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  1. Article: Millet: A "Gluten-free" and "Healthy" Cereal With the Potential to Induce Anaphylaxis.

    Baptista Serna, L / Sastre, B / Rodrigo-Muñoz, J M / Valverde-Monge, M / Sastre, J / Del Pozo, V

    Journal of investigational allergology & clinical immunology

    2022  Volume 33, Issue 2, Page(s) 145–146

    MeSH term(s) Humans ; Anaphylaxis/diagnosis ; Anaphylaxis/etiology ; Edible Grain/adverse effects ; Millets ; Seeds
    Language English
    Publishing date 2022-05-18
    Publishing country Spain
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 1128657-x
    ISSN 1018-9068
    ISSN 1018-9068
    DOI 10.18176/jiaci.0826
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 3487: Show issues Location:
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  2. Article: What Is the Limit? Anaphylaxis After Intake of a Whey Sport Supplement Shake by a Cow's Milk-Tolerant Patient.

    Villalobos-Vilda, C / Lendínez, M A / Lorente-Sorolla, C / Rodrigo-Muñoz, J M / Del Pozo, V

    Journal of investigational allergology & clinical immunology

    2022  Volume 33, Issue 3, Page(s) 228–229

    MeSH term(s) Animals ; Female ; Cattle ; Humans ; Milk/adverse effects ; Anaphylaxis/diagnosis ; Anaphylaxis/etiology ; Whey ; Whey Proteins/adverse effects ; Milk Proteins/adverse effects ; Allergens ; Milk Hypersensitivity
    Chemical Substances Whey Proteins ; Milk Proteins ; Allergens
    Language English
    Publishing date 2022-06-14
    Publishing country Spain
    Document type Journal Article
    ZDB-ID 1128657-x
    ISSN 1018-9068
    ISSN 1018-9068
    DOI 10.18176/jiaci.0836
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Obese Asthma Phenotype Is Associated with hsa-miR-26a-1-3p and hsa-miR-376a-3p Modulating the IGF Axis.

    Gil-Martínez, Marta / Lorente-Sorolla, Clara / Rodrigo-Muñoz, José M / Naharro, Sara / García-de Castro, Zahara / Sastre, Joaquín / Valverde-Monge, Marcela / Quirce, Santiago / Caballero, María L / Olaguibel, José M / Del Pozo, Victoria

    International journal of molecular sciences

    2023  Volume 24, Issue 14

    Abstract: Clarifying inflammatory processes and categorising asthma into phenotypes and endotypes improves asthma management. Obesity worsens severe asthma and reduces quality of life, although its specific molecular impact remains unclear. We previously ... ...

    Abstract Clarifying inflammatory processes and categorising asthma into phenotypes and endotypes improves asthma management. Obesity worsens severe asthma and reduces quality of life, although its specific molecular impact remains unclear. We previously demonstrated that hsa-miR-26a-1-3p and hsa-miR-376a-3p, biomarkers related to an inflammatory profile, discriminate eosinophilic from non-eosinophilic asthmatics. We aimed to study hsa-miR-26a-1-3p, hsa-miR-376a-3p, and their target genes in asthmatic subjects with or without obesity to find biomarkers and comprehend obese asthma mechanisms. Lung tissue samples were obtained from asthmatic patients (n = 16) and healthy subjects (n = 20). We measured miRNA expression using RT-qPCR and protein levels (IGF axis) by ELISA in confirmation samples from eosinophilic (n = 38) and non-eosinophilic (n = 39) obese (n = 26) and non-obese (n = 51) asthma patients. Asthmatic lungs showed higher hsa-miR-26a-1-3p and hsa-miR-376a-3p expression than healthy lungs. A study of seven genes regulated by these miRNAs revealed differential expression of
    MeSH term(s) Humans ; Asthma/complications ; Asthma/genetics ; Biomarkers ; Insulin-Like Growth Factor Binding Protein 3/genetics ; MicroRNAs/genetics ; MicroRNAs/metabolism ; Obesity/complications ; Obesity/genetics ; Phenotype ; Quality of Life
    Chemical Substances Biomarkers ; Insulin-Like Growth Factor Binding Protein 3 ; MicroRNAs ; MIRN376A1 microRNA, human
    Language English
    Publishing date 2023-07-18
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2019364-6
    ISSN 1422-0067 ; 1422-0067 ; 1661-6596
    ISSN (online) 1422-0067
    ISSN 1422-0067 ; 1661-6596
    DOI 10.3390/ijms241411620
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article: Anaphylaxis After Mango Fruit Intake: Identification of New Allergens.

    Ortega-Martín, L / Sastre, B / Rodrigo-Muñoz, J M / Cañas, J A / Valverde-Monge, M / Del Pozo, V

    Journal of investigational allergology & clinical immunology

    2021  Volume 32, Issue 5, Page(s) 401–403

    MeSH term(s) Allergens ; Anaphylaxis/diagnosis ; Anaphylaxis/etiology ; Fruit/adverse effects ; Humans ; Mangifera/adverse effects ; Plant Proteins
    Chemical Substances Allergens ; Plant Proteins
    Language English
    Publishing date 2021-11-16
    Publishing country Spain
    Document type Journal Article
    ZDB-ID 1128657-x
    ISSN 1018-9068
    ISSN 1018-9068
    DOI 10.18176/jiaci.0766
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: Changes in Serum MicroRNAs after Anti-IL-5 Biological Treatment of Severe Asthma.

    Rial, Manuel J / Cañas, José A / Rodrigo-Muñoz, José M / Valverde-Monge, Marcela / Sastre, Beatriz / Sastre, Joaquín / Del Pozo, Victoria

    International journal of molecular sciences

    2021  Volume 22, Issue 7

    Abstract: There is currently enough evidence to think that miRNAs play a role in several key points in asthma, including diagnosis, severity of the disease, and response to treatment. Cells release different types of lipid double-membrane vesicles into the ... ...

    Abstract There is currently enough evidence to think that miRNAs play a role in several key points in asthma, including diagnosis, severity of the disease, and response to treatment. Cells release different types of lipid double-membrane vesicles into the extracellular microenvironment, including exosomes, which function as very important elements in intercellular communication. They are capable of distributing genetic material, mRNA, mitochondrial DNA, and microRNAs (miRNAs). Serum miRNA screening was performed in order to analyze possible changes in serum miRNAs in 10 patients treated with reslizumab and 6 patients with mepolizumab after 8 weeks of treatment. The expression of miR-338-3p was altered after treatment (
    MeSH term(s) Adult ; Anti-Asthmatic Agents/pharmacology ; Anti-Asthmatic Agents/therapeutic use ; Antibodies, Monoclonal, Humanized/pharmacology ; Antibodies, Monoclonal, Humanized/therapeutic use ; Asthma/drug therapy ; Asthma/genetics ; Biomarkers/blood ; Female ; Gene Expression Regulation/drug effects ; Humans ; Interleukin-5/antagonists & inhibitors ; Male ; MicroRNAs/blood ; Middle Aged ; Treatment Outcome
    Chemical Substances Anti-Asthmatic Agents ; Antibodies, Monoclonal, Humanized ; Biomarkers ; IL5 protein, human ; Interleukin-5 ; MIRN338 microRNA, human ; MicroRNAs ; reslizumab (35A26E427H) ; mepolizumab (90Z2UF0E52)
    Language English
    Publishing date 2021-03-30
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2019364-6
    ISSN 1422-0067 ; 1422-0067 ; 1661-6596
    ISSN (online) 1422-0067
    ISSN 1422-0067 ; 1661-6596
    DOI 10.3390/ijms22073558
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: Role of miR-185-5p as modulator of periostin synthesis and smooth muscle contraction in asthma.

    Rodrigo-Muñoz, José M / Cañas, José A / Sastre, Beatriz / Gil-Martínez, Marta / García Latorre, Raquel / Sastre, Joaquín / Del Pozo, Victoria

    Journal of cellular physiology

    2021  Volume 237, Issue 2, Page(s) 1498–1508

    Abstract: Asthma is a chronic respiratory disease produced by an aberrant immune response that originates with breathing difficulties and cough, through airway remodeling. The above pathophysiological events of asthma emerge the regulators of effectors, like ... ...

    Abstract Asthma is a chronic respiratory disease produced by an aberrant immune response that originates with breathing difficulties and cough, through airway remodeling. The above pathophysiological events of asthma emerge the regulators of effectors, like epigenetics, which include microRNAs (miRNAs) who perform post-transcriptional regulation, controlling diverse pathways in respiratory diseases. The objective of the study was to determine how miR-185-5p regulates the secretion of periostin by airway structural cells, and smooth muscle cells contraction, both related to airway remodeling in asthma. We used miR-185-5p mimic and inhibitors in bronchial smooth muscle cells (BSMCs) and small airway epithelial cells (SAECs) from healthy subjects. Gene expression and protein levels of periostin (POSTN), CDC42, and RHOA were analyzed by RT-PCR and ELISA/Western blot, respectively. BSMC contractility was analyzed using cell-embedded collagen gels and measurement of intracellular calcium was performed using Fura-2. Additionally, miR-185-5p and periostin expression were evaluated in sputum from healthy and asthmatics. From these experiments, we observed that miR-185-5p modulation regulates periostin mRNA and protein in BSMCs and SAECs. A tendency for diminished miR-185-5p expression and higher periostin levels was seen in sputum cells from asthmatics compared to healthy, with an inverse correlation observed between POSTN and miR-185-5p. Inhibition of miR-185-5p produced higher BSMCs contraction induced by histamine. Calcium mobilization was not modified by miR-185-5p, showing that miR-185-5p role in BSMC contractility is performed by regulating CDC42 and RhoA pro-contractile factors instead. In conclusion, miR-185-5p is a modulator of periostin secretion by airway structural cells and of smooth muscle contraction, which can be related to asthma pathophysiology, and thus, might be a promising therapeutic target.
    MeSH term(s) Airway Remodeling/genetics ; Asthma/metabolism ; Calcium/metabolism ; Cell Proliferation/genetics ; Humans ; MicroRNAs/genetics ; MicroRNAs/metabolism ; Muscle Contraction/genetics ; Myocytes, Smooth Muscle/metabolism
    Chemical Substances MIRN185 microRNA, human ; MicroRNAs ; Calcium (SY7Q814VUP)
    Language English
    Publishing date 2021-10-26
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 3116-1
    ISSN 1097-4652 ; 0021-9541
    ISSN (online) 1097-4652
    ISSN 0021-9541
    DOI 10.1002/jcp.30620
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Uc I Zs.212: Show issues Location:
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  7. Article ; Online: Long-term immune response accompanies clinical outcomes in severe asthmatics treated with anti-IL-5/IL-5R biologics.

    Lorente-Sorolla, C / Bernaola, J / Sánchez-Mellado, D / Gil-Martínez, M / Naharro-González, S / Betancor, D / Fernández-Nieto, M / Pinillos-Robles, E J / Santillán Coello, J M / Villacampa-Aubá, J M / Rodríguez-Nieto, M J / Sastre, J / Valverde-Monge, M / Rodrigo-Muñoz, J M / Del Pozo, V

    Allergy

    2023  Volume 78, Issue 11, Page(s) 3027–3031

    Language English
    Publishing date 2023-08-29
    Publishing country Denmark
    Document type Letter ; Research Support, Non-U.S. Gov't
    ZDB-ID 391933-x
    ISSN 1398-9995 ; 0105-4538
    ISSN (online) 1398-9995
    ISSN 0105-4538
    DOI 10.1111/all.15872
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    Uh III Zs.150: Show issues Location:
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    Zs.MO 125: Show issues

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  8. Article: Eosinophil Response Against Classical and Emerging Respiratory Viruses: COVID-19.

    Rodrigo-Muñoz, J M / Sastre, B / Cañas, J A / Gil-Martínez, M / Redondo, N / Del Pozo, V

    Journal of investigational allergology & clinical immunology

    2020  Volume 31, Issue 2, Page(s) 94–107

    Abstract: Eosinophils were discovered more than 140 years ago. These polymorphonuclear leukocytes have a very active metabolism and contain numerous intracellular secretory granules that enable multiple effects on both health and disease status. Classically, ... ...

    Abstract Eosinophils were discovered more than 140 years ago. These polymorphonuclear leukocytes have a very active metabolism and contain numerous intracellular secretory granules that enable multiple effects on both health and disease status. Classically, eosinophils have been considered important immune cells in the pathogenesis of inflammatory processes (eg, parasitic helminth infections) and allergic or pulmonary diseases (eg, asthma) and are always associated with a type 2 immune response. Furthermore, in recent years, eosinophils have been linked to the immune response by conferring host protection against fungi, bacteria, and viruses, which they recognize through several molecules, such as toll-like receptors and the retinoic acid-inducible gene 1-like receptor. The immune protection provided by eosinophils is exerted through multiple mechanisms and properties. Eosinophils contain numerous cytoplasmatic granules that release cationic proteins, cytokines, chemokines, and other molecules, all of which contribute to their functioning. In addition to the competence of eosinophils as effector cells, their capabilities as antigen-presenting cells enable them to act in multiple situations, thus promoting diverse aspects of the immune response. This review summarizes various aspects of eosinophil biology, with emphasis on the mechanisms used and roles played by eosinophils in host defence against viral infections and response to vaccines. The review focuses on respiratory viruses, such as the new coronavirus, SARS-CoV-2.
    MeSH term(s) Animals ; COVID-19/immunology ; Eosinophils/immunology ; Humans ; SARS-CoV-2
    Keywords covid19
    Language English
    Publishing date 2020-06-16
    Publishing country Spain
    Document type Journal Article ; Review
    ZDB-ID 1128657-x
    ISSN 1018-9068
    ISSN 1018-9068
    DOI 10.18176/jiaci.0624
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article ; Online: miR-144-3p Is a Biomarker Related to Severe Corticosteroid-Dependent Asthma.

    Rodrigo-Muñoz, José M / Gil-Martínez, Marta / Lorente-Sorolla, Clara / García-Latorre, Raquel / Valverde-Monge, Marcela / Quirce, Santiago / Sastre, Joaquín / Del Pozo, Victoria

    Frontiers in immunology

    2022  Volume 13, Page(s) 858722

    Abstract: MicroRNAs are non-coding molecules that act both as regulators of the epigenetic landscape and as biomarkers for diseases, including asthma. In the era of personalized medicine, there is a need for novel disease-associated biomarkers that can help in ... ...

    Abstract MicroRNAs are non-coding molecules that act both as regulators of the epigenetic landscape and as biomarkers for diseases, including asthma. In the era of personalized medicine, there is a need for novel disease-associated biomarkers that can help in classifying diseases into phenotypes for treatment selection. Currently, severe eosinophilic asthma is one of the most widely studied phenotypes in clinical practice, as many patients require higher and higher doses of corticosteroids, which in some cases fail to achieve the desired outcome. Such patients may only benefit from alternative drugs such as biologics, for which novel biomarkers are necessary. The objective of the study was to study the expression of miR-144-3p in order to discover its possible use as a diagnostic biomarker for severe asthma. For this purpose, miR-144-3p was evaluated in airway biopsies and serum from asthmatics and healthy individuals. mRNA was studied in asthmatic biopsies and smooth muscle cells transfected with miR-144-3p mimic. An
    MeSH term(s) Adrenal Cortex Hormones/therapeutic use ; Asthma/diagnosis ; Asthma/drug therapy ; Asthma/genetics ; Biomarkers ; Eosinophilia ; Humans ; MicroRNAs/metabolism
    Chemical Substances Adrenal Cortex Hormones ; Biomarkers ; MIRN144 microRNA, human ; MicroRNAs
    Language English
    Publishing date 2022-04-01
    Publishing country Switzerland
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2606827-8
    ISSN 1664-3224 ; 1664-3224
    ISSN (online) 1664-3224
    ISSN 1664-3224
    DOI 10.3389/fimmu.2022.858722
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  10. Article: A case of anaphylaxis after oats ingestion: Research for new allergens.

    González-Afonso, M / Cañas, J A / Sastre, B / Rodrigo-Muñoz, J M / Mendoza-Alvarez, A / Martinez-Tadeo, J A / González Colino, C E / Hernández-Santana, G L / Rodriguez-Plata, E / Barrios-Recio, J / Del Pozo, V / García Robaina, J C

    Journal of investigational allergology & clinical immunology

    2022  

    Language English
    Publishing date 2022-03-02
    Publishing country Spain
    Document type Journal Article
    ZDB-ID 1128657-x
    ISSN 1018-9068
    ISSN 1018-9068
    DOI 10.18176/jiaci.0798
    Database MEDical Literature Analysis and Retrieval System OnLINE

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