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  1. Article ; Online: Potassium-rich antiperovskites K

    Okada, Koji / Fujii, Susumu / Tassel, Cédric / Gao, Shenghan / Ubukata, Hiroki / Pan, Wenli / Yamamoto, Kentaro / Uchimoto, Yoshiharu / Kuwabara, Akihide / Kageyama, Hiroshi

    Dalton transactions (Cambridge, England : 2003)

    2023  Volume 52, Issue 26, Page(s) 9026–9031

    Abstract: Unlike perovskite oxides, antiperovskites ... ...

    Abstract Unlike perovskite oxides, antiperovskites M
    Language English
    Publishing date 2023-07-04
    Publishing country England
    Document type Journal Article
    ZDB-ID 1472887-4
    ISSN 1477-9234 ; 1364-5447 ; 0300-9246 ; 1477-9226
    ISSN (online) 1477-9234 ; 1364-5447
    ISSN 0300-9246 ; 1477-9226
    DOI 10.1039/d3dt01039b
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: A single K

    Yamamoto, Kenta / Dubey, Vikas / Irie, Katsumasa / Nakanishi, Hanayo / Khandelia, Himanshu / Fujiyoshi, Yoshinori / Abe, Kazuhiro

    eLife

    2019  Volume 8

    Abstract: The gastric proton pump ( ... ...

    Abstract The gastric proton pump (H
    MeSH term(s) Binding Sites ; Cations/metabolism ; Crystallography, X-Ray ; Potassium/metabolism ; Protein Binding ; Protein Conformation ; Proton Pumps/chemistry ; Proton Pumps/metabolism
    Chemical Substances Cations ; Proton Pumps ; Potassium (RWP5GA015D)
    Language English
    Publishing date 2019-08-22
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2687154-3
    ISSN 2050-084X ; 2050-084X
    ISSN (online) 2050-084X
    ISSN 2050-084X
    DOI 10.7554/eLife.47701
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  3. Article ; Online: Gastric proton pump with two occluded K

    Abe, Kazuhiro / Yamamoto, Kenta / Irie, Katsumasa / Nishizawa, Tomohiro / Oshima, Atsunori

    Nature communications

    2021  Volume 12, Issue 1, Page(s) 5709

    Abstract: The gastric ... ...

    Abstract The gastric H
    MeSH term(s) Binding Sites/genetics ; Cations, Monovalent/metabolism ; Cell Membrane/enzymology ; Cryoelectron Microscopy ; Crystallization ; Enzyme Assays ; Gastric Mucosa/cytology ; Gastric Mucosa/enzymology ; H(+)-K(+)-Exchanging ATPase/genetics ; H(+)-K(+)-Exchanging ATPase/isolation & purification ; H(+)-K(+)-Exchanging ATPase/metabolism ; H(+)-K(+)-Exchanging ATPase/ultrastructure ; HEK293 Cells ; Humans ; Models, Molecular ; Mutation ; Potassium/metabolism ; Protein Engineering ; Recombinant Proteins/genetics ; Recombinant Proteins/isolation & purification ; Recombinant Proteins/metabolism ; Recombinant Proteins/ultrastructure ; Substrate Specificity/genetics
    Chemical Substances Cations, Monovalent ; Recombinant Proteins ; H(+)-K(+)-Exchanging ATPase (EC 3.6.3.10) ; Potassium (RWP5GA015D)
    Language English
    Publishing date 2021-09-29
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2553671-0
    ISSN 2041-1723 ; 2041-1723
    ISSN (online) 2041-1723
    ISSN 2041-1723
    DOI 10.1038/s41467-021-26024-1
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  4. Article ; Online: Thermoelectric Properties of (Ba,K)Zn

    Kunioka, Haruno / Kihou, Kunihiro / Kato, Daichi / Usui, Hidetomo / Iida, Tsutomu / Nishiate, Hirotaka / Kuroki, Kazuhiko / Yamamoto, Atsushi / Lee, Chul-Ho

    Inorganic chemistry

    2020  Volume 59, Issue 9, Page(s) 5828–5834

    Abstract: The compound ... ...

    Abstract The compound Ba
    Language English
    Publishing date 2020-04-10
    Publishing country United States
    Document type Journal Article
    ZDB-ID 1484438-2
    ISSN 1520-510X ; 0020-1669
    ISSN (online) 1520-510X
    ISSN 0020-1669
    DOI 10.1021/acs.inorgchem.9b02680
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  5. Article ; Online: Enhancement of Inhibitory Activity by Combining Allosteric Inhibitors Putatively Binding to Different Allosteric Sites on Cathepsin K.

    Sato, Shun / Yamamoto, Kana / Ito, Moeno / Nishino, Katsutoshi / Otsuka, Takanao / Irie, Kazuhiro / Nagao, Masaya

    Molecules (Basel, Switzerland)

    2023  Volume 28, Issue 10

    Abstract: Background: Cathepsin K, which is involved in bone resorption, is a good target for treating ... Cathepsin K inhibitors were isolated from the methanol extract of : Results: Two types of cathepsin K ...

    Abstract Background: Cathepsin K, which is involved in bone resorption, is a good target for treating osteoporosis, but no clinically approved medicine has been developed. Recently, allosteric inhibitors with high specificity and few side effects have been attracting attention for use in new medicines.
    Methods: Cathepsin K inhibitors were isolated from the methanol extract of
    Results: Two types of cathepsin K inhibitors were identified in the methanol extract of
    Conclusions: Different allosteric inhibitors that bind to different sites in combination, as shown in this study, may be useful for designing new allosteric inhibitory drugs with high specificity and few side effects.
    MeSH term(s) Humans ; Cathepsin K/metabolism ; Allosteric Site ; Kinetics ; Methanol ; Bone Resorption ; Cathepsins/metabolism
    Chemical Substances Cathepsin K (EC 3.4.22.38) ; Methanol (Y4S76JWI15) ; Cathepsins (EC 3.4.-)
    Language English
    Publishing date 2023-05-19
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 1413402-0
    ISSN 1420-3049 ; 1431-5165 ; 1420-3049
    ISSN (online) 1420-3049
    ISSN 1431-5165 ; 1420-3049
    DOI 10.3390/molecules28104197
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    In stock of ZB MED Cologne/Königswinter

    Zs.MO 81: Show issues

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  6. Article ; Online: Intrauterine fetal death due to fetal intracranial hemorrhage associated with maternal vitamin K deficiency: A case report.

    Yasuda, Koya / Obata, Soichiro / Kumagai, Eita / Iijima, Takayoshi / Yamamoto, Masafumi / Miyagi, Etsuko / Aoki, Shigeru

    Case reports in women's health

    2023  Volume 40, Page(s) e00566

    Abstract: Vitamin K deficiency can cause coagulopathy; therefore, supplementation is recommended to prevent ... intracranial hemorrhage in newborns. Some reports have shown that maternal vitamin K deficiency is associated ... vitamin K deficiency to prevent fetal intracranial hemorrhage. We report a case of intrauterine ...

    Abstract Vitamin K deficiency can cause coagulopathy; therefore, supplementation is recommended to prevent intracranial hemorrhage in newborns. Some reports have shown that maternal vitamin K deficiency is associated with intracranial hemorrhage in the fetus. However, no clear guidelines exist for the diagnosis and treatment of maternal vitamin K deficiency to prevent fetal intracranial hemorrhage. We report a case of intrauterine fetal death due to intracranial hemorrhage associated with maternal vitamin K deficiency resulting from hyperemesis gravidarum. In this case, maternal protein induced by vitamin K absence II (PIVKA-II) was high at the time of intrauterine fetal death. Therefore, measuring maternal PIVKA-II levels in high-risk cases may help determine the timing of therapeutic interventions for vitamin K deficiency during pregnancy.
    Language English
    Publishing date 2023-11-19
    Publishing country Netherlands
    Document type Case Reports
    ZDB-ID 2800286-6
    ISSN 2214-9112 ; 2214-9112
    ISSN (online) 2214-9112
    ISSN 2214-9112
    DOI 10.1016/j.crwh.2023.e00566
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  7. Article ; Online: Catalytic Behavior of K-doped Fe/MgO Catalysts for Ammonia Synthesis Under Mild Reaction Conditions.

    Era, Kohei / Sato, Katsutoshi / Miyahara, Shin-Ichiro / Naito, Takahiro / De Silva, Kanishka / Akrami, Saeid / Yamada, Hiroshi / Toriyama, Takaaki / Yamamoto, Tomokazu / Murakami, Yasukazu / Aika, Ken-Ichi / Inazu, Koji / Nagaoka, Katsutoshi

    ChemSusChem

    2023  Volume 16, Issue 22, Page(s) e202300942

    Abstract: ... Here, we report Fe/K(3)/MgO, fabricated via an impregnation method, as a highly active catalyst ... the activity of Fe/K(3)/MgO (17.5 mmol h ...

    Abstract An important part of realizing a carbon-neutral society using ammonia will be the development of an inexpensive yet efficient catalyst for ammonia synthesis under mild reaction conditions (<400 °C, <10 MPa). Here, we report Fe/K(3)/MgO, fabricated via an impregnation method, as a highly active catalyst for ammonia synthesis under mild reaction conditions (350 °C, 1.0 MPa). At the mentioned conditions, the activity of Fe/K(3)/MgO (17.5 mmol h
    Language English
    Publishing date 2023-11-14
    Publishing country Germany
    Document type Journal Article
    ISSN 1864-564X
    ISSN (online) 1864-564X
    DOI 10.1002/cssc.202300942
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  8. Article ; Online: Thermoelectric properties of (Ba,K)Cd

    Kunioka, H / Kihou, K / Nishiate, H / Yamamoto, A / Usui, H / Kuroki, K / Lee, C H

    Dalton transactions (Cambridge, England : 2003)

    2018  Volume 47, Issue 45, Page(s) 16205–16210

    Abstract: ... successfully substituted K for Ba up to x = 0.08, producing hole-carrier doping with concentrations up to 1.60 ... decrease with hole doping, leading to a power factor value of 1.28 mW m-1 K-2 at 762 K for x = 0.04 ... at the valence-band maximum. The lattice thermal conductivity is suppressed by the K doping to 0.46 W m-1 K-1 ...

    Abstract As-Based Zintl compounds Ba1-xKxCd2As2 crystallized in the CaAl2Si2-type structure (space group P3[combining macron]m1) were prepared using solid-state reactions followed by hot-pressing. We have successfully substituted K for Ba up to x = 0.08, producing hole-carrier doping with concentrations up to 1.60 × 1020 cm-3. We have determined the band-gap value of non-doped BaCd2As2 to be 0.40 eV from the temperature dependence of the electrical resistivity. Both the electrical resistivity and the Seebeck coefficient decrease with hole doping, leading to a power factor value of 1.28 mW m-1 K-2 at 762 K for x = 0.04. A first-principles band calculation shows that the relatively large power factor mainly originates from the two-fold degeneracy of the bands comprising As px,y orbitals and from the anisotropic band structure at the valence-band maximum. The lattice thermal conductivity is suppressed by the K doping to 0.46 W m-1 K-1 at 773 K for x = 0.08, presumably due to randomness. The effect of randomness is compensated by an increase in the electronic thermal conductivity, which keeps the total thermal conductivity approximately constant. In consequence, the dimensionless figure-of-merit ZT reaches a maximum value of 0.81 at 762 K for x = 0.04.
    Language English
    Publishing date 2018-11-02
    Publishing country England
    Document type Journal Article
    ZDB-ID 1472887-4
    ISSN 1477-9234 ; 1364-5447 ; 0300-9246 ; 1477-9226
    ISSN (online) 1477-9234 ; 1364-5447
    ISSN 0300-9246 ; 1477-9226
    DOI 10.1039/c8dt02955e
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  9. Article ; Online: The authors reply: Re: Yamamoto R, Sugiura T, Ashida R, Ohgi K, Yamada M, Otsuka S, and Uesaka K. Prognostic value of carbohydrate antigen 19-9 and the surgical margin in extrahepatic Cholangiocarcinoma.

    Yamamoto, Ryusei / Sugiura, Teiichi / Ashida, Ryo / Ohgi, Katsuhisa / Yamada, Mihoko / Otsuka, Shimpei / Uesaka, Katsuhiko

    Annals of gastroenterological surgery

    2023  Volume 7, Issue 3, Page(s) 535–536

    Abstract: The specific growth rate of the perioperative carbohydrate antigen 19-9 values was not related to the prognosis of extrahepatic cholangiocarcinoma. ...

    Abstract The specific growth rate of the perioperative carbohydrate antigen 19-9 values was not related to the prognosis of extrahepatic cholangiocarcinoma.
    Language English
    Publishing date 2023-02-21
    Publishing country Japan
    Document type Journal Article
    ISSN 2475-0328
    ISSN (online) 2475-0328
    DOI 10.1002/ags3.12667
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  10. Article ; Online: Edoxaban versus Vitamin K Antagonist for Atrial Fibrillation after TAVR.

    Van Mieghem, Nicolas M / Unverdorben, Martin / Hengstenberg, Christian / Möllmann, Helge / Mehran, Roxana / López-Otero, Diego / Nombela-Franco, Luis / Moreno, Raul / Nordbeck, Peter / Thiele, Holger / Lang, Irene / Zamorano, José L / Shawl, Fayaz / Yamamoto, Masanori / Watanabe, Yusuke / Hayashida, Kentaro / Hambrecht, Rainer / Meincke, Felix / Vranckx, Pascal /
    Jin, James / Boersma, Eric / Rodés-Cabau, Josep / Ohlmann, Patrick / Capranzano, Piera / Kim, Hyo-Soo / Pilgrim, Thomas / Anderson, Richard / Baber, Usman / Duggal, Anil / Laeis, Petra / Lanz, Hans / Chen, Cathy / Valgimigli, Marco / Veltkamp, Roland / Saito, Shigeru / Dangas, George D

    The New England journal of medicine

    2021  Volume 385, Issue 23, Page(s) 2150–2160

    Abstract: Background: The role of direct oral anticoagulants as compared with vitamin K antagonists ... comparing edoxaban with vitamin K antagonists in patients with prevalent or incident atrial fibrillation ... per 100 person-years in the edoxaban group and 16.5 per 100 person-years in the vitamin K antagonist group ...

    Abstract Background: The role of direct oral anticoagulants as compared with vitamin K antagonists for atrial fibrillation after successful transcatheter aortic-valve replacement (TAVR) has not been well studied.
    Methods: We conducted a multicenter, prospective, randomized, open-label, adjudicator-masked trial comparing edoxaban with vitamin K antagonists in patients with prevalent or incident atrial fibrillation as the indication for oral anticoagulation after successful TAVR. The primary efficacy outcome was a composite of adverse events consisting of death from any cause, myocardial infarction, ischemic stroke, systemic thromboembolism, valve thrombosis, or major bleeding. The primary safety outcome was major bleeding. On the basis of a hierarchical testing plan, the primary efficacy and safety outcomes were tested sequentially for noninferiority, with noninferiority of edoxaban established if the upper boundary of the 95% confidence interval for the hazard ratio did not exceed 1.38. Superiority testing of edoxaban for efficacy would follow if noninferiority and superiority were established for major bleeding.
    Results: A total of 1426 patients were enrolled (713 in each group). The mean age of the patients was 82.1 years, and 47.5% of the patients were women. Almost all the patients had atrial fibrillation before TAVR. The rate of the composite primary efficacy outcome was 17.3 per 100 person-years in the edoxaban group and 16.5 per 100 person-years in the vitamin K antagonist group (hazard ratio, 1.05; 95% confidence interval [CI], 0.85 to 1.31; P = 0.01 for noninferiority). Rates of major bleeding were 9.7 per 100 person-years and 7.0 per 100 person-years, respectively (hazard ratio, 1.40; 95% CI, 1.03 to 1.91; P = 0.93 for noninferiority); the difference between groups was mainly due to more gastrointestinal bleeding with edoxaban. Rates of death from any cause or stroke were 10.0 per 100 person-years in the edoxaban group and 11.7 per 100 person-years in the vitamin K antagonist group (hazard ratio, 0.85; 95% CI, 0.66 to 1.11).
    Conclusions: In patients with mainly prevalent atrial fibrillation who underwent successful TAVR, edoxaban was noninferior to vitamin K antagonists as determined by a hazard ratio margin of 38% for a composite primary outcome of adverse clinical events. The incidence of major bleeding was higher with edoxaban than with vitamin K antagonists. (Funded by Daiichi Sankyo; ENVISAGE-TAVI AF ClinicalTrials.gov number, NCT02943785.).
    MeSH term(s) 4-Hydroxycoumarins/adverse effects ; 4-Hydroxycoumarins/therapeutic use ; Aged ; Aged, 80 and over ; Anticoagulants/adverse effects ; Anticoagulants/therapeutic use ; Atrial Fibrillation/drug therapy ; Factor Xa Inhibitors/adverse effects ; Factor Xa Inhibitors/therapeutic use ; Female ; Gastrointestinal Hemorrhage/chemically induced ; Humans ; Intention to Treat Analysis ; Kaplan-Meier Estimate ; Male ; Mortality ; Phenindione/analogs & derivatives ; Phenindione/therapeutic use ; Postoperative Complications/prevention & control ; Pyridines/adverse effects ; Pyridines/therapeutic use ; Thiazoles/adverse effects ; Thiazoles/therapeutic use ; Thromboembolism/prevention & control ; Transcatheter Aortic Valve Replacement/adverse effects ; Vitamin K/antagonists & inhibitors
    Chemical Substances 4-Hydroxycoumarins ; Anticoagulants ; Factor Xa Inhibitors ; Pyridines ; Thiazoles ; Vitamin K (12001-79-5) ; Phenindione (5M7Y6274ZE) ; fluindione (EQ35YMS20Q) ; edoxaban (NDU3J18APO)
    Language English
    Publishing date 2021-08-28
    Publishing country United States
    Document type Comparative Study ; Equivalence Trial ; Journal Article ; Multicenter Study ; Randomized Controlled Trial ; Research Support, Non-U.S. Gov't
    ZDB-ID 207154-x
    ISSN 1533-4406 ; 0028-4793
    ISSN (online) 1533-4406
    ISSN 0028-4793
    DOI 10.1056/NEJMoa2111016
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