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  1. Book: Inclusion, diversity, access and equity in infectious diseases: nurturing the next generation of clinicians, scientists and leaders

    Sears, Cynthia L.

    (The journal of infectious diseases ; volume 222, supplement 6 (15 October 2020))

    2020  

    Author's details editors: Cynthia L. Sears, MD, Archana Chatterjee, MD, PhD, Jonathan Li, MD
    Series title The journal of infectious diseases ; volume 222, supplement 6 (15 October 2020)
    Collection
    Language English
    Size Seite S521-S559, Diagramme
    Publisher Oxford University Press
    Publishing place Cary, NC
    Publishing country United States
    Document type Book
    HBZ-ID HT020658653
    Database Catalogue ZB MED Medicine, Health

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    In stock of ZB MED Cologne/Königswinter

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    Uh II Zs 50 -222,Suppl.6- verfügbar in Königswinter Königswinter

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  2. Article ; Online: Introducing the New Journal of Infectious Diseases Editorial Board, Part I.

    Sears, Cynthia L

    The Journal of infectious diseases

    2023  Volume 227, Issue 2, Page(s) 167–168

    Language English
    Publishing date 2023-01-11
    Publishing country United States
    Document type Editorial
    ZDB-ID 3019-3
    ISSN 1537-6613 ; 0022-1899
    ISSN (online) 1537-6613
    ISSN 0022-1899
    DOI 10.1093/infdis/jiac444
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Introducing the New Journal of Infectious Diseases Editorial Board, Part II.

    Sears, Cynthia L

    The Journal of infectious diseases

    2023  Volume 227, Issue 3, Page(s) 307–308

    Language English
    Publishing date 2023-01-31
    Publishing country United States
    Document type Editorial
    ZDB-ID 3019-3
    ISSN 1537-6613 ; 0022-1899
    ISSN (online) 1537-6613
    ISSN 0022-1899
    DOI 10.1093/infdis/jiac463
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Introducing the New Journal of Infectious Diseases Editorial Board, Part III.

    Sears, Cynthia L

    The Journal of infectious diseases

    2023  Volume 227, Issue 4, Page(s) 469–470

    Language English
    Publishing date 2023-02-13
    Publishing country United States
    Document type Journal Article
    ZDB-ID 3019-3
    ISSN 1537-6613 ; 0022-1899
    ISSN (online) 1537-6613
    ISSN 0022-1899
    DOI 10.1093/infdis/jiac478
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  5. Article ; Online: Whittling down the bacterial subspecies that might drive colon cancer.

    Sears, Cynthia L / Queen, Jessica

    Nature

    2024  Volume 628, Issue 8007, Page(s) 275–276

    MeSH term(s) Humans ; Bacteria/genetics ; Colonic Neoplasms/genetics ; DNA, Bacterial
    Chemical Substances DNA, Bacterial
    Language English
    Publishing date 2024-03-15
    Publishing country England
    Document type News
    ZDB-ID 120714-3
    ISSN 1476-4687 ; 0028-0836
    ISSN (online) 1476-4687
    ISSN 0028-0836
    DOI 10.1038/d41586-024-00662-z
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.MO 244: Show issues

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  6. Article ; Online: Microbes and cancer: disease drivers, passengers, biomarkers, or therapeutics?

    Sears, Cynthia L

    Cancer metastasis reviews

    2022  Volume 41, Issue 2, Page(s) 247–248

    MeSH term(s) Biomarkers ; Humans ; Neoplasms/therapy
    Chemical Substances Biomarkers
    Language English
    Publishing date 2022-05-01
    Publishing country Netherlands
    Document type Editorial
    ZDB-ID 604857-2
    ISSN 1573-7233 ; 0167-7659
    ISSN (online) 1573-7233
    ISSN 0167-7659
    DOI 10.1007/s10555-022-10035-5
    Database MEDical Literature Analysis and Retrieval System OnLINE

    Full text online

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  7. Article ; Online: 2023: Looking Back and Looking Ahead.

    Li, Jonathan Z / Clancy, Corneilius J / Singh, Upinder / Sears, Cynthia L

    The Journal of infectious diseases

    2024  Volume 229, Issue 3, Page(s) 619–620

    Language English
    Publishing date 2024-02-20
    Publishing country United States
    Document type Journal Article
    ZDB-ID 3019-3
    ISSN 1537-6613 ; 0022-1899
    ISSN (online) 1537-6613
    ISSN 0022-1899
    DOI 10.1093/infdis/jiae076
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article ; Online: The microbial landscape of colorectal cancer.

    White, Maxwell T / Sears, Cynthia L

    Nature reviews. Microbiology

    2023  Volume 22, Issue 4, Page(s) 240–254

    Abstract: Colorectal cancer (CRC) is a substantial source of global morbidity and mortality in dire need of improved prevention and treatment strategies. As our understanding of CRC grows, it is becoming increasingly evident that the gut microbiota, consisting of ... ...

    Abstract Colorectal cancer (CRC) is a substantial source of global morbidity and mortality in dire need of improved prevention and treatment strategies. As our understanding of CRC grows, it is becoming increasingly evident that the gut microbiota, consisting of trillions of microorganisms in direct interface with the colon, plays a substantial role in CRC development and progression. Understanding the roles that individual microorganisms and complex microbial communities play in CRC pathogenesis, along with their attendant mechanisms, will help yield novel preventive and therapeutic interventions for CRC. In this Review, we discuss recent evidence concerning global perturbations of the gut microbiota in CRC, associations of specific microorganisms with CRC, the underlying mechanisms by which microorganisms potentially drive CRC development and the roles of complex microbial communities in CRC pathogenesis. While our understanding of the relationship between the microbiota and CRC has improved in recent years, our findings highlight substantial gaps in current research that need to be filled before this knowledge can be used to the benefit of patients.
    MeSH term(s) Humans ; Colorectal Neoplasms ; Gastrointestinal Microbiome ; Microbiota
    Language English
    Publishing date 2023-10-04
    Publishing country England
    Document type Journal Article ; Review
    ZDB-ID 2139054-X
    ISSN 1740-1534 ; 1740-1526
    ISSN (online) 1740-1534
    ISSN 1740-1526
    DOI 10.1038/s41579-023-00973-4
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article ; Online: The Role of the Gut Microbiome in Cancer: A Review, With Special Focus on Colorectal Neoplasia and Clostridioides difficile.

    Anderson, Sean M / Sears, Cynthia L

    Clinical infectious diseases : an official publication of the Infectious Diseases Society of America

    2023  Volume 77, Issue Suppl 6, Page(s) S471–S478

    Abstract: The gut microbiome has coevolved with humans to aid in physiologic functions and prevent disease. An increasing prevalence of gut dysbiosis in modern society exists and has strong linkages to multiple disease processes common in the developed world. ... ...

    Abstract The gut microbiome has coevolved with humans to aid in physiologic functions and prevent disease. An increasing prevalence of gut dysbiosis in modern society exists and has strong linkages to multiple disease processes common in the developed world. Mechanisms for microbiome-human interactions that impact host homeostasis include bacterial metabolite/toxin production, biofilm formation with mucous layer infiltration, and host immune system modulation. Most of this crosstalk occurs at the epithelial layer of the gut, and as such the role of these interactions in the induction of colorectal cancer-a highly prevalent disease globally and one undergoing significant epidemiologic shifts-is under increasing scrutiny. Although multiple individual gut bacteria have been hypothesized as possible driver organisms in the oncogenic process, no bacterium has been definitively identified as a causal agent of colorectal cancer, suggesting that host lifestyle factors, microbiome community interactions, and the mucosal and/or systemic immune response may play a critical role in the process. Recent evidence has emerged implicating the ubiquitous human pathogen Clostridioides difficile as a possible promoter of colorectal cancer through chronic toxin-mediated cellular changes. Although much remains to be defined regarding the natural history of infections caused by this pathogen and its potential for oncogenesis, it provides a strong model for the role of both individual bacteria and of the gut microbial community as a whole in the development of colorectal cancer.
    MeSH term(s) Humans ; Gastrointestinal Microbiome ; Clostridioides difficile ; Clostridioides ; Colorectal Neoplasms ; Microbiota ; Bacteria ; Bacterial Toxins ; Clostridium Infections/microbiology
    Chemical Substances Bacterial Toxins
    Language English
    Publishing date 2023-12-05
    Publishing country United States
    Document type Review ; Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
    ZDB-ID 1099781-7
    ISSN 1537-6591 ; 1058-4838
    ISSN (online) 1537-6591
    ISSN 1058-4838
    DOI 10.1093/cid/ciad640
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article ; Online: Microbial metabolites damage DNA.

    Puschhof, Jens / Sears, Cynthia L

    Science (New York, N.Y.)

    2022  Volume 378, Issue 6618, Page(s) 358–359

    Abstract: Unexpected members of the gut microbiota produce diverse host cell genotoxins. ...

    Abstract Unexpected members of the gut microbiota produce diverse host cell genotoxins.
    MeSH term(s) Colorectal Neoplasms/diagnosis ; Colorectal Neoplasms/microbiology ; DNA Damage ; Gastrointestinal Microbiome ; Morganella morganii/metabolism ; Mutagens/metabolism ; Humans ; Mice ; Animals
    Chemical Substances Mutagens
    Language English
    Publishing date 2022-10-27
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't ; Comment
    ZDB-ID 128410-1
    ISSN 1095-9203 ; 0036-8075
    ISSN (online) 1095-9203
    ISSN 0036-8075
    DOI 10.1126/science.ade6952
    Database MEDical Literature Analysis and Retrieval System OnLINE

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