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  1. Article ; Online: Reconstruction of Full-Thickness Eyelid Defects Following Tumor Resection: The Bucket Handle Modification.

    Gur, Zvi / Men, Clara / Ozzello, Daniel J / Liu, Catherine Y / Kikkawa, Don O / Korn, Bobby S

    The Journal of craniofacial surgery

    2024  

    Abstract: ... by reconstruction with a bucket handle flap. Age range was 68 to 96 years old (mean of 81 y). Five patients ...

    Abstract Purpose: To describe a modified approach for full-thickness lower eyelid defect reconstruction.
    Methods: This is a retrospective review of 5 patients with large full-thickness lower eyelid defects after tumor resection requiring reconstruction. For these lower eyelid defects, a lateral-based or superior-based tarsoconjunctival pedicle flap from the upper eyelid was used to rebuild the posterior lamella. In all cases, the anterior lamella was supplied from an adjacent myocutaneous flap in a bucket handle configuration. Data collection included tumor type and location, size of eyelid defect, presence of canalicular involvement, postoperative eyelid position, patient satisfaction, and complication rates.
    Results: Five eyelids of 5 patients underwent Mohs micrographic excision of basal cell carcinoma followed by reconstruction with a bucket handle flap. Age range was 68 to 96 years old (mean of 81 y). Five patients presented with lower eyelid involvement. The defect size ranged from 80% to 100% of the eyelid. Three patients had canalicular involvement and required bicanalicular nasolacrimal stent placement. After reconstruction, all patients showed good eyelid apposition to the globe with excellent esthetic outcome. No revision procedures were done. Average follow-up time was 13 months (range of 8 to 21 mo).
    Conclusion: The bucket handle flap for full-thickness eyelid reconstruction is a simple technique that allows for preservation of all anatomical layers of the anterior lamella. This technique shows promising functional and esthetic outcomes.
    Language English
    Publishing date 2024-02-22
    Publishing country United States
    Document type Journal Article
    ZDB-ID 1159501-2
    ISSN 1536-3732 ; 1049-2275
    ISSN (online) 1536-3732
    ISSN 1049-2275
    DOI 10.1097/SCS.0000000000010006
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Conditional deletion of Zeb1 in Csf1r

    Do, Khoi K / Wang, Fuhua / Sun, Xiaolei / Zhang, Yingnan / Liang, Wei / Liu, John Y / Jiang, Daniel Y / Lu, Xiaoqin / Wang, Wei / Zhang, Lijun / Dean, Douglas C / Liu, Yongqing

    iScience

    2024  Volume 27, Issue 5, Page(s) 109694

    Abstract: ZEB1 is an essential factor in embryonic development. In adults, it is often highly expressed in malignant tumors with low expression in normal tissues. The major biological function of ZEB1 in developing embryos and progressing cancers is to ... ...

    Abstract ZEB1 is an essential factor in embryonic development. In adults, it is often highly expressed in malignant tumors with low expression in normal tissues. The major biological function of ZEB1 in developing embryos and progressing cancers is to transdifferentiate cells from an epithelial to mesenchymal phenotype; but what roles ZEB1 plays in normal adult tissues are largely unknown. We previously reported that the reduction of Zeb1 in monoallelic global knockout (Zeb1
    Language English
    Publishing date 2024-04-09
    Publishing country United States
    Document type Journal Article
    ISSN 2589-0042
    ISSN (online) 2589-0042
    DOI 10.1016/j.isci.2024.109694
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article: A comprehensive review on

    Nadeem, Sahar / Riaz Ahmed, Syed / Luqman, Tahira / Tan, Daniel K Y / Maryum, Zahra / Akhtar, Khalid Pervaiz / Muhy Ud Din Khan, Sana / Tariq, Muhammad Sayyam / Muhammad, Nazar / Khan, Muhammad Kashif Riaz / Liu, Yongming

    Frontiers in genetics

    2024  Volume 15, Page(s) 1306469

    Abstract: Cotton ( ...

    Abstract Cotton (
    Language English
    Publishing date 2024-02-19
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2606823-0
    ISSN 1664-8021
    ISSN 1664-8021
    DOI 10.3389/fgene.2024.1306469
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: An axon-T cell feedback loop enhances inflammation and axon degeneration.

    Liu, Tingting / Wang, Huanhuan / Kutsovsky, Daniel Y / Iskols, Michael / Chen, Hongjie / Ohn, Christine Y J / Patel, Nandan / Yang, Jing / Simon, David J

    Cell reports

    2024  Volume 43, Issue 2, Page(s) 113721

    Abstract: Inflammation is closely associated with many neurodegenerative disorders. Yet, whether inflammation causes, exacerbates, or responds to neurodegeneration has been challenging to define because the two processes are so closely linked. Here, we disentangle ...

    Abstract Inflammation is closely associated with many neurodegenerative disorders. Yet, whether inflammation causes, exacerbates, or responds to neurodegeneration has been challenging to define because the two processes are so closely linked. Here, we disentangle inflammation from the axon damage it causes by individually blocking cytotoxic T cell function and axon degeneration. We model inflammatory damage in mouse skin, a barrier tissue that, despite frequent inflammation, must maintain proper functioning of a dense array of axon terminals. We show that sympathetic axons modulate skin inflammation through release of norepinephrine, which suppresses activation of γδ T cells via the β2 adrenergic receptor. Strong inflammatory stimulation-modeled by application of the Toll-like receptor 7 agonist imiquimod-causes progressive γδ T cell-mediated, Sarm1-dependent loss of these immunosuppressive sympathetic axons. This removes a physiological brake on T cells, initiating a positive feedback loop of enhanced inflammation and further axon damage.
    MeSH term(s) Animals ; Mice ; Feedback ; Inflammation ; Axons ; Dermatitis ; Presynaptic Terminals
    Language English
    Publishing date 2024-02-03
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2649101-1
    ISSN 2211-1247 ; 2211-1247
    ISSN (online) 2211-1247
    ISSN 2211-1247
    DOI 10.1016/j.celrep.2024.113721
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: Mark, magnify, map: Improving biopsy-site photography.

    Klufas, Daniel M / Lohman, Mary E / Liu, Jennifer Y / Khodosh, Rita

    Journal of the American Academy of Dermatology

    2021  Volume 87, Issue 2, Page(s) 467–469

    MeSH term(s) Biopsy ; Humans ; Photography ; Skin
    Language English
    Publishing date 2021-10-19
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 603641-7
    ISSN 1097-6787 ; 0190-9622
    ISSN (online) 1097-6787
    ISSN 0190-9622
    DOI 10.1016/j.jaad.2021.10.014
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article: Case report: Therapy-related myeloid neoplasms in three pediatric cases with medulloblastoma.

    Mak, Li Shun / Li, Xiuling / Chan, Wilson Y K / Leung, Alex W K / Cheuk, Daniel K L / Yuen, Liz Y P / So, Jason C C / Ha, Shau Yin / Liu, Anthony P Y

    Frontiers in oncology

    2024  Volume 14, Page(s) 1364199

    Abstract: Introduction: Medulloblastoma is the most common malignant brain tumor in children, often requiring intensive multimodal therapy, including chemotherapy with alkylating agents. However, therapy-related complications, such as therapy-related myeloid ... ...

    Abstract Introduction: Medulloblastoma is the most common malignant brain tumor in children, often requiring intensive multimodal therapy, including chemotherapy with alkylating agents. However, therapy-related complications, such as therapy-related myeloid neoplasms (t-MNs), can arise, particularly in patients with genetic predisposition syndromes. This case report presents three pediatric cases of medulloblastoma with subsequent development of t-MNs, highlighting the potential role of genetic predisposition and the importance of surveillance for hematological abnormalities in long-term survivors.
    Case presentation: We describe three cases of pediatric medulloblastoma who developed t-MNs after receiving chemotherapy, including alkylating agents. Two of the patients had underlying genetic predisposition syndromes (
    Conclusions: This report highlights the potential association between genetic predisposition syndromes and the development of therapy-related myeloid neoplasms in pediatric medulloblastoma survivors. It underscores the importance of surveillance for hematological abnormalities among such patients.
    Language English
    Publishing date 2024-03-26
    Publishing country Switzerland
    Document type Case Reports
    ZDB-ID 2649216-7
    ISSN 2234-943X
    ISSN 2234-943X
    DOI 10.3389/fonc.2024.1364199
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article ; Online: Reversible CO

    Alfaraidi, Abdulrahman M / Kudisch, Bryan / Ni, Nina / Thomas, Jayden / George, Thomas Y / Rajabimoghadam, Khashayar / Jiang, Haihui Joy / Nocera, Daniel G / Aziz, Michael J / Liu, Richard Y

    Journal of the American Chemical Society

    2023  Volume 145, Issue 49, Page(s) 26720–26727

    Abstract: Separation of carbon dioxide ( ... ...

    Abstract Separation of carbon dioxide (CO
    Language English
    Publishing date 2023-12-05
    Publishing country United States
    Document type Journal Article
    ZDB-ID 3155-0
    ISSN 1520-5126 ; 0002-7863
    ISSN (online) 1520-5126
    ISSN 0002-7863
    DOI 10.1021/jacs.3c08471
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article ; Online: Bound on annealing performance from stochastic thermodynamics, with application to simulated annealing.

    Luo, Yutong / Zhen, Yi-Zheng / Liu, Xiangjing / Ebler, Daniel / Dahlsten, Oscar

    Physical review. E

    2023  Volume 108, Issue 5-1, Page(s) 54119

    Abstract: ... it towards its lowest energy states. In an accompanying paper [Y. Luo et al., Phys. Rev. E 108, L052105 (2023)10.1103/PhysRevE ...

    Abstract Annealing is the process of gradually lowering the temperature of a system to guide it towards its lowest energy states. In an accompanying paper [Y. Luo et al., Phys. Rev. E 108, L052105 (2023)10.1103/PhysRevE.108.L052105], we derived a general bound on annealing performance by connecting annealing with stochastic thermodynamics tools, including a speed limit on state transformation from entropy production. We here describe the derivation of the general bound in detail. In addition, we analyze the case of simulated annealing with Glauber dynamics in depth. We show how to bound the two case-specific quantities appearing in the bound, namely the activity, a measure of the number of microstate jumps, and the change in relative entropy between the state and the instantaneous thermal state, which is due to temperature variation. We exemplify the arguments by numerical simulations on the Sherrington-Kirkpatrick (SK) model of spin glasses.
    Language English
    Publishing date 2023-12-19
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2844562-4
    ISSN 2470-0053 ; 2470-0045
    ISSN (online) 2470-0053
    ISSN 2470-0045
    DOI 10.1103/PhysRevE.108.054119
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  9. Article ; Online: Acute Promyelocytic Leukemia with Rare Genetic Aberrations: A Report of Three Cases.

    Liu, Guang / Liu, Lanting / Bartolo, Daniel Di / Li, Katie Y / Li, Xia

    Genes

    2022  Volume 14, Issue 1

    Abstract: Acute promyelocytic leukemia (APL) is a unique subtype of acute myeloid leukemia (AML) that is characterized by ... ...

    Abstract Acute promyelocytic leukemia (APL) is a unique subtype of acute myeloid leukemia (AML) that is characterized by the
    MeSH term(s) Humans ; Leukemia, Promyelocytic, Acute/drug therapy ; Leukemia, Promyelocytic, Acute/genetics ; In Situ Hybridization, Fluorescence ; Tretinoin/therapeutic use ; Arsenic Trioxide/therapeutic use ; Leukemia, Myeloid, Acute/drug therapy
    Chemical Substances Tretinoin (5688UTC01R) ; Arsenic Trioxide (S7V92P67HO)
    Language English
    Publishing date 2022-12-23
    Publishing country Switzerland
    Document type Case Reports
    ZDB-ID 2527218-4
    ISSN 2073-4425 ; 2073-4425
    ISSN (online) 2073-4425
    ISSN 2073-4425
    DOI 10.3390/genes14010046
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article ; Online: Targeted sampling of natural product space to identify bioactive natural product-like polyketide macrolides.

    Wilson, Darryl M / Driedger, Daniel J / Liu, Dennis Y / Keerthisinghe, Sandra / Hermann, Adrian / Bieniossek, Christoph / Linington, Roger G / Britton, Robert A

    Nature communications

    2024  Volume 15, Issue 1, Page(s) 2534

    Abstract: Polyketide or polyketide-like macrolides (pMLs) continue to serve as a source of inspiration for drug discovery. However, their inherent structural and stereochemical complexity challenges efforts to explore related regions of chemical space more broadly. ...

    Abstract Polyketide or polyketide-like macrolides (pMLs) continue to serve as a source of inspiration for drug discovery. However, their inherent structural and stereochemical complexity challenges efforts to explore related regions of chemical space more broadly. Here, we report a strategy termed the Targeted Sampling of Natural Product space (TSNaP) that is designed to identify and assess regions of chemical space bounded by this important class of molecules. Using TSNaP, a family of tetrahydrofuran-containing pMLs are computationally assembled from pML inspired building blocks to provide a large collection of natural product-like virtual pMLs. By scoring functional group and volumetric overlap against their natural counterparts, a collection of compounds are prioritized for targeted synthesis. Using a modular and stereoselective synthetic approach, a library of polyketide-like macrolides are prepared to sample these unpopulated regions of pML chemical space. Validation of this TSNaP approach by screening this library against a panel of whole-cell biological assays, reveals hit rates exceeding those typically encountered in small molecule libraries. This study suggests that the TSNaP approach may be more broadly useful for the design of improved chemical libraries for drug discovery.
    MeSH term(s) Polyketides ; Macrolides/pharmacology ; Biological Products/pharmacology ; Biological Products/chemistry ; Drug Discovery
    Chemical Substances Polyketides ; Macrolides ; Biological Products
    Language English
    Publishing date 2024-03-21
    Publishing country England
    Document type Journal Article
    ZDB-ID 2553671-0
    ISSN 2041-1723 ; 2041-1723
    ISSN (online) 2041-1723
    ISSN 2041-1723
    DOI 10.1038/s41467-024-46721-x
    Database MEDical Literature Analysis and Retrieval System OnLINE

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