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Article ; Online: Investigation of Pharmacological Mechanisms of Yinhua Pinggan Granule on the Treatment of Pneumonia through Network Pharmacology and

Jin, Liang / Zhang, Yumei / Yang, Jiehong / Zhou, Huifen / Jia, Gaozhi / He, Yu / Wan, Haitong

2022 Volume 2022, Page(s) 1602447

Abstract: Yinhua pinggan granule (YHPGKL), a traditional Chinese medical compound, could treat pneumonia ...

Abstract	Yinhua pinggan granule (YHPGKL), a traditional Chinese medical compound, could treat pneumonia. Although previous studies demonstrated the protective and therapeutic effects of YHPGKL on pneumonia, its potential molecular mechanisms and its effective components are still elusive. Herein, we performed a network pharmacology analysis to determine the possible signaling pathways involved in the protective effects of components of YHPGKL. A total of 119 components and 257 target proteins of YHPGKL were identified, among which 117 effective components interacted with 113 proteins related to pneumonia. Then, a compound-effective component-target protein network was established to screen the effective hub components. The top three effective components, namely luteolin, kaempferol, and quercetin, were selected. Moreover, Gene Ontology (GO) and Kyoto Encyclopedia of Genes and Genomes (KEGG) enrichment analysis of 113 proteins revealed a significant enrichment term associated with host immune and anti-infectious responses. Furthermore, by constructing a protein-protein interaction network between common proteins, ten hub proteins were identified, among which three hub components hit eight proteins. A further molecular docking analysis confirmed that the three effective hub components had a good affinity with six hub proteins. Eventually, the interactions were further visualized and screened on account of an infectious macrophage model
MeSH term(s)	Humans ; Gene Regulatory Networks ; Gene Expression Profiling/methods ; Molecular Docking Simulation ; Network Pharmacology ; Pneumonia/drug therapy
Language	English
Publishing date	2022-11-02
Publishing country	United States
Document type	Journal Article
ZDB-ID	2698540-8
ISSN	2314-6141 ; 2314-6133
ISSN (online)	2314-6141
ISSN	2314-6133
DOI	10.1155/2022/1602447
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Efficacy of integrative medicine using Yinhua-based herbal granules on herpangina

Yongcheng Sheng / Yuhui Zhang / Qin Wang / Qi Hong / Deying Kang

Phytomedicine Plus, Vol 2, Iss 4, Pp 100351- (2022)

A Bayesian network meta-analysis of randomized controlled trials

2022

Abstract: ... and Xiao'er Qingjie Granules (XQJGs), collectively named Yinhua-based herbal granules (YH-HGs) have ...

Abstract	Background: Different Traditional Chinese Medicine (TCM) in the format of granules, such as Kanggan Granules (KangGs), Kouyanqing Granules (KouGs), Lianhua Qingwen Granules (LQGs), Qingkailing Granules (QGs) and Xiao'er Qingjie Granules (XQJGs), collectively named Yinhua-based herbal granules (YH-HGs) have been widely used in the management of pediatric outpatients with herpangina. Few head-to-head randomized controlled trials (RCTs) have compared the efficacy of these agents. This network meta-analysis (NMA) was conducted to indirectly compare the efficacy of YH-HGs. Methods: This systematic review and fixed-effect NMA was conducted according to the Preferred Reporting Items for Systematic Review and Meta-analysis (PRISMA) extension statement for NMA. RCTs assessing the efficacy and safety of YH-HGs in children that were also receiving ribavirin as the conventional therapy were searched from eight databases and two trial registers up to Jan 13, 2022. The primary outcome was total effectiveness rate (TER). The secondary outcomes were total adverse events (TAEs) and the time to symptom improvement of fever, vesicles, pain and salivation. Relative risk (RR) and weighted mean difference with 95% confidence intervals (CIs) were estimated by direct pairwise meta-analysis (MA) and NMA. Results: A total of 10 RCTs, enrolling 1 017 pediatric patients, were included. YH-HGs were better than no medication (NM) in TER (RR = 1.22, 95%CIs, 1.16 – 1.28) by direct pairwise MA, in which KangGs (RR = 1.24, 95%CIs, 1.05 – 1.47), KouGs (RR = 1.17, 95%CIs, 1.08 – 1.27), LQGs (RR = 1.24, 95%CIs, 1.14 – 1.35), QGs (RR = 1.33, 95%CIs, 1.11 – 1.58) and XQJGs (RR = 1.18, 95%CIs, 1.00 – 1.40) were also more efficient than NM. As for secondary outcomes, YH-HGs was associated with a 103% increased risk of TAEs compared to NM, but no significant differences were found. YH-HGs has a more positive symptom improvement effect than NM in fever, vesicles, pain and salivation. The ranking results showed that QGs (79.2%) had the highest probability ...
Keywords	Yinhua ; Herbal granules ; Herpangina ; Bayesian model ; Network meta-analysis ; Other systems of medicine ; RZ201-999
Subject code	310
Language	English
Publishing date	2022-11-01T00:00:00Z
Publisher	Elsevier
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: In vitro and in vivo antiviral effect of Fufang Yinhua Jiedu granules (FFYH) combined with oseltamivir against influenza A virus

Zhihui Zheng / Yuqian Zhang / Ming Li / Wenlei Wang / Hailin Wei / Qin Su / Ronghua Wang / Weiqing Shi / Lei Wang / Jianxiong Wu / Shuheng He / Xiaoquan Wang / Pinghu Zhang

Phytomedicine Plus, Vol 3, Iss 1, Pp 100386- (2023)

2023

Abstract: Introduction: Our recent work demonstrated that Fufang Yinhua Jiedu granule (FFYH) exhibited a good ...

Abstract	Introduction: Our recent work demonstrated that Fufang Yinhua Jiedu granule (FFYH) exhibited a good antiviral activity against influenza A virus (IAV). However, whether the combinations of FFYH with antiviral agents show synergistic action against IAV remains unclear. Methods: In vitro combinations of FFYH and oseltamivir against IAV were evaluated using Madin-Darby canine kidney (MDCK) cell model. In vivo combinations effect against IAV (H1N1, A/FM1/1/33) was performed using Institute of Cancer Research (ICR) mice model. The potential mechanism of FFYH against IAV in vitro and in vivo was investigated by RT-PCR or Western blot. Results: In vitro combinations of FFYH and oseltamivir could synergistically inhibit the replication of IAV and prevent the cell pathogenic effect (CPE) caused by IAV. In in vivo assays, FFYH combined with oseltamivir not only could markedly improve the sick signs, food intake, weight loss, hematology parameters, inflammatory factors and lung pathological changes, but also significantly increased the survival rate and the survival time of the IAV-infected mice. In addition, virus titers in lung tissue and lung index were markedly reduced on day 6 post-infection by combination therapy of oseltamivir combined with FFYH at 0.25 and 0.5 g/kg/d. The studies of mechanism of action indicated that the combination effect of FFYH with oseltamivir against IAV might be achieved through regulating TLR7-MyD88 signaling pathway. Conclusions: The combinations of FFYH and oseltamivir not only exhibited in vitro synergistic antiviral activity on IAV, but also showed better protective effect against lethal IAV infections than oseltamivir or FFYH each on its own. These findings might provide a new option for the treatment of IAV infection in the future.
Keywords	Influenza A virus ; Synergistic effect ; Fufang-Yinhua-Jiedu granules ; TLR7/MyD88 ; Viral pneumonia ; Oseltamivir ; Other systems of medicine ; RZ201-999
Subject code	570
Language	English
Publishing date	2023-02-01T00:00:00Z
Publisher	Elsevier
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: A multicenter, double-blind, placebo-controlled parallel study to evaluate the role of Yinhua Miyanling tablets in the prevention of bacterial biofilm formation on ureteral stents: a randomised trial.

Du, Zhen / Qiao, Ludong / Yang, Weimin / Chen, Yuan / Zhang, Yong / Wu, Wenqi / Li, Jun / Wang, Wenying / Cui, Liang / Chen, Shan

Annals of palliative medicine

2022 Volume 11, Issue 5, Page(s) 1752–1761

Abstract: Background: Yinhua Miyanling tablet (YMT) not only has the functions of clearing away heat and ...

Abstract	Background: Yinhua Miyanling tablet (YMT) not only has the functions of clearing away heat and toxin, dredging drenching and diuresis, but also has antibacterial activity. The formation of bacterial biofilm in ureteral stent and its related infection have plagued the clinic. Antibacterial traditional Chinese medicine is a potential method. Methods: This multicenter, randomized, double-blind, placebo-controlled study was designed to enroll patients who underwent ureteroscopic lithotripsy associated with indwelling ureteral stents at six centers between March 2019 and June 2020. The eligible patients were randomly assigned to the experimental group to take YMT 2 g qid orally or the control group to take dummy YMT 2 g qid orally from the first day after the operation according to a random number table. The unused drugs were recalled 14±3 days after the operation and record the body temperature. Relevant laboratory tests (urinalysis and urine culture) were performed before extubation. The ureteral stent was removed. The specimen was collected for scanning electron microscopy (SEM). Biofilm formation, USSQ scores, postoperative infectious complications, stone formation, and adverse drug reactions were compared between the two groups. Results: Of the 211 patients enrolled, 165 were included in the per-protocol set (PPS), including 86 in the control group and 79 in the experimental group. No significant difference was found between the two groups in baseline parameters (P>0.05). The prevalence of biofilm formation in the control group (47%) was significantly higher than that in the experimental group (22.7%, P=0.001). There was no significant difference in total USSQ score and domain score between the two groups (all P>0.05). There were more patients with symptomatic urinary tract infection (UTI) in the control group (12.9%) than in the experimental group (2.6%, P=0.017). The incidence of other complications did not show a significant difference between the two groups (all P>0.05). The incidence of stone formation on the ureteral stent surface and adverse drug reactions did not show a significant difference between the two groups (all P>0.05). Conclusions: YMT is helpful to reduce the formation of bacterial biofilms on ureteral stents and the incidence of symptomatic UTIs related to ureteral stenting after surgery for ureteral calculi. Trial registration: Chinese Clinical Trial Registry ChiCTR2000041399.
MeSH term(s)	Anti-Bacterial Agents/therapeutic use ; Biofilms ; Drug-Related Side Effects and Adverse Reactions/etiology ; Humans ; Postoperative Complications/etiology ; Stents/adverse effects ; Stents/microbiology ; Tablets
Chemical Substances	Anti-Bacterial Agents ; Tablets
Language	English
Publishing date	2022-06-07
Publishing country	China
Document type	Journal Article ; Multicenter Study ; Randomized Controlled Trial
ZDB-ID	2828544-X
ISSN	2224-5839 ; 2224-5839
ISSN (online)	2224-5839
ISSN	2224-5839
DOI	10.21037/apm-22-324
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article: [Clinical characteristics of Yinhua Miyanling Pian users based on real world study].

Sun, Jin / Xie, Yan-Ming / Liu, Huan / Zhang, Yin / Zhang, Yong-Sheng / Zhuang, Yan

Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica

2018 Volume 43, Issue 16, Page(s) 3391–3396

Abstract: Clinical characteristics of Yinhua Miyanling Pian user group were analyzed based on real world ... conforms to the drug instruction. Based on the results of the real world HIS，Yinhua Miyanling Pian ...

Abstract	Clinical characteristics of Yinhua Miyanling Pian user group were analyzed based on real world hospital information system (HIS)database. The information was collected from the HIS in sixteen hospitals of grade Ⅲ-A. Normalizing the data and descriptive analysis was performed. Among the 5 312 cases, female patients(63.67%) were more than male patients (36.33%). The median age was 49 years old. The age of 18-65 accounted for 74.52%.The patient was admitted to the hospital's department of obstetrics and gynecology(28.71%) and urology(28.43%). The median single dose is 2 g, accounted for 49.55%. The median daily dose is 6 g. 88.80% of patients were treated for less than 7 d. The median hospitalization were 12 d, most were 7-14 d accounted for 41.70%. Most hospitalization expenses payment by medicare, accounted for 80.22%. The median hospitalization expenses was 12 211.47 RMB. Most patients with benign tumor(27.36%) and malignant tumor(15.56%), next is the obstruction of urinary tract(15.49%) and urinary calculi(10.52%). The most common syndromes were damp heat syndrome(32.46%), liver and kidney deficiency syndrome(15.33%) and splenasthenic fluid-retention syndrome(15.01%). Clinical use is combined with antibiotics, as well as traditional Chinese medicine heat clearing agents, tonic drugs and so on. Finally, 44.22% were cured and 51.05% were better. Most of the drug users were adults, and mostly were female. Most with the tumor, urinary tract obstruction or stones. TCM syndrome is mainly characterized by dampness and heat, deficiency of liver and kidney, and dampness of spleen. In clinical practice, it was mainly combined with Western medicines, and Chinese medicines were also a-vailable. And most are combined with antibiotics.The medication basically conforms to the drug instruction. Based on the results of the real world HIS，Yinhua Miyanling Pian could provide theidea and reference for regulating the medication in adolescent patients.
MeSH term(s)	Adolescent ; Adult ; Aged ; Female ; Humans ; Length of Stay ; Male ; Medicine, Chinese Traditional ; Middle Aged ; Neoplasms/therapy ; Syndrome ; Urologic Diseases/therapy ; Young Adult
Language	Chinese
Publishing date	2018-08-29
Publishing country	China
Document type	Journal Article
ZDB-ID	1004649-5
ISSN	1001-5302 ; 0254-0029
ISSN	1001-5302 ; 0254-0029
DOI	10.19540/j.cnki.cjcmm.2018.0098
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Investigation of Pharmacological Mechanisms of Yinhua Pinggan Granule on the Treatment of Pneumonia through Network Pharmacology and In Vitro

Liang Jin / Yumei Zhang / Jiehong Yang / Huifen Zhou / Gaozhi Jia / Yu He / Haitong Wan

BioMed Research International, Vol

2022 Volume 2022

Abstract: Yinhua pinggan granule (YHPGKL), a traditional Chinese medical compound, could treat pneumonia ...

Abstract	Yinhua pinggan granule (YHPGKL), a traditional Chinese medical compound, could treat pneumonia. Although previous studies demonstrated the protective and therapeutic effects of YHPGKL on pneumonia, its potential molecular mechanisms and its effective components are still elusive. Herein, we performed a network pharmacology analysis to determine the possible signaling pathways involved in the protective effects of components of YHPGKL. A total of 119 components and 257 target proteins of YHPGKL were identified, among which 117 effective components interacted with 113 proteins related to pneumonia. Then, a compound-effective component-target protein network was established to screen the effective hub components. The top three effective components, namely luteolin, kaempferol, and quercetin, were selected. Moreover, Gene Ontology (GO) and Kyoto Encyclopedia of Genes and Genomes (KEGG) enrichment analysis of 113 proteins revealed a significant enrichment term associated with host immune and anti-infectious responses. Furthermore, by constructing a protein-protein interaction network between common proteins, ten hub proteins were identified, among which three hub components hit eight proteins. A further molecular docking analysis confirmed that the three effective hub components had a good affinity with six hub proteins. Eventually, the interactions were further visualized and screened on account of an infectious macrophage model in vitro. The results noted that three components could inhibit proinflammatory related hub genes but had no effect on survival-related hub genes. Thus, the three effective hub components and corresponding hub genes may play essential roles in the treatment of YHPGKL on pneumonia.
Keywords	Medicine ; R
Subject code	570
Language	English
Publishing date	2022-01-01T00:00:00Z
Publisher	Hindawi Limited
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article: Efficacy of integrative medicine using Yinhua-based herbal granules on herpangina: A Bayesian network meta-analysis of randomized controlled trials

Sheng, Yongcheng / Zhang, Yuhui / Wang, Qin / Hong, Qi / Kang, Deying

Phytomedicine plus. 2022 Nov., v. 2, no. 4

2022

Abstract: ... Xiao'er Qingjie Granules (XQJGs), collectively named Yinhua-based herbal granules (YH-HGs) have been ...

Abstract	Different Traditional Chinese Medicine (TCM) in the format of granules, such as Kanggan Granules (KangGs), Kouyanqing Granules (KouGs), Lianhua Qingwen Granules (LQGs), Qingkailing Granules (QGs) and Xiao'er Qingjie Granules (XQJGs), collectively named Yinhua-based herbal granules (YH-HGs) have been widely used in the management of pediatric outpatients with herpangina. Few head-to-head randomized controlled trials (RCTs) have compared the efficacy of these agents. This network meta-analysis (NMA) was conducted to indirectly compare the efficacy of YH-HGs. This systematic review and fixed-effect NMA was conducted according to the Preferred Reporting Items for Systematic Review and Meta-analysis (PRISMA) extension statement for NMA. RCTs assessing the efficacy and safety of YH-HGs in children that were also receiving ribavirin as the conventional therapy were searched from eight databases and two trial registers up to Jan 13, 2022. The primary outcome was total effectiveness rate (TER). The secondary outcomes were total adverse events (TAEs) and the time to symptom improvement of fever, vesicles, pain and salivation. Relative risk (RR) and weighted mean difference with 95% confidence intervals (CIs) were estimated by direct pairwise meta-analysis (MA) and NMA. A total of 10 RCTs, enrolling 1 017 pediatric patients, were included. YH-HGs were better than no medication (NM) in TER (RR = 1.22, 95%CIs, 1.16 – 1.28) by direct pairwise MA, in which KangGs (RR = 1.24, 95%CIs, 1.05 – 1.47), KouGs (RR = 1.17, 95%CIs, 1.08 – 1.27), LQGs (RR = 1.24, 95%CIs, 1.14 – 1.35), QGs (RR = 1.33, 95%CIs, 1.11 – 1.58) and XQJGs (RR = 1.18, 95%CIs, 1.00 – 1.40) were also more efficient than NM. As for secondary outcomes, YH-HGs was associated with a 103% increased risk of TAEs compared to NM, but no significant differences were found. YH-HGs has a more positive symptom improvement effect than NM in fever, vesicles, pain and salivation. The ranking results showed that QGs (79.2%) had the highest probability ranking first in TER and KangGs (63.6%) ranked as the second, followed by LQGs (52.4%), XQJGs (50.3%), KouGs (49.7%), and NM (4.9%) at last. Our findings support the better efficacy of YH-HGs than NM as regards TER. QGs, KangGs, LQGs, XQJGs, KouGs remain superior to NM and their clinical choice should depend on the patient's conditions to improve symptoms better for the different effects. Given the limitations of NMA, head-to-head RCTs with high-quality are needed.
Keywords	Bayesian theory ; Oriental traditional medicine ; drug therapy ; enterovirus Infections ; fever ; meta-analysis ; pain ; patients ; relative risk ; salivation ; systematic review
Language	English
Dates of publication	2022-11
Publishing place	Elsevier B.V.
Document type	Article
ISSN	2667-0313
DOI	10.1016/j.phyplu.2022.100351
Database	NAL-Catalogue (AGRICOLA)

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Article ; Online: Antiviral effect of fufang yinhua jiedu (FFYH) granules against influenza A virus through regulating the inflammatory responses by TLR7/MyD88 signaling pathway.

Zhang, Yuqian / Wang, Ronghua / Shi, Weiqing / Zheng, Zhihui / Wang, Xiaoquan / Li, Cheng / Zhang, Shuofeng / Zhang, Pinghu

Journal of ethnopharmacology

2021 Volume 275, Page(s) 114063

Abstract: Ethnopharmacological relevance: Fufang-Yinhua-Jiedu Granules (FFYH) optimized from a Yin-Qiao-San ...

Abstract	Ethnopharmacological relevance: Fufang-Yinhua-Jiedu Granules (FFYH) optimized from a Yin-Qiao-San, as traditional Chinese medicine (TCM), was used to treat influenza and upper respiratory tract infection and was recommended for the prevention and treatment of SARS in 2003 and current COVID-19 in Anhui Province in 2020. Aim of study: In the clinical studies, FFYH was very effective for the treatment of influenza, but the mechanism of action against influenza A virus remains unclear. In the present study, we investigated the antiviral effect of FFYH against influenza A virus in vitro and vivo. Moreover, the potential mechanism of FFYH against influenza A virus in vivo was investigated for the first time. Materials and methods: CPE inhibition assay and HA assay were used to evaluate the in vitro antiviral effects of FFYH against influenza A virus H1N1, H3N2, H5N1, H7N9 and H9N2. Mice were used to evaluate the antiviral effect of FFYH in vivo with ribavirin and lianhuaqingwen as positive controls. RT-PCR was used to quantify the mRNA transcription of TNF-α, IL-6, IFN-γ, IP10, and IL-1β mRNA. ELISA was used to examine the expression of inflammatory factors such as TNF-α, IL-6, IFN-γ, IP10, and IL-1β in sera. The blood parameters were analyzed with auto hematology analyzer. Moreover, the potential mechanism of FFYH against influenza A virus in vivo was also investigated. Results: FFYH showed a broad-spectrum of antiviral activity against H1N1, H3N2, H5N1, H7N9, and H9N2 influenza A viruses. Furthermore, FFYH dose-dependently increased the survival rate, significantly prolonged the median survival time of mice, and markedly reduced lung injury caused by influenza A virus. Also, FFYH significantly improve the sick signs, food taken, weight loss, blood parameters, lung index, and lung pathological changes. Moreover, FFYH could markedly inhibit the inflammatory cytokine expression of TNF-α, IL-6, IFN-γ, IP10, IL-10, and IL-1β mRNA or protein via inhibition of the TLR7/MyD88/NF-κB signaling pathway in vivo. Conclusion: FFYH not only showed a broad-spectrum of anti-influenza virus activity in vitro, but also exhibited a significant protective effect against lethal influenza virus infection in vivo. Furthermore, our results indicated that the in vivo antiviral effect of FFYH against influenza virus may be attributed to suppressing the expression of inflammatory cytokines via regulating the TLR7/MyD88/NF-κB signaling pathway. These findings provide evidence for the clinical treatment of influenza A virus infection with FFYH.
MeSH term(s)	A549 Cells ; Animals ; Anti-Inflammatory Agents/pharmacology ; Antiviral Agents/pharmacology ; Cytokines/genetics ; Cytokines/metabolism ; Disease Models, Animal ; Dogs ; Drugs, Chinese Herbal/pharmacology ; Host-Pathogen Interactions ; Humans ; Inflammation Mediators/metabolism ; Influenza A virus/drug effects ; Influenza A virus/pathogenicity ; Lung/drug effects ; Lung/immunology ; Lung/metabolism ; Lung/virology ; Madin Darby Canine Kidney Cells ; Membrane Glycoproteins/metabolism ; Mice, Inbred ICR ; Myeloid Differentiation Factor 88/metabolism ; NF-kappa B/metabolism ; Orthomyxoviridae Infections/drug therapy ; Orthomyxoviridae Infections/immunology ; Orthomyxoviridae Infections/metabolism ; Orthomyxoviridae Infections/virology ; Signal Transduction ; Toll-Like Receptor 7/metabolism ; Virus Replication/drug effects ; Mice
Chemical Substances	Anti-Inflammatory Agents ; Antiviral Agents ; Cytokines ; Drugs, Chinese Herbal ; Inflammation Mediators ; Membrane Glycoproteins ; Myd88 protein, mouse ; Myeloid Differentiation Factor 88 ; NF-kappa B ; Tlr7 protein, mouse ; Toll-Like Receptor 7
Language	English
Publishing date	2021-04-01
Publishing country	Ireland
Document type	Journal Article
ZDB-ID	134511-4
ISSN	1872-7573 ; 0378-8741
ISSN (online)	1872-7573
ISSN	0378-8741
DOI	10.1016/j.jep.2021.114063
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Article: [Clinical and fundamental research Yinhua Miyanling Tablets in treating urinary tract infection].

Zhang, Wen-Ting / Miao, Run-Pei / Zhao, Qi-Han / Sun, Yue / Han, Shuai-Jie / Yang, Han-Wen / Xiong, Min / Yu, Guo-Yong / Wang, Yao-Xian

Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica

2019 Volume 44, Issue 11, Page(s) 2403–2410

Abstract: As the famous Chinese patent medicine, Yinhua Miyanling Tablets, which was derived from ancient ... A great number of scientific studies have demonstrated that Yinhua Mi-yanling Tablets played significant ... traditional antibacterial Chinese patent medicine Yinhua Miyanling Tablets has the advantage in bacterial ...

Abstract	As the famous Chinese patent medicine, Yinhua Miyanling Tablets, which was derived from ancient prescription denominated Bazhengsan, has not only the effects in clearing away heat and purging pathogenic fire, removing dampness and relieving stranguria, but also have the functions of detoxifying and tonifying. A great number of scientific studies have demonstrated that Yinhua Mi-yanling Tablets played significant roles in destroying harmful microbes and resisting inflammatory and diuresis. Compared with antibiotics, traditional antibacterial Chinese patent medicine Yinhua Miyanling Tablets has the advantage in bacterial resistance in long-term use. Fundamental studies about the content of pharmaceutical ingredients and the modern pharmacology of Yinhua Miyanling Tablets were collected and summarized, which conduces to indicating the active ingredients of Yinhua Miyanling Tablets with the medicinal efficacy from the molecular level and the internal mechanism of Yinhua Miyanling Tablets in the treatment of urinary tract infection(UTI) from the scientific perspective. In the field of clinical research, literatures associated with Yinhua Miyanling Tablets for the treatment of UTI were summarized and analyzed in terms of treatment type, administration mode, dosage, frequency of medication, course, efficiency, side effects and whether combined with healthy lifestyle. These literatures confirmed the medicinal values and the application prospect of Yinhua Miyanling Tablets in treating UTI, especially acute UTI, which provides a scientific theoretical foundation and a correct direction for the clinical application of Yinhua Miyanling Tablets. In conclusion, this article contributes to the standardization of Yinhua Miyanling Tablets in the treatment of UTI, in the expectation of giving the scientific guidance for clinical practice.
MeSH term(s)	Drugs, Chinese Herbal/therapeutic use ; Humans ; Medicine, Chinese Traditional ; Research ; Tablets ; Urinary Tract Infections/drug therapy
Chemical Substances	Drugs, Chinese Herbal ; Tablets
Language	Chinese
Publishing date	2019-07-29
Publishing country	China
Document type	Journal Article
ZDB-ID	1004649-5
ISSN	1001-5302 ; 0254-0029
ISSN	1001-5302 ; 0254-0029
DOI	10.19540/j.cnki.cjcmm.20190117.004
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Article: Antiviral effect of fufang yinhua jiedu (FFYH) granules against influenza A virus through regulating the inflammatory responses by TLR7/MyD88 signaling pathway

Zhang, Yuqian / Wang, Ronghua / Shi, Weiqing / Zheng, Zhihui / Wang, Xiaoquan / Li, Cheng / Zhang, Shuofeng / Zhang, Pinghu

Journal of ethnopharmacology. 2021 July 15, v. 275

2021

Abstract: Fufang-Yinhua-Jiedu Granules (FFYH) optimized from a Yin-Qiao-San, as traditional Chinese medicine ...

Abstract	Fufang-Yinhua-Jiedu Granules (FFYH) optimized from a Yin-Qiao-San, as traditional Chinese medicine (TCM), was used to treat influenza and upper respiratory tract infection and was recommended for the prevention and treatment of SARS in 2003 and current COVID-19 in Anhui Province in 2020.In the clinical studies, FFYH was very effective for the treatment of influenza, but the mechanism of action against influenza A virus remains unclear. In the present study, we investigated the antiviral effect of FFYH against influenza A virus in vitro and vivo. Moreover, the potential mechanism of FFYH against influenza A virus in vivo was investigated for the first time.CPE inhibition assay and HA assay were used to evaluate the in vitro antiviral effects of FFYH against influenza A virus H1N1, H3N2, H5N1, H7N9 and H9N2. Mice were used to evaluate the antiviral effect of FFYH in vivo with ribavirin and lianhuaqingwen as positive controls. RT-PCR was used to quantify the mRNA transcription of TNF-α, IL-6, IFN-γ, IP10, and IL-1β mRNA. ELISA was used to examine the expression of inflammatory factors such as TNF-α, IL-6, IFN-γ, IP10, and IL-1β in sera. The blood parameters were analyzed with auto hematology analyzer. Moreover, the potential mechanism of FFYH against influenza A virus in vivo was also investigated.FFYH showed a broad-spectrum of antiviral activity against H1N1, H3N2, H5N1, H7N9, and H9N2 influenza A viruses. Furthermore, FFYH dose-dependently increased the survival rate, significantly prolonged the median survival time of mice, and markedly reduced lung injury caused by influenza A virus. Also, FFYH significantly improve the sick signs, food taken, weight loss, blood parameters, lung index, and lung pathological changes. Moreover, FFYH could markedly inhibit the inflammatory cytokine expression of TNF-α, IL-6, IFN-γ, IP10, IL-10, and IL-1β mRNA or protein via inhibition of the TLR7/MyD88/NF-κB signaling pathway in vivo.FFYH not only showed a broad-spectrum of anti-influenza virus activity in vitro, but also exhibited a significant protective effect against lethal influenza virus infection in vivo. Furthermore, our results indicated that the in vivo antiviral effect of FFYH against influenza virus may be attributed to suppressing the expression of inflammatory cytokines via regulating the TLR7/MyD88/NF-κB signaling pathway. These findings provide evidence for the clinical treatment of influenza A virus infection with FFYH.
Keywords	COVID-19 infection ; Influenza A virus ; Oriental traditional medicine ; antiviral properties ; blood ; hematology ; influenza ; interleukin-10 ; interleukin-6 ; lungs ; mechanism of action ; protective effect ; survival rate ; weight loss ; China
Language	English
Dates of publication	2021-0715
Publishing place	Elsevier B.V.
Document type	Article
Note	NAL-AP-2-clean
ZDB-ID	134511-4
ISSN	1872-7573 ; 0378-8741
ISSN (online)	1872-7573
ISSN	0378-8741
DOI	10.1016/j.jep.2021.114063
Database	NAL-Catalogue (AGRICOLA)

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