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Article: Consortium management structures, processes, and approaches: The DELTAS Africa example.

Tagoe, Nadia / Molyneux, Sassy / Pulford, Justin / Kinyanjui, Sam

Wellcome open research

2022 Volume 7, Page(s) 139

Abstract: Background: ...

Abstract	Background:
Language	English
Publishing date	2022-04-21
Publishing country	England
Document type	Journal Article
ISSN	2398-502X
ISSN	2398-502X
DOI	10.12688/wellcomeopenres.17721.1
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article: A framework for managing health research capacity strengthening consortia: addressing tensions and enhancing capacity outcomes.

Tagoe, Nadia / Pulford, Justin / Kinyanjui, Sam / Molyneux, Sassy

BMJ global health

2022 Volume 7, Issue 10

Abstract: There has been a steady increase in health research capacity strengthening (HRCS) consortia and programmes. However, their structures and management practices and the effect on the capacity strengthening outcomes have been underexamined. We conducted a ... ...

Abstract	There has been a steady increase in health research capacity strengthening (HRCS) consortia and programmes. However, their structures and management practices and the effect on the capacity strengthening outcomes have been underexamined. We conducted a case study involving three HRCS consortia where we critically examined the consortia's decision-making processes, strategies for resolving management tensions and the potential implications for consortia outcomes. We conducted 44 in-depth interviews with a range of consortia members and employed the framework method to analyse the data. We assessed the extent to which consortia's management practices and strategies enabled or hindered research capacity strengthening using a capacity development lens. At the heart of consortium management is how tensions are navigated and the resolution strategies adopted. This study demonstrates that the management strategies adopted by consortia have capacity strengthening consequences. When deciding on tension management strategies, trade-offs often occur, sometimes to the detriment of capacity strengthening aims. When management strategies align with capacity development principles, consortium management processes become capacity strengthening mechanisms for participating individuals and institutions. Such alignment enhances programme effectiveness and value for money. Drawing on these findings, we propose an evidence-informed management framework that consortia leaders can use in practice to support decision-making to optimise research capacity gains. Considering the increasing investment in HRCS consortia, leveraging all consortium processes towards capacity strengthening will maximise the returns on investments made.
MeSH term(s)	Capacity Building ; Health Services ; Health Services Research ; Humans ; Program Evaluation
Language	English
Publishing date	2022-09-30
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ISSN	2059-7908
ISSN	2059-7908
DOI	10.1136/bmjgh-2022-009472
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Article ; Online: Designing and delivering bioinformatics project-based learning in East Africa.

Kibet, Caleb K / Entfellner, Jean-Baka Domelevo / Jjingo, Daudi / de Villiers, Etienne Pierre / de Villiers, Santie / Wambui, Karen / Kinyanjui, Sam / Masiga, Daniel

BMC bioinformatics

2024 Volume 25, Issue 1, Page(s) 150

Abstract: Background: The Eastern Africa Network for Bioinformatics Training (EANBiT) has matured through continuous evaluation, feedback, and codesign. We highlight how the program has evolved to meet challenges and achieve its goals and how experiential ... ...

Abstract	Background: The Eastern Africa Network for Bioinformatics Training (EANBiT) has matured through continuous evaluation, feedback, and codesign. We highlight how the program has evolved to meet challenges and achieve its goals and how experiential learning through mini projects enhances the acquisition of skills and collaboration. We continued to learn and grow through honest feedback and evaluation of the program, trainers, and modules, enabling us to provide robust training even during the Coronavirus disease 2019 (COVID-19) pandemic, when we had to redesign the program due to restricted travel and in person group meetings. Results: In response to the pandemic, we developed a program to maintain "residential" training experiences and benefits remotely. We had to answer the following questions: What must change to still achieve the RT goals? What optimal platforms should be used? How would we manage connectivity and data challenges? How could we avoid online fatigue? Going virtual presented an opportunity to reflect on the essence and uniqueness of the program and its ability to meet the objective of strengthening bioinformatics skills among the cohorts of students using different delivery approaches. It allowed an increase in the number of participants. Evaluating each program component is critical for improvement, primarily when feedback feeds into the program's continuous amendment. Initially, the participants noted that there were too many modules, insufficient time, and a lack of hands-on training as a result of too much focus on theory. In the subsequent iterations, we reduced the number of modules from 27 to five, created a harmonized repository for the materials on GitHub, and introduced project-based learning through the mini projects. Conclusion: We demonstrate that implementing a program design through detailed monitoring and evaluation leads to success, especially when participants who are the best fit for the program are selected on an appropriate level of skills, motivation, and commitment.
MeSH term(s)	Humans ; Learning ; Africa, Eastern ; COVID-19/epidemiology ; Computational Biology ; Pandemics
Language	English
Publishing date	2024-04-14
Publishing country	England
Document type	Journal Article
ZDB-ID	2041484-5
ISSN	1471-2105 ; 1471-2105
ISSN (online)	1471-2105
ISSN	1471-2105
DOI	10.1186/s12859-024-05680-2
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Article ; Online: Bi-isotype immunoglobulins enhance antibody-mediated neutrophil activity against

Ogwang, Rodney / Murugu, Lewis / Nkumama, Irene N / Nyamako, Lydia / Kai, Oscar / Mwai, Kennedy / Murungi, Linda / Idro, Richard / Bejon, Philip / Tuju, James / Kinyanjui, Sam Muchina / Osier, Faith H A

Frontiers in immunology

2024 Volume 15, Page(s) 1360220

Abstract: Background: Malaria remains a major global health priority, and monoclonal antibodies (mAbs) are emerging as potential new tools to support efforts to control the disease. Recent data suggest that Fc-dependent mechanisms of immunity are important ... ...

Abstract	Background: Malaria remains a major global health priority, and monoclonal antibodies (mAbs) are emerging as potential new tools to support efforts to control the disease. Recent data suggest that Fc-dependent mechanisms of immunity are important mediators of protection against the blood stages of the infection, but few studies have investigated this in the context of mAbs. We aimed to isolate mAbs agnostic to cognate antigens that target whole merozoites and simultaneously induce potent neutrophil activity measured by the level of reactive oxygen species (ROS) production using an antibody-dependent respiratory burst (ADRB) assay. Methods: We used samples from semi-immune adults living in coastal Kenya to isolate mAbs that induce merozoite-specific ADRB activity. We then tested whether modifying the expressed IgG1 isotype to an IgG-IgA Fc region chimera would enhance the level of ADRB activity. Results: We isolated a panel of nine mAbs with specificity to whole merozoites. mAb J31 induced ADRB activity in a dose-dependent fashion. Compared to IgG1, our modified antibody IgG-IgA bi-isotype induced higher ADRB activity across all concentrations tested. Further, we observed a negative hook effect at high IgG1 mAb concentrations (i.e., >200 µg/mL), but this was reversed by Fc modification. We identified MSP3.5 as the potential cognate target of mAb J31. Conclusions: We demonstrate an approach to engineer mAbs with enhanced ADRB potency against blood-stage parasites.
Language	English
Publishing date	2024-04-08
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2606827-8
ISSN	1664-3224 ; 1664-3224
ISSN (online)	1664-3224
ISSN	1664-3224
DOI	10.3389/fimmu.2024.1360220
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Article ; Online: Increasing diversity in genomics requires investment in equitable partnerships and capacity building.

Martin, Alicia R / Stroud, Rocky E / Abebe, Tamrat / Akena, Dickens / Alemayehu, Melkam / Atwoli, Lukoye / Chapman, Sinéad B / Flowers, Katelyn / Gelaye, Bizu / Gichuru, Stella / Kariuki, Symon M / Kinyanjui, Sam / Korte, Kristina J / Koen, Nastassja / Koenen, Karestan C / Newton, Charles R J C / Olivares, Ana Maria / Pollock, Sam / Post, Kristianna /

Singh, Ilina / Stein, Dan J / Teferra, Solomon / Zingela, Zukiswa / Chibnik, Lori B

Nature genetics

2022 Volume 54, Issue 6, Page(s) 740–745

MeSH term(s)	Capacity Building ; Genomics
Language	English
Publishing date	2022-05-30
Publishing country	United States
Document type	Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
ZDB-ID	1108734-1
ISSN	1546-1718 ; 1061-4036
ISSN (online)	1546-1718
ISSN	1061-4036
DOI	10.1038/s41588-022-01095-y
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Article: Considerations for an integrated population health databank in Africa: lessons from global best practices.

Igumbor, Jude O / Bosire, Edna N / Vicente-Crespo, Marta / Igumbor, Ehimario U / Olalekan, Uthman A / Chirwa, Tobias F / Kinyanjui, Sam M / Kyobutungi, Catherine / Fonn, Sharon

Wellcome open research

2021 Volume 6, Page(s) 214

Abstract: Background: ...

Abstract	Background:
Language	English
Publishing date	2021-08-23
Publishing country	England
Document type	Journal Article
ISSN	2398-502X
ISSN	2398-502X
DOI	10.12688/wellcomeopenres.17000.1
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Article: Managing health research capacity strengthening consortia: a systematised review of the published literature.

Tagoe, Nadia / Molyneux, Sassy / Pulford, Justin / Murunga, Violet I / Kinyanjui, Sam

BMJ global health

2019 Volume 4, Issue 2, Page(s) e001318

Abstract: Background: Locally relevant research is considered critical for advancing health and development in low- and middle-income countries (LMICs). Accordingly, health research capacity strengthening (HRCS) efforts have intensified, increasingly through ... ...

Abstract	Background: Locally relevant research is considered critical for advancing health and development in low- and middle-income countries (LMICs). Accordingly, health research capacity strengthening (HRCS) efforts have intensified, increasingly through consortia. Yet, the knowledge base for managing such consortia is not well defined. This review aimed to ascertain the scope and quality of published literature on HRCS consortium management processes, management-related factors influencing consortium operations and outcomes, and the knowledge gaps. Methods: Given the paucity of published HRCS literature, a 'systematised review' as outlined by Grant and Booth was conducted, modelling the systematic review process without restriction to research-based publications. A systematic search in PubMed and Scopus was carried out coupled with a manual search for papers using reference checking and citation searching. A quality appraisal of eligible articles using the Mixed Method Appraisal Tool was undertaken. Thematic synthesis was used to analyse the extracted data. Results: The search identified 55 papers, made up of 18 empirical papers and 37 commentaries focusing on consortium-based HRCS initiatives involving LMICs and reporting management-related data. The review indicates increasing efforts being made in the HRCS field in reporting consortia outcomes. However, it highlights the dearth of high-quality empirical research on HRCS consortium management and the nascent nature of the field with most papers published after 2010. The available literature highlights the importance of relational management factors such as equity and power relations in influencing consortium success, though these factors were not explored in depth. Operational management processes and their role in the capacity strengthening pathway were rarely examined. Conclusion: Findings indicate a weak evidence base for HRCS consortium management both in terms of quantity and conceptual depth, demonstrating the need for an expanded research effort to inform HRCS practice.
Language	English
Publishing date	2019-04-14
Publishing country	England
Document type	Journal Article
ISSN	2059-7908
ISSN	2059-7908
DOI	10.1136/bmjgh-2018-001318
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Article: Enhancing science preparedness for health emergencies in Africa through research capacity building.

Kinyanjui, Sam / Fonn, Sharon / Kyobutungi, Catherine / Vicente-Crespo, Marta / Bonfoh, Bassirou / Ndungu, Thumbi / Sewankambo, Nelson Kaulukusi / Djimde, Abdoulaye A / Gaye, Oumar / Chirwa, Tobias / Musenge, Eustasius / Elliot, Alison / Nakanjako, Damalie / Chibanda, Dixon / Awandare, Gordon

BMJ global health

2020 Volume 5, Issue 7

MeSH term(s)	Africa ; Capacity Building ; Disaster Planning ; Emergencies ; Humans ; Public Health
Keywords	covid19
Language	English
Publishing date	2020-07-07
Publishing country	England
Document type	Editorial ; Research Support, Non-U.S. Gov't
ISSN	2059-7908
ISSN	2059-7908
DOI	10.1136/bmjgh-2020-003072
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Article ; Online: Cadmium tolerance pathway in Anopheles gambiae senso stricto.

Rono, Martin K / Muturi, Catherine N / Ochieng, Richard / Mwakubabanya, Ramadhan / Wachira, Francis N / Mwangangi, Joseph / Kinyanjui, Sam / Njunge, James / Mireji, Paul O

Acta tropica

2019 Volume 198, Page(s) 105033

Abstract: Cadmium is one of the widely used heavy metals (HM) in commercial and industrial products and contributes to environmental contamination in an urban setting. In our previous studies, we established that An. gambiae sensu stricto, a vector of malaria, had ...

Abstract	Cadmium is one of the widely used heavy metals (HM) in commercial and industrial products and contributes to environmental contamination in an urban setting. In our previous studies, we established that An. gambiae sensu stricto, a vector of malaria, had adapted to HM pollutants in nature despite their proclivity for unpolluted aquatic habitats. We further demonstrated that heavy metal tolerance adaptation process impacts a biological cost to the fitness of the mosquito and potentially involves the induction of specific HM-responsive transcripts and proteins. Here we interrogated differential proteomic profiles of the cadmium tolerant vs. naïve strains of An. gambiae to shed light on proteomic processes that underpinned biological cost to fitness. We identified a total of 1067 larval proteins and observed significant down-regulation of proteins involved in larval immune responses, energy metabolism, antioxidant enzymes, protein synthesis, and proton transport. Our results suggest that mosquitoes can adjust their biological program through proteome changes to counter HM pollution. Since our study was done in controlled laboratory settings, we acknowledge this may not wholly represent the conditions HM polluted environments. Nevertheless, mosquitoes deploying this strategy have the potential of creating an urban enclave for breeding and thrive and become agents of sporadic malaria epidemics.
MeSH term(s)	Animals ; Anopheles/drug effects ; Cadmium/toxicity ; Gene Expression Regulation/drug effects ; Insect Proteins/genetics ; Insect Proteins/metabolism ; Larva/drug effects ; Mosquito Vectors ; Proteomics
Chemical Substances	Insect Proteins ; Cadmium (00BH33GNGH)
Language	English
Publishing date	2019-05-20
Publishing country	Netherlands
Document type	Journal Article
ZDB-ID	210415-5
ISSN	1873-6254 ; 0001-706X
ISSN (online)	1873-6254
ISSN	0001-706X
DOI	10.1016/j.actatropica.2019.05.024
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bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
ab Jg. 2022: Lesesaal (EG)

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Article ; Online: Considerations for an integrated population health databank in Africa

Edna N. Bosire / Jude O. Igumbor / Ehimario U. Igumbor / Sharon Fonn / Marta Vicente-Crespo / Tobias F. Chirwa / Uthman A. Olalekan / Sam M. Kinyanjui / Catherine Kyobutungi

Wellcome Open Research, Vol

lessons from global best practices [version 1; peer review: 2 approved]

2021 Volume 6

Abstract: Background: The rising digitisation and proliferation of data sources and repositories cannot be ignored. This trend expands opportunities to integrate and share population health data. Such platforms have many benefits, including the potential to ... ...

Abstract	Background: The rising digitisation and proliferation of data sources and repositories cannot be ignored. This trend expands opportunities to integrate and share population health data. Such platforms have many benefits, including the potential to efficiently translate information arising from such data to evidence needed to address complex global health challenges. There are pockets of quality data on the continent that may benefit from greater integration. Integration of data sources is however under-explored in Africa. The aim of this article is to identify the requirements and provide practical recommendations for developing a multi-consortia public and population health data-sharing framework for Africa. Methods: We conducted a narrative review of global best practices and policies on data sharing and its optimisation. We searched eight databases for publications and undertook an iterative snowballing search of articles cited in the identified publications. The Leximancer software © enabled content analysis and selection of a sample of the most relevant articles for detailed review. Themes were developed through immersion in the extracts of selected articles using inductive thematic analysis. We also performed interviews with public and population health stakeholders in Africa to gather their experiences, perceptions, and expectations of data sharing. Results: Our findings described global stakeholder experiences on research data sharing. We identified some challenges and measures to harness available resources and incentivise data sharing. We further highlight progress made by the different groups in Africa and identified the infrastructural requirements and considerations when implementing data sharing platforms. Furthermore, the review suggests key reforms required, particularly in the areas of consenting, privacy protection, data ownership, governance, and data access. Conclusions: The findings underscore the critical role of inclusion, social justice, public good, data security, accountability, ...
Keywords	Data sharing ; open science ; databank ; ethics ; population health ; eng ; Medicine ; R ; Science ; Q
Subject code	306
Language	English
Publishing date	2021-08-01T00:00:00Z
Publisher	Wellcome
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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