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  1. Article ; Online: Agent Orange and dioxin-induced myeloid leukemia: a weaponized vehicle of leukemogenesis.

    Shallis, Rory M / Gore, Steven D

    Leukemia & lymphoma

    2022  Volume 63, Issue 7, Page(s) 1534–1543

    Abstract: Agent Orange (AO) was the dominant weaponized herbicide employed by the United States (US) military during the Vietnam war. AO, however, was found to be regularly contaminated by 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD), the most toxic dioxin known; ... ...

    Abstract Agent Orange (AO) was the dominant weaponized herbicide employed by the United States (US) military during the Vietnam war. AO, however, was found to be regularly contaminated by 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD), the most toxic dioxin known; furthermore, AO was commonly diluted in the field with other aromatic hydrocarbons to assist with delivery mechanisms. Unbeknownst to the US military and the millions exposed, these events have likely contributed to the development of acute myeloid leukemia (AML) and myelodysplastic syndrome (MDS) that has affected many veterans. Null studies regarding an association between AO exposure and AML/MDS are limited in their methodology and application. The acknowledgement that the known carcinogen TCDD was a contaminant in AO when paired with a strong biological plausibility for its leukemogenicity and an observed increased risk of AML/MDS in TCDD-exposed individuals should suffice to establish causal association and that veterans to whom this might apply should be awarded appropriate indemnity.
    MeSH term(s) 2,4,5-Trichlorophenoxyacetic Acid/adverse effects ; 2,4-Dichlorophenoxyacetic Acid/toxicity ; Agent Orange ; Dioxins/toxicity ; Environmental Exposure/adverse effects ; Environmental Exposure/analysis ; Humans ; Leukemia, Myeloid ; Polychlorinated Dibenzodioxins/analysis ; Polychlorinated Dibenzodioxins/toxicity ; United States ; Veterans
    Chemical Substances Dioxins ; Polychlorinated Dibenzodioxins ; 2,4-Dichlorophenoxyacetic Acid (2577AQ9262) ; Agent Orange (39277-47-9) ; 2,4,5-Trichlorophenoxyacetic Acid (9Q963S4YMX)
    Language English
    Publishing date 2022-02-02
    Publishing country United States
    Document type Journal Article
    ZDB-ID 1042374-6
    ISSN 1029-2403 ; 1042-8194
    ISSN (online) 1029-2403
    ISSN 1042-8194
    DOI 10.1080/10428194.2022.2034156
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 2997: Show issues Location:
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  2. Book: Enhancing survival outcomes in the management of patients with higher-risk myelodysplastic syndromes

    Gore, Steven D. / Hermes DeSantis, Evelyn R.

    (Cancer control ; 16,4, Suppl.)

    2009  

    Author's details Steven D. Gore and Evelyn R. Hermes-DeSantis
    Series title Cancer control ; 16,4, Suppl.
    Collection
    Language English
    Size 12 S. : Ill., graph. Darst.
    Publisher Lee Moffitt Cancer Center & Research Inst
    Publishing place Tampa, FL
    Publishing country United States
    Document type Book
    HBZ-ID HT016141827
    Database Catalogue ZB MED Medicine, Health

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    In stock of ZB MED Cologne/Königswinter

    Shelf markLoan statusLocation
    Zs A 4467 -16,4,Suppl.- not available for loan Zeitschriften-Lesesaal

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  3. Article ; Online: Equitable Access to Clinical Trials: How Do We Achieve It?

    Acuña-Villaorduña, Ana / Baranda, Joaquina Celebre / Boehmer, Jessica / Fashoyin-Aje, Lola / Gore, Steven D

    American Society of Clinical Oncology educational book. American Society of Clinical Oncology. Annual Meeting

    2023  Volume 43, Page(s) e389838

    Abstract: The mismatch between the study populations participating in oncology clinical trials and the composition of the targeted cancer population requires urgent amelioration. Regulatory requirements can mandate that trial sponsors enroll diverse study ... ...

    Abstract The mismatch between the study populations participating in oncology clinical trials and the composition of the targeted cancer population requires urgent amelioration. Regulatory requirements can mandate that trial sponsors enroll diverse study populations and ensure that regulatory revue prioritizes equity and inclusivity. A variety of projects directed at increasing accrual of underserved populations to oncology clinical trials emphasize best practices: broadened eligibility requirements for trials, simplification of trial procedures, community outreach through patient navigators, decentralization of clinical trial procedures and institution of telehealth, and funding to offset costs of travel and lodging. Substantial improvement will require major changes in culture in the educational and professional practice, research, and regulatory communities and will require major increases in public, corporate, and philanthropic funding.
    MeSH term(s) Humans ; Neoplasms/epidemiology ; Neoplasms/therapy ; Medical Oncology ; Vulnerable Populations
    Language English
    Publishing date 2023-05-05
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2431126-1
    ISSN 1548-8756 ; 1548-8748
    ISSN (online) 1548-8756
    ISSN 1548-8748
    DOI 10.1200/EDBK_389838
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Book: AML

    Tallman, Martin / Gore, Steven D. / Karp, Judith E.

    current and emerging treatment approaches

    (Clinical advances in hematology & oncology ; 6,11, Suppl. 18 : Clinical roundtable monograph)

    2008  

    Author's details faculty Martin Tallman ; Steven D. Gore ; Judith Karp
    Series title Clinical advances in hematology & oncology ; 6,11, Suppl. 18 : Clinical roundtable monograph
    Collection
    Language English
    Size 10 S. : Ill.
    Publisher Millennium Medical Publ
    Publishing place New York, NY
    Publishing country United States
    Document type Book
    HBZ-ID HT016467274
    Database Catalogue ZB MED Medicine, Health

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    In stock of ZB MED Cologne/Königswinter

    Shelf markLoan statusLocation
    Zs A 6505 -6,Suppl.18- verfügbar in Königswinter Königswinter

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  5. Article ; Online: DiseaseNet: a transfer learning approach to noncommunicable disease classification.

    Gore, Steven / Meche, Bailey / Shao, Danyang / Ginnett, Benjamin / Zhou, Kelly / Azad, Rajeev K

    BMC bioinformatics

    2024  Volume 25, Issue 1, Page(s) 107

    Abstract: As noncommunicable diseases (NCDs) pose a significant global health burden, identifying effective diagnostic and predictive markers for these diseases is of paramount importance. Epigenetic modifications, such as DNA methylation, have emerged as ... ...

    Abstract As noncommunicable diseases (NCDs) pose a significant global health burden, identifying effective diagnostic and predictive markers for these diseases is of paramount importance. Epigenetic modifications, such as DNA methylation, have emerged as potential indicators for NCDs. These have previously been exploited in other contexts within the framework of neural network models that capture complex relationships within the data. Applications of neural networks have led to significant breakthroughs in various biological or biomedical fields but these have not yet been effectively applied to NCD modeling. This is, in part, due to limited datasets that are not amenable to building of robust neural network models. In this work, we leveraged a neural network trained on one class of NCDs, cancer, as the basis for a transfer learning approach to non-cancer NCD modeling. Our results demonstrate promising performance of the model in predicting three NCDs, namely, arthritis, asthma, and schizophrenia, for the respective blood samples, with an overall accuracy (f-measure) of 94.5%. Furthermore, a concept based explanation method called Testing with Concept Activation Vectors (TCAV) was used to investigate the importance of the sample sources and understand how future training datasets for multiple NCD models may be improved. Our findings highlight the effectiveness of transfer learning in developing accurate diagnostic and predictive models for NCDs.
    MeSH term(s) Humans ; Noncommunicable Diseases ; Neural Networks, Computer ; Machine Learning
    Language English
    Publishing date 2024-03-11
    Publishing country England
    Document type Journal Article
    ZDB-ID 2041484-5
    ISSN 1471-2105 ; 1471-2105
    ISSN (online) 1471-2105
    ISSN 1471-2105
    DOI 10.1186/s12859-024-05734-5
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: Validation of a robust and rapid liquid chromatography tandem mass spectrometric method for the quantitative analysis of navitoclax.

    Scott, Susan C / Anders, Nicole M / He, Ping / Hemingway, Avelina / Gore, Steven D / Hann, Christine L / Rudek, Michelle A

    Biomedical chromatography : BMC

    2022  Volume 36, Issue 6, Page(s) e5383

    Language English
    Publishing date 2022-04-18
    Publishing country England
    Document type Published Erratum
    ZDB-ID 632848-9
    ISSN 1099-0801 ; 0269-3879
    ISSN (online) 1099-0801
    ISSN 0269-3879
    DOI 10.1002/bmc.5383
    Database MEDical Literature Analysis and Retrieval System OnLINE

    Full text online

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 2166: Show issues Location:
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  7. Article ; Online: High Burden of In-Person Kidney Cancer Surveillance in a Low Resource Population.

    Raskolnikov, Dima / Ngo, Steven D / Gore, John L

    Urology practice

    2019  Volume 7, Issue 5, Page(s) 373–377

    Abstract: Introduction: Postoperative kidney cancer surveillance is predominantly based on imaging and laboratory evaluation rather than physical exam. We sought to characterize the burden of kidney cancer surveillance in a low resource population with an aim to ... ...

    Abstract Introduction: Postoperative kidney cancer surveillance is predominantly based on imaging and laboratory evaluation rather than physical exam. We sought to characterize the burden of kidney cancer surveillance in a low resource population with an aim to identify opportunities for telehealth implementation.
    Methods: We retrospectively reviewed patients who underwent partial or radical nephrectomy between November, 2016 and May, 2018 at an academic medical center. We reviewed patient demographic characteristics, travel distance to hospital, and Center for Medicare & Medicaid Services designation of home ZIP code as low income area or health professional shortage area. Followup visits were reviewed for imaging and laboratory studies as well as new physical exam findings.
    Results: We identified 156 patients who attended 234 followup visits at mean 2.4 months (SD=2.9 months) postoperatively. Patient home ZIP codes were designated as low income area or health professional shortage area in 93 (59.6%) cases. One-way travel was mean 194 miles (SD=438 miles) per visit. When intended, laboratory or imaging studies were not obtained ahead of followup visits in 34 of 196 cases (17%). Based on the absence of new physical exam findings or procedures performed 201 (86%) visits could have potentially been performed remotely.
    Conclusions: Patients living in low income areas and health professional shortage areas are asked to travel long distances to perform kidney cancer surveillance often to review data that could be obtained remotely. Necessary imaging or laboratory studies are frequently not obtained ahead of appointments, further diminishing visit value. Kidney cancer surveillance may offer a promising opportunity for telehealth implementation within urology.
    Language English
    Publishing date 2019-10-03
    Publishing country United States
    Document type Journal Article
    ISSN 2352-0787
    ISSN (online) 2352-0787
    DOI 10.1097/UPJ.0000000000000105
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  8. Article ; Online: A clandestine culprit with critical consequences: Benzene and acute myeloid leukemia.

    Shallis, Rory M / Weiss, Julian J / Deziel, Nicole C / Gore, Steven D

    Blood reviews

    2020  Volume 47, Page(s) 100736

    Abstract: While most clinicians recognize adult therapy-related leukemias following cytotoxic chemotherapy and radiation, environmental regulatory agencies evaluate exposure to "safe levels" of leukemogenic compounds. Benzene represents the most notorious ... ...

    Abstract While most clinicians recognize adult therapy-related leukemias following cytotoxic chemotherapy and radiation, environmental regulatory agencies evaluate exposure to "safe levels" of leukemogenic compounds. Benzene represents the most notorious leukemogenic chemical. Used in the production of ubiquitous items such as plastics, lubricants, rubbers, dyes, and pesticides, benzene may be responsible for the higher risk of acute myeloid leukemia (AML) among automobile, janitorial, construction, and agricultural workers. It is possible that ambient benzene may contribute to many cases of "de novo" AML not arising out of germline predispositions. In this appraisal of the available literature, we evaluate and discuss the association between chronic, low-dose and ambient exposure to environmental benzene and the development of adult AML.
    MeSH term(s) Adult ; Benzene/toxicity ; Environmental Exposure/adverse effects ; Humans ; Leukemia, Myeloid, Acute/chemically induced ; Leukemia, Myeloid, Acute/epidemiology ; Leukemia, Myeloid, Acute/genetics ; Leukemia, Myeloid, Acute/metabolism ; Occupational Exposure/adverse effects ; Risk Factors
    Chemical Substances Benzene (J64922108F)
    Language English
    Publishing date 2020-07-22
    Publishing country England
    Document type Journal Article ; Review
    ZDB-ID 639015-8
    ISSN 1532-1681 ; 0268-960X
    ISSN (online) 1532-1681
    ISSN 0268-960X
    DOI 10.1016/j.blre.2020.100736
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 2207: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
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  9. Article ; Online: Challenging the concept of de novo acute myeloid leukemia: Environmental and occupational leukemogens hiding in our midst.

    Shallis, Rory M / Weiss, Julian J / Deziel, Nicole C / Gore, Steven D

    Blood reviews

    2020  Volume 47, Page(s) 100760

    Abstract: Myeloid neoplasms like acute myeloid leukemia (AML) originate from genomic disruption, usually in a multi-step fashion. Hematopoietic stem/progenitor cell acquisition of abnormalities in vital cellular processes, when coupled with intrinsic factors such ... ...

    Abstract Myeloid neoplasms like acute myeloid leukemia (AML) originate from genomic disruption, usually in a multi-step fashion. Hematopoietic stem/progenitor cell acquisition of abnormalities in vital cellular processes, when coupled with intrinsic factors such as germline predisposition or extrinsic factors such as the marrow microenvironment or environmental agents, can lead to requisite pre-leukemic clonal selection, expansion and evolution. Several of these entities have been invoked as "leukemogens." The known leukemogens are numerous and are found in the therapeutic, occupational and ambient environments, however they are often difficult to implicate for individual patients. Patients treated with particular chemotherapeutic agents or radiotherapy accept a calculated risk of therapy-related AML. Occupational exposures to benzene, dioxins, formaldehyde, electromagnetic and particle radiation have been associated with an increased risk of AML. Although regulatory agencies have established acceptable exposure limits in the workplace, accidental exposures and even ambient exposures to leukemogens are possible. It is plausible that inescapable exposure to non-anthropogenic ambient leukemogens may be responsible for many cases of non-inherited de novo AML. In this review, we discuss the current understanding of leukemogens as they relate to AML, assess to what extent the term "de novo" leukemia is meaningful, and describe the potential to identify and characterize new leukemogens.
    MeSH term(s) Bone Marrow/metabolism ; Bone Marrow/pathology ; Carcinogenesis/chemically induced ; Carcinogenesis/metabolism ; Carcinogenesis/pathology ; Carcinogens/toxicity ; Environmental Exposure/adverse effects ; Humans ; Leukemia, Myeloid, Acute/chemically induced ; Leukemia, Myeloid, Acute/metabolism ; Leukemia, Myeloid, Acute/pathology ; Occupational Exposure/adverse effects ; Risk Factors ; Tumor Microenvironment/drug effects
    Chemical Substances Carcinogens
    Language English
    Publishing date 2020-09-22
    Publishing country England
    Document type Journal Article ; Review
    ZDB-ID 639015-8
    ISSN 1532-1681 ; 0268-960X
    ISSN (online) 1532-1681
    ISSN 0268-960X
    DOI 10.1016/j.blre.2020.100760
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article ; Online: New ways to use DNA methyltransferase inhibitors for the treatment of myelodysplastic syndrome.

    Gore, Steven D

    Hematology. American Society of Hematology. Education Program

    2011  Volume 2011, Page(s) 550–555

    Abstract: Ongoing analysis of the seminal AZA-001 study has taught many important lessons in the use of DNA methyltransferase (DNMT) inhibitors. The data emphasize the importance of patience in the use of these drugs, with several cycles required for the ... ...

    Abstract Ongoing analysis of the seminal AZA-001 study has taught many important lessons in the use of DNA methyltransferase (DNMT) inhibitors. The data emphasize the importance of patience in the use of these drugs, with several cycles required for the manifestations of hematologic responses. Improved survival in patients with high-risk myelodysplastic syndrome (MDS) treated with azacitidine extends to patients with any International Working Group-defined hematologic response; however, the benefit to patients with stable disease is less clear. A great deal remains to be learned about the optimal dosing and scheduling of the DNMT inhibitors, alone and in combination. New information on the impact of DNMT inhibitors on the immune system and on stem cells will likely lead to novel uses of these drugs in MDS and other hematologic and nonhematologic malignancies.
    MeSH term(s) Azacitidine/therapeutic use ; Bone Marrow Neoplasms/drug therapy ; DNA Modification Methylases/antagonists & inhibitors ; DNA Modification Methylases/metabolism ; Enzyme Inhibitors/therapeutic use ; Humans ; Maintenance Chemotherapy ; Myelodysplastic Syndromes/drug therapy ; Myelodysplastic Syndromes/enzymology
    Chemical Substances Enzyme Inhibitors ; DNA Modification Methylases (EC 2.1.1.-) ; Azacitidine (M801H13NRU)
    Language English
    Publishing date 2011-12-09
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 2084287-9
    ISSN 1520-4383 ; 1520-4391
    ISSN (online) 1520-4383
    ISSN 1520-4391
    DOI 10.1182/asheducation-2011.1.550
    Database MEDical Literature Analysis and Retrieval System OnLINE

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