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  1. Article: "You Never Get a Second Chance": First Impressions of Physicians Depend on Their Body Posture and Gender.

    Grün, Felix C / Heibges, Maren / Westfal, Viola / Feufel, Markus A

    Frontiers in psychology

    2022  Volume 13, Page(s) 836157

    Abstract: A first impression matters, in particular when encounters are brief as in most doctor-patient interactions. In this study, we investigate how physicians' body postures impact patients' first impressions of them and extend previous research by exploring ... ...

    Abstract A first impression matters, in particular when encounters are brief as in most doctor-patient interactions. In this study, we investigate how physicians' body postures impact patients' first impressions of them and extend previous research by exploring posture effects on the perception of
    Language English
    Publishing date 2022-03-21
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2563826-9
    ISSN 1664-1078
    ISSN 1664-1078
    DOI 10.3389/fpsyg.2022.836157
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article: The obesogen tributyltin.

    Grün, Felix

    Vitamins and hormones

    2014  Volume 94, Page(s) 277–325

    Abstract: The obesogen hypothesis postulates the role of environmental chemical pollutants that disrupt homeostatic controls and adaptive mechanisms to promote adipose-dependent weight gain leading to obesity and metabolic syndrome complications. One of the most ... ...

    Abstract The obesogen hypothesis postulates the role of environmental chemical pollutants that disrupt homeostatic controls and adaptive mechanisms to promote adipose-dependent weight gain leading to obesity and metabolic syndrome complications. One of the most direct molecular mechanisms for coupling environmental chemical exposures to perturbed physiology invokes pollutants mimicking endogenous endocrine hormones or bioactive dietary signaling metabolites that serve as nuclear receptor ligands. The organotin pollutant tributyltin can exert toxicity through multiple mechanisms but most recently has been shown to bind, activate, and mediate RXR-PPARγ transcriptional regulation central to lipid metabolism and adipocyte biology. Data in support of long-term obesogenic effects on whole body adipose tissue are also reported. Organotins represent an important model test system for evaluating the impact and epidemiological significance of chemical insults as contributing factors for obesity and human metabolic health.
    MeSH term(s) Adipogenesis/drug effects ; Adipose Tissue/drug effects ; Adipose Tissue/metabolism ; Adipose Tissue/pathology ; Animals ; Endocrine Disruptors/toxicity ; Environmental Exposure/adverse effects ; Environmental Pollutants/toxicity ; Epigenesis, Genetic/drug effects ; Humans ; Lipid Metabolism/drug effects ; Models, Biological ; Obesity/chemically induced ; Obesity/metabolism ; Obesity/pathology ; Trialkyltin Compounds/toxicity
    Chemical Substances Endocrine Disruptors ; Environmental Pollutants ; Trialkyltin Compounds ; tributyltin (4XDX163P3D)
    Language English
    Publishing date 2014
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't ; Review
    ZDB-ID 201161-x
    ISSN 2162-2620 ; 0083-6729
    ISSN (online) 2162-2620
    ISSN 0083-6729
    DOI 10.1016/B978-0-12-800095-3.00011-0
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Breath biomarkers of total body irradiation in non-human primates.

    Phillips, Michael / Grun, Felix / Schmitt, Peter

    Journal of breath research

    2022  Volume 16, Issue 2

    Abstract: Background. ...

    Abstract Background.
    MeSH term(s) Animals ; Biomarkers/analysis ; Breath Tests/methods ; Primates/metabolism ; Volatile Organic Compounds/analysis ; Whole-Body Irradiation
    Chemical Substances Biomarkers ; Volatile Organic Compounds
    Language English
    Publishing date 2022-01-11
    Publishing country England
    Document type Journal Article ; Research Support, N.I.H., Extramural
    ZDB-ID 2381007-5
    ISSN 1752-7163 ; 1752-7155
    ISSN (online) 1752-7163
    ISSN 1752-7155
    DOI 10.1088/1752-7163/ac39aa
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Book ; Online ; Thesis: Vor dem Computer, aber beim Patienten: Wie sich Kameraeinstellungen und ärztliche Körperhaltungen im Telemedizinsetting auf die Wahrnehmung der Arzt-Patienten-Beziehung auswirken

    Grün, Felix Christian [Verfasser] / Feufel, Markus [Akademischer Betreuer] / Feufel, Markus [Gutachter] / Kendel, Friederike [Gutachter]

    2023  

    Author's details Felix Christian Grün ; Gutachter: Markus Feufel, Friederike Kendel ; Betreuer: Markus Feufel
    Keywords Psychologie ; Psychology
    Subject code sg150
    Language German
    Publisher Technische Universität Berlin
    Publishing place Berlin
    Document type Book ; Online ; Thesis
    Database Digital theses on the web

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  5. Article ; Online: Adjuvant re-irradiation vs. no early re-irradiation of resected recurrent glioblastoma: pooled comparative cohort analysis from two tertiary centers.

    Straube, Christoph / Combs, Stephanie E / Bernhardt, Denise / Gempt, Jens / Meyer, Bernhard / Zimmer, Claus / Schmidt-Graf, Friederike / Vajkoczy, Peter / Grün, Arne / Ehret, Felix / Zips, Daniel / Kaul, David

    Journal of neuro-oncology

    2024  

    Abstract: Background: The optimal management strategy for recurrent glioblastoma (rGBM) remains uncertain, and the impact of re-irradiation (Re-RT) on overall survival (OS) is still a matter of debate. This study included patients who achieved gross total ... ...

    Abstract Background: The optimal management strategy for recurrent glioblastoma (rGBM) remains uncertain, and the impact of re-irradiation (Re-RT) on overall survival (OS) is still a matter of debate. This study included patients who achieved gross total resection (GTR) after a second surgery after recurrence, following the GlioCave criteria.
    Methods: Inclusion criteria include being 18 years or older, having histologically confirmed locally recurrent IDHwt or IDH unknown GBM, achieving MRI-proven GTR after the second surgery, having a Karnofsky performance status of at least 60% after the second surgery, having a minimum interval of 6 months between the first radiotherapy and the second surgery, and a maximum of 8 weeks from second surgery to the start of Re-RT.
    Results: A total of 44 patients have met the inclusion criteria. The median OS after the second surgery was 14 months. All patients underwent standard treatment after initial diagnosis, including maximum safe resection, adjuvant radiochemotherapy and adjuvant chemotherapy. Re-RT did not significantly impact OS. However, MGMT promoter methylation status and a longer interval (> 12 months) between treatments were associated with better OS. Multivariate analysis revealed the MGMT status as the only significant predictor of OS.
    Conclusion: Factors such as MGMT promoter methylation status and treatment interval play crucial roles in determining patient outcomes after second surgery. Personalized treatment strategies should consider these factors to optimize the management of rGBM. Prospective research is needed to define the value of re-RT after second surgery and to inform decision making in this situation.
    Language English
    Publishing date 2024-03-23
    Publishing country United States
    Document type Journal Article
    ZDB-ID 604875-4
    ISSN 1573-7373 ; 0167-594X
    ISSN (online) 1573-7373
    ISSN 0167-594X
    DOI 10.1007/s11060-024-04633-2
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: Obesogens.

    Grün, Felix

    Current opinion in endocrinology, diabetes, and obesity

    2010  Volume 17, Issue 5, Page(s) 453–459

    Abstract: Purpose of review: The environmental obesogen hypothesis postulates chemical pollutants that are able to promote obesity by altering homeostatic metabolic set-points, disrupting appetite controls, perturbing lipid homeostasis to promote adipocyte ... ...

    Abstract Purpose of review: The environmental obesogen hypothesis postulates chemical pollutants that are able to promote obesity by altering homeostatic metabolic set-points, disrupting appetite controls, perturbing lipid homeostasis to promote adipocyte hypertrophy, or stimulating adipogenic pathways that enhance adipocyte hyperplasia during development or in adults. This review focuses on recent experimental advances for candidate obesogens that target nuclear hormone receptors when a direct link between exposure, modulation of transcriptional networks and adipogenic phenotypes can be rationalized.
    Recent findings: Various endocrine disrupting chemicals can disrupt hormonal signaling relevant to adipose tissue biology. In this review, progress on one identified obesogen, the organotin tributyltin, will be outlined to highlight principles and novel insights into its high-affinity nuclear hormone receptor-mediated mechanism, its effects on adipocyte biology, its potential to promote long-term obesogenic changes and its epidemiological relevance. When appropriate, important results for other suspected obesogenic ligands, including bisphenol A, phthalates, polybrominated diphenyl ethers and perfluoro-compounds, will highlight corroborating principles.
    Summary: These examples serve to provide perspective on the potential harm that man-made obesogenic pollutants pose to human health, focus attention on areas in which knowledge remains inadequate and prompt a re-evaluation of the causative risk factors driving the current changes in obesity rates.
    MeSH term(s) Adipocytes/drug effects ; Adipocytes/metabolism ; Adipose Tissue/drug effects ; Adipose Tissue/metabolism ; Animals ; Appetite Regulation/drug effects ; Benzhydryl Compounds ; Endocrine Disruptors/metabolism ; Endocrine Disruptors/toxicity ; Environmental Exposure/adverse effects ; Environmental Pollutants/metabolism ; Environmental Pollutants/toxicity ; Female ; Fluorocarbons/metabolism ; Fluorocarbons/toxicity ; Halogenated Diphenyl Ethers/metabolism ; Halogenated Diphenyl Ethers/toxicity ; Homeostasis/drug effects ; Humans ; Male ; Mice ; Obesity/chemically induced ; Obesity/epidemiology ; Obesity/metabolism ; PPAR gamma/agonists ; Phenols/metabolism ; Phenols/toxicity ; Phenotype ; Phthalic Acids/metabolism ; Phthalic Acids/toxicity ; Receptors, Cytoplasmic and Nuclear/metabolism ; Retinoid X Receptors/agonists ; Transcription, Genetic/drug effects ; Trialkyltin Compounds/metabolism ; Trialkyltin Compounds/toxicity
    Chemical Substances Benzhydryl Compounds ; Endocrine Disruptors ; Environmental Pollutants ; Fluorocarbons ; Halogenated Diphenyl Ethers ; PPAR gamma ; Phenols ; Phthalic Acids ; Receptors, Cytoplasmic and Nuclear ; Retinoid X Receptors ; Trialkyltin Compounds ; tributyltin (4XDX163P3D) ; phthalic acid (6O7F7IX66E) ; bisphenol A (MLT3645I99)
    Language English
    Publishing date 2010-10
    Publishing country England
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't ; Review
    ZDB-ID 2272017-0
    ISSN 1752-2978 ; 1752-296X
    ISSN (online) 1752-2978
    ISSN 1752-296X
    DOI 10.1097/MED.0b013e32833ddea0
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Book ; Online: Invariance to Quantile Selection in Distributional Continuous Control

    Grün, Felix / Saif-ur-Rehman, Muhammad / Glasmachers, Tobias / Iossifidis, Ioannis

    2022  

    Abstract: In recent years distributional reinforcement learning has produced many state of the art results. Increasingly sample efficient Distributional algorithms for the discrete action domain have been developed over time that vary primarily in the way they ... ...

    Abstract In recent years distributional reinforcement learning has produced many state of the art results. Increasingly sample efficient Distributional algorithms for the discrete action domain have been developed over time that vary primarily in the way they parameterize their approximations of value distributions, and how they quantify the differences between those distributions. In this work we transfer three of the most well-known and successful of those algorithms (QR-DQN, IQN and FQF) to the continuous action domain by extending two powerful actor-critic algorithms (TD3 and SAC) with distributional critics. We investigate whether the relative performance of the methods for the discrete action space translates to the continuous case. To that end we compare them empirically on the pybullet implementations of a set of continuous control tasks. Our results indicate qualitative invariance regarding the number and placement of distributional atoms in the deterministic, continuous action setting.
    Keywords Computer Science - Machine Learning ; Computer Science - Artificial Intelligence ; I.2.8 ; I.2.6
    Publishing date 2022-12-29
    Publishing country us
    Document type Book ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  8. Article: "You never get a second chance"

    Grün, Felix C. / Heibges, Maren / Westfal, Viola / Feufel, Markus A.

    Frontiers in Psychology

    First impressions of physicians depend on their body posture and gender

    2022  

    Abstract: A first impression matters, in particular when encounters are brief as in most doctor-patient interactions. In this study, we investigate how physicians' body postures impact patients' first impressions of them and extend previous research by exploring ... ...

    Title translation "Man bekommt nie eine zweite Chance": Der erste Eindruck von Ärzten hängt von ihrer Körperhaltung und ihrem Geschlecht ab (DeepL)
    Abstract A first impression matters, in particular when encounters are brief as in most doctor-patient interactions. In this study, we investigate how physicians' body postures impact patients' first impressions of them and extend previous research by exploring posture effects on the perception of all roles of a physician - not just single aspects such as scholarly expertise or empathy. In an online survey, 167 participants ranked photographs of 4 physicians (2 female, 2 male) in 4 postures (2 open, 2 closed). The results show that male physicians were rated more positively when assuming open rather than closed postures with respect to all professional physician roles. Female physicians in open postures were rated similarly positive for items related to medical competence, but they tended to be rated less favorably with respect to social skills (such as the ability to communicate with and relate to the patient). These findings extend what is known about the effects of physicians' body postures on the first impressions patients form to judge physicians' medical versus social competencies. We discuss practical implications and the need for more research on interaction effects of body postures and physician gender on first impressions.
    Keywords Eindrucksbildung ; Geschlecht ; Impression Formation ; Körperhaltung ; Nonverbal Communication ; Nonverbale Kommunikation ; Patientinnen und Patienten ; Patients ; Physicians ; Posture ; Sex ; Social Perception ; Soziale Wahrnehmung ; Ärztinnen und Ärzte
    Language English
    Document type Article
    DOI 10.3389/fpsyg.2022.836157
    Database PSYNDEX

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  9. Article: Spatially resolved detection of small molecules from press-dried plant tissue using MALDI imaging.

    Long, Zane G / Le, Jonathan V / Katz, Benjamin B / Lopez, Belen G / Tenenbaum, Emily D / Semmling, Bonnie / Schmidt, Ryan J / Grün, Felix / Butts, Carter T / Martin, Rachel W

    Applications in plant sciences

    2023  Volume 11, Issue 5, Page(s) e11539

    Abstract: Premise: Matrix-assisted laser desorption/ionization mass spectrometry imaging (MALDI-MSI) is a chemical imaging method that can visualize spatial distributions of particular molecules. Plant tissue imaging has so far mostly used cryosectioning, which ... ...

    Abstract Premise: Matrix-assisted laser desorption/ionization mass spectrometry imaging (MALDI-MSI) is a chemical imaging method that can visualize spatial distributions of particular molecules. Plant tissue imaging has so far mostly used cryosectioning, which can be impractical for the preparation of large-area imaging samples, such as full flower petals. Imaging unsectioned plant tissue presents its own difficulties in extracting metabolites to the surface due to the waxy cuticle.
    Methods: We address this by using established delipidation techniques combined with a solvent vapor extraction prior to applying the matrix with many low-concentration sprays.
    Results: Using this procedure, we imaged tissue from three different plant species (two flowers and one carnivorous plant leaf). Material factorization analysis of the resulting data reveals a wide range of plant-specific small molecules with varying degrees of localization to specific portions of the tissue samples, while facilitating detection and removal of signal from background sources.
    Conclusions: This work demonstrates applicability of MALDI-MSI to press-dried plant samples without freezing or cryosectioning, setting the stage for spatially resolved molecule identification. Increased mass resolution and inclusion of tandem mass spectrometry are necessary next steps to allow more specific and reliable compound identification.
    Language English
    Publishing date 2023-09-11
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2699923-7
    ISSN 2168-0450
    ISSN 2168-0450
    DOI 10.1002/aps3.11539
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Book ; Online ; Thesis: Etablierung und Charakterisierung der neuen cholangiozellulären Zelllinie CCC-5

    Grün, Johanna [Verfasser] / Rückert, Felix [Akademischer Betreuer]

    2018  

    Author's details Johanna Luisa Grün ; Betreuer: Felix Rückert
    Keywords Medizin, Gesundheit ; Medicine, Health
    Subject code sg610
    Language German
    Publisher Universitätsbibliothek Heidelberg
    Publishing place Heidelberg
    Document type Book ; Online ; Thesis
    Database Digital theses on the web

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