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  1. Book: Long non-coding RNAs

    Zhang, Lin / Hu, Xiaowen

    methods and protocols

    (Methods in molecular biology ; 2372 ; Springer protocols)

    2021  

    Author's details edited by Lin Zhang and Xiaowen Hu
    Series title Methods in molecular biology ; 2372
    Springer protocols
    Collection
    Keywords RNA, Long Noncoding
    Language English
    Size xiii, 308 Seiten, Illustrationen, Diagramme, 26 cm
    Edition Second edition
    Publisher Humana Press
    Publishing place New York, NY
    Publishing country United States
    Document type Book
    HBZ-ID HT021067485
    ISBN 978-1-0716-1696-3 ; 9781071616970 ; 1-0716-1696-X ; 1071616978
    Database Catalogue ZB MED Medicine, Health

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    In stock of ZB MED Cologne/Königswinter

    Shelf markLoan statusLocation
    Zs A 7042 -2372- verfügbar in Königswinter Königswinter

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  2. Article ; Online: Exploring ncRNA-Drug Sensitivity Associations Via Graph Contrastive Learning.

    Hu, Xiaowen / Jiang, Ying / Deng, Lei

    IEEE/ACM transactions on computational biology and bioinformatics

    2024  Volume PP

    Abstract: Increasing evidence has shown that noncoding RNAs (ncRNAs) can affect drug efficiency by modulating drug sensitivity genes. Exploring the association between ncRNAs and drug sensitivity is essential for drug discovery and disease prevention. However, ... ...

    Abstract Increasing evidence has shown that noncoding RNAs (ncRNAs) can affect drug efficiency by modulating drug sensitivity genes. Exploring the association between ncRNAs and drug sensitivity is essential for drug discovery and disease prevention. However, traditional biological experiments for identifying ncRNA-drug sensitivity associations are time-consuming and laborious. In this study, we develop a novel graph contrastive learning approach named NDSGCL to predict ncRNA-drug sensitivity. NDSGCL uses graph convolutional networks to learn feature representations of ncRNAs and drugs in ncRNA-drug bipartite graphs. It integrates local structural neighbours and global semantic neighbours to learn a more comprehensive representation by contrastive learning. Specifically, the local structural neighbours aim to capture the higher-order relationship in the ncRNA-drug graph, while the global semantic neighbours are defined based on semantic clusters of the graph that can alleviate the impact of data sparsity. The experimental results show that NDSGCL outperforms basic graph convolutional network methods, existing contrastive learning methods, and state-of-the-art prediction methods. Visualization experiments show that the contrastive objectives of local structural neighbours and global semantic neighbours play a significant role in contrastive learning. Case studies on two drugs show that NDSGCL is an effective tool for predicting ncRNA-drug sensitivity associations. Source code and datasets can be available on https://github.com/altriavin/NDSGCL.
    Language English
    Publishing date 2024-04-05
    Publishing country United States
    Document type Journal Article
    ISSN 1557-9964
    ISSN (online) 1557-9964
    DOI 10.1109/TCBB.2024.3385423
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Ammonia-responsive chitosan/polymethacrylamide double network hydrogels with high-stretchability, fatigue resistance and anti-freezing for real-time chicken breast spoilage monitoring.

    Luo, Siyao / Hu, Chang-Ying / Xu, Xiaowen

    International journal of biological macromolecules

    2024  , Page(s) 131617

    Abstract: Hydrogels are a promising option for detecting food spoilage in humid conditions, but current indicators are prone to mechanical flaws, posing a concern for packaging systems that require strong mechanical properties. Herein, a double network hydrogel ... ...

    Abstract Hydrogels are a promising option for detecting food spoilage in humid conditions, but current indicators are prone to mechanical flaws, posing a concern for packaging systems that require strong mechanical properties. Herein, a double network hydrogel was prepared by polymerizing methacrylamide in a chitosan system with aluminum chloride and glycerol. The resulting hydrogel demonstrated high stretchability (strain >1500 %), notch insensitivity, excellent fatigue resistance, and exceptional anti-freezing capabilities even at -21 °C. When incorporating bromothymol blue (BB) or methyl red (MR), or mixtures of these dyes into the hydrogels as indicators, they exhibited sensitive colorimetric responses to pH and NH
    Language English
    Publishing date 2024-04-15
    Publishing country Netherlands
    Document type Journal Article
    ZDB-ID 282732-3
    ISSN 1879-0003 ; 0141-8130
    ISSN (online) 1879-0003
    ISSN 0141-8130
    DOI 10.1016/j.ijbiomac.2024.131617
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article: Shade Increased Seed Yield and Quality of

    Wang, Yan / Wang, Jingjing / Chen, Dali / Hui, Zhenning / Hu, Xiaowen

    Plants (Basel, Switzerland)

    2023  Volume 12, Issue 16

    Abstract: Incarvillea ... ...

    Abstract Incarvillea sinensis
    Language English
    Publishing date 2023-08-14
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2704341-1
    ISSN 2223-7747
    ISSN 2223-7747
    DOI 10.3390/plants12162934
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: A novel repair strategy using knotless squeeze anchors for lumbar disc herniation with endplate junction lesions under biportal endoscopic spinal surgery.

    Jiang, Lejian / Jing, Xiaowei / Qiu, Xiaowen / Hu, Qingfeng

    Acta neurochirurgica

    2024  Volume 166, Issue 1, Page(s) 171

    Abstract: Background: Annulus fibrosus-endplate (AF-EP) junction lesions are important determinants for lumbar disc herniation (LDH). Utilizing biportal endoscopic spinal surgery (BESS), we introduce a novel repair method using bioabsorbable PushLock anchors with ...

    Abstract Background: Annulus fibrosus-endplate (AF-EP) junction lesions are important determinants for lumbar disc herniation (LDH). Utilizing biportal endoscopic spinal surgery (BESS), we introduce a novel repair method using bioabsorbable PushLock anchors with suture fibers to stretch disconnected AF tissues to the vertebral cortex.
    Methods: The viewing and working portals are established to excise herniated disc materials causing radiculopathy. Through the working portal, a suture strand is passed through the intact AF tissue near the lesion and retrieved using the Suture Crossing Device. Then, the knotless suture limbs are secured into the cortical bone socket of the vertebral body with a PushLock anchor.
    Conclusion: The procedure is a simple, safe, and feasible knotless suturing technique for the treatment of LDH with AF-EP junction lesions.
    MeSH term(s) Humans ; Intervertebral Disc Displacement/diagnostic imaging ; Intervertebral Disc Displacement/surgery ; Endoscopy ; Neurosurgical Procedures ; Spine ; Accidental Injuries
    Language English
    Publishing date 2024-04-09
    Publishing country Austria
    Document type Journal Article
    ZDB-ID 80010-7
    ISSN 0942-0940 ; 0001-6268
    ISSN (online) 0942-0940
    ISSN 0001-6268
    DOI 10.1007/s00701-024-06065-3
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: Label-free detection of biomolecules using inductively coupled plasma mass spectrometry (ICP-MS).

    Hu, Jianyu / Yan, Xiaowen / Chris Le, X

    Analytical and bioanalytical chemistry

    2024  Volume 416, Issue 11, Page(s) 2625–2640

    Abstract: Bioassays using inductively coupled plasma mass spectrometry (ICP-MS) have gained increasing attention because of the high sensitivity of ICP-MS and the various strategies of labeling biomolecules with detectable metal tags. The classic strategy to tag ... ...

    Abstract Bioassays using inductively coupled plasma mass spectrometry (ICP-MS) have gained increasing attention because of the high sensitivity of ICP-MS and the various strategies of labeling biomolecules with detectable metal tags. The classic strategy to tag the target biomolecules is through direct antibody-antigen interaction and DNA hybridization, and requires the separation of the bound from the unbound tags. Label-free ICP-MS techniques for biomolecular assays do not require direct labeling: they generate detectable metal ions indirectly from specific biomolecular reactions, such as enzymatic cleavage. Here, we highlight the development of three main strategies of label-free ICP-MS assays for biomolecules: (1) enzymatic cleavage of metal-labeled substrates, (2) release of immobilized metal ions from the DNA backbone, and (3) nucleic acid amplification-assisted aggregation and release of metal tags to achieve amplified detection. We briefly describe the fundamental basis of these label-free ICP-MS assays and discuss the benefits and drawbacks of various designs. Future research is needed to reduce non-specific adsorption and minimize background and interference. Analytical innovations are also required to confront challenges faced by in vivo applications.
    MeSH term(s) Mass Spectrometry/methods ; DNA/chemistry ; Nucleic Acid Hybridization ; Spectrum Analysis ; Metals ; Ions
    Chemical Substances DNA (9007-49-2) ; Metals ; Ions
    Language English
    Publishing date 2024-01-04
    Publishing country Germany
    Document type Journal Article ; Review
    ZDB-ID 201093-8
    ISSN 1618-2650 ; 0016-1152 ; 0372-7920
    ISSN (online) 1618-2650
    ISSN 0016-1152 ; 0372-7920
    DOI 10.1007/s00216-023-05106-7
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Bonn / Germany

    Z 4' 69/97: Show issues
    Archiv 3: Show issues
    Z 9.4: Show issues

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  7. Article ; Online: The effects of urbanization and urban sprawl on CO2 emissions in China

    Cheng, Zhonghua / Hu, Xiaowen

    Environ Dev Sustain. 2023 Feb., v. 25, no. 2 p.1792-1808

    2023  

    Abstract: With the steady increase in urbanization that has occurred, China has begun to suffer from serious urban sprawl. Both the increase in urbanization and the subsequent urban sprawl have led to major changes in CO₂ emissions. In this paper, we expand the ... ...

    Abstract With the steady increase in urbanization that has occurred, China has begun to suffer from serious urban sprawl. Both the increase in urbanization and the subsequent urban sprawl have led to major changes in CO₂ emissions. In this paper, we expand the STIRPAT model to empirically analyse the effects of China’s urbanization and urban sprawl on CO₂ emissions from 1997 to 2018, with regression results showing that both urbanization and urban sprawl have increased CO₂ emissions. Further analyses of the mechanisms indicate that urbanization can increase overall CO₂ emissions by not only increasing industrial CO₂ emissions, but also by increasing construction CO₂ emissions and residential consumption CO₂ emissions as well. Urban sprawl can increase overall carbon emissions by increasing CO₂ emissions from transport, construction and industry. We then make specific suggestions for China’s carbon reduction and low-carbon development based on these findings.
    Keywords carbon ; carbon dioxide ; industry ; models ; urbanization ; China
    Language English
    Dates of publication 2023-02
    Size p. 1792-1808.
    Publishing place Springer Netherlands
    Document type Article ; Online
    ZDB-ID 1438730-x
    ISSN 1387-585X
    ISSN 1387-585X
    DOI 10.1007/s10668-022-02123-x
    Database NAL-Catalogue (AGRICOLA)

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    Z 7620: Show issues

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  8. Article ; Online: Graph Convolutional Network and Contrastive Learning Small Nucleolar RNA (snoRNA) Disease Associations (GCLSDA): Predicting snoRNA-Disease Associations via Graph Convolutional Network and Contrastive Learning.

    Zhang, Liangliang / Chen, Ming / Hu, Xiaowen / Deng, Lei

    International journal of molecular sciences

    2023  Volume 24, Issue 19

    Abstract: Small nucleolar RNAs (snoRNAs) constitute a prevalent class of noncoding RNAs localized within the nucleoli of eukaryotic cells. Their involvement in diverse diseases underscores the significance of forecasting associations between snoRNAs and diseases. ... ...

    Abstract Small nucleolar RNAs (snoRNAs) constitute a prevalent class of noncoding RNAs localized within the nucleoli of eukaryotic cells. Their involvement in diverse diseases underscores the significance of forecasting associations between snoRNAs and diseases. However, conventional experimental techniques for such predictions suffer limitations in scalability, protracted timelines, and suboptimal success rates. Consequently, efficient computational methodologies are imperative to realize the accurate predictions of snoRNA-disease associations. Herein, we introduce GCLSDA-
    MeSH term(s) RNA, Small Nucleolar/genetics ; Computational Biology/methods ; RNA, Untranslated ; Databases, Factual
    Chemical Substances RNA, Small Nucleolar ; RNA, Untranslated
    Language English
    Publishing date 2023-09-22
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2019364-6
    ISSN 1422-0067 ; 1422-0067 ; 1661-6596
    ISSN (online) 1422-0067
    ISSN 1422-0067 ; 1661-6596
    DOI 10.3390/ijms241914429
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article ; Online: Antimicrobial polysaccharide hydrogels embedded with methyl-β-cyclodextrin/thyme oil inclusion complexes for exceptional mechanical performance and chilled chicken breast preservation.

    Chen, Mingshan / Hu, Zhiyu / Zheng, Haoyuan / Wang, Jiesheng / Xu, Xiaowen

    International journal of biological macromolecules

    2024  Volume 267, Issue Pt 2, Page(s) 131586

    Abstract: While hydrogels have potential for food packaging, limited research on hydrogels with excellent mechanical performance and antibacterial activity for preserving chicken breasts. Herein, we created antibacterial hydrogels by embedding methyl-β- ... ...

    Abstract While hydrogels have potential for food packaging, limited research on hydrogels with excellent mechanical performance and antibacterial activity for preserving chicken breasts. Herein, we created antibacterial hydrogels by embedding methyl-β-cyclodextrin/thyme oil inclusion complexes (MCD/TO-ICs) into a polyvinyl alcohol matrix containing dendrobium polysaccharides and guar gum in varying ratios using freeze-thaw cycling method. The resulting hydrogels exhibited a more compact structure than those without MCD/TO-ICs, enhancing thermal stability and increasing glass transition temperature due to additional intermolecular interactions between polymer chains that inhibited chain movement. XRD analysis showed no significant changes in crystalline phase, enabling formation of a 3D network through abundant hydrogen bonding. Moreover, the hydrogel demonstrated exceptional durability, with a toughness of 350 ± 25 kJ/m
    Language English
    Publishing date 2024-04-13
    Publishing country Netherlands
    Document type Journal Article
    ZDB-ID 282732-3
    ISSN 1879-0003 ; 0141-8130
    ISSN (online) 1879-0003
    ISSN 0141-8130
    DOI 10.1016/j.ijbiomac.2024.131586
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article: 

    Hu, Renchuan / Liao, Xiaowen / Luo, Binsheng / Liu, Cheng / Nong, You / Wu, Lei

    PhytoKeys

    2023  Volume 232, Page(s) 67–75

    Abstract: ... ...

    Abstract Mitreolaquanruii
    Language English
    Publishing date 2023-09-08
    Publishing country Bulgaria
    Document type Journal Article
    ZDB-ID 2579891-1
    ISSN 1314-2003 ; 1314-2011
    ISSN (online) 1314-2003
    ISSN 1314-2011
    DOI 10.3897/phytokeys.232.108986
    Database MEDical Literature Analysis and Retrieval System OnLINE

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