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  1. Book: Shi yong Guang zhou hua fen lei ci dian

    Mai, Yun / Tan, Buyun

    1997  

    Author's details Mai Yun, Tan Buyun bianzhu
    Language Chinese
    Size 16, 577 p
    Edition Di 1 ban
    Publisher Guangdong renmin chubanshe
    Publishing place s.l.
    Document type Book
    ISBN 7218024920 ; 9787218024929
    Database Former special subject collection: coastal and deep sea fishing

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  2. Article ; Online: MCM4 acts as a biomarker for LUAD prognosis.

    Tan, Yue / Ding, Lei / Li, Guiyuan

    Journal of cellular and molecular medicine

    2023  Volume 27, Issue 21, Page(s) 3354–3362

    Abstract: MCM4 forms the pre-replication complex (MCM2-7) with five other minichromosome maintenance (MCM) proteins. This complex binds to replication origins at G1 stage in cell cycle process, playing a critical role in DNA replication initiation. Recently, MCM4 ... ...

    Abstract MCM4 forms the pre-replication complex (MCM2-7) with five other minichromosome maintenance (MCM) proteins. This complex binds to replication origins at G1 stage in cell cycle process, playing a critical role in DNA replication initiation. Recently, MCM4 is reported to have a complex interaction with multiple cancer progression, including gastric, ovarian and cervical cancer. Here, this study mainly focused on the expression of MCM4 and its values in lung adenocarcinoma (LUAD). MCM4 was highly expressed in LUAD tumours and cells, and had an important effect on the overall survival. Overexpression of MCM4 promoted the proliferation, and suppressed the apoptosis in LUAD cells. However, MCM4 silence led to the opposite results. In vivo, knockdown of MCM4 inhibited tumour volume and weight in xenograft mouse model. As a member of DNA helicase, knockdown of MCM4 caused cell cycle arrest at G1 stage through inducing the expression of P21, a CDK inhibitor. These findings indicate that MCM4 may be a possible new therapeutic target for LUAD in the future.
    MeSH term(s) Humans ; Animals ; Mice ; Cell Cycle Proteins/genetics ; Cell Cycle Proteins/metabolism ; DNA-Binding Proteins/genetics ; Minichromosome Maintenance Complex Component 4/genetics ; Minichromosome Maintenance Proteins/genetics ; Minichromosome Maintenance Proteins/metabolism ; Adenocarcinoma of Lung/genetics ; Lung Neoplasms/genetics ; Biomarkers
    Chemical Substances Cell Cycle Proteins ; DNA-Binding Proteins ; Minichromosome Maintenance Complex Component 4 (EC 3.6.4.12) ; Minichromosome Maintenance Proteins (EC 3.6.4.12) ; Biomarkers ; MCM4 protein, human (EC 3.6.4.12)
    Language English
    Publishing date 2023-10-10
    Publishing country England
    Document type Journal Article
    ZDB-ID 2074559-X
    ISSN 1582-4934 ; 1582-4934 ; 1582-1838
    ISSN (online) 1582-4934
    ISSN 1582-4934 ; 1582-1838
    DOI 10.1111/jcmm.17819
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 5752: Show issues Location:
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    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

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  3. Article: The Adherence of Skin and Levator Palpebrae Superior Is Not Necessary in Blepharoplasty of Asian Patients.

    Lei, Shaorong / Tan, Wuyuan

    Plastic and reconstructive surgery. Global open

    2023  Volume 11, Issue 1, Page(s) e4732

    Language English
    Publishing date 2023-01-11
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2851682-5
    ISSN 2169-7574 ; 2169-7574
    ISSN (online) 2169-7574
    ISSN 2169-7574
    DOI 10.1097/GOX.0000000000004732
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 7091: Show issues Location:
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  4. Article: A novel cuproptosis-related gene signature for predicting prognosis in cervical cancer.

    Lei, Lei / Tan, Liao / Sui, Long

    Frontiers in genetics

    2022  Volume 13, Page(s) 957744

    Abstract: Purpose: ...

    Abstract Purpose:
    Language English
    Publishing date 2022-08-25
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2606823-0
    ISSN 1664-8021
    ISSN 1664-8021
    DOI 10.3389/fgene.2022.957744
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: Primary rectal Hodgkin lymphoma mimicking neuroendocrine tumor successfully removed by endoscopic submucosal dissection.

    Liu, Tao / Shi, Lei / Tan, Yuyong

    Digestive endoscopy : official journal of the Japan Gastroenterological Endoscopy Society

    2024  

    Language English
    Publishing date 2024-04-01
    Publishing country Australia
    Document type Journal Article
    ZDB-ID 1171589-3
    ISSN 1443-1661 ; 0915-5635
    ISSN (online) 1443-1661
    ISSN 0915-5635
    DOI 10.1111/den.14790
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 3854: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
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    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

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  6. Article ; Online: Sex difference in the association between BMI and cognitive impairment in Chinese older adults.

    Zhu, Lin / Lei, Mei / Tan, Li / Zou, Mingjun

    Journal of affective disorders

    2024  Volume 349, Page(s) 39–47

    Abstract: Background: The association between body mass index (BMI) and cognitive impairment (CI) has been the subject of extensive research, yet the precise dose-response effects remain undefined.: Methods: Older adults were selected from the 2011/2012 survey ...

    Abstract Background: The association between body mass index (BMI) and cognitive impairment (CI) has been the subject of extensive research, yet the precise dose-response effects remain undefined.
    Methods: Older adults were selected from the 2011/2012 survey at baseline and the new recruits from the 2014 and 2018 waves of the Chinese Longitudinal Healthy Longevity Survey (CLHLS). Multiple logistic regression models were used to evaluate the association between BMI categories and CI, and Restricted Cubic Spline (RCS) was used to explore the nonlinear relationship between BMI and CI.
    Results: The study included 29,380 older adults aged from 65 to 117 years, with an average age of 82 years. Of these, 13,465 were men, and 5359 exhibited cognitive impairment. The logistic model indicated that in female participants, being underweight was positively correlated with CI (OR:1.32; 95%CI 1.20-1.46), whereas being overweight was inversely correlated with CI (OR:0.86; 95%CI 0.75-0.99), and we didn't find any association between BMI category and CI in male participants. RCS modeling revealed a U-shaped relationship between BMI and CI. When stratified by sex, men exhibited a similar trend, with the lowest risk at a BMI of 22.774 kg/ m
    Limitation: This was a cross-sectional study, it cannot provide information on causal relationships.
    Conclusion: A U-shaped relationship was observed between BMI and CI in older adults, more pronounced in the male population, suggesting that male older adults may need to manage their BMI more rigorously.
    MeSH term(s) Humans ; Female ; Male ; Aged ; Aged, 80 and over ; Body Mass Index ; Cross-Sectional Studies ; Sex Characteristics ; Cognitive Dysfunction/epidemiology ; Logistic Models ; China/epidemiology
    Language English
    Publishing date 2024-01-06
    Publishing country Netherlands
    Document type Journal Article
    ZDB-ID 135449-8
    ISSN 1573-2517 ; 0165-0327
    ISSN (online) 1573-2517
    ISSN 0165-0327
    DOI 10.1016/j.jad.2024.01.021
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 1485: Show issues Location:
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  7. Article ; Online: Matrin-3 acts as a potential biomarker and promotes hepatocellular carcinoma progression by interacting with cell cycle-regulating genes.

    He, Hengjing / Jamal, Muhammad / Zeng, Xingruo / Lei, Yufei / Xiao, Di / Wei, Zimeng / Zhang, Chengjie / Zhang, Xiaoyu / Pan, Shan / Ding, Qianshan / Tan, Haiyan / Xie, Songping / Zhang, Qiuping

    Cell cycle (Georgetown, Tex.)

    2024  Volume 23, Issue 1, Page(s) 15–35

    Abstract: Hepatocellular carcinoma (HCC) is one of the leading causes of cancer-related mortality worldwide. The oncogenic role of Matrin-3 (MATR3), an a nuclear matrix protein, in HCC remains largely unknown. Here, we document the biological function of MATR3 in ... ...

    Abstract Hepatocellular carcinoma (HCC) is one of the leading causes of cancer-related mortality worldwide. The oncogenic role of Matrin-3 (MATR3), an a nuclear matrix protein, in HCC remains largely unknown. Here, we document the biological function of MATR3 in HCC based on integrated bioinformatics analysis and functional studies. According to the TCGA database, MATR3 expression was found to be positively correlated with clinicopathological characteristics in HCC. The receiver operating characteristic (ROC) curve and Kaplan-Meier (KM) curve displayed the diagnostic and prognostic potentials of MATR3 in HCC patients, respectively. Pathway enrichment analysis represented the enrichment of MATR3 in various molecular pathways, including the regulation of the cell cycle. Functional assays in HCC cell lines showed reduced proliferation of cells with stable silencing of MATR3. At the same time, the suppressive effects of MATR3 depletion on HCC development were verified by xenograft tumor experiments. Moreover, MATR3 repression also resulted in cell cycle arrest by modulating the expression of cell cycle-associated genes. In addition, the interaction of MATR3 with cell cycle-regulating factors in HCC cells was further corroborated with co-immunoprecipitation and mass spectrometry (Co-IP/MS). Furthermore, CIBERSORT and TIMER analyses showed an association between MATR3 and immune infiltration in HCC. In general, this study highlights the novel oncogenic function of MATR3 in HCC, which could comprehensively address how aberrant changes in the cell cycle promote HCC development. MATR3 might serve as a prognostic predictor and therapeutic target for HCC patients.
    MeSH term(s) Humans ; Carcinoma, Hepatocellular/genetics ; Liver Neoplasms/genetics ; Cell Cycle/genetics ; Cell Division ; Biomarkers ; RNA-Binding Proteins ; Nuclear Matrix-Associated Proteins/genetics
    Chemical Substances Biomarkers ; MATR3 protein, human ; RNA-Binding Proteins ; Nuclear Matrix-Associated Proteins
    Language English
    Publishing date 2024-01-22
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2146183-1
    ISSN 1551-4005 ; 1538-4101 ; 1554-8627
    ISSN (online) 1551-4005
    ISSN 1538-4101 ; 1554-8627
    DOI 10.1080/15384101.2024.2305535
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 5881: Show issues Location:
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  8. Article ; Online: Preclinical validation for the use of an automated ampule opener.

    Hu, Tian-Ting / Zuo, Rui / Lei, Wei / Xiang, Tao-Ying / Tan, Ji-Ping / Yan, Ruo-Fen

    Asian journal of surgery

    2024  Volume 47, Issue 4, Page(s) 1925–1927

    Language English
    Publishing date 2024-01-10
    Publishing country Netherlands
    Document type Letter
    ZDB-ID 1068461-x
    ISSN 0219-3108 ; 1015-9584
    ISSN (online) 0219-3108
    ISSN 1015-9584
    DOI 10.1016/j.asjsur.2023.12.084
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.B 2831: Show issues Location:
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  9. Book ; Online: CFD Based Researches and Applications for Fluid Machinery and Fluid Device

    Kim, Jin-Hyuk / Kim, Sung-Min / Choi, Minsuk / Tan, Lei / Huang, Bin / Pei, Ji

    2021  

    Keywords Technology: general issues ; centrifugal fan ; noise characteristics ; power consumption ; negative pressure ; sound pressure ; mechanical seal ; dynamic characteristics ; extrusion fault ; numerical simulation ; sealing performance ; fluent ; inducer ; step casing ; varying pitch ; cavitating flow and instabilities ; partial similarity principle ; flow similarity ; stability improvement ; multi-condition optimization ; cavitation performance ; artificial neural networks (ANN) ; net positive suction head (NPSH) ; double suction ; cascade ; aerodynamic ; parameterization ; plane cascade design ; incidence angle ; PSO-MVFSA ; optimization ; two-vane pump ; Computational Fluid Dynamics (CFD) ; Reynolds-averaged Navier-Stokes (RANS) ; machine learning ; energy recovery ; pump as turbine ; vortex ; hydraulic losses ; pressure fluctuation ; transient characteristics ; centrifugal pump ; startup period ; solar air heater ; ribs ; Nusselt number ; friction factor ; Reynolds-averaged Navier-Stokes equations ; thrust coefficient ; power coefficient ; figure of merit ; frozen rotor ; UAV ; octorotor SUAV ; aerodynamic performance ; rotor spacing ; hover ; CFD ; vortices distribution ; shape optimization ; Francis turbine ; fixed flow passage ; flow uniformity ; blade outlet angle ; Sirocco fan ; URANS ; volute tongue radius ; internal flow ; noise ; film cooling ; large eddy simulation ; triple holes ; blowing ratio ; adiabatic film-cooling effectiveness ; proper orthogonal decomposition ; axial compressor ; tip clearance ; flow field ; clearance ; flow function ; gas turbine ; leakage ; pressure ratio ; stepped labyrinth seal ; axial-flow pump ; root clearance radius ; computational fluid dynamics ; entropy production ; energy dissipation ; vortex pump ; lateral cavity ; open-design ; spiral flow ; reactor coolant pump (RCP) ; waviness ; leakage rate ; liquid film ; axial fan ; reversible ; jet ; design ; thrust ; energy characteristics ; mixing ; pitched blade turbine ; impeller ; inverse design method ; matching optimization ; diffuser ; small hydropower ; tubular turbine ; fish farm ; performance test ; design factors ; optimum model ; the mixed free-surface-pressurized flow ; characteristic implicit method ; relative roughness ; vent holes ; optimization control ; microchannel heat sink ; wavy microchannel ; groove ; heat transfer performance ; laminar flow ; multi-objective optimization ; LHS ; full factorial methods ; pump-turbine ; dynamic stress ; start-up process ; vortex generator (VG) ; computational fluid dynamics (CFD) ; cell-set model ; RANS ; LES ; multistage centrifugal pump ; double-suction impeller ; twin-volute ; inducer-type guide vane ; trailing edge flap (TEF) ; trailing edge flap with Micro-Tab ; deflection angle of the flap (αF) ; n/a
    Size 1 electronic resource (539 pages)
    Publisher MDPI - Multidisciplinary Digital Publishing Institute
    Publishing place Basel, Switzerland
    Document type Book ; Online
    Note English ; Open Access
    HBZ-ID HT021291524
    ISBN 9783036518152 ; 3036518150
    Database ZB MED Catalogue: Medicine, Health, Nutrition, Environment, Agriculture

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  10. Article ; Online: Network Analysis of Mental Health Problems in Young People: Reflections on the 5 Ts.

    Shek, Daniel Tan-Lei

    The Journal of adolescent health : official publication of the Society for Adolescent Medicine

    2023  Volume 73, Issue 2, Page(s) 219–220

    MeSH term(s) Humans ; Adolescent ; Mental Health ; Mental Disorders/psychology
    Language English
    Publishing date 2023-06-14
    Publishing country United States
    Document type Editorial ; Research Support, Non-U.S. Gov't ; Comment
    ZDB-ID 1063374-1
    ISSN 1879-1972 ; 1054-139X
    ISSN (online) 1879-1972
    ISSN 1054-139X
    DOI 10.1016/j.jadohealth.2023.05.004
    Database MEDical Literature Analysis and Retrieval System OnLINE

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