LIVIVO - Search results -

Search results

Result 1 - 10 of total 17

Search options

Article ; Online: Enhancing Graduate and Postdoctoral Education To Create a Sustainable Biomedical Workforce.

Fuhrmann, Cynthia N

2016 Volume 27, Issue 11, Page(s) 871–879

Abstract: PhD-trained biomedical scientists are moving into an increasingly diverse variety of careers within the sciences. However, graduate and postdoctoral training programs have historically focused on academic career preparation, and have not sufficiently ... ...

Abstract	PhD-trained biomedical scientists are moving into an increasingly diverse variety of careers within the sciences. However, graduate and postdoctoral training programs have historically focused on academic career preparation, and have not sufficiently prepared trainees for transitioning into other scientific careers. Advocates for science have raised the concern that the collective disregard of the broader career-development needs for predoctoral and postdoctoral trainees could drive talent away from science in upcoming generations. A shift is occurring, wherein universities are increasingly investing in centralized career development programs to address this need. In this Perspective, I reflect on the movement that brought biomedical PhD career development to the spotlight in recent years, and how this movement has influenced both the academic biomedical community and the field of career development. I offer recommendations for universities looking to establish or strengthen their career development programs, including recommendations for how to develop a campus culture that values career development as part of pre- and postdoctoral training. I also suggest steps that faculty might take to facilitate the career development of their mentees, regardless of the mentee's career aspirations. Finally, I reflect on recent national efforts to incentivize innovation, evaluation, and research in the field of biomedical PhD career development, and propose actions that the scientific community can take to support biomedical career development further as a scholarly discipline. These investments will enable new approaches to be rigorously tested and efficiently disseminated to support this rapidly growing field. Ultimately, strengthening biomedical career development will be essential for attracting the best talent to science and helping them efficiently move into careers that will sustain our nation's scientific enterprise.
MeSH term(s)	Biological Science Disciplines/education ; Biomedical Research ; Career Choice ; Education, Graduate/standards ; Education, Graduate/statistics & numerical data ; Education, Graduate/trends ; Humans ; Mentors ; Professional Competence ; Research Personnel/education ; Workforce
Language	English
Publishing date	2016-10-20
Publishing country	United States
Document type	Journal Article
ZDB-ID	1028152-6
ISSN	1557-7422 ; 1043-0342
ISSN (online)	1557-7422
ISSN	1043-0342
DOI	10.1089/hum.2016.154
Database	MEDical Literature Analysis and Retrieval System OnLINE

Full text online

Accessible to users with ZB MED library card

In stock of ZB MED Cologne/Königswinter

Zs.A 2988: Show issues

Location:
Je nach Verfügbarkeit (siehe Angabe bei Bestand)
bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
Jg. 1995 - 2021: Lesesall (2.OG)
ab Jg. 2022: Lesesaal (EG)

Order via subito

This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

Details ▾

Article ; Online: Citizenship status and career self-efficacy: An intersectional study of biomedical trainees in the United States.

Chatterjee, Deepshikha / Nogueira, Ana T / Wefes, Inge / Chalkley, Roger / Sturzenegger Varvayanis, Susi / Fuhrmann, Cynthia N / Varadarajan, Janani / Jacob, Gabrielle A / Gaines, Christiann H / Hubbard, Nisan M / Chaudhary, Sunita / Layton, Rebekah L

PloS one

2024 Volume 19, Issue 3, Page(s) e0296246

Abstract: This study examines the intersectional role of citizenship and gender with career self-efficacy amongst 10,803 doctoral and postdoctoral trainees in US universities. These biomedical trainees completed surveys administered by 17 US institutions that ... ...

Abstract	This study examines the intersectional role of citizenship and gender with career self-efficacy amongst 10,803 doctoral and postdoctoral trainees in US universities. These biomedical trainees completed surveys administered by 17 US institutions that participated in the National Institutes of Health Broadening Experiences in Scientific Training (NIH BEST) Programs. Findings indicate that career self-efficacy of non-citizen trainees is significantly lower than that of US citizen trainees. While lower career efficacy was observed in women compared with men, it was even lower for non-citizen female trainees. Results suggest that specific career interests may be related to career self-efficacy. Relative to US citizen trainees, both male and female non-citizen trainees showed higher interest in pursuing a career as an academic research investigator. In comparison with non-citizen female trainees and citizen trainees of all genders, non-citizen male trainees expressed the highest interest in research-intensive (and especially principal investigator) careers. The authors discuss potential causes for these results and offer recommendations for increasing trainee career self-efficacy which can be incorporated into graduate and postdoctoral training.
MeSH term(s)	Humans ; Male ; Female ; United States ; Biomedical Research ; Education, Graduate ; Citizenship ; National Institutes of Health (U.S.) ; Research Personnel/education ; Career Choice
Language	English
Publishing date	2024-03-20
Publishing country	United States
Document type	Journal Article
ZDB-ID	2267670-3
ISSN	1932-6203 ; 1932-6203
ISSN (online)	1932-6203
ISSN	1932-6203
DOI	10.1371/journal.pone.0296246
Database	MEDical Literature Analysis and Retrieval System OnLINE

Order via subito

Article ; Online: Career self-efficacy disparities in underrepresented biomedical scientist trainees.

Chatterjee, Deepshikha / Jacob, Gabrielle A / Varvayanis, Susi Sturzenegger / Wefes, Inge / Chalkley, Roger / Nogueira, Ana T / Fuhrmann, Cynthia N / Varadarajan, Janani / Hubbard, Nisaan M / Gaines, Christiann H / Layton, Rebekah L / Chaudhary, Sunita

PloS one

2023 Volume 18, Issue 3, Page(s) e0280608

Abstract: The present study examines racial, ethnic, and gender disparities in career self-efficacy amongst 6077 US citizens and US naturalized graduate and postdoctoral trainees. Respondents from biomedical fields completed surveys administered by the National ... ...

Abstract	The present study examines racial, ethnic, and gender disparities in career self-efficacy amongst 6077 US citizens and US naturalized graduate and postdoctoral trainees. Respondents from biomedical fields completed surveys administered by the National Institutes of Health Broadening Experiences in Scientific Training (NIH BEST) programs across 17 US institutional sites. Graduate and postdoctoral demographic and survey response data were examined to evaluate the impact of intersectional identities on trainee career self-efficacy. The study hypothesized that race, ethnicity and gender, and the relations between these identities, would impact trainee career self-efficacy. The analysis demonstrated that racial and ethnic group, gender, specific career interests (academic principal investigator vs. other careers), and seniority (junior vs. senior trainee level) were, to various degrees, all associated with trainee career self-efficacy and the effects were consistent across graduate and postdoctoral respondents. Implications for differing levels of self-efficacy are discussed, including factors and events during training that may contribute to (or undermine) career self-efficacy. The importance of mentorship for building research and career self-efficacy of trainees is discussed, especially with respect to those identifying as women and belonging to racial/ethnic populations underrepresented in biomedical sciences. The results underscore the need for change in the biomedical academic research community in order to retain a diverse biomedical workforce.
MeSH term(s)	United States ; Female ; Humans ; Self Efficacy ; Biomedical Research ; Ethnicity ; Health Facilities ; Intersectional Framework
Language	English
Publishing date	2023-03-01
Publishing country	United States
Document type	Journal Article ; Research Support, N.I.H., Extramural
ZDB-ID	2267670-3
ISSN	1932-6203 ; 1932-6203
ISSN (online)	1932-6203
ISSN	1932-6203
DOI	10.1371/journal.pone.0280608
Database	MEDical Literature Analysis and Retrieval System OnLINE

Order via subito

Article ; Online: Career self-efficacy disparities in underrepresented biomedical scientist trainees

Deepshikha Chatterjee / Gabrielle A. Jacob / Susi Sturzenegger Varvayanis / Inge Wefes / Roger Chalkley / Ana T. Nogueira / Cynthia N. Fuhrmann / Janani Varadarajan / Nisaan M. Hubbard / Christiann H. Gaines / Rebekah L. Layton / Sunita Chaudhary

PLoS ONE, Vol 18, Iss

2023 Volume 3

Abstract	The present study examines racial, ethnic, and gender disparities in career self-efficacy amongst 6077 US citizens and US naturalized graduate and postdoctoral trainees. Respondents from biomedical fields completed surveys administered by the National Institutes of Health Broadening Experiences in Scientific Training (NIH BEST) programs across 17 US institutional sites. Graduate and postdoctoral demographic and survey response data were examined to evaluate the impact of intersectional identities on trainee career self-efficacy. The study hypothesized that race, ethnicity and gender, and the relations between these identities, would impact trainee career self-efficacy. The analysis demonstrated that racial and ethnic group, gender, specific career interests (academic principal investigator vs. other careers), and seniority (junior vs. senior trainee level) were, to various degrees, all associated with trainee career self-efficacy and the effects were consistent across graduate and postdoctoral respondents. Implications for differing levels of self-efficacy are discussed, including factors and events during training that may contribute to (or undermine) career self-efficacy. The importance of mentorship for building research and career self-efficacy of trainees is discussed, especially with respect to those identifying as women and belonging to racial/ethnic populations underrepresented in biomedical sciences. The results underscore the need for change in the biomedical academic research community in order to retain a diverse biomedical workforce.
Keywords	Medicine ; R ; Science ; Q
Subject code	796
Language	English
Publishing date	2023-01-01T00:00:00Z
Publisher	Public Library of Science (PLoS)
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

Full text online

Full text

Inter-library loan at ZB MED

Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

Article ; Online: Career self-efficacy disparities in underrepresented biomedical scientist trainees.

Deepshikha Chatterjee / Gabrielle A Jacob / Susi Sturzenegger Varvayanis / Inge Wefes / Roger Chalkley / Ana T Nogueira / Cynthia N Fuhrmann / Janani Varadarajan / Nisaan M Hubbard / Christiann H Gaines / Rebekah L Layton / Sunita Chaudhary

PLoS ONE, Vol 18, Iss 3, p e

2023 Volume 0280608

Abstract	The present study examines racial, ethnic, and gender disparities in career self-efficacy amongst 6077 US citizens and US naturalized graduate and postdoctoral trainees. Respondents from biomedical fields completed surveys administered by the National Institutes of Health Broadening Experiences in Scientific Training (NIH BEST) programs across 17 US institutional sites. Graduate and postdoctoral demographic and survey response data were examined to evaluate the impact of intersectional identities on trainee career self-efficacy. The study hypothesized that race, ethnicity and gender, and the relations between these identities, would impact trainee career self-efficacy. The analysis demonstrated that racial and ethnic group, gender, specific career interests (academic principal investigator vs. other careers), and seniority (junior vs. senior trainee level) were, to various degrees, all associated with trainee career self-efficacy and the effects were consistent across graduate and postdoctoral respondents. Implications for differing levels of self-efficacy are discussed, including factors and events during training that may contribute to (or undermine) career self-efficacy. The importance of mentorship for building research and career self-efficacy of trainees is discussed, especially with respect to those identifying as women and belonging to racial/ethnic populations underrepresented in biomedical sciences. The results underscore the need for change in the biomedical academic research community in order to retain a diverse biomedical workforce.
Keywords	Medicine ; R ; Science ; Q
Subject code	796
Language	English
Publishing date	2023-01-01T00:00:00Z
Publisher	Public Library of Science (PLoS)
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

Full text online

Full text

Inter-library loan at ZB MED

Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

Article ; Online: Applying inter-rater reliability to improve consistency in classifying PhD career outcomes.

Stayart, C Abigail / Brandt, Patrick D / Brown, Abigail M / Dahl, Tamara / Layton, Rebekah L / Petrie, Kimberly A / Flores-Kim, Emma N / Peña, Christopher G / Fuhrmann, Cynthia N / Monsalve, Gabriela C

F1000Research

2020 Volume 9, Page(s) 8

Abstract: Background: ...

Abstract	Background:
MeSH term(s)	Career Choice ; Education, Graduate ; Faculty ; Humans ; Reproducibility of Results
Language	English
Publishing date	2020-01-09
Publishing country	England
Document type	Journal Article ; Research Support, N.I.H., Extramural
ZDB-ID	2699932-8
ISSN	2046-1402 ; 2046-1402
ISSN (online)	2046-1402
ISSN	2046-1402
DOI	10.12688/f1000research.21046.2
Database	MEDical Literature Analysis and Retrieval System OnLINE

Order via subito

Article ; Online: Transforming training to reflect the workforce.

Mathur, Ambika / Meyers, Frederick J / Chalkley, Roger / O'Brien, Theresa C / Fuhrmann, Cynthia N

Science translational medicine

2015 Volume 7, Issue 285, Page(s) 285ed4

MeSH term(s)	Inservice Training/organization & administration ; National Institutes of Health (U.S.) ; Organizational Innovation ; Practice Guidelines as Topic ; United States
Language	English
Publishing date	2015-05-01
Publishing country	United States
Document type	Editorial ; Research Support, N.I.H., Extramural
ZDB-ID	2518854-9
ISSN	1946-6242 ; 1946-6234
ISSN (online)	1946-6242
ISSN	1946-6234
DOI	10.1126/scitranslmed.aaa8200
Database	MEDical Literature Analysis and Retrieval System OnLINE

In stock of ZB MED Cologne/Königswinter

Zs.A 6941: Show issues

Location:
Je nach Verfügbarkeit (siehe Angabe bei Bestand)
bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
ab Jg. 2022: Lesesaal (EG)

Order via subito

Details ▾
- See ZB MED holdings
- Order with fees

Article: An individual development plan will help you get where you want to go.

Clifford, Philip S / Fuhrmann, Cynthia N / Lindstaedt, Bill / Hobin, Jennifer A

The Physiologist

2013 Volume 56, Issue 2, Page(s) 43–44

MeSH term(s)	Biomedical Research/education ; Biomedical Research/organization & administration ; Career Choice ; Career Mobility ; Humans ; Organizational Objectives ; Physiology/education ; Physiology/organization & administration ; Research Personnel/education ; Research Personnel/organization & administration ; Staff Development/organization & administration
Language	English
Publishing date	2013-03
Publishing country	United States
Document type	Journal Article
ZDB-ID	208883-6
ISSN	1522-1202 ; 0031-9376
ISSN (online)	1522-1202
ISSN	0031-9376
Database	MEDical Literature Analysis and Retrieval System OnLINE

In stock of ZB MED Cologne/Königswinter

Zs.B 380: Show issues

Location:
Je nach Verfügbarkeit (siehe Angabe bei Bestand)
bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
ab Jg. 2022: Lesesaal (EG)

Order via subito

Details ▾
- See ZB MED holdings
- Order with fees

Article ; Online: Applying inter-rater reliability to improve consistency in classifying PhD career outcomes [version 1; peer review

C. Abigail Stayart / Patrick D. Brandt / Abigail M. Brown / Tamara Dahl / Rebekah L. Layton / Kimberly A. Petrie / Emma N. Flores-Kim / Christopher G. Peña / Cynthia N. Fuhrmann / Gabriela C. Monsalve

F1000Research, Vol

2 approved]

2020 Volume 9

Abstract: Background: There has been a groundswell of national support for transparent tracking and dissemination of PhD career outcomes. In 2017, individuals from multiple institutions and professional organizations met to create the Unified Career Outcomes ... ...

Abstract	Background: There has been a groundswell of national support for transparent tracking and dissemination of PhD career outcomes. In 2017, individuals from multiple institutions and professional organizations met to create the Unified Career Outcomes Taxonomy (UCOT 2017), a three-tiered taxonomy to help institutions uniformly classify career outcomes of PhD graduates. Early adopters of UCOT 2017, noted ambiguity in some categories of the career taxonomy, raising questions about its consistent application within and across institutions. Methods: To test and evaluate the consistency of UCOT 2017, we calculated inter-rater reliability across two rounds of iterative refinement of the career taxonomy, classifying over 800 PhD alumni records via nine coders. Results: We identified areas of discordance in the taxonomy, and progressively refined UCOT 2017 and an accompanying Guidance Document to improve inter-rater reliability across all three tiers of the career taxonomy. However, differing interpretations of the classifications, especially for faculty classifications in the third tier, resulted in continued discordance among the coders. We addressed this discordance with clarifying language in the Guidance Document, and proposed the addition of a flag system for identification of the title, rank, and prefix of faculty members. This labeling system provides the additional benefit of highlighting the granularity and the intersectionality of faculty job functions, while maintaining the ability to sort by - and report data on - faculty and postdoctoral trainee roles, as is required by some national and federal reporting guidelines. We provide specific crosswalk guidance for how a user may choose to incorporate our suggestions while maintaining the ability to report in accordance with UCOT 2017. Conclusions: Our findings underscore the importance of detailed guidance documents, coder training, and periodic collaborative review of career outcomes taxonomies as PhD careers evolve in the global workforce. Implications for coder-training and use of novice coders are also discussed.
Keywords	Medicine ; R ; Science ; Q
Subject code	300
Language	English
Publishing date	2020-01-01T00:00:00Z
Publisher	F1000 Research Ltd
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

Full text online

Full text

Inter-library loan at ZB MED

Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

Article: Subangstrom crystallography reveals that short ionic hydrogen bonds, and not a His-Asp low-barrier hydrogen bond, stabilize the transition state in serine protease catalysis.

Fuhrmann, Cynthia N / Daugherty, Matthew D / Agard, David A

Journal of the American Chemical Society

2006 Volume 128, Issue 28, Page(s) 9086–9102

Abstract: To address questions regarding the mechanism of serine protease catalysis, we have solved two X-ray crystal structures of alpha-lytic protease (alphaLP) that mimic aspects of the transition states: alphaLP at pH 5 (0.82 A resolution) and alphaLP bound to ...

Abstract	To address questions regarding the mechanism of serine protease catalysis, we have solved two X-ray crystal structures of alpha-lytic protease (alphaLP) that mimic aspects of the transition states: alphaLP at pH 5 (0.82 A resolution) and alphaLP bound to the peptidyl boronic acid inhibitor, MeOSuc-Ala-Ala-Pro-boroVal (0.90 A resolution). Based on these structures, there is no evidence of, or requirement for, histidine-flipping during the acylation step of the reaction. Rather, our data suggests that upon protonation of His57, Ser195 undergoes a conformational change that destabilizes the His57-Ser195 hydrogen bond, preventing the back-reaction. In both structures the His57-Asp102 hydrogen bond in the catalytic triad is a normal ionic hydrogen bond, and not a low-barrier hydrogen bond (LBHB) as previously hypothesized. We propose that the enzyme has evolved a network of relatively short hydrogen bonds that collectively stabilize the transition states. In particular, a short ionic hydrogen bond (SIHB) between His57 Nepsilon2 and the substrate's leaving group may promote forward progression of the TI1-to-acylenzyme reaction. We provide experimental evidence that refutes use of either a short donor-acceptor distance or a downfield 1H chemical shift as sole indicators of a LBHB.
MeSH term(s)	Asparagine/chemistry ; Catalysis ; Crystallography ; Histidine/chemistry ; Hydrogen/chemistry ; Hydrogen Bonding ; Models, Molecular ; Protein Conformation ; Serine/chemistry ; Serine Endopeptidases/chemistry ; Serine Endopeptidases/metabolism
Chemical Substances	Serine (452VLY9402) ; Histidine (4QD397987E) ; Asparagine (7006-34-0) ; Hydrogen (7YNJ3PO35Z) ; Serine Endopeptidases (EC 3.4.21.-)
Language	English
Publishing date	2006-07-19
Publishing country	United States
Document type	Journal Article ; Research Support, U.S. Gov't, Non-P.H.S.
ZDB-ID	3155-0
ISSN	1520-5126 ; 0002-7863
ISSN (online)	1520-5126
ISSN	0002-7863
DOI	10.1021/ja057721o
Database	MEDical Literature Analysis and Retrieval System OnLINE

In stock of ZB MED Bonn / Germany

Z 4' 55/32: Show issues
Z 7.3: Show issues

Order via subito

Inter-library loan at ZB MED

Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

Details ▾
- See ZB MED holdings
- Order with fees

To top

Full text online

More links

Kategorien

In stock of ZB MED Cologne/Königswinter

Order via subito

More links

Kategorien

Order via subito

More links

Kategorien

Order via subito

Full text online

More links

Kategorien

Inter-library loan at ZB MED

Full text online

More links

Kategorien

Inter-library loan at ZB MED

More links

Kategorien

Order via subito

More links

Kategorien

In stock of ZB MED Cologne/Königswinter

Order via subito

More links

Kategorien

In stock of ZB MED Cologne/Königswinter

Order via subito

Full text online

More links

Kategorien

Inter-library loan at ZB MED

More links

Kategorien

In stock of ZB MED Bonn / Germany

Order via subito

Inter-library loan at ZB MED