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Article ; Online: A sequence similar to tRNA 3 Lys gene is embedded in HIV-1 U3-R and promotes minus-strand transfer.

Piekna-Przybylska, Dorota / DiChiacchio, Laura / Mathews, David H / Bambara, Robert A

2009 Volume 17, Issue 1, Page(s) 83–89

Abstract: We identified a sequence embedded in the U3-R region of HIV-1 RNA that is highly complementary ...

Abstract	We identified a sequence embedded in the U3-R region of HIV-1 RNA that is highly complementary to human tRNA(3)(Lys). The free energy of annealing to tRNA(3)(Lys) is significantly lower for this sequence and the primer-binding site than for other viral sequences of similar length. The only interruption in complementarity is a 29-nucleotide segment inserted where a tRNA intron would be expected. The insert contains the TATA box for viral RNA transcription. The embedded sequence includes a 9-nucleotide segment previously reported to aid minus-strand transfer by binding the primer tRNA(3)(Lys). Reconstituting transfer in vitro, we show that including segments from the embedded sequence in the acceptor template, beyond the 9 nucleotides, further increases transfer efficiency. We propose that a gene encoding tRNA(3)(Lys) was incorporated during HIV-1 evolution and retained, largely intact, because of its roles in transcription and strand transfer.
MeSH term(s)	Base Sequence ; Computational Biology ; Conserved Sequence/genetics ; Evolution, Molecular ; HIV-1/genetics ; Humans ; Molecular Sequence Data ; Oligonucleotides/genetics ; RNA, Transfer, Lys/genetics ; RNA, Viral/genetics ; Sequence Alignment ; Transcription, Genetic/genetics
Chemical Substances	Oligonucleotides ; RNA, Transfer, Lys ; RNA, Viral
Language	English
Publishing date	2009-12-06
Publishing country	United States
Document type	Journal Article ; Research Support, N.I.H., Extramural
ZDB-ID	2126708-X
ISSN	1545-9985 ; 1545-9993
ISSN (online)	1545-9985
ISSN	1545-9993
DOI	10.1038/nsmb.1687
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Article ; Online: Représentation sociale de la chimiothérapie et du cancer chez les étudiants de troisième cycle d’études médicales à Ouagadougou.

Tozoula Bambara, Augustin / Akanni, Fayçal / Zerbo, Roger

Bulletin du cancer

2019 Volume 106, Issue 10, Page(s) 860–867

Abstract: Introduction: The perceptions that postgraduate medical students have about cancer and chemotherapy could have an impact on the quality of their interactions with their future patients. We conducted this study in order to highlight their ... ...

Title translation	Social representation of chemotherapy and cancer among intern trainee doctor in Ouagadougou.
Abstract	Introduction: The perceptions that postgraduate medical students have about cancer and chemotherapy could have an impact on the quality of their interactions with their future patients. We conducted this study in order to highlight their representational field for chemotherapy and cancer. Method: From February 1st to May 31st 2018, 618 students from the 3rd cycle in medical studies from Saint-Thomas d'Aquin University and Ouaga I Pr Joseph Ki-Zerbo of the city of Ouagadougou took part in the study. They were given self-administered questionnaire, which include a collection of free and hierarchical evocations in response to the inducers "cancer" and "chemotherapy". They were also asked to propose arguments to convince and gain trust of a fictitious patient waiting for chemotherapy. Results: The fatal aspect of cancer was largely present in their representational world. The representational field of chemotherapy was related to the side effects and the expensive aspect of anticancer drugs. In spite of a negative representation of cancer, students were able to find words with positive connotations to convince patients waiting for chemotherapy to follow treatment. Discussion: Knowing these representations makes it possible to understand the stakes of the doctor-patient relationship in order to improve the training of future doctors, as well as the care of patients.
MeSH term(s)	Antineoplastic Agents/adverse effects ; Antineoplastic Agents/economics ; Antineoplastic Agents/therapeutic use ; Attitude of Health Personnel ; Burkina Faso ; Cross-Sectional Studies ; Drug Costs ; Education, Medical, Continuing ; Female ; Humans ; Male ; Neoplasms/drug therapy ; Neoplasms/mortality ; Neoplasms/psychology ; Patient Acceptance of Health Care/psychology ; Students, Medical/psychology ; Surveys and Questionnaires
Chemical Substances	Antineoplastic Agents
Language	French
Publishing date	2019-05-23
Publishing country	France
Document type	Journal Article
ZDB-ID	213270-9
ISSN	1769-6917 ; 0007-4551
ISSN (online)	1769-6917
ISSN	0007-4551
DOI	10.1016/j.bulcan.2019.04.005
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Article: Combining Procedural and Behavioral Treatments for Chronic Low Back Pain: A Pilot Feasibility Randomized Controlled Trial.

Tanus, Adrienne D / Nishio, Isuta / Williams, Rhonda / Friedly, Janna / Soares, Bosco / Anderson, Derek / Bambara, Jennifer / Dawson, Timothy / Hsu, Amy / Kim, Peggy Y / Krashin, Daniel / Piero, Larissa Del / Korpak, Anna / Timmons, Andrew / Suri, Pradeep

medRxiv : the preprint server for health sciences

2023

Abstract: Individual treatments for chronic low back pain (CLBP) have small magnitude effects. Combining different types of treatments may produce larger effects. This study used a 2×2 factorial randomized controlled trial (RCT) design to combine procedural and ... ...

Abstract	Individual treatments for chronic low back pain (CLBP) have small magnitude effects. Combining different types of treatments may produce larger effects. This study used a 2×2 factorial randomized controlled trial (RCT) design to combine procedural and behavioral treatments for CLBP. The study aims were to: (1) assess feasibility of conducting a factorial RCT of these treatments; and (2) estimate individual and combined treatment effects of (a) lumbar radiofrequency ablation (LRFA) of the dorsal ramus medial branch nerves (vs. a simulated LRFA control procedure) and (b) Activity Tracker-Informed Video-Enabled Cognitive Behavioral Therapy program for CLBP (AcTIVE-CBT) (vs. an educational control treatment) on back-related disability at 3 months post-randomization. Participants (n=13) were randomized in a 1:1:1:1 ratio. Feasibility goals included an enrollment proportion ≥30%, a randomization proportion ≥80%, and a ≥80% proportion of randomized participants completing the 3-month Roland-Morris Disability Questionnaire (RMDQ) primary outcome endpoint. An intent-to-treat analysis was used. The enrollment proportion was 62%, the randomization proportion was 81%, and all randomized participants completed the primary outcome. Though not statistically significant, there was a beneficial, moderate-magnitude effect of LRFA vs. control on 3-month RMDQ (-3.25 RMDQ points; 95% CI: -10.18, 3.67). There was a significant, beneficial, large-magnitude effect of AcTIVECBT vs. control (-6.29, 95% CI: -10.97, -1.60). Though not statistically significant, there was a beneficial, large effect of LRFA+AcTIVE-CBT vs. control (-8.37; 95% CI: -21.47, 4.74). We conclude that it is feasible to conduct an RCT combining procedural and behavioral treatments for CLBP.
Language	English
Publishing date	2023-06-05
Publishing country	United States
Document type	Preprint
DOI	10.1101/2023.06.02.23290392
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Article ; Online: Undernutrition in children aged 0-59 months by region and over time: secondary analysis of the Burkina Faso 2012-2018 National Nutrition Surveys.

Boua, Palwende Romuald / Rouamba, Toussaint / Bambara, Estelle / Kaboré, Saidou / Compaore, Ella W R / Ouedraogo, Boureima / Tinto, Halidou / Newell, Marie-Louise / Ward, Kate / Sorgho, Hermann

BMJ open

2023 Volume 13, Issue 9, Page(s) e066509

Abstract: The global burden of undernutrition remains high, responsible for significant under-five mortality in resource-limited settings. Numerous sustainable development goals (SDGs) are linked to nutrition, and nationally representative nutrition surveillance ... ...

Abstract	The global burden of undernutrition remains high, responsible for significant under-five mortality in resource-limited settings. Numerous sustainable development goals (SDGs) are linked to nutrition, and nationally representative nutrition surveillance is a key activity to track progress towards SDGs and guide efficient programmes. Objectives: The aim of this study is to look at spatial and temporal trends in undernutrition in children under 5 years age in Burkina Faso. Setting: We used data from annual National Nutrition Surveys using Standardised Monitoring and Assessment of Relief and Transitions methodology (anthropometry, morbidity) over 7 years (2012-2018) in Burkina Faso. Participants: Children of under 5 years from households selected through systemic sampling at countrywide level. Main outcome measures: Prevalence of stunting (height-for-age z-score, <-2), underweight (weight-for-age z-score, <-2) and wasting (weight-for-height z-score, <-2) at regional and national. We used general linear mixed models, adjusted by age, survey year, sex, presence of fever and/or diarrhoea, and poverty index to quantify the risk of undernutrition over time and by region of residence. Results: Between 2012 and 2018, decreases were observed overall in the prevalence of growth retardation (stunting) decreased from 33.0% (95% CI 32.3 to 33.8) in 2012 to 26.7% (95% CI 26.2 to 27.3) in 2018. Underweight reduced from 24.4% (95% CI 23.7 to 25.1) to 18.7% (95% CI 18.2 to 19.2) for the same period and wasting decreased from 10.8% (95% CI 10.3 to 11.3) in 2012 to 8.4% (95% CI 8.1 to 8.8) in 2018. However, there was substantial variation across the country, with increased risk of undernutrition in the regions of Sahel, East and Cascades primarily. High-risk regions were characterised by a lower poverty index and limited access to healthcare services. Conclusions: Our findings could inform national policymakers in refining and optimising resource allocation based on the identification of high-risk areas.
MeSH term(s)	Child ; Humans ; Child, Preschool ; Thinness/epidemiology ; Burkina Faso/epidemiology ; Malnutrition/epidemiology ; Cachexia ; Nutrition Surveys ; Growth Disorders/epidemiology
Language	English
Publishing date	2023-09-06
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2599832-8
ISSN	2044-6055 ; 2044-6055
ISSN (online)	2044-6055
ISSN	2044-6055
DOI	10.1136/bmjopen-2022-066509
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Article: Characterizing cassava farmer typologies and their seed sourcing practices to explore opportunities for economically sustainable seed business models in Rwanda.

Kilwinger, Fleur / Mugambi, Samuel / Manners, Rhys / Schut, Marc / Tumwegamire, Silver / Nduwumuremyi, Athanase / Bambara, Sylvie / Paauwe, Marthe / Almekinders, Conny

Outlook on agriculture

2021 Volume 50, Issue 4, Page(s) 441–454

Abstract: The overdependency on local cassava varieties and informal seed sources by farmers in Rwanda has contributed to the spread of cassava viral diseases. The use of improved planting materials made available through formal seed sources, that assure seed ... ...

Abstract	The overdependency on local cassava varieties and informal seed sources by farmers in Rwanda has contributed to the spread of cassava viral diseases. The use of improved planting materials made available through formal seed sources, that assure seed quality, is one way to prevent future disease outbreaks. In order to increase the availability of, and farmers access to, such materials there is increasing interest to develop seed business models. This study aims to understand seed sourcing practices of different farm typologies to inform the development of tailored seed business models. A total of 390 farmers were interviewed and the collected data was analyzed into clusters, resulting in seven farm typologies. Seed sourcing strategies, seed replacement dynamics and purchasing behavior of these typologies were explored via a seed tracing study. We find that more commercial oriented farmers have better access to formal seed sources. Nevertheless, the majority of farmers in all typologies accessed new varieties and quality cassava seed via informal channels. At both formal and informal sources, cash investments in seed were mainly made by the categories of better-off farmers, and were one-time investments to acquire a new variety. Based on farmers current seed sourcing practices, clarifications on the differences between farmers and their willingness-to-pay, the roles of seed degeneration, cost-benefit analysis, value propositions and profit formulas seem important requirements for the further development of viable cassava seed business models. We conclude that tailoring seed business models can have a high potential as it acknowledges differences among farmers, but that careful coordination is needed to ensure that one approach or intervention does not contrast with and/or undermine the others.
Language	English
Publishing date	2021-11-30
Publishing country	England
Document type	Journal Article
ZDB-ID	417465-3
ISSN	0030-7270
ISSN	0030-7270
DOI	10.1177/00307270211045408
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Article ; Online: So-called "historical" necrotic breast cancers: a terrifying actuality in Africa. The case of Burkina Faso.

Zongo, N / Windsouri, M / Bambara, H A / Some, O R / Bambara, A T / Ouangré, E / Zida, M / Bonkoungou, G / Sanou, A / Dubot, C / Dem, A

Medecine et sante tropicales

2019 Volume 28, Issue 4, Page(s) 434–438

Abstract: Study the epidemiological, diagnostic, and treatment features and outcomes of necrotic breast cancer in women. This observational, longitudinal, and descriptive study covered the period from January, 2011, to the end of May, 2016 at the Surgery and ... ...

Title translation	Les cancers du sein nécrotiques ou historiques : une réalité terrifiante en milieu africain. Cas du Burkina Faso.
Abstract	Study the epidemiological, diagnostic, and treatment features and outcomes of necrotic breast cancer in women. This observational, longitudinal, and descriptive study covered the period from January, 2011, to the end of May, 2016 at the Surgery and Gynecology Departments of Yalgado Ouedraogo University Hospital and Schiphra Medical Center. The study included all women with necrotic breast cancers. Survival was calculated by the Kaplan Meier method and survival comparison was possible with the log-rank method. À risk of error of 0.05 was allowed. Necrotic cancer accounted for 9.1% of all breast cancers. The median age of the patients was 46 years old. The median interval before consultation was 12.4 months. The histological type was invasive ductal carcinoma in 90.8% of cases. Surgery was performed in 51 patients (52%). It was a palliative (cleaning) procedure in 92.2% of cases. Chemotherapy was performed in 28 patients. Overall survival was 61.8% at 6 months, 39.5% at 1 year, and 9.2% at 3 years. Median survival was 10 months: 13 months for women with surgery and 6 months for those without it (p<0.001). Necrotic breast cancer is still common in Ouagadougou. Surgery is the mainstay of the treatment. Survival is mediocre. It therefore seems urgent to focus on raising population awareness and organizing screening campaigns.
MeSH term(s)	Adolescent ; Adult ; Aged ; Aged, 80 and over ; Anemia/epidemiology ; Breast Neoplasms/mortality ; Breast Neoplasms/pathology ; Breast Neoplasms/therapy ; Burkina Faso ; Carcinoma, Ductal, Breast ; Chemotherapy, Adjuvant/statistics & numerical data ; Female ; Humans ; Leukocytosis/epidemiology ; Longitudinal Studies ; Mastectomy/statistics & numerical data ; Middle Aged ; Necrosis ; Palliative Care/statistics & numerical data ; Time-to-Treatment ; Young Adult
Language	English
Publishing date	2019-02-22
Publishing country	France
Document type	Journal Article
ISSN	2261-2211
ISSN (online)	2261-2211
DOI	10.1684/mst.2018.0854
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Article ; Online: Characterizing cassava farmer typologies and their seed sourcing practices to explore opportunities for economically sustainable seed business models in Rwanda

Kilwinger, F.B. / Mugambi, S. / Manners, Rhys / Schut, Marc / Tumwegamire, S. / Nduwumuremyi, A. / Bambara, S. / Paauwe, M. / Almekinders, C.J.

Outlook on Agriculture

2022

Abstract	The overdependency on local cassava varieties and informal seed sources by farmers in Rwanda has contributed to the spread of cassava viral diseases. The use of improved planting materials made available through formal seed sources, that assure seed quality, is one way to prevent future disease outbreaks. In order to increase the availability of, and farmers access to, such materials there is increasing interest to develop seed business models. This study aims to understand seed sourcing practices of different farm typologies to inform the development of tailored seed business models. A total of 390 farmers were interviewed and the collected data was analyzed into clusters, resulting in seven farm typologies. Seed sourcing strategies, seed replacement dynamics and purchasing behavior of these typologies were explored via a seed tracing study. We find that more commercial oriented farmers have better access to formal seed sources. Nevertheless, the majority of farmers in all typologies accessed new varieties and quality cassava seed via informal channels. At both formal and informal sources, cash investments in seed were mainly made by the categories of better-off farmers, and were one-time investments to acquire a new variety. Based on farmers current seed sourcing practices, clarifications on the differences between farmers and their willingness-to-pay, the roles of seed degeneration, cost-benefit analysis, value propositions and profit formulas seem important requirements for the further development of viable cassava seed business models. We conclude that tailoring seed business models can have a high potential as it acknowledges differences among farmers, but that careful coordination is needed to ensure that one approach or intervention does not contrast with and/or undermine the others.
Keywords	seeds ; adoption ; cassava ; manihot esculenta ; varieties ; rwanda
Language	English
Publishing date	2022-01-31T11:43:20Z
Publisher	SAGE Publications
Publishing country	fr
Document type	Article ; Online
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Article ; Online: Les isoenzymes de l'anhydrase carbonique erythrocytaire des zebus et taurins Baoule

Queval, R. / Bambara, L.

Revue d’élevage et de médecine vétérinaire des pays tropicaux

2015

Abstract: Analyse des variants electrophoretiques de l'anhydrase carbonique erythrocytaire chez des taurins de race Baoule, dans une population locale de zebus, de croisements N'Dama x Baoule et de metis taurins x zebus au moyen de l'electrophorese sur acetate de ... ...

Abstract	Analyse des variants electrophoretiques de l'anhydrase carbonique erythrocytaire chez des taurins de race Baoule, dans une population locale de zebus, de croisements N'Dama x Baoule et de metis taurins x zebus au moyen de l'electrophorese sur acetate de cellulose, avec donnees sur les frequences geniques et alleliques et la distribution des phenotypes de l'anhydrase carbonique.
Keywords	cattle ; enzymes ; carbonate dehydratase ; electrophoresis
Language	French
Publishing date	2015-06-05T12:17:35Z
Publishing country	fr
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Characterizing cassava farmer typologies and their seed sourcing practices to explore opportunities for economically sustainable seed business models in Rwanda

Kilwinger, Fleur / Mugambi, Samuel / Manners, Rhys / Schut, Marc / Tumwegamire, Silver / Nduwumuremyi, Athanase / Bambara, Sylvie / Paauwe, Marthe / Almekinders, Conny

Outlook on Agriculture

2021 Volume 50, Issue 4

Abstract	The overdependency on local cassava varieties and informal seed sources by farmers in Rwanda has contributed to the spread of cassava viral diseases. The use of improved planting materials made available through formal seed sources, that assure seed quality, is one way to prevent future disease outbreaks. In order to increase the availability of, and farmers access to, such materials there is increasing interest to develop seed business models. This study aims to understand seed sourcing practices of different farm typologies to inform the development of tailored seed business models. A total of 390 farmers were interviewed and the collected data was analyzed into clusters, resulting in seven farm typologies. Seed sourcing strategies, seed replacement dynamics and purchasing behavior of these typologies were explored via a seed tracing study. We find that more commercial oriented farmers have better access to formal seed sources. Nevertheless, the majority of farmers in all typologies accessed new varieties and quality cassava seed via informal channels. At both formal and informal sources, cash investments in seed were mainly made by the categories of better-off farmers, and were one-time investments to acquire a new variety. Based on farmers current seed sourcing practices, clarifications on the differences between farmers and their willingness-to-pay, the roles of seed degeneration, cost-benefit analysis, value propositions and profit formulas seem important requirements for the further development of viable cassava seed business models. We conclude that tailoring seed business models can have a high potential as it acknowledges differences among farmers, but that careful coordination is needed to ensure that one approach or intervention does not contrast with and/or undermine the others.
Keywords	Seed-sourcing strategies ; adoption ; manihot esculenta ; seed tracing ; tailored approaches
Subject code	028
Language	English
Publishing country	nl
Document type	Article ; Online
ZDB-ID	417465-3
ISSN	0030-7270
ISSN	0030-7270
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Cidofovir Diphosphate Inhibits Adenovirus 5 DNA Polymerase via both Nonobligate Chain Termination and Direct Inhibition, and Polymerase Mutations Confer Cidofovir Resistance on Intact Virus.

Chamberlain, Jeffrey M / Sortino, Katherine / Sethna, Phiroze / Bae, Andrew / Lanier, Randall / Bambara, Robert A / Dewhurst, Stephen

Antimicrobial agents and chemotherapy

2018 Volume 63, Issue 1

Abstract: Human adenovirus (AdV) can cause fatal disease in immune-suppressed individuals, but treatment options are limited, in part because the antiviral cytidine analog cidofovir (CDV) is nephrotoxic. The investigational agent brincidofovir (BCV) is orally ... ...

Abstract	Human adenovirus (AdV) can cause fatal disease in immune-suppressed individuals, but treatment options are limited, in part because the antiviral cytidine analog cidofovir (CDV) is nephrotoxic. The investigational agent brincidofovir (BCV) is orally bioavailable, nonnephrotoxic, and generates the same active metabolite, cidofovir diphosphate (CDVpp). However, its mechanism of action against AdV is poorly understood. Therefore, we have examined the effect of CDVpp on DNA synthesis by a purified adenovirus 5 (AdV5) DNA polymerase (Pol). CDVpp was incorporated into nascent DNA strands and promoted a nonobligate form of chain termination (i.e., AdV5 Pol can extend, albeit inefficiently, a DNA chain even after the incorporation of a first CDVpp molecule). Moreover, unlike a conventional mismatched base pair, misincorporated CDVpp was not readily excised by the AdV5 Pol. At elevated concentrations, CDVpp inhibited AdV5 Pol in a manner consistent with both chain termination and direct inhibition of Pol activity. Finally, a recombinant AdV5 was constructed, containing Pol mutations (V303I and T87I) that were selected following an extended passage of wild-type AdV5 in the presence of BCV. This virus had a 2.1-fold elevated 50% effective concentration (EC
MeSH term(s)	Adenovirus Infections, Human/virology ; Adenoviruses, Human/drug effects ; Adenoviruses, Human/enzymology ; Adenoviruses, Human/genetics ; Adenoviruses, Human/isolation & purification ; Antiviral Agents/pharmacology ; Cidofovir/pharmacology ; Cytosine/analogs & derivatives ; Cytosine/metabolism ; Cytosine/pharmacology ; DNA Primers/chemical synthesis ; DNA Primers/genetics ; DNA, Viral/antagonists & inhibitors ; DNA, Viral/biosynthesis ; DNA, Viral/genetics ; DNA-Directed DNA Polymerase/genetics ; DNA-Directed DNA Polymerase/metabolism ; Dose-Response Relationship, Drug ; Humans ; Kinetics ; Mutation ; Organophosphonates/metabolism ; Organophosphonates/pharmacology ; Real-Time Polymerase Chain Reaction ; Recombinant Proteins/genetics ; Recombinant Proteins/metabolism ; Viral Proteins/genetics ; Viral Proteins/metabolism ; Virus Replication/drug effects ; Virus Replication/genetics
Chemical Substances	Antiviral Agents ; DNA Primers ; DNA, Viral ; Organophosphonates ; Recombinant Proteins ; Viral Proteins ; brincidofovir (6794O900AX) ; Cytosine (8J337D1HZY) ; DNA-Directed DNA Polymerase (EC 2.7.7.7) ; Cidofovir (JIL713Q00N)
Language	English
Publishing date	2018-12-21
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	217602-6
ISSN	1098-6596 ; 0066-4804
ISSN (online)	1098-6596
ISSN	0066-4804
DOI	10.1128/AAC.01925-18
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