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Article ; Online: Exploration of Factors Associated with Reported Medication Administration Errors in North Carolina Public School Districts.

Best, Nakia C / Nichols, Ann O / Pierre-Louis, Bosny / Hernandez, Jessica

The Journal of school nursing : the official publication of the National Association of School Nurses

2022 , Page(s) 10598405221127453

Abstract: School nurses are pivotal to the safety of school-aged children, particularly those who receive medications in the school setting. The purpose of this study was to explore factors associated with medication administration errors in North Carolina school ... ...

Abstract	School nurses are pivotal to the safety of school-aged children, particularly those who receive medications in the school setting. The purpose of this study was to explore factors associated with medication administration errors in North Carolina school districts between 2012/2013 and 2017/2018. A longitudinal study using repeated measures analysis of school health services data collected in the North Carolina Annual School Health Services and Programs Survey was conducted. Over time, the number of medication errors (
Language	English
Publishing date	2022-09-21
Publishing country	United States
Document type	Journal Article
ZDB-ID	1217746-5
ISSN	1546-8364 ; 1059-8405 ; 0048-945X
ISSN (online)	1546-8364
ISSN	1059-8405 ; 0048-945X
DOI	10.1177/10598405221127453
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Article ; Online: Early childhood language gains, kindergarten readiness, and Grade 3 reading achievement.

Logan, Jessica A R / Piasta, Shayne B / Purtell, Kelly M / Nichols, Robert / Schachter, Rachel E

Child development

2023 Volume 95, Issue 2, Page(s) 609–624

Abstract: In this preregistered study, we used latent change score models to address two research aims: (1) whether preschool-aged children's language gains, over a year of early childhood education, were associated with later performance on state-mandated, ... ...

Abstract	In this preregistered study, we used latent change score models to address two research aims: (1) whether preschool-aged children's language gains, over a year of early childhood education, were associated with later performance on state-mandated, literacy-focused kindergarten readiness and Grade 3 reading achievement assessments, and (2) whether gains in language, a more complex skill, predicted these outcomes after controlling for more basic emergent literacy skills. There were 724 participating children (mean = 57 months; 51% male; 76% White, 12% Black, 6% multiple races, and 5% Hispanic or Latino). We found that language gains significantly predicted kindergarten readiness when estimated in isolation (effect = 0.24 SDs, p < .001), but not when gains in letter knowledge and phonological awareness were also included.
MeSH term(s)	Child ; Child, Preschool ; Humans ; Male ; Female ; Reading ; Educational Status ; Schools ; Language ; Literacy
Language	English
Publishing date	2023-10-20
Publishing country	United States
Document type	Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
ZDB-ID	215602-7
ISSN	1467-8624 ; 0009-3920
ISSN (online)	1467-8624
ISSN	0009-3920
DOI	10.1111/cdev.14019
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Article ; Online: Structural insights into the formation of repulsive netrin guidance complexes.

Priest, Jessica M / Nichols, Ev L / Smock, Robert G / Hopkins, Jesse B / Mendoza, Juan L / Meijers, Rob / Shen, Kang / Özkan, Engin

Science advances

2024 Volume 10, Issue 7, Page(s) eadj8083

Abstract: Netrins dictate attractive and repulsive responses during axon growth and cell migration, where the presence of the receptor Uncoordinated-5 (UNC-5) on target cells results in repulsion. Here, we showed that UNC-5 is a heparin-binding protein, determined ...

Abstract	Netrins dictate attractive and repulsive responses during axon growth and cell migration, where the presence of the receptor Uncoordinated-5 (UNC-5) on target cells results in repulsion. Here, we showed that UNC-5 is a heparin-binding protein, determined its structure bound to a heparin fragment, and could modulate UNC-5-heparin affinity using a directed evolution platform or structure-based rational design. We demonstrated that UNC-5 and UNC-6/netrin form a large, stable, and rigid complex in the presence of heparin, and heparin and UNC-5 exclude the attractive UNC-40/DCC receptor from binding to UNC-6/netrin to a large extent.
MeSH term(s)	Animals ; Netrins/metabolism ; Axons/metabolism ; Caenorhabditis elegans Proteins/genetics ; Caenorhabditis elegans Proteins/metabolism ; Nerve Tissue Proteins/genetics ; Nerve Tissue Proteins/metabolism ; Caenorhabditis elegans/metabolism ; Heparin ; Receptors, Cell Surface/genetics ; Receptors, Cell Surface/metabolism ; Cell Adhesion Molecules/genetics
Chemical Substances	Netrins ; Caenorhabditis elegans Proteins ; Nerve Tissue Proteins ; Heparin (9005-49-6) ; UNC-5 protein, C elegans (149592-60-9) ; Receptors, Cell Surface ; UNC-40 protein, C elegans ; Cell Adhesion Molecules
Language	English
Publishing date	2024-02-16
Publishing country	United States
Document type	Journal Article
ZDB-ID	2810933-8
ISSN	2375-2548 ; 2375-2548
ISSN (online)	2375-2548
ISSN	2375-2548
DOI	10.1126/sciadv.adj8083
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Article ; Online: History of Infertility and Midlife Cardiovascular Health in Female Individuals.

Nichols, Amy R / Rifas-Shiman, Sheryl L / Switkowski, Karen M / Zhang, Mingyu / Young, Jessica G / Hivert, Marie-France / Chavarro, Jorge E / Oken, Emily

JAMA network open

2024 Volume 7, Issue 1, Page(s) e2350424

Abstract: Importance: Fertility status is a marker for future health, and infertility has been associated with risk for later cancer and diabetes, but associations with midlife cardiovascular health (CVH) in female individuals remain understudied.: Objective: ... ...

Abstract	Importance: Fertility status is a marker for future health, and infertility has been associated with risk for later cancer and diabetes, but associations with midlife cardiovascular health (CVH) in female individuals remain understudied. Objective: To evaluate the association of infertility history with CVH at midlife (approximately age 50 years) among parous individuals. Design, setting, and participants: Project Viva is a prospective cohort study of pregnant participants enrolled between 1999 and 2002 who delivered a singleton live birth in the greater Boston, Massachusetts, area. Infertility history was collected at a midlife visit between 2017 and 2021, approximately 18 years after enrollment. Data analysis was performed from January to June 2023. Exposures: The primary exposure was any lifetime history of infertility identified by self-report, medical record, diagnosis, or claims for infertility treatment. Main outcomes and measures: The American Heart Association's Life's Essential 8 (LE8) is a construct for ranking CVH that includes scores from 0 to 100 (higher scores denote better health status) in 4 behavioral (diet, physical activity, sleep, and smoking status) and 4 biomedical (body mass index, blood pressure, blood lipids, and glycemia) domains to form an overall assessment of CVH. Associations of a history of infertility (yes or no) with mean LE8 total, behavioral, biomedical, and blood biomarker (lipids and glycemia) scores were examined, adjusting for age at outcome (midlife visit), race and ethnicity, education, household income, age at menarche, and perceived body size at age 10 years. Results: Of 468 included participants (mean [SD] age at the midlife visit, 50.6 [5.3] years) with exposure and outcome data, 160 (34.2%) experienced any infertility. Mean (SD) LE8 scores were 76.3 (12.2) overall, 76.5 (13.4) for the behavioral domain, 76.0 (17.5) for the biomedical domain, and 78.9 (19.2) for the blood biomarkers subdomain. In adjusted models, the estimated overall LE8 score at midlife was 2.94 points lower (95% CI, -5.13 to -0.74 points), the biomedical score was 4.07 points lower (95% CI, -7.33 to -0.78 points), and the blood subdomain score was 5.98 points lower (95% CI, -9.71 to -2.26 points) among those with vs without history of infertility. The point estimate also was lower for the behavioral domain score (β = -1.81; 95% CI, -4.28 to 0.66), although the result was not statistically significant. Conclusions and relevance: This cohort study of parous individuals found evidence for an association between a history of infertility and lower overall and biomedical CVH scores. Future study of enhanced cardiovascular preventive strategies among those who experience infertility is warranted.
MeSH term(s)	United States ; Pregnancy ; Female ; Humans ; Child ; Middle Aged ; Cohort Studies ; Prospective Studies ; Heart ; Infertility ; Lipids
Chemical Substances	Lipids
Language	English
Publishing date	2024-01-02
Publishing country	United States
Document type	Journal Article
ISSN	2574-3805
ISSN (online)	2574-3805
DOI	10.1001/jamanetworkopen.2023.50424
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Article ; Online: Multistate nontyphoidal

Habrun, Caroline A / Birhane, Meseret G / François Watkins, Louise K / Benedict, Katharine / Bottichio, Lyndsay / Nemechek, Kaylea / Tolar, Beth / Schroeder, Morgan N / Chen, Jessica C / Caidi, Hayat / Robyn, Misha / Nichols, Megin

Epidemiology and infection

2024 Volume 152, Page(s) e17

Abstract: Enteric bacterial infections are common among people who travel internationally. During 2017-2020, the Centers for Disease Control and Prevention investigated 41 multistate outbreaks of ... ...

Abstract	Enteric bacterial infections are common among people who travel internationally. During 2017-2020, the Centers for Disease Control and Prevention investigated 41 multistate outbreaks of nontyphoidal
MeSH term(s)	Humans ; United States/epidemiology ; Shiga-Toxigenic Escherichia coli ; Travel ; Escherichia coli Infections/epidemiology ; Escherichia coli Infections/microbiology ; Salmonella ; Disease Outbreaks ; Anti-Infective Agents
Chemical Substances	Anti-Infective Agents
Language	English
Publishing date	2024-01-11
Publishing country	England
Document type	Journal Article
ZDB-ID	632982-2
ISSN	1469-4409 ; 0950-2688
ISSN (online)	1469-4409
ISSN	0950-2688
DOI	10.1017/S0950268823002017
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Article ; Online: Using generic picture cues to promote verbal initiations during play.

Mattson, Stephanie L / Higbee, Thomas S / Campbell, Vincent E / Lindgren, Nicholas A / Osos, Jessica A / Nichols, Beverly

Journal of applied behavior analysis

2023 Volume 56, Issue 4, Page(s) 816–830

Abstract: Children with autism spectrum disorder often demonstrate difficulty communicating with others, and this may affect the extent to which they can engage in contextually appropriate language during play. This study examined the effects of a social script- ... ...

Abstract	Children with autism spectrum disorder often demonstrate difficulty communicating with others, and this may affect the extent to which they can engage in contextually appropriate language during play. This study examined the effects of a social script-training intervention using generic picture cues on the number of contextually appropriate play statements for children with autism spectrum disorder. We also examined the extent to which responding generalized to novel toy sets and analyzed play statement types. A nonconcurrent multiple-baseline-across-participants design with embedded reversal components was used to evaluate the effects of the generic picture-cue intervention on contextually appropriate play statements. Three participants demonstrated a higher number of contextually appropriate play statements in the training condition as compared with the baseline and no-cue conditions. Further, two out of three participants continued to emit a similar number of contextually appropriate play statements when we introduced novel toy sets.
Language	English
Publishing date	2023-08-30
Publishing country	United States
Document type	Journal Article
ZDB-ID	218065-0
ISSN	1938-3703 ; 0021-8855
ISSN (online)	1938-3703
ISSN	0021-8855
DOI	10.1002/jaba.1014
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Article ; Online: Novel neutrophil phenotypic signature in pediatric patients with type 1 diabetes and diabetic ketoacidosis.

Nichols, Blake E / Hook, Jessica S / Weng, Kayson / Ahn, Chul / Moreland, Jessica G

Journal of leukocyte biology

2021 Volume 111, Issue 4, Page(s) 849–856

Abstract: Type 1 diabetes (T1D) is a chronic inflammatory condition sometimes complicated by acute diabetic ketoacidosis (DKA). A subset of patients with T1D develop DKA independent of known risk factors. This study tested the hypothesis that circulating ... ...

Abstract	Type 1 diabetes (T1D) is a chronic inflammatory condition sometimes complicated by acute diabetic ketoacidosis (DKA). A subset of patients with T1D develop DKA independent of known risk factors. This study tested the hypothesis that circulating polymorphonuclear leukocytes (PMN) from children with T1D and DKA would exhibit a primed phenotype and that the signature would be unique in patients predisposed to have DKA. Using a prospective cohort study design, neutrophil phenotype was assessed in 30 patients with T1D seen in endocrinology clinic for routine care, 30 patients with acute DKA, and 36 healthy donors. Circulating PMN from patients with DKA display a primed phenotype with increased basal cell-surface CD11b, L-selectin shedding, and enhanced fMLF-elicited reactive oxygen species (ROS) production. Moreover, PMN from T1D patients both with and without DKA lack the capacity to be further primed by incubation with TNF-α, a classic priming stimulus. Primed PMN phenotypic signatures demonstrated are independent of hemoglobin A1c, the premier biological marker for DKA risk, and are consistent with a hyperinflammatory state. A single nucleotide polymorphism in TLR-1 (1805G>T), known to be associated with a hyperinflammatory PMN phenotype, correlated with DKA. This study elucidated a novel phenotypic signature in circulating PMN from children with T1D with and without DKA, and suggests the possibility of a previously unrecognized PMN phenotype with potential clinical implications. Immunophenotype and genotype may be applicable as biomarkers for DKA risk stratification in patients with T1D.
MeSH term(s)	Biomarkers ; Child ; Diabetes Mellitus, Type 1/complications ; Diabetic Ketoacidosis/complications ; Humans ; Neutrophils ; Phenotype ; Prospective Studies
Chemical Substances	Biomarkers
Language	English
Publishing date	2021-08-03
Publishing country	United States
Document type	Journal Article ; Research Support, N.I.H., Extramural
ZDB-ID	605722-6
ISSN	1938-3673 ; 0741-5400
ISSN (online)	1938-3673
ISSN	0741-5400
DOI	10.1002/JLB.3A1220-826R
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Article ; Online: Late endocrine diseases in survivors of adolescent and young adult cancer in California: a population-based study.

Abrahão, Renata / Brunson, Ann / Ruddy, Kathryn J / Li, Qian / Li, Judy / Ryder, Mabel M / Chubak, Jessica / Nichols, Hazel B / Sauder, Candice A M / Gray, Marlaine F / Hahn, Erin E / Wun, Ted / Keegan, Theresa H M

British journal of cancer

2024 Volume 130, Issue 7, Page(s) 1166–1175

Abstract: Background: Cancer survivors have increased risk of endocrine complications, but there is a lack of information on the occurrence of specific endocrinopathies at the population-level.: Methods: We used data from the California Cancer Registry (2006- ... ...

Abstract	Background: Cancer survivors have increased risk of endocrine complications, but there is a lack of information on the occurrence of specific endocrinopathies at the population-level. Methods: We used data from the California Cancer Registry (2006-2018) linked to statewide hospitalisation, emergency department, and ambulatory surgery databases. We estimated the cumulative incidence of and factors associated with endocrinopathies among adolescents and young adults (AYA, 15-39 years) who survived ≥2 years after diagnosis. Results: Among 59,343 AYAs, 10-year cumulative incidence was highest for diabetes (4.7%), hypothyroidism (4.6%), other thyroid (2.2%) and parathyroid disorders (1.6%). Hypothyroidism was most common in Hodgkin lymphoma, leukaemia, breast, and cervical cancer survivors, while diabetes was highest among survivors of leukaemias, non-Hodgkin lymphoma, colorectal, cervical, and breast cancer. In multivariable models, factors associated with increased hazard of endocrinopathies were treatment, advanced stage, public insurance, residence in low/middle socioeconomic neighbourhoods, older age, and non-Hispanic Black or Hispanic race/ethnicity. Haematopoietic cell transplant was associated with most endocrinopathies, while chemotherapy was associated with a higher hazard of ovarian dysfunction and hypothyroidism. Conclusions: We observed a high burden of endocrinopathies among AYA cancer survivors, which varied by treatment and social factors. Evidence-based survivorship guidelines are needed for surveillance of these diseases.
MeSH term(s)	Humans ; Adolescent ; Young Adult ; Hematopoietic Stem Cell Transplantation ; Neoplasms/complications ; Neoplasms/epidemiology ; Neoplasms/therapy ; Survivors ; Hodgkin Disease ; California/epidemiology ; Diabetes Mellitus ; Hypothyroidism/epidemiology
Language	English
Publishing date	2024-02-08
Publishing country	England
Document type	Journal Article
ZDB-ID	80075-2
ISSN	1532-1827 ; 0007-0920
ISSN (online)	1532-1827
ISSN	0007-0920
DOI	10.1038/s41416-024-02594-x
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Article ; Online: Healing Exposed Calvarial Hardware Using Negative-Pressure Wound Therapy and Vashe Wound Solution: Case Report.

Ockerman, Kyle M / Cox, Elizabeth A / Wiesemann, Gayle / Nichols, D Spencer / Murad, Gregory J A / Ching, Jessica / Sorice-Virk, Sarah

Advances in skin & wound care

2023 Volume 36, Issue 7, Page(s) 385–391

Abstract: Objective: The management of cranioplasty infections has historically been explantation followed by delayed reimplantation/reconstruction. This treatment algorithm necessitates surgery, tissue expansion, and prolonged disfigurement. In this report, the ... ...

Abstract	Objective: The management of cranioplasty infections has historically been explantation followed by delayed reimplantation/reconstruction. This treatment algorithm necessitates surgery, tissue expansion, and prolonged disfigurement. In this report, the authors describe a treatment approach consisting of serial vacuum-assisted closure (VAC) with hypochlorous acid (HOCl) solution (Vashe Wound Solution; URGO Medical) as a salvage strategy. Methods: A 35-year-old man who sustained head trauma, neurosurgical complications, and severe syndrome of the trephined (SOT; devastating neurologic decline treated by cranioplasty) underwent titanium cranioplasty with free flap. Three weeks postoperation, he presented with pressure-related wound dehiscence/partial flap necrosis, exposed hardware, and bacterial infection. Given the severity of his precranioplasty SOT, hardware salvage was critical. He was treated with serial VAC with HOCl solution for 11 days followed by VAC for 18 days and definitive split-thickness skin graft placement over resulting granulation tissue. Authors also conducted a literature review of cranial reconstruction infection management. Results: The patient remained healed 7 months postoperatively without recurrent infection. Importantly, his original hardware was retained, and his SOT remained resolved. Findings from the literature review support the use of conservative modalities to salvage cranial reconstructions without hardware removal. Conclusions: This study investigates a new strategy for managing cranioplasty infections. The VAC with HOCl solution regimen was effective in treating the infection and salvaging the cranioplasty, thus obviating the complications associated with explantation, new cranioplasty, and recurrence of SOT. There is limited literature on the management of cranioplasty infections using conservative treatments. A larger study to better determine the efficacy of VAC with HOCl solution is underway.
MeSH term(s)	Male ; Humans ; Adult ; Negative-Pressure Wound Therapy/methods ; Treatment Outcome ; Surgical Wound Infection/therapy ; Wound Healing ; Surgical Flaps ; Postoperative Complications
Language	English
Publishing date	2023-05-19
Publishing country	United States
Document type	Review ; Case Reports ; Journal Article
ZDB-ID	2012792-3
ISSN	1538-8654 ; 1527-7941
ISSN (online)	1538-8654
ISSN	1527-7941
DOI	10.1097/01.ASW.0000926628.10995.fc
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Article ; Online: Text Messages to Support Caregivers in a Health Care System: Development and Pilot and National Rollout Evaluation.

Martindale-Adams, Jennifer Lynn / Clark, Carolyn Davis / Martin, Jessica Roxy / Henderson, Charles Richard / Nichols, Linda Olivia

Journal of participatory medicine

2022 Volume 14, Issue 1, Page(s) e35318

Abstract: Background: Although there are many interventions to support caregivers, SMS text messaging has not been used widely.: Objective: In this paper, we aimed to describe development of the Department of Veterans Affairs (VA) Annie Stress Management SMS ... ...

Abstract	Background: Although there are many interventions to support caregivers, SMS text messaging has not been used widely. Objective: In this paper, we aimed to describe development of the Department of Veterans Affairs (VA) Annie Stress Management SMS text messaging protocol for caregivers of veterans, its pilot test, and subsequent national rollout. Methods: The stress management protocol was developed with text messages focusing on education, motivation, and stress-alleviating activities based on the Resources for Enhancing All Caregivers Health (REACH) VA caregiver intervention. This protocol was then tested in a pilot study. On the basis of the pilot study results, a national rollout of the protocol was executed and evaluated. Caregivers were referred from VA facilities nationally for the pilot and national rollout. Pilot caregivers were interviewed by telephone; national rollout caregivers were sent a web-based evaluation link at 6 months. For both evaluations, questions were scored on a Likert scale ranging from completely disagree to completely agree. For both the pilot and national rollout, quantitative data were analyzed with frequencies and means; themes were identified from open-ended qualitative responses. Results: Of the 22 caregivers in the pilot study, 18 (82%) provided follow-up data. On a 5-point scale, they reported text messages had been useful in managing stress (mean score 3.8, SD 1.1), helping them take care of themselves (mean score 3.7, SD 1.3), and making them feel cared for (mean score 4.1, SD 1.7). Texts were easy to read (mean score 4.5, SD 1.2), did not come at awkward times (mean score 2.2, SD 1.4), were not confusing (mean score 1.1, SD 0.2), and did not cause problems in responding (mean score 1.9, 1.1); however, 83% (15/18) of caregivers did not want to request an activity when stressed. Consequently, the national protocol did not require caregivers to respond. In the national rollout, 22.17% (781/3522) of the eligible caregivers answered the web-based survey and reported that the messages had been useful in managing stress (mean score 4.3, SD 0.8), helping them take care of themselves (mean score 4.3, SD 0.8) and loved ones (mean score 4.2, SD 0.8), and making them feel cared for (mean score 4.5, SD 0.8). Almost two-thirds (509/778, 65.4%) of the participants tried all or most of the strategies. A total of 5 themes were identified. The messages were appreciated, helped with self-care, and made them feel less alone, looking on Annie as a friend. The caregivers reported that the messages were on target and came when they were most needed and did not want them to stop. This success has led to four additional caregiver texting protocols: bereavement, dementia behaviors and stress management, (posttraumatic stress disorder) PTSD behaviors, and taking care of you, with 7274 caregivers enrolled as of February 2022. Conclusions: Caregivers reported the messages made them feel cared for and more confident. SMS text messaging, which is incorporated into clinical settings and health care systems, may represent a low-cost way to provide useful and meaningful support to caregivers.
Language	English
Publishing date	2022-10-17
Publishing country	Canada
Document type	Journal Article
ZDB-ID	2573853-7
ISSN	2152-7202 ; 2152-7202
ISSN (online)	2152-7202
ISSN	2152-7202
DOI	10.2196/35318
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