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  1. Article ; Online: Eosinopenia as an early diagnostic marker of COVID-19 at the time of the epidemic.

    Xia, Zhengyuan

    EClinicalMedicine

    2020  Volume 23, Page(s) 100398

    Keywords covid19
    Language English
    Publishing date 2020-06-18
    Publishing country England
    Document type Journal Article
    ISSN 2589-5370
    ISSN (online) 2589-5370
    DOI 10.1016/j.eclinm.2020.100398
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Eosinopenia as an early diagnostic marker of COVID-19 at the time of the epidemic

    Zhengyuan Xia

    EClinicalMedicine, Vol 23, Iss , Pp 100398- (2020)

    2020  

    Keywords Medicine (General) ; R5-920 ; covid19
    Language English
    Publishing date 2020-06-01T00:00:00Z
    Publisher Elsevier
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  4. Article ; Online: Eosinopenia as an early diagnostic marker of COVID-19 at the time of the epidemic

    Xia, Zhengyuan

    EClinicalMedicine

    2020  Volume 23, Page(s) 100398

    Keywords covid19
    Language English
    Publisher Elsevier BV
    Publishing country us
    Document type Article ; Online
    ISSN 2589-5370
    DOI 10.1016/j.eclinm.2020.100398
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

    Full text online

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  5. Article: Salvianolic acids and its potential for cardio-protection against myocardial ischemic reperfusion injury in diabetes.

    Jiang, Yuxin / Cai, Yin / Han, Ronghui / Xu, Youhua / Xia, Zhengyuan / Xia, Weiyi

    Frontiers in endocrinology

    2024  Volume 14, Page(s) 1322474

    Abstract: The incidence of diabetes and related mortality rate increase yearly in modern cities. Additionally, elevated glucose levels can result in an increase of reactive oxygen species (ROS), ferroptosis, and the disruption of protective pathways in the heart. ... ...

    Abstract The incidence of diabetes and related mortality rate increase yearly in modern cities. Additionally, elevated glucose levels can result in an increase of reactive oxygen species (ROS), ferroptosis, and the disruption of protective pathways in the heart. These factors collectively heighten the vulnerability of diabetic individuals to myocardial ischemia. Reperfusion therapies have been effectively used in clinical practice. There are limitations to the current clinical methods used to treat myocardial ischemia-reperfusion injury. As a result, reducing post-treatment ischemia/reperfusion injury remains a challenge. Therefore, efforts are underway to provide more efficient therapy. Salvia miltiorrhiza Bunge (Danshen) has been used for centuries in ancient China to treat cardiovascular diseases (CVD) with rare side effects. Salvianolic acid is a water-soluble phenolic compound with potent antioxidant properties and has the greatest hydrophilic property in Danshen. It has recently been discovered that salvianolic acids A (SAA) and B (SAB) are capable of inhibiting apoptosis by targeting the JNK/Akt pathway and the NF-κB pathway, respectively. This review delves into the most recent discoveries regarding the therapeutic and cardioprotective benefits of salvianolic acid for individuals with diabetes. Salvianolic acid shows great potential in myocardial protection in diabetes mellitus. A thorough understanding of the protective mechanism of salvianolic acid could expand its potential uses in developing medicines for treating diabetes mellitus related myocardial ischemia-reperfusion.
    MeSH term(s) Humans ; Myocardial Reperfusion Injury/drug therapy ; Myocardial Reperfusion Injury/prevention & control ; Myocardial Reperfusion Injury/metabolism ; Heart ; Myocardium/metabolism ; Diabetes Mellitus/metabolism ; Alkenes ; Polyphenols
    Chemical Substances salvianolic acid ; Alkenes ; Polyphenols
    Language English
    Publishing date 2024-01-12
    Publishing country Switzerland
    Document type Journal Article ; Review ; Research Support, Non-U.S. Gov't
    ZDB-ID 2592084-4
    ISSN 1664-2392
    ISSN 1664-2392
    DOI 10.3389/fendo.2023.1322474
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: Author's reply.

    Lei, Shaoqing / Xia, Zhong-Yuan / Xia, Zhengyuan

    EClinicalMedicine

    2020  Volume 23, Page(s) 100386

    Keywords covid19
    Language English
    Publishing date 2020-05-18
    Publishing country England
    Document type Journal Article
    ISSN 2589-5370
    ISSN (online) 2589-5370
    DOI 10.1016/j.eclinm.2020.100386
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article ; Online: Author's reply - factors affecting the mortality of patients with COVID-19 undergoing surgery and the safety of medical staff: A systematic review and meta-analysis.

    Wang, Kun / Wu, Changshuai / Xia, Zhengyuan

    EClinicalMedicine

    2021  Volume 31, Page(s) 100704

    Language English
    Publishing date 2021-01-15
    Publishing country England
    Document type Journal Article
    ISSN 2589-5370
    ISSN (online) 2589-5370
    DOI 10.1016/j.eclinm.2020.100704
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article ; Online: Author's reply - factors affecting the mortality of patients with COVID-19 undergoing surgery and the safety of medical staff

    Kun Wang / Changshuai Wu / Zhengyuan Xia

    EClinicalMedicine, Vol 31, Iss , Pp 100704- (2021)

    A systematic review and meta-analysis

    2021  

    Keywords Medicine (General) ; R5-920
    Language English
    Publishing date 2021-01-01T00:00:00Z
    Publisher Elsevier
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

    Full text online

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    Inter-library loan at ZB MED

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  9. Article ; Online: Exploring the therapeutic potential of tetrahydrobiopterin for heart failure with preserved ejection fraction: A path forward.

    Xia, Weiyi / Zhang, Miao / Liu, Chang / Wang, Sheng / Xu, Aimin / Xia, Zhengyuan / Pang, Lei / Cai, Yin

    Life sciences

    2024  Volume 345, Page(s) 122594

    Abstract: A large number of patients are affected by classical heart failure (HF) symptomatology with preserved ejection fraction (HFpEF) and multiorgan syndrome. Due to high morbidity and mortality rate, hospitalization and mortality remain serious socioeconomic ... ...

    Abstract A large number of patients are affected by classical heart failure (HF) symptomatology with preserved ejection fraction (HFpEF) and multiorgan syndrome. Due to high morbidity and mortality rate, hospitalization and mortality remain serious socioeconomic problems, while the lack of effective pharmacological or device treatment means that HFpEF presents a major unmet medical need. Evidence from clinical and basic studies demonstrates that systemic inflammation, increased oxidative stress, and impaired mitochondrial function are the common pathological mechanisms in HFpEF. Tetrahydrobiopterin (BH4), beyond being an endogenous co-factor for catalyzing the conversion of some essential biomolecules, has the capacity to prevent systemic inflammation, enhance antioxidant resistance, and modulate mitochondrial energy production. Therefore, BH4 has emerged in the last decade as a promising agent to prevent or reverse the progression of disorders such as cardiovascular disease. In this review, we cover the clinical progress and limitations of using downstream targets of nitric oxide (NO) through NO donors, soluble guanylate cyclase activators, phosphodiesterase inhibitors, and sodium-glucose co-transporter 2 inhibitors in treating cardiovascular diseases, including HFpEF. We discuss the use of BH4 in association with HFpEF, providing new evidence for its potential use as a pharmacological option for treating HFpEF.
    MeSH term(s) Humans ; Heart Failure/drug therapy ; Stroke Volume ; Biopterins/therapeutic use ; Biopterins/analogs & derivatives ; Inflammation ; Sodium-Glucose Transporter 2 Inhibitors/pharmacology
    Chemical Substances sapropterin (EGX657432I) ; Biopterins ; Sodium-Glucose Transporter 2 Inhibitors
    Language English
    Publishing date 2024-03-25
    Publishing country Netherlands
    Document type Journal Article ; Review
    ZDB-ID 3378-9
    ISSN 1879-0631 ; 0024-3205
    ISSN (online) 1879-0631
    ISSN 0024-3205
    DOI 10.1016/j.lfs.2024.122594
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article ; Online: Author's reply - Clinical characteristics and outcomes of patients undergoing surgeries during the incubation period of COVID-19 infection.

    Lei, Shaoqing / Jiang, Fang / Xia, Zhong-Yuan / Xia, Zhengyuan

    EClinicalMedicine

    2020  Volume 22, Page(s) 100363

    Keywords covid19
    Language English
    Publishing date 2020-04-29
    Publishing country England
    Document type Journal Article
    ISSN 2589-5370
    ISSN (online) 2589-5370
    DOI 10.1016/j.eclinm.2020.100363
    Database MEDical Literature Analysis and Retrieval System OnLINE

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