomas are rare tumors of childhood, frequently characterized by specific chromosome translocations. Despite improvements in treatment, their clinical management is often challenging due to the low responsiveness of metastatic forms and aggressive variants to conventional therapeutic approaches, which leads to poor overall survival. It is widely thought that soft tissue sarcomas derive from mesenchymal progenitor cells that, during embryonic life, have developed chromosomal aberrations with de-regulation of the main pathways governing tissue morphogenesis. The Notch signaling pathway is one of the most important molecular networks involved in differentiation processes. Emerging evidence highlights the role of Notch signaling de-regulation in the biology of these pediatric sarcomas. In this review, we present an outline of recently gathered evidence on the role of Notch signaling in soft tissue sarcomas, highlighting its importance in tumor cell biology. The potential challenges and opportunities of targeting Notch signaling in the treatment of pediatric soft tissue sarcomas are also discussed.
Keywords	soft tissue sarcoma ; Notch ; mesenchymal cells ; γ-secretase ; Synovial sarcoma ; Ewing sarcoma ; Rhabdomyosarcoma ; Medicine ; R
Subject code	571
Language	English
Publishing date	2012-11-01T00:00:00Z
Publisher	BMC
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: MicroRNAs in rhabdomyosarcoma: pathogenetic implications and translational potentiality.

Rota, Rossella / Ciarapica, Roberta / Giordano, Antonio / Miele, Lucio / Locatelli, Franco

Molecular cancer

2011 Volume 10, Page(s) 120

Abstract: There is growing evidence that interconnections among molecular pathways governing tissue differentiation are nodal points for malignant transformation. In this scenario, microRNAs appear as crucial players. This class of non-coding small regulatory RNA ... ...

Abstract	There is growing evidence that interconnections among molecular pathways governing tissue differentiation are nodal points for malignant transformation. In this scenario, microRNAs appear as crucial players. This class of non-coding small regulatory RNA molecules controls developmental programs by modulating gene expression through post-transcriptional silencing of target mRNAs. During myogenesis, muscle-specific and ubiquitously-expressed microRNAs tightly control muscle tissue differentiation. In recent years, microRNAs have emerged as prominent players in cancer as well. Rhabdomyosarcoma is a pediatric skeletal muscle-derived soft-tissue sarcoma that originates from myogenic precursors arrested at different stages of differentiation and that continue to proliferate indefinitely. MicroRNAs involved in muscle cell fate determination appear down-regulated in rhabdomyosarcoma primary tumors and cell lines compared to their normal counterparts. More importantly, they behave as tumor suppressors in this malignancy, as their re-expression is sufficient to restore the differentiation capability of tumor cells and to prevent tumor growth in vivo. In addition, up-regulation of pro-oncogenic microRNAs has also been recently detected in rhabdomyosarcoma.In this review, we provide an overview of current knowledge on microRNAs de-regulation in rhabdomyosarcoma. Additionally, we examine the potential of microRNAs as prognostic and diagnostic markers in this soft-tissue sarcoma, and discuss possible therapeutic applications and challenges of a "microRNA therapy".
MeSH term(s)	Animals ; Base Sequence ; Cell Differentiation/genetics ; Gene Expression Regulation, Neoplastic ; Humans ; MicroRNAs/genetics ; MicroRNAs/metabolism ; MicroRNAs/therapeutic use ; Muscle Development/genetics ; Muscle, Skeletal/physiopathology ; Polycomb-Group Proteins ; Repressor Proteins/genetics ; Repressor Proteins/metabolism ; Rhabdomyosarcoma/genetics ; Rhabdomyosarcoma/metabolism ; Rhabdomyosarcoma/therapy
Chemical Substances	MicroRNAs ; Polycomb-Group Proteins ; Repressor Proteins
Language	English
Publishing date	2011-09-24
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't ; Review
ISSN	1476-4598
ISSN (online)	1476-4598
DOI	10.1186/1476-4598-10-120
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Article ; Online: Enhancer of zeste homolog 2 (EZH2) in pediatric soft tissue sarcomas: first implications.

Ciarapica, Roberta / Miele, Lucio / Giordano, Antonio / Locatelli, Franco / Rota, Rossella

BMC medicine

2011 Volume 9, Page(s) 63

Abstract: Soft tissue sarcomas of childhood are a group of heterogeneous tumors thought to be derived from mesenchymal stem cells. Surgical resection is effective only in about 50% of cases and resistance to conventional chemotherapy is often responsible for ... ...

Abstract	Soft tissue sarcomas of childhood are a group of heterogeneous tumors thought to be derived from mesenchymal stem cells. Surgical resection is effective only in about 50% of cases and resistance to conventional chemotherapy is often responsible for treatment failure. Therefore, investigations on novel therapeutic targets are of fundamental importance. Deregulation of epigenetic mechanisms underlying chromatin modifications during stem cell differentiation has been suggested to contribute to soft tissue sarcoma pathogenesis. One of the main elements in this scenario is enhancer of zeste homolog 2 (EZH2), a methyltransferase belonging to the Polycomb group proteins. EZH2 catalyzes histone H3 methylation on gene promoters, thus repressing genes that induce stem cell differentiation to maintain an embryonic stem cell signature. EZH2 deregulated expression/function in soft tissue sarcomas has been recently reported. In this review, an overview of the recently reported functions of EZH2 in soft tissue sarcomas is given and the hypothesis that its expression might be involved in soft tissue sarcomagenesis is discussed. Finally, the therapeutic potential of epigenetic therapies modulating EZH2-mediated gene repression is considered.
MeSH term(s)	DNA-Binding Proteins/biosynthesis ; Enhancer of Zeste Homolog 2 Protein ; Epigenesis, Genetic ; Gene Expression Regulation ; Histones/metabolism ; Humans ; Methylation ; Polycomb Repressive Complex 2 ; Sarcoma/pathology ; Transcription Factors/biosynthesis
Chemical Substances	DNA-Binding Proteins ; Histones ; Transcription Factors ; EZH2 protein, human (EC 2.1.1.43) ; Enhancer of Zeste Homolog 2 Protein (EC 2.1.1.43) ; Polycomb Repressive Complex 2 (EC 2.1.1.43)
Language	English
Publishing date	2011-05-25
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't ; Review
ISSN	1741-7015
ISSN (online)	1741-7015
DOI	10.1186/1741-7015-9-63
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Article ; Online: MicroRNAs in rhabdomyosarcoma

Giordano Antonio / Ciarapica Roberta / Rota Rossella / Miele Lucio / Locatelli Franco

Molecular Cancer, Vol 10, Iss 1, p

pathogenetic implications and translational potentiality

2011 Volume 120

Abstract: Abstract There is growing evidence that interconnections among molecular pathways governing tissue differentiation are nodal points for malignant transformation. In this scenario, microRNAs appear as crucial players. This class of non-coding small ... ...

Abstract	Abstract There is growing evidence that interconnections among molecular pathways governing tissue differentiation are nodal points for malignant transformation. In this scenario, microRNAs appear as crucial players. This class of non-coding small regulatory RNA molecules controls developmental programs by modulating gene expression through post-transcriptional silencing of target mRNAs. During myogenesis, muscle-specific and ubiquitously-expressed microRNAs tightly control muscle tissue differentiation. In recent years, microRNAs have emerged as prominent players in cancer as well. Rhabdomyosarcoma is a pediatric skeletal muscle-derived soft-tissue sarcoma that originates from myogenic precursors arrested at different stages of differentiation and that continue to proliferate indefinitely. MicroRNAs involved in muscle cell fate determination appear down-regulated in rhabdomyosarcoma primary tumors and cell lines compared to their normal counterparts. More importantly, they behave as tumor suppressors in this malignancy, as their re-expression is sufficient to restore the differentiation capability of tumor cells and to prevent tumor growth in vivo . In addition, up-regulation of pro-oncogenic microRNAs has also been recently detected in rhabdomyosarcoma. In this review, we provide an overview of current knowledge on microRNAs de-regulation in rhabdomyosarcoma. Additionally, we examine the potential of microRNAs as prognostic and diagnostic markers in this soft-tissue sarcoma, and discuss possible therapeutic applications and challenges of a "microRNA therapy".
Keywords	Neoplasms. Tumors. Oncology. Including cancer and carcinogens ; RC254-282 ; Internal medicine ; RC31-1245 ; Medicine ; R ; DOAJ:Oncology ; DOAJ:Medicine (General) ; DOAJ:Health Sciences
Subject code	571 ; 610
Language	English
Publishing date	2011-09-01T00:00:00Z
Publisher	BioMed Central
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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