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Article ; Online: Thermodynamic and kinetic analysis of the response surface method for phenol removal from aqueous solution using graphene oxide-polyacrylonitrile nanofiber mats.

Eweida, Basant Yousri / Abd El-Aziz, Asmaa M / El-Maghraby, Azza / Serag, Eman

2024 Volume 14, Issue 1, Page(s) 3531

Abstract: Phenolic compound even at low concentrations, are considered to be priority pollutants due to their significant toxicity. Electrospinning was used to create a polyacrylonitril (PAN) nanofiber, which was then impregnated with graphene oxide (GO). After a ... ...

Abstract	Phenolic compound even at low concentrations, are considered to be priority pollutants due to their significant toxicity. Electrospinning was used to create a polyacrylonitril (PAN) nanofiber, which was then impregnated with graphene oxide (GO). After a preliminary investigation into the electrospinning parameters (e.g., using various voltages and polymer concentrations), the electrospun nanofibres were tuned, this study evaluated the effectiveness of these materials in removing phenolic compounds from wastewater through adsorption. Scanning electron microscopy (SEM) and Fourier transform infrared spectroscopy (FTIR) were used to analyze the synthesized nanofiber mats. The scanning electron microscopy (SEM) analysis revealed that the structure of nanofiber mats was altered by the addition of graphene oxide (GO) in different ratios. Specifically, the surface of the fibres exhibited increased roughness, and the diameter of the fibres also experienced an increase. The average diameter of the fibres was measured to be (134.9 ± 21.43 nm) for the PAN/2.5% GO composite and (198 ± 33.94 nm) for the PAN/5% GO composite. FTIR spectra of the PAN/GO nanocomposites nanofiber displayed distinct peaks associated with graphene oxide (GO). These included a wide peak at 3400 cm
Language	English
Publishing date	2024-02-12
Publishing country	England
Document type	Journal Article
ZDB-ID	2615211-3
ISSN	2045-2322 ; 2045-2322
ISSN (online)	2045-2322
ISSN	2045-2322
DOI	10.1038/s41598-024-53572-5
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Infrapatellar fat pad area on knee MRI

Eman Ragab / Dena Serag

The Egyptian Journal of Radiology and Nuclear Medicine, Vol 52, Iss 1, Pp 1-

does it correlate with the extent of knee osteoarthritis?

2021 Volume 9

Abstract: Abstract Background Osteoarthritis (OA) of the knee joint is a common cause of chronic disability in older adults. During the past 10 years, the infrapatellar fat pad (IPFP) has emerged as a new player in the pathogenesis of knee OA. Its exact role in ... ...

Abstract	Abstract Background Osteoarthritis (OA) of the knee joint is a common cause of chronic disability in older adults. During the past 10 years, the infrapatellar fat pad (IPFP) has emerged as a new player in the pathogenesis of knee OA. Its exact role in the pathogenesis of knee OA remains uncertain. While many studies focused on the detrimental effect of the chemical mediators released by IPFP and their role in the accentuation of the development of OA, only few studies elucidated the beneficial effect of IPFP maximal area as a local shock absorber protecting the adjacent articular structures from progressive damage. The aim of this study was to evaluate the relation between the IPFP maximal area and the prevalence of OA manifestations. We also studied the relation between the subcutaneous (SC) fat thicknesses on the medial aspect of the knee as a surrogate marker of body obesity and the IPFP area. Results A total of 216 knee scans for 188 adult patients (64 males and 124 females) who met the inclusion criteria were examined. They were between 45 and 66 years (mean 52.5 years). The mean IPFP area for all patients was 6.9 cm2 (± 1.6 SD) (ranged from 4.5 to 11 cm2). After adjustment for potential confounders, there was a significant negative association between IPFP area and radiographic manifestations of OA (osteophites, joint space narrowing, and grade of OA) (P value < 0.001 for each), as well as MRI manifestations of OA (cartilage defects and subchondral bone marrow lesions) (P value < 0.001 and < 0.003, respectively). There was a negative but non-significant association between IPFP area and SC fat thickness. Conclusion In our study, we found supportive evidence that IPFP maximal area is associated with fewer osteoarthritic knee changes and less cartilage damage, suggesting that it plays a protective role against the development and progression of OA. Further large-scale clinical studies are awaited to confirm the obtained results. Based on our findings, it would be recommended to avoid IPFP resection ...
Keywords	Infrapatellar fat pad ; Knee osteoarthritis ; MRI ; Medical physics. Medical radiology. Nuclear medicine ; R895-920
Subject code	796
Language	English
Publishing date	2021-01-01T00:00:00Z
Publisher	SpringerOpen
Document type	Article ; Online
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Article ; Online: Prevalence of incidentally discovered findings on brain MRI in adult Egyptian population

Dena Serag / Eman Ragab

The Egyptian Journal of Radiology and Nuclear Medicine, Vol 51, Iss 1, Pp 1-

2020 Volume 7

Abstract: Abstract Background Apparently, asymptomatic intracranial anomalies of potential clinical significance are becoming problematic, especially with the increase of use of brain MRI by clinicians and researchers. Performing MRI at higher resolution and ... ...

Abstract	Abstract Background Apparently, asymptomatic intracranial anomalies of potential clinical significance are becoming problematic, especially with the increase of use of brain MRI by clinicians and researchers. Performing MRI at higher resolution and stronger magnetic field and with more selective sequences has led to the detection of subtle brain anomalies that were not detected previously. Incidental findings are defined as previously undetected anomalies of potential clinical relevance that are unexpectedly detected and not related to the indication of the scan. Knowing about their existence would help clinicians to inform their patients of the potential risks and plan for long-term follow-up when indicated. Results Seven hundred fifty-three neurologically healthy subjects (389 males and 364 females) who underwent MRI scanning of the brain were screened for the presence of incidental findings, and the prevalence of each finding was recorded. Incidental findings were recorded in 11.7% of the subjects with meningiomas being the most commonly encountered finding (2.5%) followed by vascular malformations (aneurysms, cavernomas) in about 2% of the subjects. Meningiomas, cavernomas, and aneurysms had significantly higher prevalence in females than in males. The prevalence of neoplastic incidental findings increased with age, while the detection of non-neoplastic findings seemed to decrease with age. Conclusion Incidental findings were relatively common in the adult Egyptian population. The most common findings were meningiomas, followed by vascular malformations and arachnoids cysts. Knowing about their existence will help directing patients towards the proper specialist and plan for appropriate follow-up to avoid potential clinical hazards. It also raises the awareness of the importance of screening the brain scans while scanning the patient for other purposes like scanning the paranasal sinuses, orbits, and petrous temporal bones.
Keywords	Incidental brain findings ; MRI ; Medical physics. Medical radiology. Nuclear medicine ; R895-920
Subject code	610
Language	English
Publishing date	2020-04-01T00:00:00Z
Publisher	SpringerOpen
Document type	Article ; Online
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Article ; Online: Diffusion-weighted MRI in staging of post hepatitis C fibrosis

Dena Serag / Eman Ragab

The Egyptian Journal of Radiology and Nuclear Medicine, Vol 51, Iss 1, Pp 1-

does ADC value challenge liver biopsy?

2020 Volume 9

Abstract: Abstract Background There is obvious interest in finding a non-invasive diagnostic tool to detect the development of hepatic fibrosis and distinguish between its various stages. Chronic inflammation of the liver secondary to viral hepatitis, autoimmune ... ...

Abstract	Abstract Background There is obvious interest in finding a non-invasive diagnostic tool to detect the development of hepatic fibrosis and distinguish between its various stages. Chronic inflammation of the liver secondary to viral hepatitis, autoimmune conditions, sclerosing cholangitis, drug toxicity, chronic alcohol intake, different metabolic disorders, and steatosis lead to fibrosis and maybe cirrhosis. The current study aimed to assess the usefulness of diffusion-weighted magnetic resonance imaging (DW-MRI) in diagnosis of post hepatitis C fibrosis and detection of its stage. Results A prospective study had included 232 participants; 120 patients had chronic hepatitis C with/without HCC and 112 subjects had normal liver. There was no significant difference between the two groups regarding age or gender (p 0.192 and 0.227 respectively). DW-MRI was performed using 1.5 T machine. The mean liver ADC values and normalized liver ADC (liver ADC/spleen ADC) were measured at b value 800 s/mm2; both were significantly lower among cases than controls. Cutoff values of liver ADC were 1.531 × 10−3 mm2/s, 1.409 × 10−3 mm2/s, 1.192 × 10−3 mm2/s, and 1.093 × 10−3 mm2/s for METAVIR stages ≥ F1, ≥ F2, ≥ F3, and F4, respectively. Normalized liver ADC showed larger area under the curve (AUC) than mean liver ADC in all differentiation categories except for differentiating between F0 and all other fibrosis stages. Conclusion In line with the literature, DW-MR imaging using b value of 800 s/mm2 has proved to be a valuable diagnostic technique for detection and staging of post hepatitis C fibrosis/cirrhosis being noninvasive procedure with acceptable accuracy. DWI using liver/spleen ADC values raised the diagnostic performance with AUC more than 90% in all fibrosis stages on METAVIR score.
Keywords	Liver fibrosis ; Cirrhosis ; Diffusion magnetic resonance imaging ; Hepatitis C ; Medical physics. Medical radiology. Nuclear medicine ; R895-920
Subject code	610
Language	English
Publishing date	2020-09-01T00:00:00Z
Publisher	SpringerOpen
Document type	Article ; Online
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Article ; Online: Introducing a Revised Tissue Saving Protocol for Combined Topography-Guided Photorefractive Keratectomy and Cross-Linking in Keratoconic Corneas.

Yousif, Mohamed Omar / Elkitkat, Rania Serag / Edrees, Eman Samir / Alaarag, Noha Abdelsadek

Cornea

2023 Volume 42, Issue 6, Page(s) 755–765

Abstract: Purpose: The aim of this study was to introduce a revised tissue-saving technique for combined topography-guided photorefractive keratectomy (PRK) and cross-linking for keratoconus (KC) treatment and to evaluate its efficacy, safety, and stability.: ... ...

Abstract	Purpose: The aim of this study was to introduce a revised tissue-saving technique for combined topography-guided photorefractive keratectomy (PRK) and cross-linking for keratoconus (KC) treatment and to evaluate its efficacy, safety, and stability. Methods: This retrospective, noncontrolled study was performed at Maadi Eye Subspecialty Center and Eye Care Center, Cairo, Egypt. The technique was performed on virgin keratoconic corneas with 3 different morphological patterns of ectasia. It involves performing topography-guided PRK before epithelial removal, followed by customized phototherapeutic keratectomy (PTK) that is tailored to each cornea after studying the treatment profile on the laser treatment screen. The electronic medical records were explored for preoperative and postoperative data, including subjective refraction and topographic data (using Sirius topographer). Results: The study was conducted on 123 eyes of 93 patients with a mean age of 27.98 years ±6.06. The follow-up ranged from 6 to 36 months (mean ± SD of 16.2 months ±10.4). The results showed statistically nonsignificant differences among the 3 ectasia subgroups in treatment spherical equivalent, treatment maximum depth, thickness of removed epithelium, and thinnest residual stromal bed. There were statistically significant differences in almost all values between the preoperative and postoperative data, with significant postoperative patients' improvement ( P value <0.001). The subgroups' results were almost the same as the whole cohort's results. The safety and efficacy indices of the performed procedure showed remarkably high values (1.48 ± 0.21 and 0.87 ± 0.40, respectively). Conclusions: This revised protocol for KC management maximally preserves stromal tissue with proven efficacy, safety, and stability.
MeSH term(s)	Humans ; Adult ; Photorefractive Keratectomy/methods ; Retrospective Studies ; Dilatation, Pathologic/surgery ; Visual Acuity ; Photosensitizing Agents/therapeutic use ; Riboflavin/therapeutic use ; Corneal Stroma/surgery ; Corneal Topography/methods ; Cornea ; Refraction, Ocular ; Keratoconus/drug therapy ; Keratoconus/surgery ; Cross-Linking Reagents/therapeutic use
Chemical Substances	Photosensitizing Agents ; Riboflavin (TLM2976OFR) ; Cross-Linking Reagents
Language	English
Publishing date	2023-01-11
Publishing country	United States
Document type	Journal Article
ZDB-ID	604826-2
ISSN	1536-4798 ; 0277-3740
ISSN (online)	1536-4798
ISSN	0277-3740
DOI	10.1097/ICO.0000000000003225
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Article: Hydrothermally reinforcing hydroxyaptatite and bioactive glass on carbon nanofiber scafold for bone tissue engineering.

Abd El-Aziz, Asmaa M / Serag, Eman / Kenawy, Marwa Y / El-Maghraby, Azza / Kandil, Sherif H

Frontiers in bioengineering and biotechnology

2023 Volume 11, Page(s) 1170097

Abstract: As a bone tissue engineering scaffold, the objective of this study was to design hierarchical bioceramics based on an electrospun composite of carbon nanofibers (CNF) reinforced with hydroxyapatite (HA) and bioactive glasses (BGs) nanoparticles. The ... ...

Abstract	As a bone tissue engineering scaffold, the objective of this study was to design hierarchical bioceramics based on an electrospun composite of carbon nanofibers (CNF) reinforced with hydroxyapatite (HA) and bioactive glasses (BGs) nanoparticles. The performance of the nanofiber as a scaffold for bone tissue engineering was enhanced by reinforcing it with hydroxyapatite and bioactive glass nanoparticles through a hydrothermal process. The influence of HA and BGs on the morphology and biological properties of carbon nanofibers was examined. The prepared materials were evaluated for cytotoxicity
Language	English
Publishing date	2023-05-24
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2719493-0
ISSN	2296-4185
ISSN	2296-4185
DOI	10.3389/fbioe.2023.1170097
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Article ; Online: Bi-caudate ratio as a MRI marker of white matter atrophy in multiple sclerosis and ischemic leukocencephalopathy

Dena Serag / Eman Ragab

The Egyptian Journal of Radiology and Nuclear Medicine, Vol 50, Iss 1, Pp 1-

2019 Volume 6

Abstract: Abstract Background Brain atrophy measurement is now a cornerstone in basic neuro-imaging science. While assessment of white matter atrophy by visual inspection is subjective, volumetric approaches are time-consuming and not often feasible. Bi-caudate ... ...

Abstract	Abstract Background Brain atrophy measurement is now a cornerstone in basic neuro-imaging science. While assessment of white matter atrophy by visual inspection is subjective, volumetric approaches are time-consuming and not often feasible. Bi-caudate ratio represents a linear surrogate parameter of brain volume that can be derived from standard imaging sequences. This study highlights the value of the bi-caudate ratio (BCR) as a MRI marker of white matter atrophy in patients with multiple sclerosis and ischemic leukoencephalopathy and set a cut-off value to differentiate between patients with white matter atrophy and normal subjects. Results A total of 115 patients (54 males and 61 females) diagnosed with white matter leukoencephalopathy (MS in 51 patients and ischemic leukoencephalopathy in 64 patients) were included. Another group of 60 subjects with a normal white matter signal was recruited as a control group. BCR for the patient group ranged from 0.13 to 0.27 (mean (± SD) = 0.16 ± 0.02), while for the control group, it ranged from 0.05 mm to 0.13 (mean (± SD) = 0.09 ± 0.01). The difference between the two groups was statistically significant (P value < 0.001). A cut-off value of 0.13 was used to differentiate between the BCR in both patients and control groups with sensitivity, specificity, and accuracy of 99.2%, 100%, and 99%, respectively. The difference in BCR for patients diagnosed with MS and ischemic leukoencephalopathy was also statistically significant (P value < 0.001). Conclusion The bi-caudate ratio represents a linear measurement of subcortical atrophy that can be useful as a surrogate marker of global supra-tentorial white matter atrophy instead of the usually performed visual and therefore subjective assessment. It is an easily obtained measure that can be performed without complex time-consuming volumetric studies. Our findings also revealed that the BCR is higher in patients with ischemic leukoencephalopathy than in patients with MS.
Keywords	Bi-caudate ratio ; MRI ; White matter atrophy ; Medical physics. Medical radiology. Nuclear medicine ; R895-920
Subject code	616
Language	English
Publishing date	2019-12-01T00:00:00Z
Publisher	SpringerOpen
Document type	Article ; Online
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Article ; Online: Electrospun non-wovens potential wound dressing material based on polyacrylonitrile/chicken feathers keratin nanofiber.

Serag, Eman / El-Aziz, Asmaa M Abd / El-Maghraby, Azza / Taha, Nahla A

Scientific reports

2022 Volume 12, Issue 1, Page(s) 15460

Abstract: Electrospinning nanofibers have a tremendous interest in biomedical applications such as tissue engineering, drug administration, and wound healing because of their ability to replicate and restore the function of the natural extracellular matrix found ... ...

Abstract	Electrospinning nanofibers have a tremendous interest in biomedical applications such as tissue engineering, drug administration, and wound healing because of their ability to replicate and restore the function of the natural extracellular matrix found in tissues. The study's highlight is the electrospinning preparation and characterization of polyacrylonitrile with chicken feather keratin as an additive. In this study, keratin was extracted from chicken feather waste using an environmentally friendly method and used to reinforce polymeric nanofiber mats. Scanning electron microscopy, energy dispersive spectroscopy, and transmission electron microscopy were used to examine the morphology and the structure of the prepared nanofiber mats. The effect of keratin on the porosity and the tensile strength of reinforcing nanofibers is investigated. The porosity ratio of the nanofiber mats goes up from 24.52 ± 2.12 for blank polyacrylonitrile (PAN (NF)) to 90.89 ± 1.91% for polyacrylonitrile nanofiber with 0.05 wt% keratin (PAN/0.05% K). Furthermore, keratin reinforcement improves the nanofiber's mechanical properties, which are important for wound dressing application, as well as its antibacterial activity without causing hemolysis (less than 2%). The best antibacterial activities were observed against Pseudomonas aeruginosa (30 ± 0.17 mm inhibition zone) and Staphylococcus aureus (29 ± 0.31 mm inhibition zone) for PAN/0.05% K sample, according to the antibacterial test. This research has a good potential to broaden the use of feather keratin-based nanofibers in wound healing.
MeSH term(s)	Animals ; Acrylic Resins ; Anti-Bacterial Agents/chemistry ; Anti-Bacterial Agents/pharmacology ; Bandages/microbiology ; Chickens ; Feathers ; Keratins ; Nanofibers/chemistry
Chemical Substances	Acrylic Resins ; Anti-Bacterial Agents ; Keratins (68238-35-7) ; polyacrylonitrile (25014-41-9)
Language	English
Publishing date	2022-09-14
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2615211-3
ISSN	2045-2322 ; 2045-2322
ISSN (online)	2045-2322
ISSN	2045-2322
DOI	10.1038/s41598-022-19390-3
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Article ; Online: Assessment of cytochrome P450 1A1 gene polymorphism and vitamin A serum level in psoriasis vulgaris.

Bazid, Heba A S / Marae, Alaa / Tayel, Nermin / Serag, Etab / Selim, Hadeer / Mostafa, Mohammed I / Abd El Gayed, Eman

Journal of immunoassay & immunochemistry

2023 Volume 44, Issue 3, Page(s) 269–282

Abstract: Psoriasis is characterized by cutaneous hyperproliferation, secondary to immune system dysregulation. Vitamin A regulates the immune response and sustains epithelial tissue hemostasis. The CYP1A1 gene, has many biological actions, including vitamin A ... ...

Abstract	Psoriasis is characterized by cutaneous hyperproliferation, secondary to immune system dysregulation. Vitamin A regulates the immune response and sustains epithelial tissue hemostasis. The CYP1A1 gene, has many biological actions, including vitamin A metabolism. To evaluate CYP1A1 gene polymorphism and serum vitamin A level in patients with psoriasis vulgaris, a case-control study involving two groups was conducted: group 1 (45 patients with psoriasis vulgaris) served as the cased group and group 2 (45 healthy participants who were sex and age matched) acted as the control group. CYP1A1 (rs1048943) gene polymorphism and vitamin A serum level were assessed by TaqMan allelic discrimination (PCR) and ELISA, respectively. AG genotype was present only in cases (22.2%), while AA genotype was present in all controls (
MeSH term(s)	Humans ; Vitamin A ; Genetic Predisposition to Disease ; Cytochrome P-450 CYP1A1/genetics ; Case-Control Studies ; Polymorphism, Genetic/genetics ; Genotype ; Psoriasis/genetics ; Polymorphism, Single Nucleotide/genetics
Chemical Substances	Vitamin A (11103-57-4) ; Cytochrome P-450 CYP1A1 (EC 1.14.14.1)
Language	English
Publishing date	2023-03-15
Publishing country	England
Document type	Journal Article
ZDB-ID	2050610-7
ISSN	1532-4230 ; 1532-1819
ISSN (online)	1532-4230
ISSN	1532-1819
DOI	10.1080/15321819.2023.2189471
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Zs.A 1606: Show issues

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ab Jg. 2022: Lesesaal (EG)

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Article: New Ionic Liquid Microemulsion-Mediated Synthesis of Silver Nanoparticles for Skin Bacterial Infection Treatments.

Althobaiti, Fayez / Abu Ali, Ola A / Kamal, Islam / Alfaifi, Mohammad Y / Shati, Ali A / Fayad, Eman / Elbehairi, Serag Eldin I / Elshaarawy, Reda F M / El-Fattah, W Abd

Antibiotics (Basel, Switzerland)

2023 Volume 12, Issue 2

Abstract: This work reports a new approach for the synthesis of extremely small monodispersed silver nanoparticles (AgNPs) (2.9-1.5) by reduction of silver nitrate in a new series of benzyl alkyl imidazolium ionic liquids (BAIILs)-based microemulsions (3a-f) as ... ...

Abstract	This work reports a new approach for the synthesis of extremely small monodispersed silver nanoparticles (AgNPs) (2.9-1.5) by reduction of silver nitrate in a new series of benzyl alkyl imidazolium ionic liquids (BAIILs)-based microemulsions (3a-f) as media and stabilizing agents. Interestingly, AgNPs isolated from the IILMEs bearing the bulkiest substituents (
Language	English
Publishing date	2023-01-25
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2681345-2
ISSN	2079-6382
ISSN	2079-6382
DOI	10.3390/antibiotics12020247
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