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  1. Article ; Online: Antibiotics for travelers' diarrhea in children?: To SBET or not to SBET?

    Leshem, Eyal

    Travel medicine and infectious disease

    2020  Volume 34, Page(s) 101681

    MeSH term(s) Anti-Bacterial Agents/therapeutic use ; Child ; Diarrhea/drug therapy ; Humans ; Travel
    Chemical Substances Anti-Bacterial Agents
    Language English
    Publishing date 2020-04-18
    Publishing country Netherlands
    Document type Editorial ; Comment
    ZDB-ID 2170891-5
    ISSN 1873-0442 ; 1477-8939
    ISSN (online) 1873-0442
    ISSN 1477-8939
    DOI 10.1016/j.tmaid.2020.101681
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    Zs.A 6236: Show issues Location:
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  2. Article ; Online: Norovirus as a frequent cause of traveller's diarrhoea.

    Leshem, Eyal

    Journal of travel medicine

    2018  Volume 26, Issue 8

    MeSH term(s) Diarrhea/microbiology ; Gastroenteritis/epidemiology ; Humans ; Norovirus/pathogenicity ; Travel
    Language English
    Publishing date 2018-12-26
    Publishing country England
    Document type Letter
    ZDB-ID 1212504-0
    ISSN 1708-8305 ; 1195-1982
    ISSN (online) 1708-8305
    ISSN 1195-1982
    DOI 10.1093/jtm/tay159
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    Zs.A 4120: Show issues Location:
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  3. Article ; Online: Population immunity and vaccine protection against infection.

    Leshem, Eyal / Lopman, Benjamin Alan

    Lancet (London, England)

    2021  Volume 397, Issue 10286, Page(s) 1685–1687

    MeSH term(s) Antibodies, Viral ; Humans ; Vaccination ; Vaccines
    Chemical Substances Antibodies, Viral ; Vaccines
    Language English
    Publishing date 2021-04-23
    Publishing country England
    Document type Journal Article ; Comment
    ZDB-ID 3306-6
    ISSN 1474-547X ; 0023-7507 ; 0140-6736
    ISSN (online) 1474-547X
    ISSN 0023-7507 ; 0140-6736
    DOI 10.1016/S0140-6736(21)00870-9
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    Ua VI Zs.5: Show issues Location:
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  4. Article ; Online: Post-traumatic stress in war veterans and secondary traumatic stress among parents of war veterans five years after the 2014 Israel-Gaza military conflict.

    Leshem, Shahaf / Keha, Eldad / Kalanthroff, Eyal

    European journal of psychotraumatology

    2023  Volume 14, Issue 2, Page(s) 2235983

    Abstract: Secondary traumatic stress (STS) has been studied in therapists, spouses, and mainly in children of traumatised individuals. To date, the relationship between children's posttraumatic stress disorder (PTSD) symptoms and their parents' mental health ... ...

    Abstract Secondary traumatic stress (STS) has been studied in therapists, spouses, and mainly in children of traumatised individuals. To date, the relationship between children's posttraumatic stress disorder (PTSD) symptoms and their parents' mental health outcomes have been understudied, and specifically, long term STS symptoms of parents of war veterans were not investigated. The current study examined PTSD symptoms among veterans of the 2014 Israel-Gaza war and STS among their parents, five years after the war. The control group consisted of veterans from combat military units who were on active duty at the time of the war but did not actively participate in the war (stand-by units) - providing a natural experiment condition. We found that PTSD symptoms were almost twice as high in the directly active war veterans (DAV,
    MeSH term(s) Child ; Female ; Humans ; Veterans/psychology ; Compassion Fatigue ; Stress Disorders, Post-Traumatic/psychology ; Israel/epidemiology ; Parents/psychology
    Language English
    Publishing date 2023-07-25
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2586642-4
    ISSN 2000-8066 ; 2000-8066
    ISSN (online) 2000-8066
    ISSN 2000-8066
    DOI 10.1080/20008066.2023.2235983
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  5. Article ; Online: COVID-19 vaccine impact in Israel and a way out of the pandemic.

    Leshem, Eyal / Wilder-Smith, Annelies

    Lancet (London, England)

    2021  Volume 397, Issue 10287, Page(s) 1783–1785

    MeSH term(s) BNT162 Vaccine ; COVID-19 ; COVID-19 Vaccines ; Hospitalization ; Humans ; Immunization Programs ; Israel/epidemiology ; Pandemics/prevention & control ; RNA, Messenger ; SARS-CoV-2 ; Vaccines
    Chemical Substances COVID-19 Vaccines ; RNA, Messenger ; Vaccines ; BNT162 Vaccine (N38TVC63NU)
    Language English
    Publishing date 2021-05-05
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't ; Comment
    ZDB-ID 3306-6
    ISSN 1474-547X ; 0023-7507 ; 0140-6736
    ISSN (online) 1474-547X
    ISSN 0023-7507 ; 0140-6736
    DOI 10.1016/S0140-6736(21)01018-7
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    Ua VI Zs.5: Show issues Location:
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  6. Article ; Online: Severe breakthrough COVID-19 infections in Scotland-implications for immunisation programmes.

    Leshem, Eyal / Nelson, Kristin / Lopman, Benjamin Alan

    The Lancet. Respiratory medicine

    2021  Volume 9, Issue 12, Page(s) 1354–1356

    MeSH term(s) COVID-19 ; COVID-19 Vaccines ; Humans ; Immunization Programs ; SARS-CoV-2 ; Scotland/epidemiology ; Vaccination
    Chemical Substances COVID-19 Vaccines
    Language English
    Publishing date 2021-09-29
    Publishing country England
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Comment
    ZDB-ID 2686754-0
    ISSN 2213-2619 ; 2213-2600
    ISSN (online) 2213-2619
    ISSN 2213-2600
    DOI 10.1016/S2213-2600(21)00413-6
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    Zs.A 7041: Show issues Location:
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  7. Article ; Online: Don't rash it! The clinical significance of positive Varicella zoster virus PCR in cerebrospinal fluid of patients with neurological symptoms.

    Kriger, Or / Dovrat, Sarah / Fratty, Ilana S / Leshem, Eyal / Oikawa, Michal Tepperberg / Sofer, Danit / Amit, Sharon

    Journal of clinical virology : the official publication of the Pan American Society for Clinical Virology

    2024  Volume 171, Page(s) 105648

    Abstract: Background: Varicella zoster virus (VZV) is among the leading pathogens causing meningitis and encephalitis. While VZV-PCR-positive CSF is considered a gold-standard for diagnosis, it is not-uncommon to detect VZV-DNA in CSF of patients with other acute ...

    Abstract Background: Varicella zoster virus (VZV) is among the leading pathogens causing meningitis and encephalitis. While VZV-PCR-positive CSF is considered a gold-standard for diagnosis, it is not-uncommon to detect VZV-DNA in CSF of patients with other acute or chronic illness. Our goal was to determine the clinical relevance of VZV-PCR-positive CSF when investigating patients with neurological symptoms.
    Methods: In this retrospective cohort from the largest hospital in Israel, we collected demographic, clinical and laboratory data of patients with VZV-PCR-positive CSF, analyzing the significance of various parameters.
    Results: During a 5-years study, 125 patient-unique VZV-PCR-positive CSFs were recorded, in which only 9 alternative diagnoses were noted. The commonest symptoms were headache (N = 104, 83 %) and rash (N = 96, 76 %). PCR-cycle-threshold (Ct), a surrogate of viral burden, did not significantly vary across the clinical manifestations; however, patients with rash and Ct<35 were prone to develop stroke in the following year (N = 6, 7 %). Empiric nucleoside-analogue treatment was not associated with a better outcome compared to treatment administered upon a positive-PCR result.
    Discussion: Our findings suggest that in patients with neurological symptoms, detection of VZV-DNA in CSF renders VZV the probable culprit. Nevertheless, a systematic evaluation of treatment and follow-up algorithms of patients with suspected or proved VZV meningitis and encephalitis is needed. The benefits of a prompt treatment should be weighed against the potential complications of nucleoside-analogue. Conversely, the propensity for stroke in patients with higher viral-burden, necessitates further studies assessing VZV causal role, directing additional workup, treatment and monitoring policy.
    MeSH term(s) Humans ; Herpesvirus 3, Human/genetics ; Clinical Relevance ; Retrospective Studies ; Nucleosides ; DNA, Viral/cerebrospinal fluid ; Meningitis ; Encephalitis ; Exanthema ; Polymerase Chain Reaction ; Stroke/complications ; Herpes Zoster/diagnosis ; Cerebrospinal Fluid
    Chemical Substances Nucleosides ; DNA, Viral
    Language English
    Publishing date 2024-01-22
    Publishing country Netherlands
    Document type Journal Article
    ZDB-ID 1446080-4
    ISSN 1873-5967 ; 1386-6532
    ISSN (online) 1873-5967
    ISSN 1386-6532
    DOI 10.1016/j.jcv.2024.105648
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    Zs.A 3790: Show issues Location:
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  8. Article ; Online: Lower Coverage Rates of Full Rotavirus Vaccine Series in Libyan Children

    Salem ALKOSHI / Eyal LESHEM

    Iranian Journal of Public Health, Vol 49, Iss

    A Prospective Cross-Sectional Study, 2016

    2020  Volume 3

    Abstract: Background: There are little data on the current condition of national immunization programme (NIP) in Libya. In 2013, pentavalent rotavirus vaccines were added to the NIP. Incomplete rotavirus vaccine series may result in lower vaccine effectiveness. ... ...

    Abstract Background: There are little data on the current condition of national immunization programme (NIP) in Libya. In 2013, pentavalent rotavirus vaccines were added to the NIP. Incomplete rotavirus vaccine series may result in lower vaccine effectiveness. The study aimed to assess timeliness and coverage rates of routine NIP vaccinations including the newly introduced rotavirus vaccine in Libya. Methods: A prospective cross-sectional study of children aged 0 to 18 months was carried out in vaccination centers of two north-western cities. Data were collected during Nov-Dec 2016 from vaccination cards of children. Child age and doses received in previous visits were documented. Results: Overall, we included 1023 children assessed in 29 visits at six vaccination centers. In children aged 18 months, coverage rates for all doses of BCG, OPV, HepB, pneumococcal, Meningococcal and MMR vaccines exceeded 95%. Coverage rates for second and third doses of rotavirus vaccines were 89% and 68%, respectively. Most (75%) children who missed the third dose of rotavirus vaccine were aged >8 months when at the time of appointment for the third dose. Conclusion: Overall, the coverage rate for routine vaccination in children assessed at immunization centers in northwest Libya was high. Lower coverage of full pentavalent rotavirus vaccine series may have been the result of exceeding the age restriction. Measures to improve timeliness of vaccination appointments should be assessed. Lifting the age restriction on rotavirus vaccines should be considered for at-risk population.
    Keywords Routine vaccination ; Coverage rate ; Rotavirus vaccine ; Age restrictions ; Libya ; Public aspects of medicine ; RA1-1270
    Subject code 360
    Language English
    Publishing date 2020-03-01T00:00:00Z
    Publisher Tehran University of Medical Sciences
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  9. Article ; Online: Acute schistosomiasis in paediatric travellers and comparison with their companion adults.

    Rabinowicz, Shira / Leshem, Eyal / Schwartz, Eli

    Journal of travel medicine

    2021  Volume 28, Issue 6

    Abstract: Background: Schistosomiasis in non-immune travellers can cause acute schistosomiasis, a multi-systemic hypersensitivity reaction. Little is known regarding acute schistosomiasis in children. We describe acute schistosomiasis in paediatric travellers and ...

    Abstract Background: Schistosomiasis in non-immune travellers can cause acute schistosomiasis, a multi-systemic hypersensitivity reaction. Little is known regarding acute schistosomiasis in children. We describe acute schistosomiasis in paediatric travellers and compare them with adult travellers.
    Methods: A retrospective study of paediatric travellers (0-18 years old) diagnosed with schistosomiasis at Sheba Medical Center. Patients' findings are compared with those of adult travellers from the same travel groups.
    Results: in total, 18 children and 24 adults from five different trips to Tanzania, Uganda, Nigeria and Laos were infected (90% of the exposed travellers). The median bathing time of the infected children was 30 min (interquartile range (IQR) 15-30 min). The most common presentations were respiratory symptoms in 13 (72%), eosinophilia in 13 (72%) and fever in 11 (61%). Acute illness included a median of 2.5 symptoms. Three children required hospitalization and three were asymptomatic. Fatigue was significantly less common in children compared with similarly exposed adults (33% vs 71%, P = 0.03). Rates of hospitalization and steroid treatment were similar. The median eosinophil count in children was 1045 cells/μl (IQR 625-2575), lower than adults [2900 cells/μl (IQR 1170-4584)], P = 0.02.
    Conclusions: Children may develop acute schistosomiasis following short exposure to contaminated freshwater, demonstrating a high infection rate. Severity seems to be similar to adults, although children report fatigue less commonly and show lower eosinophil counts. The disease should be suspected in children with multi-systemic illness and in asymptomatic children with relevant travel history.
    MeSH term(s) Adolescent ; Adult ; Child ; Child, Preschool ; Eosinophilia ; Fever ; Humans ; Infant ; Infant, Newborn ; Retrospective Studies ; Schistosomiasis/diagnosis ; Schistosomiasis/epidemiology ; Travel
    Language English
    Publishing date 2021-01-04
    Publishing country England
    Document type Journal Article
    ZDB-ID 1212504-0
    ISSN 1708-8305 ; 1195-1982
    ISSN (online) 1708-8305
    ISSN 1195-1982
    DOI 10.1093/jtm/taaa238
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  10. Article ; Online: Reply by the Authors of the Original Article.

    Bitan, Ohad / Leshem, Eyal

    The Thoracic and cardiovascular surgeon

    2017  Volume 66, Issue 6, Page(s) 499

    MeSH term(s) Endarterectomy ; Humans
    Language English
    Publishing date 2017-05-30
    Publishing country Germany
    Document type Letter ; Comment
    ZDB-ID 800050-5
    ISSN 1439-1902 ; 0171-6425 ; 0946-4778 ; 0172-6137
    ISSN (online) 1439-1902
    ISSN 0171-6425 ; 0946-4778 ; 0172-6137
    DOI 10.1055/s-0037-1603463
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