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  1. Article ; Online: On the temperature dependence of H-U(iso) in the riding hydrogen model.

    Lübben, Jens / Volkmann, Christian / Grabowsky, Simon / Edwards, Alison / Morgenroth, Wolfgang / Fabbiani, Francesca P A / Sheldrick, George M / Dittrich, Birger

    Acta crystallographica. Section A, Foundations and advances

    2014  Volume 70, Issue Pt 4, Page(s) 309–316

    Abstract: The temperature dependence of H-U(iso) in N-acetyl-L-4-hydroxyproline monohydrate is investigated ... to be inaccurate, and severely underestimates H-U(iso) below 100 K. Neutron diffraction data ... a more precise determination of the magnitude of H-atom displacements than independent-atom model ...

    Abstract The temperature dependence of H-U(iso) in N-acetyl-L-4-hydroxyproline monohydrate is investigated. Imposing a constant temperature-independent multiplier of 1.2 or 1.5 for the riding hydrogen model is found to be inaccurate, and severely underestimates H-U(iso) below 100 K. Neutron diffraction data at temperatures of 9, 150, 200 and 250 K provide benchmark results for this study. X-ray diffraction data to high resolution, collected at temperatures of 9, 30, 50, 75, 100, 150, 200 and 250 K (synchrotron and home source), reproduce neutron results only when evaluated by aspherical-atom refinement models, since these take into account bonding and lone-pair electron density; both invariom and Hirshfeld-atom refinement models enable a more precise determination of the magnitude of H-atom displacements than independent-atom model refinements. Experimental efforts are complemented by computing displacement parameters following the TLS+ONIOM approach. A satisfactory agreement between all approaches is found.
    Language English
    Publishing date 2014-07
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2020844-3
    ISSN 2053-2733 ; 1600-5724 ; 0108-7673
    ISSN (online) 2053-2733 ; 1600-5724
    ISSN 0108-7673
    DOI 10.1107/S2053273314010626
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  2. Article: Fractures ouvertes de jambe - La série du C.H.U. Hautepierre.

    Simon, P / Babin, S R / Géraud, H / Vogt, F

    European journal of orthopaedic surgery & traumatology : orthopedie traumatologie

    1996  Volume 6, Issue 1, Page(s) 37–40

    Abstract: Nineteen cases were studied retrospectively between 1982 and 1993. All had been stabilised immediately by external fixators. Free or pedicle flap and early bone graft was carried out as required.Bone stability was obtained by Hoffmann or Orthofix ... ...

    Title translation Open fractures of the leg - Series from the University Hospital Hautepierre.
    Abstract Nineteen cases were studied retrospectively between 1982 and 1993. All had been stabilised immediately by external fixators. Free or pedicle flap and early bone graft was carried out as required.Bone stability was obtained by Hoffmann or Orthofix fixators which allowed later manoeuvres for skin covers. The stabilisation by the fibula was attempted by intertibio-fibula grafting (ITF). Skin cover was obtained in 13 cases by pedicle flaps, in 4 by a free flap and 2 cases healed by secondary intention. The local flaps were 5 medial gastrocnemius or soleus flaps, 4 fasciocutaneous flaps, 3 medial gastrocnemius muscular cutaneous flaps and one cross-leg flap. These flaps were done on average at the 17th day (between 4th and 45th day). Four free flaps were done: 2 pure cutaneous flaps and 2 osteo-cutaneous flaps. A second flap was required in 3 cases because of infection or loss of soft tissue. A medial gastrocnemius flap and 2 free fibula flaps were done at the 105th and 210th day.Bony union was obtained primarily in 6 cases. Thirteen bone grafts were necessary of which 7 were done electively before three months (4 decortication grafts, 3 ITF). Additional bone graft was needed in 4 cases. Six non-unions were seen, 2 sterile which were treated by one decortication/graft and one ITF and 4 infected (21%) which were treated successfully by 2 ITF grafts and 2 free fibula flaps. Overall consolidation occurred by 9.9. months with good alignment in 15 cases. The complications were 2 varus and one 15° external rotation malunions and one shortening of 2 cm. Ankle movements were normal in 5 cases, reduced by 25% in 5 cases and by half in one case. There was one fixed equinus of 15° and one arhtrodesis. Five patients were able to run. The average number of general anaesthetics required was 5.7 and the average length of hospitalisation 120 days.In conclusion, the authors emphasise the beneficial role of early skin cover in the outcome of these fractures which is otherwise characterised by secondary contamination. They were extremely satisfied with the results of composite free grafts in cases of loss of substance of bone and soft tissue. At present, they tend towards locked nailing for these fractures preferably without reaming whenever possible. Skin cover can than be planned during the first 5 days after injury.
    Language French
    Publishing date 1996-02
    Publishing country France
    Document type English Abstract ; Journal Article
    ZDB-ID 1231084-0
    ISSN 1432-1068 ; 1633-8065 ; 0948-4817 ; 0940-3264
    ISSN (online) 1432-1068
    ISSN 1633-8065 ; 0948-4817 ; 0940-3264
    DOI 10.1007/BF02718696
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 3479: Show issues Location:
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  3. Book ; Online ; Conference proceedings: Exploring complexity in health

    de Keizer, Nicolette / Lusignan, Simon de / Hoerbst, Alexander / Hackl, Werner O. / Prokosch, Hans-Ulrich / Hercigonja-Szekeres, Mira

    an interdisciplinary systems approach : proceedings of MIE2016 at HEC2016

    (Studies in health technology and informatics ; 228)

    2016  

    Event/congress Medical Informatics Europe Conference (27., 2016, München)
    Author's details MIE 2016 ; edited by Alexander Hoerbst, Werner O. Hackl, Nicolette de Keizer, Hans-Ulrich Prokosch, Mira Hercigonja-Szekeres, Simon de Lusignan
    Series title Studies in health technology and informatics ; 228
    Collection
    Language English
    Size 1 Online-Ressource (xxiv, 852 Seiten)
    Publisher IOS Press
    Publishing place Amsterdam ; Berlin ; Washington, DC
    Publishing country Netherlands
    Document type Book ; Online ; Conference proceedings
    HBZ-ID HT019101454
    ISBN 978-1-61499-678-1 ; 9781614996774 ; 1-61499-678-4 ; 1614996776
    Database ZB MED Catalogue: Medicine, Health, Nutrition, Environment, Agriculture

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  4. Article ; Online: Allergy-Committed to progress in allergy and immunology.

    Simon, H-U / Bieber, T

    Allergy

    2018  Volume 73, Issue 3, Page(s) 527

    MeSH term(s) Allergy and Immunology ; Humans ; Periodicals as Topic
    Language English
    Publishing date 2018-01-09
    Publishing country Denmark
    Document type Editorial
    ZDB-ID 391933-x
    ISSN 1398-9995 ; 0105-4538
    ISSN (online) 1398-9995
    ISSN 0105-4538
    DOI 10.1111/all.13412
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  5. Article ; Online: Eosinophile Granulozyten – Physiologie und Pathophysiologie.

    Sokollik, C / Simon, H-U

    Zeitschrift fur Rheumatologie

    2019  Volume 78, Issue 4, Page(s) 306–312

    Abstract: Eosinophilic granulocytes are a subpopulation of leucocytes and part of the innate immune cell pool. Additionally, they have homeostatic functions in different tissues. Classically, an increased number of eosinophils is associated with allergies and ... ...

    Title translation Eosinophilic granulocytes-Physiology and pathophysiology.
    Abstract Eosinophilic granulocytes are a subpopulation of leucocytes and part of the innate immune cell pool. Additionally, they have homeostatic functions in different tissues. Classically, an increased number of eosinophils is associated with allergies and parasitic infections; however, eosinophilia can also be found in vasculitides and malignant tumors. The most important controlling factors of eosinophils are the cytokine interleukin 5 and eotaxins. Eosinophils are able to produce a broad range of signalling factors and toxic proteins, which are stored in cytoplasmic granules and can be quickly and specifically released when needed depending on the stimulus. To combat pathogens, eosinophils can catapult extracellular traps consisting of mitochondrial DNA and toxic proteins into the intercellular space. This review focuses on the basic structure, control and function of eosinophils in health and disease.
    MeSH term(s) Cytokines ; Eosinophilia ; Eosinophils/immunology ; Eosinophils/pathology ; Humans ; Inflammation/immunology ; Inflammation/pathology
    Chemical Substances Cytokines
    Language German
    Publishing date 2019-01-09
    Publishing country Germany
    Document type Journal Article ; Review
    ZDB-ID 124985-x
    ISSN 1435-1250 ; 0340-1855 ; 0301-6382
    ISSN (online) 1435-1250
    ISSN 0340-1855 ; 0301-6382
    DOI 10.1007/s00393-018-0574-7
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  6. Article ; Online: Role of Patient-Derived Models of Cancer in Translational Oncology

    K. F. Idrisova / H.-U. Simon / M. O. Gomzikova

    Cancers, Vol 15, Iss 1, p

    2022  Volume 139

    Abstract: Cancer is a heterogeneous disease. Each individual tumor is unique and characterized by structural, cellular, genetic and molecular features. Therefore, patient-derived cancer models are indispensable tools in cancer research and have been actively ... ...

    Abstract Cancer is a heterogeneous disease. Each individual tumor is unique and characterized by structural, cellular, genetic and molecular features. Therefore, patient-derived cancer models are indispensable tools in cancer research and have been actively introduced into the healthcare system. For instance, patient-derived models provide a good reproducibility of susceptibility and resistance of cancer cells against drugs, allowing personalized therapy for patients. In this article, we review the advantages and disadvantages of the following patient-derived models of cancer: (1) PDC—patient-derived cell culture, (2) PDS—patient-derived spheroids and PDO—patient-derived organoids, (3) PDTSC—patient-derived tissue slice cultures, (4) PDX—patient-derived xenografts, humanized PDX, as well as PDXC—PDX-derived cell cultures and PDXO—PDX-derived organoids. We also provide an overview of current clinical investigations and new developments in the area of patient-derived cancer models. Moreover, attention is paid to databases of patient-derived cancer models, which are collected in specialized repositories. We believe that the widespread use of patient-derived cancer models will improve our knowledge in cancer cell biology and contribute to the development of more effective personalized cancer treatment strategies.
    Keywords patient-derived models ; patient-derived xenografts ; patient-derived organoids ; clinical investigation ; 2D and 3D culture ; personalized medicine ; Neoplasms. Tumors. Oncology. Including cancer and carcinogens ; RC254-282
    Subject code 616 ; 610
    Language English
    Publishing date 2022-12-01T00:00:00Z
    Publisher MDPI AG
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  7. Article ; Online: Institutional Failures as Structural Determinants of Suicide: The Opioid Epidemic and the Great Recession in the United States.

    Simon, Daniel H / Masters, Ryan K

    Journal of health and social behavior

    2024  , Page(s) 221465231223723

    Abstract: We investigate recent trends in U.S. suicide mortality using a "structural determinants of health ... framework. We access restricted-use multiple cause of death files to track suicide rates among U.S. Black ... and Great Recession. These findings suggest that institutional failures elevated U.S. suicide risk ...

    Abstract We investigate recent trends in U.S. suicide mortality using a "structural determinants of health" framework. We access restricted-use multiple cause of death files to track suicide rates among U.S. Black, White, American Indian/Alaska Native, and Latino/a men and women between 1990 and 2017. We examine suicide deaths separately by poisonings and nonpoisonings to illustrate that (1) women's suicide rates from poisonings track strongly with increases in prescription drug availability and (2) nonpoisoning suicide rates among all adult Americans track strongly with worsening economic conditions coinciding with the financial crash and Great Recession. These findings suggest that institutional failures elevated U.S. suicide risk between 1990 and 2017 by increasing access to more lethal means of self-harm and by increasing both exposure and vulnerability to economic downturns. Together, these results support calls to scale up to focus on the structural determinants of U.S. suicide.
    Language English
    Publishing date 2024-01-18
    Publishing country United States
    Document type Journal Article
    ZDB-ID 218206-3
    ISSN 2150-6000 ; 0022-1465
    ISSN (online) 2150-6000
    ISSN 0022-1465
    DOI 10.1177/00221465231223723
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  8. Article: Freiheit der Selbstbestimmung in allen Abschnitten des Lebens

    Überall, Michael A. / Obst, U. / Rambach, G. / Rathmann, H. / Simon, M. / Gibson, B.

    Schmerzmedizin - angewandte Schmerztherapie und Palliativmedizin

    2021  Volume 37, Issue 5, Page(s) 10

    Language German
    Document type Article
    ZDB-ID 2822543-0
    ISSN 2194-2536
    Database Current Contents Medicine

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  9. Article: Leserbrief zum Beitrag Hypereosinophilie

    Simon, D. / Simon, H.-U.

    Swiss medical forum

    2016  Volume 16, Issue 4, Page(s) 104

    Language German
    Document type Article
    ZDB-ID 2220114-2
    ISSN 1424-3784
    Database Current Contents Medicine

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    Zs.A 5471: Show issues Location:
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  10. Book ; Conference proceedings: Papers presented at the Second International Symposium on Dredging Technology at Texas A & M University, U.S.A., 1977 / [editors, H. S. Stephens, N. G. Coles, J. A. Clarke]. --

    Stephens, Herbert Simon / Coles, N. G / Clarke, J. A

    1977  

    Institution Center for Dredging Studies.
    BHRA (Association)
    Event/congress International Symposium on Dredging Technology (2d, 1977, TexasA&MUniversity)
    Keywords Dredging/Congresses.
    Language English
    Size 2 v. :, ill.
    Publisher BHRA Fluid Engineering
    Publishing place Cranfield, Eng
    Document type Book ; Conference proceedings
    Note Cover title: Second International Symposium on Dredging Technology. ; Symposium organized by BHRA Fluid Engineering in association with Texas A & M University, Center for Dredging Studies.
    ISBN 0900983744 ; 9780900983740
    Database NAL-Catalogue (AGRICOLA)

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