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  1. Article ; Online: Adjuvant CDK4/6 inhibitors: can they improve clinical outcomes in hormone receptor-positive (HR+) early breast cancer?

    Johnston, Stephen R D

    Annals of palliative medicine

    2023  Volume 12, Issue 2, Page(s) 421–426

    MeSH term(s) Humans ; Female ; Breast Neoplasms/drug therapy ; Pyridines/therapeutic use ; Antineoplastic Agents/therapeutic use ; Cyclin-Dependent Kinase 4/therapeutic use
    Chemical Substances Pyridines ; Antineoplastic Agents ; Cyclin-Dependent Kinase 4 (EC 2.7.11.22) ; CDK4 protein, human (EC 2.7.11.22)
    Language English
    Publishing date 2023-01-16
    Publishing country China
    Document type Journal Article
    ZDB-ID 2828544-X
    ISSN 2224-5839 ; 2224-5839
    ISSN (online) 2224-5839
    ISSN 2224-5839
    DOI 10.21037/apm-22-981
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Book: Handbook of metastatic breast cancer

    Johnston, Stephen R. D.

    2006  

    Title variant Metastatic breast cancer
    Author's details ed. by Stephen R. D. Johnston
    Keywords Breast Neoplasms / pathology ; Neoplasm Metastasis ; Breast/Cancer ; Metastasis
    Subject code 616.99449
    Language English
    Size VIII, 232 S. : Ill., graph. Darst., 25cm
    Publisher Informa Healthcare
    Publishing place Abingdon
    Publishing country Great Britain
    Document type Book
    Note Includes bibliographical references and index. - Formerly CIP
    HBZ-ID HT014859512
    ISBN 1-84184-488-8 ; 978-1-84184-488-6
    Database Catalogue ZB MED Medicine, Health

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    In stock of ZB MED Cologne/Königswinter

    Shelf markLoan statusLocation
    2007 A 245 order for loan Magazin

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  3. Article ; Online: Adjuvant Systemic Therapy for Postmenopausal, Hormone Receptor-Positive Early Breast Cancer.

    Johnston, Stephen R D

    Hematology/oncology clinics of North America

    2022  Volume 37, Issue 1, Page(s) 89–102

    Abstract: There is now a deeper understanding of the biology of hormone receptor-positive (HR+) early breast cancer (EBC) that can be used to inform assessment of risk and prognosis, and also guide more effective adjuvant systemic therapies. For postmenopausal HR+  ...

    Abstract There is now a deeper understanding of the biology of hormone receptor-positive (HR+) early breast cancer (EBC) that can be used to inform assessment of risk and prognosis, and also guide more effective adjuvant systemic therapies. For postmenopausal HR+ EBC endocrine therapy remains the mainstay of treatment with extended duration up to 10 years for some, the addition of targeted CDK 4/6 inhibitors for those with node-positive high-risk disease, and de-escalation of chemotherapy use for those in whom it is unlikely to be of benefit. As such, systemic adjuvant therapy is now highly tailored and individualized.
    MeSH term(s) Humans ; Female ; Breast Neoplasms/drug therapy ; Breast Neoplasms/genetics ; Chemotherapy, Adjuvant ; Postmenopause ; Combined Modality Therapy ; Prognosis
    Language English
    Publishing date 2022-11-23
    Publishing country United States
    Document type Journal Article ; Review ; Research Support, Non-U.S. Gov't
    ZDB-ID 93115-9
    ISSN 1558-1977 ; 0889-8588
    ISSN (online) 1558-1977
    ISSN 0889-8588
    DOI 10.1016/j.hoc.2022.08.011
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Se 1077: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
    ab Jg. 2022: Lesesaal (EG)

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  4. Article ; Online: Abemaciclib plus endocrine therapy for hormone receptor-positive, HER2-negative, node-positive, high-risk, early breast cancer - Authors' reply.

    Johnston, Stephen R D / André, Valérie

    The Lancet. Oncology

    2022  Volume 24, Issue 3, Page(s) e104

    MeSH term(s) Humans ; Female ; Breast Neoplasms ; Aminopyridines ; Benzimidazoles ; Immunologic Factors
    Chemical Substances abemaciclib (60UAB198HK) ; Aminopyridines ; Benzimidazoles ; Immunologic Factors
    Language English
    Publishing date 2022-11-08
    Publishing country England
    Document type Letter ; Comment
    ZDB-ID 2049730-1
    ISSN 1474-5488 ; 1470-2045
    ISSN (online) 1474-5488
    ISSN 1470-2045
    DOI 10.1016/S1470-2045(23)00065-7
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 5696: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)
    Zs.MO 460: Show issues

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  5. Article: Estrogen/HER2 receptor crosstalk in breast cancer: combination therapies to improve outcomes for patients with hormone receptor-positive/HER2-positive breast cancer.

    Pegram, Mark / Jackisch, Christian / Johnston, Stephen R D

    NPJ breast cancer

    2023  Volume 9, Issue 1, Page(s) 45

    Abstract: The human epidermal growth factor receptor 2 (HER2) is overexpressed in 13-22% of breast cancers (BC). Approximately 60-70% of HER2+ BC co-express hormone receptors (HRs). HR/HER2 co-expression modulates response to both anti-HER2-directed and endocrine ... ...

    Abstract The human epidermal growth factor receptor 2 (HER2) is overexpressed in 13-22% of breast cancers (BC). Approximately 60-70% of HER2+ BC co-express hormone receptors (HRs). HR/HER2 co-expression modulates response to both anti-HER2-directed and endocrine therapy due to "crosstalk" between the estrogen receptor (ER) and HER2 pathways. Combined HER2/ER blockade may be an effective treatment strategy for patients with HR+/HER2+ BC in the appropriate clinical setting(s). In this review, we provide an overview of crosstalk between the ER and HER2 pathways, summarize data from recently published and ongoing clinical trials, and discuss clinical implications for targeted treatment of HR+/HER2+ BC.
    Language English
    Publishing date 2023-05-31
    Publishing country United States
    Document type Journal Article ; Review
    ISSN 2374-4677
    ISSN 2374-4677
    DOI 10.1038/s41523-023-00533-2
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: Quantifying Clinical Utility of Adjuvant Abemaciclib in Patients With High-risk Early Breast Cancer Who Received Neoadjuvant Chemotherapy-Reply.

    Wei, Ran Jennifer / Martin, Miguel / Johnston, Stephen R D

    JAMA oncology

    2022  Volume 8, Issue 11, Page(s) 1702

    MeSH term(s) Humans ; Female ; Neoadjuvant Therapy ; Breast Neoplasms/drug therapy ; Aminopyridines/adverse effects ; Benzimidazoles/adverse effects ; Chemotherapy, Adjuvant ; Antineoplastic Combined Chemotherapy Protocols/adverse effects ; Receptor, ErbB-2
    Chemical Substances abemaciclib (60UAB198HK) ; Aminopyridines ; Benzimidazoles ; Receptor, ErbB-2 (EC 2.7.10.1)
    Language English
    Publishing date 2022-09-29
    Publishing country United States
    Document type Letter ; Comment
    ISSN 2374-2445
    ISSN (online) 2374-2445
    DOI 10.1001/jamaoncol.2022.4531
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article ; Online: Reply to S. Sorscher.

    Johnston, Stephen R D / Gradishar, William J

    Journal of clinical oncology : official journal of the American Society of Clinical Oncology

    2021  Volume 39, Issue 10, Page(s) 1188–1189

    Language English
    Publishing date 2021-02-18
    Publishing country United States
    Document type Letter ; Comment
    ZDB-ID 604914-x
    ISSN 1527-7755 ; 0732-183X
    ISSN (online) 1527-7755
    ISSN 0732-183X
    DOI 10.1200/JCO.20.03479
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 1847: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)
    Zs.MO 650: Show issues

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  8. Article: Colonization with

    Johnston, Brian D / Clabots, Connie / Bender, Tricia / Porter, Stephen B / van den Dobbelsteen, Germie / Poolman, Jan / Thuras, Paul / Johnson, James R

    Pathogens (Basel, Switzerland)

    2023  Volume 12, Issue 4

    Abstract: An exceptional gut-colonizing ability may underlie the dramatic epidemiological success of the multidrug- ... ...

    Abstract An exceptional gut-colonizing ability may underlie the dramatic epidemiological success of the multidrug-resistant
    Language English
    Publishing date 2023-04-15
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2695572-6
    ISSN 2076-0817
    ISSN 2076-0817
    DOI 10.3390/pathogens12040603
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article: Bacteriophage Cocktail and Microcin-Producing Probiotic

    Porter, Stephen B / Johnston, Brian D / Kisiela, Dagmara / Clabots, Connie / Sokurenko, Evgeni V / Johnson, James R

    Frontiers in microbiology

    2022  Volume 13, Page(s) 887799

    Abstract: Non-antibiotic measures are needed to reduce the rate of infections due to multidrug-resistant organisms (MDROs), including by eliminating the commensal reservoir that underlies such strains' dissemination and leads to recurrent infections. Here, we ... ...

    Abstract Non-antibiotic measures are needed to reduce the rate of infections due to multidrug-resistant organisms (MDROs), including by eliminating the commensal reservoir that underlies such strains' dissemination and leads to recurrent infections. Here, we tested a cocktail of pre-selected bacteriophages and an engineered microcin C7-producing probiotic
    Language English
    Publishing date 2022-04-25
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2587354-4
    ISSN 1664-302X
    ISSN 1664-302X
    DOI 10.3389/fmicb.2022.887799
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article ; Online: Review of the monarchE trial suggests no evidence to support use of adjuvant abemaciclib in women with breast cancer - Authors' reply.

    Johnston, Stephen R D / Tolaney, Sara M / O'Shaughnessy, Joyce / Rastogi, Priya / Harbeck, Nadia / Martin, Miguel

    The Lancet. Oncology

    2023  Volume 24, Issue 6, Page(s) e238

    MeSH term(s) Female ; Humans ; Breast Neoplasms/drug therapy ; Aminopyridines/adverse effects ; Benzimidazoles/adverse effects ; Antineoplastic Combined Chemotherapy Protocols/adverse effects
    Chemical Substances abemaciclib (60UAB198HK) ; Aminopyridines ; Benzimidazoles
    Language English
    Publishing date 2023-05-02
    Publishing country England
    Document type Letter ; Comment
    ZDB-ID 2049730-1
    ISSN 1474-5488 ; 1470-2045
    ISSN (online) 1474-5488
    ISSN 1470-2045
    DOI 10.1016/S1470-2045(23)00214-0
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 5696: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)
    Zs.MO 460: Show issues

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