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  1. Article ; Online: Risk disclosure prior to bronchoscopy.

    Bianchi, Stephen M / Saha, Shironjit / Anderson, Paul

    Thorax

    2011  Volume 66, Issue 4, Page(s) 357–8; author reply 357–8

    MeSH term(s) Anxiety/prevention & control ; Bronchoscopy/adverse effects ; England ; Humans ; Informed Consent ; Risk Assessment/methods ; Truth Disclosure
    Language English
    Publishing date 2011-04
    Publishing country England
    Document type Comment ; Letter
    ZDB-ID 204353-1
    ISSN 1468-3296 ; 0040-6376
    ISSN (online) 1468-3296
    ISSN 0040-6376
    DOI 10.1136/thx.2010.150391
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Mepolizumab for Treating Severe Eosinophilic Asthma: An Evidence Review Group Perspective of a NICE Single Technology Appraisal.

    Bermejo, Iñigo / Stevenson, Matt / Cooper, Katy / Harnan, Sue / Hamilton, Jean / Clowes, Mark / Carroll, Christopher / Harrison, Tim / Saha, Shironjit

    PharmacoEconomics

    2017  Volume 36, Issue 2, Page(s) 131–144

    Abstract: As part of its single technology appraisal (STA) process, the National Institute for Health and Care Excellence (NICE) invited the company (GlaxoSmithKline) that manufactures mepolizumab ( ... ...

    Abstract As part of its single technology appraisal (STA) process, the National Institute for Health and Care Excellence (NICE) invited the company (GlaxoSmithKline) that manufactures mepolizumab (Nucala
    MeSH term(s) Adult ; Anti-Asthmatic Agents/economics ; Anti-Asthmatic Agents/therapeutic use ; Antibodies, Monoclonal, Humanized/economics ; Antibodies, Monoclonal, Humanized/therapeutic use ; Asthma/drug therapy ; Asthma/economics ; Cost-Benefit Analysis ; Eosinophilia/drug therapy ; Eosinophilia/economics ; Humans ; Quality of Life ; Quality-Adjusted Life Years ; Randomized Controlled Trials as Topic ; Severity of Illness Index ; Technology Assessment, Biomedical
    Chemical Substances Anti-Asthmatic Agents ; Antibodies, Monoclonal, Humanized ; mepolizumab (90Z2UF0E52)
    Language English
    Publishing date 2017-09-21
    Publishing country New Zealand
    Document type Comparative Study ; Journal Article ; Research Support, Non-U.S. Gov't ; Review
    ZDB-ID 1100273-6
    ISSN 1179-2027 ; 1170-7690
    ISSN (online) 1179-2027
    ISSN 1170-7690
    DOI 10.1007/s40273-017-0571-8
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article: Eosinophilic airway inflammation in COPD.

    Saha, Shironjit / Brightling, Christopher E

    International journal of chronic obstructive pulmonary disease

    2007  Volume 1, Issue 1, Page(s) 39–47

    Abstract: Chronic obstructive pulmonary disease is a common condition and a major cause of mortality. COPD is characterized by irreversible airflow obstruction. The physiological abnormalities observed in COPD are due to a combination of emphysema and obliteration ...

    Abstract Chronic obstructive pulmonary disease is a common condition and a major cause of mortality. COPD is characterized by irreversible airflow obstruction. The physiological abnormalities observed in COPD are due to a combination of emphysema and obliteration of the small airways in association with airway inflammation. The predominant cells involved in this inflammatory response are CD8+ lymphocytes, neutrophils, and macrophages. Although eosinophilic airway inflammation is usually considered a feature of asthma, it has been demonstrated in large and small airway tissue samples and in 20%-40% of induced sputum samples from patients with stable COPD. This airway eosinophilia is increased in exacerbations. Thus, modifying eosinophilic inflammation may be a potential therapeutic target in COPD. Eosinophilic airway inflammation is resistant to inhaled corticosteroid therapy, but does respond to systemic corticosteroid therapy, and the degree of response is related to the intensity of the eosinophilic inflammation. In COPD, targeting treatment to normalize the sputum eosinophilia reduced the number of hospital admissions. Whether controlling eosinophilic inflammation in COPD patients with an airway eosinophilia will modify disease progression and possibly alter mortality is unknown, but warrants further investigation.
    MeSH term(s) Administration, Inhalation ; Administration, Oral ; Adrenal Cortex Hormones/administration & dosage ; Adrenal Cortex Hormones/therapeutic use ; Cross-Over Studies ; Disease Progression ; Eosinophils ; Forced Expiratory Volume ; Hospitalization ; Humans ; Leukocyte Count ; Pulmonary Disease, Chronic Obstructive/drug therapy ; Pulmonary Disease, Chronic Obstructive/mortality ; Pulmonary Disease, Chronic Obstructive/physiopathology ; Pulmonary Eosinophilia/drug therapy ; Pulmonary Eosinophilia/physiopathology ; Randomized Controlled Trials as Topic ; Respiratory Function Tests ; Sputum/cytology ; Treatment Outcome
    Chemical Substances Adrenal Cortex Hormones
    Language English
    Publishing date 2007-11-29
    Publishing country New Zealand
    Document type Comparative Study ; Journal Article ; Review
    ZDB-ID 2212419-6
    ISSN 1178-2005 ; 1176-9106
    ISSN (online) 1178-2005
    ISSN 1176-9106
    DOI 10.2147/copd.2006.1.1.39
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Increased sputum and bronchial biopsy IL-13 expression in severe asthma.

    Saha, Shironjit K / Berry, Mike A / Parker, Deborah / Siddiqui, Salman / Morgan, Angela / May, Richard / Monk, Phillip / Bradding, Peter / Wardlaw, Andrew J / Pavord, Ian D / Brightling, Christopher E

    The Journal of allergy and clinical immunology

    2008  Volume 121, Issue 3, Page(s) 685–691

    Abstract: Background: The importance of IL-13 in the asthma paradigm is supported by increased expression in human subjects, particularly in patients with mild-to-moderate asthma. However, the role of IL-13 in severe asthma needs to be further defined.: ... ...

    Abstract Background: The importance of IL-13 in the asthma paradigm is supported by increased expression in human subjects, particularly in patients with mild-to-moderate asthma. However, the role of IL-13 in severe asthma needs to be further defined.
    Objective: We sought to assess IL-13 expression in sputum and bronchial biopsy specimens from subjects with mild-to-severe asthma.
    Methods: Sputum IL-13 concentrations were measured in 32 control subjects, 34 subjects with mild asthma, 21 subjects with moderate asthma, and 26 subjects with severe asthma. Enumeration of mast cells, eosinophils, and IL-13+ cells in the bronchial submucosa and airway smooth muscle (ASM) bundle was performed in 7 control subjects, 14 subjects with mild asthma, 7 subjects with moderate asthma, and 7 subjects with severe asthma.
    Results: The proportion of subjects with measurable IL-13 in the sputum was increased in the mild asthma group (15/34) and severe asthma group (10/26) compared with that seen in the control group (4/32; P = .004). IL-13+ cells were increased within the submucosa in all asthma severity groups compared with control subjects (P = .006). The number of IL-13+ cells were increased within the ASM bundle in the severe asthma group compared with that seen in the other groups (P < .05). Asthma control questionnaire scores positively correlated with sputum IL-13 concentrations (R(s) = 0.35, P = .04) and mast cells in the ASM bundle (R(s) = 0.7, P = .007). IL-13+ cells within the submucosa and ASM correlated with sputum eosinophilia (R(s) = 0.4, P < or = .05).
    Conclusions: IL-13 overexpression in sputum and bronchial biopsy specimens is a feature of severe asthma.
    MeSH term(s) Asthma/immunology ; Asthma/metabolism ; Asthma/physiopathology ; Biopsy ; Bronchi/cytology ; Bronchi/immunology ; Bronchi/metabolism ; Cross-Sectional Studies ; Enzyme-Linked Immunosorbent Assay ; Female ; Humans ; Interleukin-13/biosynthesis ; Male ; Mast Cells/immunology ; Middle Aged ; Muscle, Smooth/immunology ; Respiratory Function Tests ; Sputum/chemistry ; Sputum/immunology
    Chemical Substances Interleukin-13
    Language English
    Publishing date 2008-03-06
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 121011-7
    ISSN 1097-6825 ; 1085-8725 ; 0091-6749
    ISSN (online) 1097-6825 ; 1085-8725
    ISSN 0091-6749
    DOI 10.1016/j.jaci.2008.01.005
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Uh III Zs.92: Show issues Location:
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