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Article ; Online: Radical electron-induced cellulose-semiconductors.

Fukuhara, Mikio / Yokotsuka, Tomonori / Samoto, Tetsuo / Kumadaki, Masahiko / Takeda, Mitsuhiro / Hashida, Toshiyuki

2024 Volume 14, Issue 1, Page(s) 8692

Abstract: Bio-semiconductors are expected to be similar to organic semiconductors; however, they have not been utilized in application yet. In this study, we show the origin of electron appearance, N- and S-type negative resistances, rectification, and switching ... ...

Abstract	Bio-semiconductors are expected to be similar to organic semiconductors; however, they have not been utilized in application yet. In this study, we show the origin of electron appearance, N- and S-type negative resistances, rectification, and switching effects of semiconductors with energy storage capacities of up to 418.5 mJ/m
Language	English
Publishing date	2024-04-15
Publishing country	England
Document type	Journal Article
ZDB-ID	2615211-3
ISSN	2045-2322 ; 2045-2322
ISSN (online)	2045-2322
ISSN	2045-2322
DOI	10.1038/s41598-024-59499-1
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Endoscopic features with linked-color imaging of non-

Takeda, Tsutomu / Asaoka, Daisuke / Hirai, Shu / Nakamura, Masahiko / Nagahara, Akihito

VideoGIE : an official video journal of the American Society for Gastrointestinal Endoscopy

2023 Volume 9, Issue 3, Page(s) 123–127

Abstract: Background and aims: The endoscopic findings of non-: Methods: We report the case of a 72-year-old woman in whom an NHPH species was found during EGD using LCI.: Results: The EGD did not reveal any endoscopic findings of diffuse redness, patchy ... ...

Abstract	Background and aims: The endoscopic findings of non- Methods: We report the case of a 72-year-old woman in whom an NHPH species was found during EGD using LCI. Results: The EGD did not reveal any endoscopic findings of diffuse redness, patchy redness, or atrophy. However, erosions, nonuniform redness, and crack-like mucosa were seen in the antrum, as well as LCI-enhanced endoscopic findings. In addition, nodular gastritis and a white marbled appearance were also observed in the antrum. LCI and blue-laser imaging enhanced the endoscopic findings. Floating bacterial bodies with a fine coil-like shape and diameter longer than that of Conclusions: Our case demonstrates that IEE is useful in diagnosing NHPH. The detection of NHPH using IEE enabled us to contribute to an improved diagnosis of NHPH.
Language	English
Publishing date	2023-10-21
Publishing country	United States
Document type	Journal Article
ISSN	2468-4481
ISSN (online)	2468-4481
DOI	10.1016/j.vgie.2023.10.009
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Article ; Online: Commitment profiles among nurses: combinations of organizational commitment forms and work engagement, psychological distress, and turnover intention.

Fukuzaki, Toshiki / Takeda, Shinya / Iwata, Noboru / Ooba, Sawako / Inoue, Masahiko

Industrial health

2022 Volume 61, Issue 3, Page(s) 232–236

Abstract: To clarify the combined effect of the sub-factors of organizational commitment, this study examined the relationships between organizational commitment profiles and work engagement, psychological distress, and turnover intention among nurses. A cross- ... ...

Abstract	To clarify the combined effect of the sub-factors of organizational commitment, this study examined the relationships between organizational commitment profiles and work engagement, psychological distress, and turnover intention among nurses. A cross-sectional survey was conducted; 455 nurses (38 men and 417 women) were included in the statistical analysis. We extracted six clusters through k-means cluster analysis and applied a one-way analysis of variance and χ
MeSH term(s)	Male ; Humans ; Female ; Intention ; Nursing Staff, Hospital/psychology ; Work Engagement ; Cross-Sectional Studies ; Job Satisfaction ; Personnel Turnover ; Psychological Distress ; Surveys and Questionnaires
Language	English
Publishing date	2022-03-29
Publishing country	Japan
Document type	Journal Article
ZDB-ID	214185-1
ISSN	1880-8026 ; 0019-8366
ISSN (online)	1880-8026
ISSN	0019-8366
DOI	10.2486/indhealth.2021-0237
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Article: [The Relationship Between Pathophysiology and Neurotransmitters in Parkinson's Disease].

Takeda, Atsushi / Tomiyama, Masahiko / Hanajima, Ritsuko

Brain and nerve = Shinkei kenkyu no shinpo

2021 Volume 73, Issue 7, Page(s) 829–837

Abstract: Parkinson's disease (PD) is a progressive neurodegenerative disorder. The major motor symptoms of PD are mainly caused by dopamine (DA) deficiency due to the loss of dopaminergic neurons in the substantia nigra. Most patients also show non-motor symptoms, ...

Abstract	Parkinson's disease (PD) is a progressive neurodegenerative disorder. The major motor symptoms of PD are mainly caused by dopamine (DA) deficiency due to the loss of dopaminergic neurons in the substantia nigra. Most patients also show non-motor symptoms, such as cognitive impairment, mood disturbance, pain, and sleep disturbance. These symptoms cannot be explained by DA deficiency alone and are likely involved with other neurotransmitter systems, including glutamate, serotonin, noradrenaline, or gamma aminobutyric acid. Other neurotransmitters may have therapeutic effects on some symptoms of PD. In this review, we discuss the pathophysiology of Parkinsonian symptoms, with a focus on neurotransmitters. (Received 2 February, 2021; Accepted 16 February, 2021; Published 1 July, 2021).
Language	Japanese
Publishing date	2021-07-07
Publishing country	Japan
Document type	English Abstract ; Journal Article
ZDB-ID	390389-8
ISSN	1344-8129 ; 1881-6096 ; 0006-8969
ISSN (online)	1344-8129
ISSN	1881-6096 ; 0006-8969
DOI	10.11477/mf.1416201843
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Article ; Online: Cell Responses of the Ventrolateral Medulla to PAR1 Activation and Changes in Respiratory Rhythm in Newborn Rat En Bloc Brainstem-Spinal Cord Preparations.

Onimaru, Hiroshi / Fukushi, Isato / Ikeda, Keiko / Yazawa, Itaru / Takeda, Kotaro / Okada, Yasumasa / Izumizaki, Masahiko

Neuroscience

2023 Volume 528, Page(s) 89–101

Abstract: Proteinase-activated receptor-1 (PAR1) is expressed in astrocytes of various brain regions, and its activation is involved in the modulation of neuronal activity. Here, we report effects of PAR1 selective agonist TFLLR on respiratory rhythm generation in ...

Abstract	Proteinase-activated receptor-1 (PAR1) is expressed in astrocytes of various brain regions, and its activation is involved in the modulation of neuronal activity. Here, we report effects of PAR1 selective agonist TFLLR on respiratory rhythm generation in brainstem-spinal cord preparations. Preparations were isolated from newborn rats (P0-P4) under deep isoflurane anesthesia and were transversely cut at the rostral medulla. Preparations were superfused with artificial cerebrospinal fluid (25-26 °C), and inspiratory C4 ventral root activity was monitored. The responses to TFLLR of cells close to the cut surface were detected by calcium imaging or membrane potential recordings. Application of 10 μM TFLLR (4 min) induced a rapid and transient increase of calcium signal in cells of the ventrolateral respiratory regions of the medulla. More than 88% of responding cells (223/254 cells from 13 preparations) were also activated by low (0.2 mM) K
MeSH term(s)	Animals ; Rats ; Animals, Newborn ; Receptor, PAR-1 ; Calcium ; Rats, Wistar ; Brain Stem/physiology ; Medulla Oblongata ; Spinal Cord
Chemical Substances	Receptor, PAR-1 ; Calcium (SY7Q814VUP)
Language	English
Publishing date	2023-08-07
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	196739-3
ISSN	1873-7544 ; 0306-4522
ISSN (online)	1873-7544
ISSN	0306-4522
DOI	10.1016/j.neuroscience.2023.08.002
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Article ; Online: The predictive value of modified soluble urokinase plasminogen activator receptor (suPAR) with National Early Warning Score (NEWS) for mortality in emergency elderly patients in Japan: a prospective pilot study.

Mitsunaga, Toshiya / Ohtaki, Yuhei / Seki, Yutaka / Mashiko, Kunihiro / Uzura, Masahiko / Okuno, Kenji / Takeda, Satoshi

Acute medicine & surgery

2023 Volume 10, Issue 1, Page(s) e840

Abstract: Aim: The aim of this study is to evaluate the ability of soluble urokinase plasminogen activator receptor (suPAR) and modified suPAR with National Early Warning Score (NEWS) for detecting mortality in elderly emergency patients who are older than 70 ... ...

Abstract	Aim: The aim of this study is to evaluate the ability of soluble urokinase plasminogen activator receptor (suPAR) and modified suPAR with National Early Warning Score (NEWS) for detecting mortality in elderly emergency patients who are older than 70 years. Methods: This is a secondary analysis of our previous study, which was a single-center prospective pilot study, carried out for 21 months in the emergency department of a secondary emergency institution in Japan. This study was carried out between September 16, 2020, and June 21, 2022. The study included all patients without trauma aged 70 years or older who presented to the emergency department. Discrimination was assessed by plotting the receiver-operating characteristic curve and calculating the area under the receiver-operating characteristic curve (AUC). Results: During the study period, 47 eligible older patients were included, among which 8 (17.0%) patients died. The median suPAR was significantly lower in the survivor's group than in the nonsurvivor's group ( Conclusion: Our single-center study has demonstrated the high utility of modified suPAR with NEWS as a predictive tool of mortality in elderly emergency patients. Evidence from multicenter studies is needed for introducing modified suPAR with NEWS in the emergency department setting.
Language	English
Publishing date	2023-05-30
Publishing country	United States
Document type	Journal Article
ZDB-ID	2751184-4
ISSN	2052-8817 ; 2052-8817
ISSN (online)	2052-8817
ISSN	2052-8817
DOI	10.1002/ams2.840
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Article: Levodopa Prescription Patterns in Patients with Advanced Parkinson's Disease: A Japanese Database Analysis.

Takeda, Atsushi / Baba, Toru / Watanabe, Jun / Nakayama, Masahiko / Hozawa, Hiroyuki / Ishido, Miwako

Parkinson's disease

2023 Volume 2023, Page(s) 9404207

Abstract: Prescription doses of levodopa in patients with advanced Parkinson's disease (PD) are generally lower in Japan than in the United States or Europe, although Japanese guidelines for the management of PD recommend increasing the dosage as the disease ... ...

Abstract	Prescription doses of levodopa in patients with advanced Parkinson's disease (PD) are generally lower in Japan than in the United States or Europe, although Japanese guidelines for the management of PD recommend increasing the dosage as the disease progresses. However, data regarding levodopa prescription practices in patients with advanced PD in the clinical setting are limited. This retrospective observational study analyzed patterns of drug use for patients with advanced PD in Japan using claims data from hospitalized patients in the Medical Data Vision Co. database. Eligible patients had at least two PD-associated claims in two different quarters between April 1, 2008, and November 30, 2018, and a 10-item activities of daily living score <60 upon hospital discharge (as a proxy for advanced PD). The primary endpoint was the prescribed dosage of levodopa at the index hospitalization. Dosages of other PD drugs (medications with an on-label indication for PD) and non-PD drugs were also assessed. Overall, 4029 patients met the inclusion criteria (mean age, 76.9 years; 83.3% aged ≥70 years). At the index date, 74.0% were receiving levodopa. Patients received a median of one PD drug in addition to levodopa, and 27.4% and 20.2% received one or two concomitant PD drugs, respectively. Patients received a median of two non-PD drugs. The median levodopa dosage and total levodopa equivalent dosage (LED) at the index hospitalization were 418.2 and 634.8 mg/day (adjusted for body weight, 9.0 and 13.7 mg/kg/day), respectively. The median levodopa and total LED dosage in each 6-month increment during the 5 years before and after the index date ranged between 263.9 and 330.2 mg/day (5.0 and 6.5 mg/kg/day) and 402.0 and 504.9 mg/day (8.3 and 10.1 mg/kg/day), respectively. This study suggests that many Japanese patients with advanced PD could receive more intensive treatment with higher doses of levodopa.
Language	English
Publishing date	2023-09-27
Publishing country	United States
Document type	Journal Article
ZDB-ID	2573854-9
ISSN	2042-0080 ; 2090-8083
ISSN (online)	2042-0080
ISSN	2090-8083
DOI	10.1155/2023/9404207
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Article ; Online: Conformational change in an engineered biliverdin-binding cyanobacteriochrome during the photoconversion process

Takeda, Yuka / Ohtsu, Itsuki / Suzuki, Takahisa / Nakasone, Yusuke / Fushimi, Keiji / Ikeuchi, Masahiko / Terazima, Masahide / Dohra, Hideo / Narikawa, Rei

Archives of Biochemistry and Biophysics. 2023 Sept., v. 745 p.109715-

2023

Abstract: Cyanobacteriochromes (CBCRs) derived from cyanobacteria are linear-tetrapyrrole-binding photoreceptors related to the canonical red/far-red reversible phytochrome photoreceptors. CBCRs contain chromophore-binding cGMP-specific phosphodiesterase/adenylate ...

Abstract	Cyanobacteriochromes (CBCRs) derived from cyanobacteria are linear-tetrapyrrole-binding photoreceptors related to the canonical red/far-red reversible phytochrome photoreceptors. CBCRs contain chromophore-binding cGMP-specific phosphodiesterase/adenylate cyclase/FhlA (GAF) domains that are highly diverse in their primary sequences and are categorized into many subfamilies. Among this repertoire, the biliverdin (BV)-binding CBCR GAF domains receive considerable attention for their in vivo optogenetic and bioimaging applications because BV is a mammalian intrinsic chromophore and can absorb far-red light that penetrates deep into the mammalian body. The typical BV-binding CBCR GAF domain exhibits reversible photoconversion between far-red-absorbing dark-adapted and orange-absorbing photoproduct states. Herein, we applied various biochemical and spectral studies to identify the details of the conformational change during this photoconversion process. No oligomeric state change was observed, whereas the surface charge would change with a modification of the α-helix structures during the photoconversion process. Combinatorial analysis using partial protease digestion and mass spectrometry identified the region where the conformational change occurred. These results provide clues for the future development of optogenetic tools.
Keywords	Cyanobacteria ; adenylate cyclase ; bioimaging ; biophysics ; digestion ; far-red light ; mammals ; mass spectrometry ; optogenetics ; phytochrome ; proteinases ; Native PAGE ; Size-exclusion chromatography ; Circular dichroism spectroscopy ; Thermal relaxation
Language	English
Dates of publication	2023-09
Publishing place	Elsevier Inc.
Document type	Article ; Online
ZDB-ID	523-x
ISSN	1096-0384 ; 0003-9861
ISSN (online)	1096-0384
ISSN	0003-9861
DOI	10.1016/j.abb.2023.109715
Database	NAL-Catalogue (AGRICOLA)

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Book ; Online: Bangladesh

Takeda, Masahiko

joint staff advisory note on the poverty reduction strategy paper

(IMF country report ; 13/62)

2013

Author's details	[approved by Masahiko Takeda ...]
Series title	IMF country report ; 13/62
Keywords	Armutsbekämpfung ; Bangladesch
Language	English
Size	Online-Ressource (11 S.)
Publisher	IMF
Publishing place	Washington, DC
Document type	Book ; Online
Note	IMD-Felder maschinell generiert
Database	ECONomics Information System

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Article: The Effect of Nurses' Work-Life Balance on Work Engagement: The Adjustment Effect of Affective Commitment.

Fukuzaki, Toshiki / Iwata, Noboru / Ooba, Sawako / Takeda, Shinya / Inoue, Masahiko

Yonago acta medica

2021 Volume 64, Issue 3, Page(s) 269–281

Abstract: Background: This study aimed to examine the effects of nurses' work-life balance (WLB), job demands and resources, and organizational attachment on their work engagement (WE). The second aim was to shed light on whether the relationships among WLB, job ... ...

Abstract	Background: This study aimed to examine the effects of nurses' work-life balance (WLB), job demands and resources, and organizational attachment on their work engagement (WE). The second aim was to shed light on whether the relationships among WLB, job demands, resources, and WE are modulated by organizational attachment. Methods: In total, 425 nurses working in a university hospital responded to the questionnaire. The primary statistical analysis method was hierarchical multiple regression with WE as the dependent variable. Results: In the model in which all variables were applied, affective commitment (AC) ( Conclusion: These results confirmed that to improve nurses' WE, hospital organizations should implement initiatives to facilitate WLB that considers nurses' household roles. Furthermore, high organizational attachment buffered the home's negative influence on work, thereby helping nurses work energetically.
Language	English
Publishing date	2021-07-29
Publishing country	Japan
Document type	Journal Article
ZDB-ID	840719-8
ISSN	1346-8049 ; 0513-5710
ISSN (online)	1346-8049
ISSN	0513-5710
DOI	10.33160/yam.2021.08.005
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