Article ; Online: Cohorting for preventing the nosocomial spread of Carbapenemase-Producing Enterobacterales, in non-epidemic settings: is it mandatory?
The Journal of hospital infection
2020
Abstract: Background: Worldwide dissemination of Carbapenemase-Producing Enterobacterales (CPE) has led to national and international guidance recommending the implementation of cohorting in healthcare settings (HS). However, in view of recent data regarding the ... ...
| Abstract | Background: Worldwide dissemination of Carbapenemase-Producing Enterobacterales (CPE) has led to national and international guidance recommending the implementation of cohorting in healthcare settings (HS). However, in view of recent data regarding the spread of Extended-spectrum Beta-lactamase-producing Enterobacterales, we may wonder about the usefulness of this measure in a non-outbreak settings; here, individual contact isolation may be sufficient to control the risk of dissemination. Aim/methods: We conducted a narrative review of the literature and discussed the role of cohorting. Findings: CPE are responsible for outbreaks in HS, which are considered the epicentre of spread of resistance strains. CPE are responsible for adverse effects such as increases in hospital stay and costs, less therapeutic options and thus higher risk of clinical failures and mortality. Environment and materials have also been described contaminated with CPE and can be the source of outbreak. Even if guidelines and publications have supported implementation of cohorting, there are no randomized studies demonstrating the mandatory nature of this measure. Most studies are descriptive and cohorting is usually one of several other measures to control outbreaks. Cohorting is not adapted to all HS, which requires human and material resources. Other measures must be strengthened such as compliance of hand hygiene, antibiotic stewardship and surveillance of contact patients. Individual risk factors of acquisition should also be evaluated. Conclusion: Local epidemiology and resources must be assessed before implementing cohorting. |
|---|---|
| Language | English |
| Publishing date | 2020-04-18 |
| Publishing country | England |
| Document type | Journal Article ; Review |
| ZDB-ID | 779366-2 |
| ISSN | 1532-2939 ; 0195-6701 |
| ISSN (online) | 1532-2939 |
| ISSN | 0195-6701 |
| DOI | 10.1016/j.jhin.2020.04.022 |
| Database | MEDical Literature Analysis and Retrieval System OnLINE |
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