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Article ; Online: Dramatic improvement in the "Bulk" hyperpolarization of

Molway, Michael J / Bales-Shaffer, Liana / Ranta, Kaili / Ball, James / Sparling, Eleanor / Prince, Mia / Cocking, Daniel / Basler, Dustin / Murphy, Megan / Kidd, Bryce E / Gafar, Abdulbasit Tobi / Porter, Justin / Albin, Kierstyn / Rosen, Matthew S / Chekmenev, Eduard Y / Michael Snow, W / Barlow, Michael J / Goodson, Boyd M

Journal of magnetic resonance (San Diego, Calif. : 1997)

2023 Volume 354, Page(s) 107521

Abstract: We report on hyperpolarization of quadrupolar (I=3/2) ...

Abstract	We report on hyperpolarization of quadrupolar (I=3/2)
Language	English
Publishing date	2023-07-10
Publishing country	United States
Document type	Journal Article
ZDB-ID	1469665-4
ISSN	1096-0856 ; 1557-8968 ; 1090-7807 ; 0022-2364
ISSN (online)	1096-0856 ; 1557-8968
ISSN	1090-7807 ; 0022-2364
DOI	10.1016/j.jmr.2023.107521
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article: Radiolabeled Aminopyrazoles as Novel Isoform Selective Probes for pJNK3 Quantification.

Bales, Brian C / Cotero, Victoria / Meyer, Dan E / Roberts, Jeannette C / Rodriguez-Silva, Monica / Siclovan, Tiberiu M / Chambers, Jeremy W / Rishel, Michael J

ACS medicinal chemistry letters

2022 Volume 13, Issue 10, Page(s) 1606–1614

Abstract: The c-Jun N-terminal kinase 3 (JNK3) is a stress-activated kinase primarily expressed in the brain and implicated as an early mediator of neuronal apoptosis. We sought to develop a PET tracer to visualize pathological JNK3 activation. Because regional ... ...

Abstract	The c-Jun N-terminal kinase 3 (JNK3) is a stress-activated kinase primarily expressed in the brain and implicated as an early mediator of neuronal apoptosis. We sought to develop a PET tracer to visualize pathological JNK3 activation. Because regional JNK3 activation precedes apoptosis, such an imaging agent might enable the detection of "at risk" brain regions prior to neuronal death. We prepared a set of
Language	English
Publishing date	2022-09-28
Publishing country	United States
Document type	Journal Article
ISSN	1948-5875
ISSN	1948-5875
DOI	10.1021/acsmedchemlett.2c00278
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Article: A Retrospective Case Study of Successful Translational Research: Cardiovascular Disease Risk Assessment, Experiences in Community Engagement.

Bales, Michael E / Zhu, Jifeng / Ganzer, Christine A / Aboharb, Farid / Keeler, Allegra / Ryon, Krista A / Ehrmann, Brett J / Imperato-McGinley, Julianne

medRxiv : the preprint server for health sciences

2023

Abstract: In underserved communities in New York City, uninsured adults encounter a greater risk of cardiovascular disease and diabetes. The Heart-to-Heart Community Outreach Program (H2H) is addressing these disparities by providing screenings for diabetes and ... ...

Abstract	In underserved communities in New York City, uninsured adults encounter a greater risk of cardiovascular disease and diabetes. The Heart-to-Heart Community Outreach Program (H2H) is addressing these disparities by providing screenings for diabetes and other cardiovascular disease risk factors, fostering community engagement in translational research at our CTSC. Screening events are hosted in partnership with community faith-based institutions. Participants provide medical history, complete a survey, and receive individualized counseling by clinicians with referrals for follow-up care. The population served is disproportionately non-white, uninsured, with low-income, and underserved. The program empowers participants to make beneficial lifestyle changes using myriad strategies to reach those most in need. This required strong foundational program leadership, effective inter-institutional collaboration, and maintaining of community trust. Leveraging partnerships with faith-based institutions and community centers in at-risk NYC neighborhoods, H2H addresses the increasing burden of diabetes and cardiovascular disease risk factors in vulnerable individuals and provides a model for similar initiatives.
Language	English
Publishing date	2023-09-27
Publishing country	United States
Document type	Preprint
DOI	10.1101/2023.09.26.23296161
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Article ; Online: The effects of a 6-month weight loss intervention on physical function and serum biomarkers in older adults with and without osteoarthritis.

Coppock, James A / McNulty, Amy L / Porter Starr, Kathryn N / Holt, Abigail G / Borack, Michael S / Kosinski, Andrzej S / Collins, Amber T / Bales, Connie W / DeFrate, Louis E

Osteoarthritis and cartilage open

2023 Volume 5, Issue 3, Page(s) 100376

Abstract: Objective: To examine the effects of a 6-month weight loss intervention on physical function, inflammatory biomarkers, and metabolic biomarkers in both those with and without osteoarthritis (OA).: Design: 59 individuals ≥60 years old with obesity and ...

Abstract	Objective: To examine the effects of a 6-month weight loss intervention on physical function, inflammatory biomarkers, and metabolic biomarkers in both those with and without osteoarthritis (OA). Design: 59 individuals ≥60 years old with obesity and a functional impairment were enrolled into this IRB approved clinical trial and randomized into one of two 6-month weight loss arms: a higher protein hypocaloric diet or a standard protein hypocaloric diet. All participants were prescribed individualized 500-kcal daily-deficit diets, with a goal of 10% weight loss. Additionally, participants participated in three, low-intensity, exercise sessions per week. Physical function, serum biomarkers and body composition data were assessed at the baseline and 6-month timepoints. Statistical analyses assessed the relationships between biomarkers, physical function, body composition, and OA status as a result of the intervention. Results: No group effects of dietary intervention were detected on any outcome measures (multiple p > 0.05). During the 6-month trial, participants lost 6.2 ± 4.0% of their bodyweight (p < 0.0001) and experienced improved physical function on the Short-Performance-Physical-Battery (p < 0.0001), 8-foot-up-and-go (p < 0.0001), and time to complete 10-chair-stands (p < 0.0001). Adiponectin concentrations (p = 0.0480) were elevated, and cartilage oligomeric matrix protein (COMP) concentrations (p < 0.0001) were reduced; further analysis revealed that reductions in serum COMP concentrations were greater in OA-negative individuals. Conclusions: These results suggest that weight loss in older adults with and without OA may provide a protective effect to cartilage and OA. In particular, OA-negative individuals may be able to mitigate changes associated with OA through weight loss.
Language	English
Publishing date	2023-05-26
Publishing country	England
Document type	Journal Article
ISSN	2665-9131
ISSN (online)	2665-9131
DOI	10.1016/j.ocarto.2023.100376
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Article ; Online: Application of Topic Modeling to Tweets as the Foundation for Health Disparity Research for COVID-19.

Odlum, Michelle / Cho, Hwayoung / Broadwell, Peter / Davis, Nicole / Patrao, Maria / Schauer, Deborah / Bales, Michael E / Alcantara, Carmela / Yoon, Sunmoo

Studies in health technology and informatics

2020 Volume 272, Page(s) 24–27

Abstract: ... by others, positive sentiments, cohesively encouraging online discussions (e.g., Black strong 27.1%, growing ... behaviors (e.g., masks 4.7%, encouraging social distancing 9.4%) were uniquely observed in African American ...

Abstract	We randomly extracted publicly available Tweets mentioning COVID-19 related terms (n=2,558,474 Tweets) from Tweet corpora collected daily using an API from Jan 21st to May 3rd, 2020. We applied a clustering algorithm to publicly available Tweets authored by African Americans (n=1,763) to detect topics and sentiment applying natural language processing (NLP). We visualized fifteen topics (four themes) using network diagrams (Newman modularity 0.74). Compared to the COVID-19 related Tweets authored by others, positive sentiments, cohesively encouraging online discussions (e.g., Black strong 27.1%, growing up Blacks 22.8%, support Black business 17.0%, how to build resilience 7.8%), and COVID-19 prevention behaviors (e.g., masks 4.7%, encouraging social distancing 9.4%) were uniquely observed in African American Twitter communities. Application of topic modeling techniques to streaming social media Twitter provides the foundation for research team insights regarding information and future virtual based intervention and social media based health disparity research for COVID-19.
MeSH term(s)	Betacoronavirus ; COVID-19 ; Coronavirus Infections ; Humans ; Pandemics ; Pneumonia, Viral ; SARS-CoV-2 ; Social Media
Keywords	covid19
Language	English
Publishing date	2020-06-26
Publishing country	Netherlands
Document type	Journal Article
ISSN	1879-8365
ISSN (online)	1879-8365
DOI	10.3233/SHTI200484
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Article ; Online: Batch-Mode Clinical-Scale Optical Hyperpolarization of Xenon-129 Using an Aluminum Jacket with Rapid Temperature Ramping.

Birchall, Jonathan R / Nikolaou, Panayiotis / Coffey, Aaron M / Kidd, Bryce E / Murphy, Megan / Molway, Michael / Bales, Liana B / Goodson, Boyd M / Irwin, Robert K / Barlow, Michael J / Chekmenev, Eduard Y

Analytical chemistry

2020 Volume 92, Issue 6, Page(s) 4309–4316

Abstract: We present spin-exchange optical pumping (SEOP) using a third-generation (GEN-3) automated batch-mode clinical- ... ...

Abstract	We present spin-exchange optical pumping (SEOP) using a third-generation (GEN-3) automated batch-mode clinical-scale
Language	English
Publishing date	2020-03-02
Publishing country	United States
Document type	Journal Article ; Research Support, U.S. Gov't, Non-P.H.S.
ZDB-ID	1508-8
ISSN	1520-6882 ; 0003-2700
ISSN (online)	1520-6882
ISSN	0003-2700
DOI	10.1021/acs.analchem.9b05051
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Zs.A 4033: Show issues

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Article ; Online: XeUS: A second-generation automated open-source batch-mode clinical-scale hyperpolarizer.

Birchall, Jonathan R / Irwin, Robert K / Nikolaou, Panayiotis / Coffey, Aaron M / Kidd, Bryce E / Murphy, Megan / Molway, Michael / Bales, Liana B / Ranta, Kaili / Barlow, Michael J / Goodson, Boyd M / Rosen, Matthew S / Chekmenev, Eduard Y

Journal of magnetic resonance (San Diego, Calif. : 1997)

2020 Volume 319, Page(s) 106813

Abstract: We present a second-generation open-source automated batch- ... ...

Abstract	We present a second-generation open-source automated batch-mode
MeSH term(s)	Automation ; Magnetic Resonance Spectroscopy ; Radiopharmaceuticals/chemical synthesis ; Reproducibility of Results ; Software ; Xenon Isotopes/chemical synthesis
Chemical Substances	Radiopharmaceuticals ; Xenon Isotopes
Language	English
Publishing date	2020-09-01
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't ; Research Support, U.S. Gov't, Non-P.H.S.
ZDB-ID	1469665-4
ISSN	1096-0856 ; 1557-8968 ; 1090-7807 ; 0022-2364
ISSN (online)	1096-0856 ; 1557-8968
ISSN	1090-7807 ; 0022-2364
DOI	10.1016/j.jmr.2020.106813
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Article ; Online: Fe-HBED Analogs: A Promising Class of Iron-Chelate Contrast Agents for Magnetic Resonance Imaging.

Bales, Brian C / Grimmond, Brian / Johnson, Bruce F / Luttrell, M Todd / Meyer, Dan E / Polyanskaya, Tatyana / Rishel, Michael J / Roberts, Jeannette

Contrast media & molecular imaging

2019 Volume 2019, Page(s) 8356931

Abstract: Contrast-enhanced magnetic resonance imaging is an essential tool for disease diagnosis and management; all marketed clinical magnetic resonance imaging (MRI) contrast agents (CAs) are gadolinium (Gd) chelates and most are extracellular fluid (ECF) ... ...

Abstract	Contrast-enhanced magnetic resonance imaging is an essential tool for disease diagnosis and management; all marketed clinical magnetic resonance imaging (MRI) contrast agents (CAs) are gadolinium (Gd) chelates and most are extracellular fluid (ECF) agents. After intravenous injection, these agents rapidly distribute to the extracellular space and are also characterized by low serum protein binding and predominant renal clearance. Gd is an abiotic element with no biological recycling processes; low levels of Gd have been detected in the central nervous system and bone long after administration. These observations have prompted interest in the development of new MRI contrast agents based on biotic elements such as iron (Fe); Fe-HBED (HBED =
MeSH term(s)	Animals ; Contrast Media/chemical synthesis ; Contrast Media/chemistry ; Contrast Media/pharmacology ; Edetic Acid/analogs & derivatives ; Edetic Acid/chemical synthesis ; Edetic Acid/chemistry ; Edetic Acid/pharmacology ; Gadolinium/chemistry ; Gadolinium DTPA/pharmacology ; Humans ; Iron Chelating Agents/chemical synthesis ; Iron Chelating Agents/chemistry ; Iron Chelating Agents/pharmacology ; Liver/diagnostic imaging ; Liver/drug effects ; Magnetic Resonance Imaging/methods ; Mice ; Molecular Structure ; Organometallic Compounds/chemical synthesis ; Organometallic Compounds/chemistry ; Organometallic Compounds/pharmacology ; Tissue Distribution/drug effects
Chemical Substances	Contrast Media ; Fe-HBED ; Iron Chelating Agents ; Organometallic Compounds ; Edetic Acid (9G34HU7RV0) ; Gadolinium (AU0V1LM3JT) ; Gadolinium DTPA (K2I13DR72L)
Language	English
Publishing date	2019-12-20
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2232678-9
ISSN	1555-4317 ; 1555-4309
ISSN (online)	1555-4317
ISSN	1555-4309
DOI	10.1155/2019/8356931
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Zs.A 6273: Show issues

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Article ; Online: Current Use and Barriers to Point-of-Care Ultrasound in Primary Care: A National Survey of VA Medical Centers.

Nathanson, Robert / Williams, Jason P / Gupta, Neil / Rezigh, Austin / Mader, Michael J / Haro, Elizabeth K / Drum, Brandy / O'Brien, Edward / Khosla, Rahul / Boyd, Jeremy S / Bales, Brian / Wetherbee, Erin / Sauthoff, Harald / Schott, Christopher K / Basrai, Zahir / Resop, Dana / Lucas, Brian P / Soni, Nilam J

The American journal of medicine

2023 Volume 136, Issue 6, Page(s) 592–595.e2

Abstract: Background: More primary care providers (PCPs) have begun to embrace the use of point-of-care ultrasound (POCUS), but little is known about how PCPs are currently using POCUS and what barriers exist. In this prospective study, the largest systematic ... ...

Abstract	Background: More primary care providers (PCPs) have begun to embrace the use of point-of-care ultrasound (POCUS), but little is known about how PCPs are currently using POCUS and what barriers exist. In this prospective study, the largest systematic survey of POCUS use among PCPs, we assessed the current use, barriers to use, program management, and training needs for POCUS in primary care. Methods: We conducted a prospective observational study of all VA Medical Centers (VAMCs) between June 2019 and March 2020 using a web-based survey sent to all VAMC Chiefs of Staff and Chiefs of primary care clinics (PCCs). Results: Chiefs of PCCs at 105 VAMCs completed the survey (82% response rate). Only 13% of PCCs currently use POCUS, and the most common applications used were bladder and musculoskeletal ultrasound. Desire for POCUS training exceeded current use, but lack of trained providers (78%), ultrasound equipment (66%), and funding for training (41%) were common barriers. Program infrastructure to support POCUS use was uncommon, and only 9% of VAMCs had local policies related to POCUS. Most PCC chiefs (64%) would support POCUS training. Conclusions: Current use of POCUS in primary care is low despite the recent growth of POCUS training in Internal Medicine residency programs. Investment in POCUS training and program infrastructure is needed to expand POCUS use in primary care and ensure adequate supervision of trainees.
MeSH term(s)	Humans ; Point-of-Care Systems ; Prospective Studies ; Internship and Residency ; Clinical Competence ; Ultrasonography ; Primary Health Care
Language	English
Publishing date	2023-02-23
Publishing country	United States
Document type	Observational Study ; Journal Article ; Research Support, U.S. Gov't, Non-P.H.S. ; Research Support, U.S. Gov't, P.H.S.
ZDB-ID	80015-6
ISSN	1555-7162 ; 1873-2178 ; 0002-9343 ; 1548-2766
ISSN (online)	1555-7162 ; 1873-2178
ISSN	0002-9343 ; 1548-2766
DOI	10.1016/j.amjmed.2023.01.038
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Article ; Online: Novel Detection and Restorative Levodopa Treatment for Preclinical Diabetic Retinopathy.

Motz, Cara T / Chesler, Kyle C / Allen, Rachael S / Bales, Katie L / Mees, Lukas M / Feola, Andrew J / Maa, April Y / Olson, Darin E / Thule, Peter M / Iuvone, P Michael / Hendrick, Andrew M / Pardue, Machelle T

Diabetes

2020 Volume 69, Issue 7, Page(s) 1518–1527

Abstract: Diabetic retinopathy (DR) is diagnosed clinically by directly viewing retinal vascular changes during ophthalmoscopy or through fundus photographs. However, electroretinography (ERG) studies in humans and rodents have revealed that retinal dysfunction is ...

Abstract	Diabetic retinopathy (DR) is diagnosed clinically by directly viewing retinal vascular changes during ophthalmoscopy or through fundus photographs. However, electroretinography (ERG) studies in humans and rodents have revealed that retinal dysfunction is demonstrable prior to the development of visible vascular defects. Specifically, delays in dark-adapted ERG oscillatory potential (OP) implicit times in response to dim-flash stimuli (<-1.8 log cd · s/m
MeSH term(s)	Adult ; Aged ; Carbidopa/therapeutic use ; Diabetic Retinopathy/diagnosis ; Diabetic Retinopathy/drug therapy ; Diabetic Retinopathy/physiopathology ; Drug Combinations ; Electroretinography/methods ; Female ; Humans ; Levodopa/therapeutic use ; Male ; Middle Aged
Chemical Substances	Drug Combinations ; carbidopa, levodopa drug combination ; Levodopa (46627O600J) ; Carbidopa (MNX7R8C5VO)
Language	English
Publishing date	2020-02-12
Publishing country	United States
Document type	Journal Article ; Randomized Controlled Trial ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't ; Research Support, U.S. Gov't, Non-P.H.S.
ZDB-ID	80085-5
ISSN	1939-327X ; 0012-1797
ISSN (online)	1939-327X
ISSN	0012-1797
DOI	10.2337/db19-0869
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