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  1. Article ; Online: Serum LDH levels may predict poor neurological outcome after aneurysmal subarachnoid hemorrhage.

    Cavalli, Irene / Stella, Claudia / Stoll, Timothée / Mascia, Luciana / Salvagno, Michele / Coppalini, Giacomo / Diosdado, Alberto / Menozzi, Marco / Diaferia, Daniela / Ndieugnou Djangang, Narcisse / Oliveira, Fernando / Schuind, Sophie / Taccone, Fabio Silvio / Gouvêa Bogossian, Elisa

    BMC neurology

    2023  Volume 23, Issue 1, Page(s) 228

    Abstract: Introduction: Serum lactate dehydrogenase (LDH) levels are often elevated in cardiovascular diseases. Their prognostic role after subarachnoid hemorrhage (SAH) remains poorly evaluated.: Methods: This is a retrospective single-center study of ... ...

    Abstract Introduction: Serum lactate dehydrogenase (LDH) levels are often elevated in cardiovascular diseases. Their prognostic role after subarachnoid hemorrhage (SAH) remains poorly evaluated.
    Methods: This is a retrospective single-center study of patients with non-traumatic SAH admitted to the intensive care unit (ICU) of an University Hospital from 2007 to 2022. Exclusion criteria were pregnancy and incomplete medical records or follow-up data. Baseline information, clinical data, radiologic data, the occurrence of neurological complications as well as serum LDH levels during the first 14 days of ICU stay were collected. Unfavorable neurological outcome (UO) at 3 months was defined as a Glasgow Outcome Scale of 1-3.
    Results: Five hundred and forty-seven patients were included; median serum LDH values on admission and the highest LDH values during the ICU stay were 192 [160-230] IU/L and 263 [202-351] IU/L, respectively. The highest LDH value was recorded after a median of 4 [2-10] days after ICU admission. LDH levels on admission were significantly higher in patients with UO. When compared with patients with favorable outcome (FO), patients with UO had higher serum LDH values over time. In the multivariate logistic regression model, the highest LDH value over the ICU stay (OR 1.004 [95% CI 1.002 - 1.006]) was independently associated with the occurrence of UO; the area under the receiving operator (AUROC) curve for the highest LDH value over the ICU stay showed a moderate accuracy to predict UO (AUC 0.76 [95% CI 0.72-0.80]; p < 0.001), with an optimal threshold of > 272 IU/L (69% sensitivity and 74% specificity).
    Conclusions: The results in this study suggest that high serum LDH levels are associated with the occurrence of UO in SAH patients. As a readily and available biomarker, serum LDH levels should be evaluated to help with the prognostication of SAH patients.
    MeSH term(s) Female ; Pregnancy ; Humans ; Subarachnoid Hemorrhage/complications ; Retrospective Studies ; Cardiovascular Diseases ; Glasgow Outcome Scale ; Hospitalization
    Language English
    Publishing date 2023-06-13
    Publishing country England
    Document type Journal Article
    ZDB-ID 2041347-6
    ISSN 1471-2377 ; 1471-2377
    ISSN (online) 1471-2377
    ISSN 1471-2377
    DOI 10.1186/s12883-023-03282-8
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Phosphatase alkaline levels are not associated with poor outcomes in subarachnoid hemorrhage patients.

    Diosdado, Alberto / Ndieugnou Djangang, Narcisse / Diaferia, Daniela / Minini, Andrea / Casu, Giuseppe Stefano / Peluso, Lorenzo / Menozzi, Marco / Schuind, Sophie / Creteur, Jacques / Taccone, Fabio Silvio / Gouvêa Bogossian, Elisa

    Clinical neurology and neurosurgery

    2022  Volume 215, Page(s) 107185

    Abstract: Introduction: Alkaline phosphatase (ALP) levels are often elevated in cerebrovascular and cardiovascular disease. Their prognostic role after subarachnoid hemorrhage (SAH) remains to be elucidated.: Methods: We performed a retrospective single center ...

    Abstract Introduction: Alkaline phosphatase (ALP) levels are often elevated in cerebrovascular and cardiovascular disease. Their prognostic role after subarachnoid hemorrhage (SAH) remains to be elucidated.
    Methods: We performed a retrospective single center study of patients with non-traumatic SAH admitted to the intensive care unit (ICU) of Erasme Hospital (Brussels, Belgium) from 2006 to 2019. Exclusion criteria were previous history of liver cirrhosis or malignancies and early death (i.e. within 24 h from ICU admission). Baseline information, clinical data, radiologic data were collected, the occurrence of DCI as well as serum ALP levels during the first 12 days of ICU stay. Unfavorable neurological outcome (UO) at 3 months was defined as a Glasgow Outcome Scale of 1-3.
    Results: Six hundred and fifty patients were included; ALP levels increased from baseline after day 6 from admission, in particular among patients with an initial poor clinical status. There was no difference in the ALP levels between patients with or without DCI over time. Patients with UO had higher ALP levels over time than others; however, in the multivariable analysis, nor ALP levels on admission or the highest ALP value during the ICU stay were independently associated with UO.
    Conclusions: The results of this study suggested that ALP levels had no prognostic role in SAH patients. Other possible prognostic biomarkers should be evaluated in this setting.
    MeSH term(s) Glasgow Outcome Scale ; Humans ; Intensive Care Units ; Phosphoric Monoester Hydrolases ; Retrospective Studies ; Subarachnoid Hemorrhage/complications
    Chemical Substances Phosphoric Monoester Hydrolases (EC 3.1.3.2)
    Language English
    Publishing date 2022-02-24
    Publishing country Netherlands
    Document type Journal Article
    ZDB-ID 193107-6
    ISSN 1872-6968 ; 0303-8467
    ISSN (online) 1872-6968
    ISSN 0303-8467
    DOI 10.1016/j.clineuro.2022.107185
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Evaluation of nociception in unconscious critically ill patients using a multimodal approach.

    Fratino, Sara / Garré, Annalisa / Garufi, Alessandra / Hafidi, Sofia / Migliorino, Ernesto / Stropeni, Serena / Bogossian, Elisa Gouvea / Ndieugnou Djangang, Narcisse / Albano, Giovanni / Creteur, Jacques / Peluso, Lorenzo / Taccone, Fabio Silvio

    Anaesthesia, critical care & pain medicine

    2022  Volume 42, Issue 2, Page(s) 101175

    Abstract: This prospective observational study included 80 adults (>18 years) patients admitted to the intensive care unit who were unconscious (Glasgow Coma Scale [GCS] score <9 with a motor response <5) and receiving mechanical ventilation. A tetanic stimulation ...

    Abstract This prospective observational study included 80 adults (>18 years) patients admitted to the intensive care unit who were unconscious (Glasgow Coma Scale [GCS] score <9 with a motor response <5) and receiving mechanical ventilation. A tetanic stimulation was used to assess nociception; automated pupillometry (Algiscan, ID-MED, France) was used to compute the pupillary pain index score (PPI), with a PPI > 4 considered as nociception. Concomitantly, the number of skin conductance fluctuations (NSCF) per second, measured using a Skin Conductance Algesimeter (SCA, MEDSTORM Innovation AS, Norway; > 0.27 fluctuations/sec indicating nociception), and the instantaneous Analgesia Nociception Index (iANI, MDoloris Medical Systems, France; <50 indicating nociception) were collected. Tetanic stimulation resulted in a median pupillary dilation of 16 [6-25]% and a PPI of 5 [2-7]. According to the PPI assessment, 44 patients (55%) had nociception, whereas 23 (29%) and 18 (23%) showed nociception according to the algesimeter and iANI assessment, respectively. No significant changes in measured physiologic variables were observed after the tetanic stimulation. There were no correlations between PPI, post-stimulation iANI, and SCA-derived variables. There were no differences in PPI, iANI, and SCA variables in patients with low and normal baseline EEG power at baseline. PERSPECTIVES: Detection of nociception varies across different devices in unconscious critically ill patients. Further studies are required to understand which method to implement for analgesic administration in this patient population.
    MeSH term(s) Adult ; Humans ; Nociception/physiology ; Critical Illness ; Pain ; Analgesia/methods ; Pain Management
    Language English
    Publishing date 2022-11-14
    Publishing country France
    Document type Observational Study ; Journal Article
    ISSN 2352-5568
    ISSN (online) 2352-5568
    DOI 10.1016/j.accpm.2022.101175
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article: Eosinopenia in COVID-19 Patients: A Retrospective Analysis.

    Ndieugnou Djangang, Narcisse / Peluso, Lorenzo / Talamonti, Marta / Izzi, Antonio / Gevenois, Pierre Alain / Garufi, Alessandra / Goffard, Jean-Christophe / Henrard, Sophie / Severgnini, Paolo / Vincent, Jean-Louis / Creteur, Jacques / Taccone, Fabio Silvio

    Microorganisms

    2020  Volume 8, Issue 12

    Abstract: ... ...

    Abstract Objectives
    Language English
    Publishing date 2020-12-04
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2720891-6
    ISSN 2076-2607
    ISSN 2076-2607
    DOI 10.3390/microorganisms8121929
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: Brain tissue oxygenation guided therapy and outcome in non-traumatic subarachnoid hemorrhage.

    Gouvea Bogossian, Elisa / Diaferia, Daniela / Ndieugnou Djangang, Narcisse / Menozzi, Marco / Vincent, Jean-Louis / Talamonti, Marta / Dewitte, Olivier / Peluso, Lorenzo / Barrit, Sami / Al Barajraji, Mejdeddine / Andre, Joachim / Schuind, Sophie / Creteur, Jacques / Taccone, Fabio Silvio

    Scientific reports

    2021  Volume 11, Issue 1, Page(s) 16235

    Abstract: Brain hypoxia can occur after non-traumatic subarachnoid hemorrhage (SAH), even when levels of intracranial pressure (ICP) remain normal. Brain tissue oxygenation ( ... ...

    Abstract Brain hypoxia can occur after non-traumatic subarachnoid hemorrhage (SAH), even when levels of intracranial pressure (ICP) remain normal. Brain tissue oxygenation (PbtO
    MeSH term(s) Cohort Studies ; Female ; Follow-Up Studies ; Humans ; Hypoxia, Brain/pathology ; Hypoxia, Brain/therapy ; Male ; Middle Aged ; Outcome Assessment, Health Care ; Oxygen/administration & dosage ; Oxygen Inhalation Therapy/methods ; Prognosis ; Subarachnoid Hemorrhage/pathology ; Subarachnoid Hemorrhage/therapy ; Survival Rate
    Chemical Substances Oxygen (S88TT14065)
    Language English
    Publishing date 2021-08-10
    Publishing country England
    Document type Journal Article
    ZDB-ID 2615211-3
    ISSN 2045-2322 ; 2045-2322
    ISSN (online) 2045-2322
    ISSN 2045-2322
    DOI 10.1038/s41598-021-95602-6
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article: Automated Pupillometry for Prediction of Electroencephalographic Reactivity in Critically Ill Patients: A Prospective Cohort Study.

    Peluso, Lorenzo / Ferlini, Lorenzo / Talamonti, Marta / Ndieugnou Djangang, Narcisse / Gouvea Bogossian, Elisa / Menozzi, Marco / Annoni, Filippo / Macchini, Elisabetta / Legros, Benjamin / Severgnini, Paolo / Creteur, Jacques / Oddo, Mauro / Vincent, Jean-Louis / Gaspard, Nicolas / Taccone, Fabio Silvio

    Frontiers in neurology

    2022  Volume 13, Page(s) 867603

    Abstract: Background: Electroencephalography (EEG) is widely used to monitor critically ill patients. However, EEG interpretation requires the presence of an experienced neurophysiologist and is time-consuming. Aim of this study was to evaluate whether parameters ...

    Abstract Background: Electroencephalography (EEG) is widely used to monitor critically ill patients. However, EEG interpretation requires the presence of an experienced neurophysiologist and is time-consuming. Aim of this study was to evaluate whether parameters derived from an automated pupillometer (AP) might help to assess the degree of cerebral dysfunction in critically ill patients.
    Methods: Prospective study conducted in the Department of Intensive Care of Erasme University Hospital in Brussels, Belgium. Pupillary assessments were performed using the AP in three subgroups of patients, concomitantly monitored with continuous EEG: "anoxic brain injury", "Non-anoxic brain injury" and "other diseases". An independent neurologist blinded to patient's history and AP results scored the degree of encephalopathy and reactivity on EEG using a standardized scale. The mean value of Neurologic Pupil Index (NPi), pupillary size, constriction rate, constriction and dilation velocity (CV and DV) and latency for both eyes, obtained using the NPi®-200 (Neuroptics, Laguna Hills, CA, USA), were reported.
    Results: We included 214 patients (mean age 60 years, 55% male). EEG tracings were categorized as: mild (
    Conclusions: This study suggests that low DV measured by the AP might effectively identify an unreactive EEG background, in particular in critically ill patients without anoxic brain injury.
    Language English
    Publishing date 2022-03-21
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2564214-5
    ISSN 1664-2295
    ISSN 1664-2295
    DOI 10.3389/fneur.2022.867603
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article ; Online: Time course of outcome in poor grade subarachnoid hemorrhage patients: a longitudinal retrospective study.

    Gouvêa Bogossian, Elisa / Diaferia, Daniela / Minini, Andrea / Ndieugnou Djangang, Narcisse / Menozzi, Marco / Peluso, Lorenzo / Annoni, Filippo / Creteur, Jacques / Schuind, Sophie / Dewitte, Olivier / Taccone, Fabio Silvio

    BMC neurology

    2021  Volume 21, Issue 1, Page(s) 196

    Abstract: Background: Neurological outcome and mortality of patients suffering from poor grade subarachnoid hemorrhage (SAH) may have changed over time. Several factors, including patients' characteristics, the presence of hydrocephalus and intraparenchymal ... ...

    Abstract Background: Neurological outcome and mortality of patients suffering from poor grade subarachnoid hemorrhage (SAH) may have changed over time. Several factors, including patients' characteristics, the presence of hydrocephalus and intraparenchymal hematoma, might also contribute to this effect. The aim of this study was to assess the temporal changes in mortality and neurologic outcome in SAH patients and identify their predictors.
    Methods: We performed a single center retrospective cohort study from 2004 to 2018. All non-traumatic SAH patients with poor grade on admission (WFNS score of 4 or 5) who remained at least 24 h in the hospital were included. Time course was analyzed into four groups according to the years of admission (2004-2007; 2008-2011; 2012-2015 and 2016-2018).
    Results: A total of 353 patients were included in this study: 202 patients died (57 %) and 260 (74 %) had unfavorable neurological outcome (UO) at 3 months. Mortality tended to decrease in in 2008-2011 and 2016-2018 periods (HR 0.55 [0.34-0.89] and HR 0.33 [0.20-0.53], respectively, when compared to 2004-2007). The proportion of patients with UO remained high and did not vary significantly over time. Patients with WFNS 5 had higher mortality (68 % vs. 34 %, p = 0.001) and more frequent UO (83 % vs. 54 %, p = 0.001) than those with WFNS 4. In the multivariable analysis, WFNS 5 was independently associated with mortality (HR 2.12 [1.43-3.14]) and UO (OR 3.23 [1.67-6.25]). The presence of hydrocephalus was associated with a lower risk of mortality (HR 0.60 [0.43-0.84]).
    Conclusions: Both hospital mortality and UO remained high in poor grade SAH patients. Patients with WFNS 5 on admission had worse prognosis than others; this should be taken into consideration for future clinical studies.
    MeSH term(s) Adult ; Aged ; Cohort Studies ; Female ; Hematoma/pathology ; Hospital Mortality ; Humans ; Longitudinal Studies ; Male ; Middle Aged ; Retrospective Studies ; Subarachnoid Hemorrhage/mortality ; Subarachnoid Hemorrhage/pathology ; Treatment Outcome
    Language English
    Publishing date 2021-05-13
    Publishing country England
    Document type Journal Article
    ISSN 1471-2377
    ISSN (online) 1471-2377
    DOI 10.1186/s12883-021-02229-1
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article ; Online: Fever management in critically ill COVID-19 patients: a retrospective analysis.

    Peluso, Lorenzo / Montanaro, Federica / Izzi, Antonio / Garufi, Alessandra / Ndieugnou Djangang, Narcisse / Polain, Amandine / Minini, Andrea / Gouvea Bogossian, Elisa / Annoni, Filippo / Spadaro, Savino / Creteur, Jacques / Taccone, Fabio S

    Minerva anestesiologica

    2021  Volume 87, Issue 11, Page(s) 1217–1225

    Abstract: Background: Fever has been reported as a common symptom in COVID-19 patients. The aim of the study was to describe the characteristics of COVID-19 critically ill patients with fever and to assess if fever management had an impact on some physiologic ... ...

    Abstract Background: Fever has been reported as a common symptom in COVID-19 patients. The aim of the study was to describe the characteristics of COVID-19 critically ill patients with fever and to assess if fever management had an impact on some physiologic variables.
    Methods: This is a retrospective monocentric cohort analysis of critically ill COVID-19 patients admitted to the Department of Intensive Care Unit (ICU) of Erasme Hospital, Brussels, Belgium, between March 2020 and May 2020. Fever was defined as body temperature ≥38 °C during the ICU stay. We assessed the independent predictors of fever during ICU stay. We reported the clinical and physiological variables before and after the first treated episode of fever during the ICU stay.
    Results: A total of 72 critically ill COVID-19 patients were admitted to the ICU over the study period and were all eligible for the final analysis; 53 (74%) of them developed fever, after a median of 4 [0-13] hours since ICU admission. In the multivariable analysis, male gender (OR 5.41 [C.I. 95% 1.34-21.92]; P=0.02) and low PaO<inf>2</inf>/FiO<inf>2</inf> ratio (OR 0.99 [C.I. 95% 0.99-1.00]; P=0.04) were independently associated with fever. After the treatment of the first febrile episode, heart rate and respiratory rate significantly decreased together with an increase in PaO<inf>2</inf> and SaO<inf>2</inf>.
    Conclusions: In our study, male gender and severe impairment of oxygenation were independently associated with fever in critically ill COVID-19 patients. Fever treatment reduced heart rate and respiratory rate and improved systemic oxygenation.
    MeSH term(s) COVID-19 ; Critical Illness ; Humans ; Intensive Care Units ; Male ; Retrospective Studies ; SARS-CoV-2
    Language English
    Publishing date 2021-08-02
    Publishing country Italy
    Document type Journal Article
    ZDB-ID 123584-9
    ISSN 1827-1596 ; 0026-4717 ; 0375-9393
    ISSN (online) 1827-1596
    ISSN 0026-4717 ; 0375-9393
    DOI 10.23736/S0375-9393.21.15711-6
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article ; Online: Interleukine-6 in critically ill COVID-19 patients: A retrospective analysis.

    Gorham, Julie / Moreau, Anthony / Corazza, Francis / Peluso, Lorenzo / Ponthieux, Fanny / Talamonti, Marta / Izzi, Antonio / Nagant, Carole / Ndieugnou Djangang, Narcisse / Garufi, Alessandra / Creteur, Jacques / Taccone, Fabio Silvio

    PloS one

    2020  Volume 15, Issue 12, Page(s) e0244628

    Abstract: Introduction: Coronavirus disease 2019 (COVID-19) appeared in China in December 2019 and has spread around the world. High Interleukin-6 (IL-6) levels in COVID-19 patients suggest that a cytokine storm may play a major role in the pathophysiology and ... ...

    Abstract Introduction: Coronavirus disease 2019 (COVID-19) appeared in China in December 2019 and has spread around the world. High Interleukin-6 (IL-6) levels in COVID-19 patients suggest that a cytokine storm may play a major role in the pathophysiology and are considered as a relevant parameter in predicting most severe course of disease. The aim of this study was to assess repeated IL-6 levels in critically ill COVID-19 patients admitted to our Intensive Care Unit (ICU) and to evaluate their relationship with patient's severity and outcome.
    Methods: We conducted a retrospective study on patients admitted to the ICU with a diagnosis of COVID-19 between March 10 (i.e. the date of the first admitted patients) and April 30, 2020. Demographic, clinical and laboratory data were collected at admission. On the day of IL-6 blood concentration measurement, we also collected results of D-Dimers, C-Reactive Protein, white blood cells and lymphocytes count, lactate dehydrogenase (LDH) and ferritin as well as microbiological samples, whenever present.
    Results: Of a total of 65 patients with COVID-19 admitted to our ICU we included 41 patients with repeated measure of IL-6. There was a significant difference in IL-6 levels between survivors and non-survivors over time (p = 0.001); moreover, non survivors had a significantly higher IL-6 maximal value when compared to survivors (720 [349-2116] vs. 336 [195-646] pg/mL, p = 0.01). The IL-6 maximal value had a significant predictive value of ICU mortality (AUROC 0.73 [95% CI 0.57-0.89]; p = 0.01).
    Conclusions: Repeated measurements of IL-6 can help clinicians in identifying critically ill COVID-19 patients with the highest risk of poor prognosis.
    MeSH term(s) COVID-19/blood ; COVID-19/mortality ; Critical Illness ; Cytokine Release Syndrome/blood ; Cytokine Release Syndrome/mortality ; Disease-Free Survival ; Female ; Humans ; Interleukin-6/blood ; Male ; Middle Aged ; Retrospective Studies ; SARS-CoV-2 ; Severity of Illness Index ; Survival Rate
    Chemical Substances IL6 protein, human ; Interleukin-6
    Language English
    Publishing date 2020-12-31
    Publishing country United States
    Document type Clinical Trial ; Journal Article
    ZDB-ID 2267670-3
    ISSN 1932-6203 ; 1932-6203
    ISSN (online) 1932-6203
    ISSN 1932-6203
    DOI 10.1371/journal.pone.0244628
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  10. Article: Eosinopenia in COVID-19 Patients: A Retrospective Analysis

    Ndieugnou Djangang, Narcisse / Peluso, Lorenzo / Talamonti, Marta / Izzi, Antonio / Gevenois, Pierre Alain / Garufi, Alessandra / Goffard, Jean-Christophe / Henrard, Sophie / Severgnini, Paolo / Vincent, Jean-Louis / Creteur, Jacques / Taccone, Fabio Silvio

    Microorganisms. 2020 Dec. 04, v. 8, no. 12

    2020  

    Abstract: Objectives: The aim of this study was to assess the diagnostic role of eosinophils count in COVID-19 patients. Methods: Retrospective analysis of patients admitted to our hospital with suspicion of COVID-19. Demographic, clinical and laboratory data were ...

    Abstract Objectives: The aim of this study was to assess the diagnostic role of eosinophils count in COVID-19 patients. Methods: Retrospective analysis of patients admitted to our hospital with suspicion of COVID-19. Demographic, clinical and laboratory data were collected on admission. Eosinopenia was defined as eosinophils < 100 cells/mm³. The outcomes of this study were the association between eosinophils count on admission and positive real-time reverse transcription polymerase chain reaction (rRT-PCR) test and with suggestive chest computerized tomography (CT) of COVID-19 pneumonia. Results: A total of 174 patients was studied. Of those, 54% had positive rRT-PCR for SARS-CoV-2. A chest CT-scan was performed in 145 patients; 71% showed suggestive findings of COVID-19. Eosinophils on admission had a high predictive accuracy for positive rRT-PCR and suggestive chest CT-scan (area under the receiver operating characteristic—ROC curve, 0.84 (95% CIs 0.78–0.90) and 0.84 (95% CIs 0.77–0.91), respectively). Eosinopenia and high LDH were independent predictors of positive rRT-PCR, whereas eosinopenia, high body mass index and hypertension were predictors for suggestive CT-scan findings. Conclusions: Eosinopenia on admission could predict positive rRT-PCR test or suggestive chest CT-scan for COVID-19. This laboratory finding could help to identify patients at high-risk of COVID-19 in the setting where gold standard diagnostic methods are not available.
    Keywords Coronavirus infections ; accuracy ; area ; body mass index ; chest ; diagnostic techniques ; eosinophils ; gold ; hospitals ; hypertension ; laboratories ; microorganisms ; objectives ; patients ; pneumonia ; retrospective studies ; reverse transcriptase polymerase chain reaction ; tomography
    Language English
    Dates of publication 2020-1204
    Publishing place Multidisciplinary Digital Publishing Institute
    Document type Article
    Note NAL-light
    ZDB-ID 2720891-6
    ISSN 2076-2607
    ISSN 2076-2607
    DOI 10.3390/microorganisms8121929
    Database NAL-Catalogue (AGRICOLA)

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