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  1. Article ; Online: In-process volumetric sensing of defects in multiple parts during powder bed fusion using ultrasound.

    Kizer, Nathan J / Dickman, Corey J / Nassar, Abdalla R / Reutzel, Edward W / Kube, Christopher M

    JASA express letters

    2023  Volume 3, Issue 9

    Abstract: This letter reports on the integration of eight ultrasonic transducers into a build substrate for individual in-process monitoring of eight parts fabricated using powder bed fusion additive manufacturing. Ultrasound is shown to be able to sense poor ... ...

    Abstract This letter reports on the integration of eight ultrasonic transducers into a build substrate for individual in-process monitoring of eight parts fabricated using powder bed fusion additive manufacturing. Ultrasound is shown to be able to sense poor fusion of parts to the substrate and also sensitivity to porosity. This technique demonstrates the utility of ultrasound as one of a few techniques able to interrogate the volume of additively manufactured parts during the process. Additionally, the ability to measure several parts during a single build can be used for efficient process parameter development studies, as the ultrasonic measurements can offer rapid information about part quality and integrity.
    Language English
    Publishing date 2023-09-01
    Publishing country United States
    Document type Journal Article
    ISSN 2691-1191
    ISSN (online) 2691-1191
    DOI 10.1121/10.0020739
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Association of thyroid dysfunction in individuals ≥ 65 years of age with subclinical cardiac abnormalities.

    Barasch, Eddy / Gottdiener, John / Buzkova, Petra / Cappola, Anne / Shah, Sanjiv / DeFilippi, Christopher / Gardin, Julius / Kizer, Jorge R

    The Journal of clinical endocrinology and metabolism

    2024  

    Abstract: Context: The relationship between thyroid dysfunction and measures of myocardial disease in older individuals remains to be defined.: Objective: To evaluate the impact of thyroid dysfunction on structure and function of the left-heart chambers and ... ...

    Abstract Context: The relationship between thyroid dysfunction and measures of myocardial disease in older individuals remains to be defined.
    Objective: To evaluate the impact of thyroid dysfunction on structure and function of the left-heart chambers and blood markers of cardiac disease.
    Design: Cross-sectional analysis.
    Setting: The Cardiovascular Health Study, a community-based cohort of older individuals recruited from four urban areas in the United States.
    Patients: Of 3163 participants studied, 2477 were euthyroid, 465 had subclinical hypothyroidism (SCH), 47 overt hypothyroidism (OH), 45 endogenous (endo) subclinical hyperthyroidism (endo-SCT), and 129 had exogenous (exo) SCT due to thyroid hormone supplementation.
    Interventions: Clinical evaluation, blood sampling and biomarker measurement, 2-dimensional and speckle-tracking echocardiography.
    Main outcome measure(s): Left heart myocardial deformation, circulating biomarkers of diastolic overload (NT-proBNP), fibrosis (sST2, gal-3), and cardiomyocyte injury (hs-cTnT).
    Results: SCH was associated with higher NT-proBNP (beta = 0.17, p = 0.004), whereas OH was associated with higher hs-cTnT (beta = 0.29, p = 0.005). There were also suggestive associations of SCH with higher sST2, as well as endo-SCT with higher gal-3 and lower (worse) left atrial reservoir strain. Left ventricular longitudinal strain and end-diastolic strain rate did not differ significantly from euthyroid participants in SCH, OH, or exo-SCT.
    Conclusions: In this free-living elderly cohort, subclinical and overt hypothyroidism were associated with abnormalities of blood biomarkers consistent with diastolic overload and myocardial necrosis respectively, whereas subclinical hyperthyroidism tended to be associated with myocardial fibrosis and decreased left atrial strain. Our findings could represent stage B heart failure and illuminate distinct aspects of the pathobiology of heart disease related to thyroid gland dysfunction with potential clinical implications.
    Language English
    Publishing date 2024-01-06
    Publishing country United States
    Document type Journal Article
    ZDB-ID 3029-6
    ISSN 1945-7197 ; 0021-972X
    ISSN (online) 1945-7197
    ISSN 0021-972X
    DOI 10.1210/clinem/dgae001
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Erratum. The Association of Measures of Cardiovascular Autonomic Function, Heart Rate, and Orthostatic Hypotension With Incident Glucose Disorders: The Cardiovascular Health Study. Diabetes Care 2022;45:2376-2382.

    Barzilay, Joshua I / Tressel, William / Biggs, Mary L / Stein, Phyllis K / Kizer, Jorge R / Shitole, Sanyog G / Bene-Alhasan, Yakubu / Mukamal, Kenneth J

    Diabetes care

    2023  Volume 46, Issue 6, Page(s) 1311

    Language English
    Publishing date 2023-06-01
    Publishing country United States
    Document type Published Erratum
    ZDB-ID 441231-x
    ISSN 1935-5548 ; 0149-5992
    ISSN (online) 1935-5548
    ISSN 0149-5992
    DOI 10.2337/dc23-er06a
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: The determinants of fasting and post-load non-esterified fatty acids in older adults: The cardiovascular health study.

    Bene-Alhasan, Yakubu / Siscovick, David S / Ix, Joachim H / Kizer, Jorge R / Tracy, Russell / Djoussé, Luc / Mukamal, Kenneth J

    Metabolism open

    2023  Volume 20, Page(s) 100261

    Abstract: Aim: Non-esterified fatty acids (NEFA) are potential targets for prevention of key cardiometabolic diseases of aging, but their population-level correlates remain uncertain. We sought to identify modifiable factors associated with fasting and post-load ... ...

    Abstract Aim: Non-esterified fatty acids (NEFA) are potential targets for prevention of key cardiometabolic diseases of aging, but their population-level correlates remain uncertain. We sought to identify modifiable factors associated with fasting and post-load NEFA levels in older adults.
    Methods: We used linear regression to determine the cross-sectional associations of demographic, anthropometric, and lifestyle characteristics and medication use with serum fasting and post-load NEFA concentrations amongst community-dwelling older adults enrolled in the Cardiovascular Health Study (n = 1924).
    Results: Fasting NEFA levels generally demonstrated a broader set of determinants, while post-load NEFA were more consistently associated with metabolic factors. Waist circumference and weight were associated with higher fasting and post-load NEFA. Cigarette smoking and caffeine intake were associated with lower levels of both species, and moderate alcohol intake was associated with higher fasting levels whereas greater consumption was associated with lower post-load levels. Unique factors associated with higher fasting NEFA included female sex, higher age, loop and thiazide diuretic use and calcium intake, while factors associated with lower fasting levels included higher educational attainment, beta-blocker use, and protein intake. Hours spent sleeping during the daytime were associated with higher post-load NEFA, while DASH score was associated with lower levels.
    Conclusion: Fasting and post-load NEFA have both common and unique modifiable risk factors, including sociodemographics, anthropometric, medications, and diet. Post-load NEFA were particularly sensitive to metabolic factors, while a broader range of determinants were associated with fasting levels. These factors warrant study as targets for lowering levels of NEFA in older adults.
    Language English
    Publishing date 2023-10-23
    Publishing country England
    Document type Journal Article
    ISSN 2589-9368
    ISSN (online) 2589-9368
    DOI 10.1016/j.metop.2023.100261
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: Cardiac Mechanics and Kidney Function Decline in the Cardiovascular Health Study.

    Mehta, Rupal / Buzkova, Petra / Patel, Harnish / Cheng, Jeanette / Kizer, Jorge R / Gottdiener, John S / Psaty, Bruce / Khan, Sadiya S / Ix, Joachim H / Isakova, Tamara / Shlipak, Michael G / Bansal, Nisha / Shah, Sanjiv J

    Kidney360

    2023  Volume 4, Issue 5, Page(s) 622–630

    MeSH term(s) Heart ; Kidney ; Cardiovascular System
    Language English
    Publishing date 2023-03-08
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
    ISSN 2641-7650
    ISSN (online) 2641-7650
    DOI 10.34067/KID.0000000000000100
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: The Association of Measures of Cardiovascular Autonomic Function, Heart Rate, and Orthostatic Hypotension With Incident Glucose Disorders: The Cardiovascular Health Study.

    Barzilay, Joshua I / Tressel, William / Biggs, Mary L / Stein, Phyllis K / Kizer, Jorge R / Shitole, Sanyog G / Bene-Alhasan, Yakubu / Mukamal, Kenneth J

    Diabetes care

    2022  Volume 45, Issue 10, Page(s) 2376–2382

    Abstract: Objective: The autonomic nervous system (ANS) innervates pancreatic endocrine cells, muscle, and liver, all of which participate in glucose metabolism. We tested whether measures of cardiovascular ANS function are independently associated with incident ... ...

    Abstract Objective: The autonomic nervous system (ANS) innervates pancreatic endocrine cells, muscle, and liver, all of which participate in glucose metabolism. We tested whether measures of cardiovascular ANS function are independently associated with incident diabetes and annual change in fasting glucose (FG) levels as well as with insulin secretion and insulin sensitivity in older adults without diabetes.
    Research design and methods: Heart rate (HR) and measures of HR variability (HRV) were derived from 24-h electrocardiographic monitoring. Blood pressure, seated and standing, was measured. Cox proportional hazards models and linear mixed models were used to analyze the associations between HRV, HR, and orthostatic hypotension (SBP >20 mmHg decline) and incident diabetes or longitudinal FG change.
    Results: The mean annual unadjusted FG change was 1 mg/dL. Higher detrended fluctuation analyses (DFA) values, averaged over 4-11 (DFA1) or 12-20 beats (DFA2)-reflecting greater versus less organization of beat-to-beat intervals-were associated with less FG increase over time (per 1-SD increment: DFA1: -0.49 mg/dL/year [-0.96, -0.03]; DFA2: -0.55 mg/dL/year [-1.02, -0.09]). In mutually adjusted analyses, higher SD of the N-N interval (SDNN) was associated with less FG increase over time (per 1-SD increment: SDNN: -0.62 mg/dL/year [-1.22, -0.03]). Higher values of DFA1, DFA2, and SDNN were each associated with greater insulin secretion and insulin sensitivity but not with incident diabetes. We observed no association of HR or orthostatic hypotension with diabetes or FG change.
    Conclusions: Specific measures of cardiac autonomic function are prospectively related to FG level changes and insulin secretion and action.
    MeSH term(s) Aged ; Autonomic Nervous System ; Blood Glucose/metabolism ; Diabetes Mellitus ; Glucose ; Heart Rate ; Humans ; Hypotension, Orthostatic/epidemiology ; Insulin Resistance
    Chemical Substances Blood Glucose ; Glucose (IY9XDZ35W2)
    Language English
    Publishing date 2022-08-01
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Extramural
    ZDB-ID 441231-x
    ISSN 1935-5548 ; 0149-5992
    ISSN (online) 1935-5548
    ISSN 0149-5992
    DOI 10.2337/dc22-0553
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article ; Online: Race-Ethnic Differences of ST-Elevation Myocardial Infarction: Findings from a New York Health System Registry.

    Murray, Christopher S G / Zamora, Cristian / Shitole, Sanyog G / Christa, Panagiota / Lee, Un Jung / Bortnick, Anna E / Kizer, Jorge R / Rodriguez, Carlos J

    Ethnicity & disease

    2022  Volume 32, Issue 3, Page(s) 193–202

    Abstract: Background: Race and ethnicity are major considerations in the incidence, management, and long-term outcome of ST-elevation myocardial infarction (STEMI) in the United States, but there is limited existing comparative data.: Methods: We assembled a ... ...

    Abstract Background: Race and ethnicity are major considerations in the incidence, management, and long-term outcome of ST-elevation myocardial infarction (STEMI) in the United States, but there is limited existing comparative data.
    Methods: We assembled a registry in a health system serving Bronx, NY of STEMI patients from 2008-2014 and analyzed differences in presentation, treatment and mortality between Hispanic/Latino (H/L), non-Hispanic Black (NHB) and non-Hispanic White (NHW). Upon discharge post-treatment for STEMI, all patients were followed for a median of 4.4 years (interquartile range 2.5, 6.0). Out of 966 STEMI patients, mean age was 61 years, 46% were H/L and 65% were male. H/Ls and NHBs had a higher prevalence of hypertension and diabetes mellitus than their NHW counterparts, coinciding with a lower socioeconomic status (SES).
    Results: The number of critically diseased vessels found at cardiac catheterization and mean troponin levels did not vary by race-ethnicity; neither did the adjusted hazard ratios (HR) for death. However, age-sex adjusted rates of general hospital readmission were higher in NHBs vs NHWs (HR 1.30, P=.03). Age-sex adjusted cardiovascular readmissions rates were higher in H/Ls than NHWs (HR 1.42, P=.03). Age-sex adjusted heart failure readmissions were increased for both H/Ls (HR 2.14, P=.01) and NHBs (HR 2.12, P=.02) over NHWs.
    Conclusions: Among STEMI patients, a higher prevalence of modifiable cardiovascular risk factors and a lower SES was seen among NHBs and H/Ls compared to NHWs. Despite similar coronary disease severity and in-hospital death, NHBs and H/Ls had a greater risk of general, cardiovascular and heart failure readmissions post-STEMI compared to NHWs.
    MeSH term(s) Ethnicity ; Female ; Health Status Disparities ; Heart Failure ; Hospital Mortality/ethnology ; Humans ; Male ; Middle Aged ; New York ; Racial Groups ; Registries ; Risk Factors ; ST Elevation Myocardial Infarction/ethnology ; ST Elevation Myocardial Infarction/mortality ; United States ; White People
    Language English
    Publishing date 2022-07-21
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't ; Research Support, N.I.H., Extramural
    ZDB-ID 1274267-3
    ISSN 1945-0826 ; 1049-510X
    ISSN (online) 1945-0826
    ISSN 1049-510X
    DOI 10.18865/ed.32.3.193
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article ; Online: Dysregulated carbohydrate and lipid metabolism and risk of atrial fibrillation in advanced old age.

    Pellegrini, Cara N / Buzkova, Petra / Oesterle, Adam / Heckbert, Susan R / Tracy, Russell P / Siscovick, David S / Mukamal, Kenneth J / Djoussé, Luc / Kizer, Jorge R

    Heart (British Cardiac Society)

    2023  Volume 109, Issue 8, Page(s) 606–611

    Abstract: Objective: Obesity and dysmetabolism are major risk factors for atrial fibrillation (AF). Fasting and postload levels of glucose and non-esterified fatty acids (NEFAs) reflect different facets of metabolic regulation. We sought to study their respective ...

    Abstract Objective: Obesity and dysmetabolism are major risk factors for atrial fibrillation (AF). Fasting and postload levels of glucose and non-esterified fatty acids (NEFAs) reflect different facets of metabolic regulation. We sought to study their respective contributions to AF risk concurrently.
    Methods: We assessed levels of fasting and postload glucose and NEFA in the Cardiovascular Health Study to identify associations with AF incidence and, secondarily, with ECG parameters of AF risk available at baseline. Linear and Cox regressions were performed.
    Results: The study included 1876 participants (age 77.7±4.4). During the median follow-up of 11.4 years, 717 cases of incident AF occurred. After adjustment for potential confounders, postload glucose showed an association with incident AF (HR per SD increment of postload glucose=1.11, 95% CI 1.02 to 1.21, p=0.017). Both glucose measures, but not NEFA, were positively associated with higher P wave terminal force in V1 (PTFV1); the association remained significant only for postload glucose when the two measures were entered together (β per SD increment=138 μV·ms, 95% CI 15 to 260, p=0.028). Exploratory analyses showed significant interaction by sex for fasting NEFA (p
    Conclusions: Among older adults, postload glucose was positively associated with incident AF, with consistent findings for PTFV1. In exploratory analyses, the relationship with AF appeared specific to women. These findings require further study but suggest that interventions to address postprandial dysglycaemia late in life might reduce AF.
    MeSH term(s) Male ; Humans ; Female ; Aged ; Aged, 80 and over ; Atrial Fibrillation/diagnosis ; Atrial Fibrillation/epidemiology ; Atrial Fibrillation/etiology ; Lipid Metabolism ; Follow-Up Studies ; Prospective Studies ; Electrocardiography ; Risk Factors ; Glucose ; Incidence
    Chemical Substances Glucose (IY9XDZ35W2)
    Language English
    Publishing date 2023-03-27
    Publishing country England
    Document type Journal Article ; Research Support, N.I.H., Extramural
    ZDB-ID 1303417-0
    ISSN 1468-201X ; 1355-6037
    ISSN (online) 1468-201X
    ISSN 1355-6037
    DOI 10.1136/heartjnl-2022-321633
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article ; Online: Circulating Growth Differentiation Factors 11 and 8, Their Antagonists Follistatin and Follistatin-Like-3, and Risk of Heart Failure in Elders.

    Kizer, Jorge R / Patel, Sheena / Ganz, Peter / Newman, Anne B / Bhasin, Shalender / Lee, Se-Jin / Cawthon, Peggy M / LeBrasseur, Nathan K / Shah, Sanjiv J / Psaty, Bruce M / Tracy, Russell P / Cummings, Steven R

    The journals of gerontology. Series A, Biological sciences and medical sciences

    2023  Volume 79, Issue 1

    Abstract: Background: Heterochronic parabiosis has identified growth differentiation factor (GDF)-11 as a potential means of cardiac rejuvenation, but findings have been inconsistent. A major barrier has been lack of assay specificity for GDF-11 and its homolog ... ...

    Abstract Background: Heterochronic parabiosis has identified growth differentiation factor (GDF)-11 as a potential means of cardiac rejuvenation, but findings have been inconsistent. A major barrier has been lack of assay specificity for GDF-11 and its homolog GDF-8.
    Methods: We tested the hypothesis that GDF-11 and GDF-8, and their major antagonists follistatin and follistatin-like (FSTL)-3, are associated with incident heart failure (HF) and its subtypes in elders. Based on validation experiments, we used liquid chromatography-tandem mass spectrometry to measure total serum GDF-11 and GDF-8, along with follistatin and FSTL-3 by immunoassay, in 2 longitudinal cohorts of older adults.
    Results: In 2 599 participants (age 75.2 ± 4.3) followed for 10.8 ± 5.6 years, 721 HF events occurred. After adjustment, neither GDF-11 (HR per doubling: 0.93 [0.67, 1.30]) nor GDF-8 (HR: 1.02 per doubling [0.83, 1.27]) was associated with incident HF or its subtypes. Positive associations with HF were detected for follistatin (HR: 1.15 [1.00, 1.32]) and FLST-3 (HR: 1.38 [1.03, 1.85]), and with HF with preserved ejection fraction for FSTL-3 (HR: 1.77 [1.03, 3.02]). (All HRs per doubling of biomarker.) FSTL-3 associations with HF appeared stronger at higher follistatin levels and vice versa, and also for men, Blacks, and lower kidney function.
    Conclusions: Among older adults, serum follistatin and FSTL-3, but not GDF-11 or GDF-8, were associated with incident HF. These findings do not support the concept that low serum levels of total GDF-11 or GDF-8 contribute to HF late in life, but do implicate transforming growth factor-β superfamily pathways as potential therapeutic targets.
    MeSH term(s) Aged ; Humans ; Male ; Biomarkers ; Follistatin ; Growth Differentiation Factor 15 ; Heart Failure/blood ; Heart Failure/epidemiology ; Myostatin/blood ; Bone Morphogenetic Proteins/blood ; Growth Differentiation Factors/blood
    Chemical Substances Biomarkers ; Follistatin ; Growth Differentiation Factor 15 ; Myostatin ; GDF11 protein, human ; MSTN protein, human ; Bone Morphogenetic Proteins ; Growth Differentiation Factors
    Language English
    Publishing date 2023-08-26
    Publishing country United States
    Document type Journal Article
    ZDB-ID 1223643-3
    ISSN 1758-535X ; 1079-5006
    ISSN (online) 1758-535X
    ISSN 1079-5006
    DOI 10.1093/gerona/glad206
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article ; Online: Elevated Plasma Levels of Ketone Bodies Are Associated With All-Cause Mortality and Incidence of Heart Failure in Older Adults: The CHS.

    Niezen, Sebastian / Connelly, Margery A / Hirsch, Calvin / Kizer, Jorge R / Benitez, Maria E / Minchenberg, Scott / Perez-Matos, Maria Camila / Jiang, Zhenghui Gordon / Mukamal, Kenneth J

    Journal of the American Heart Association

    2023  Volume 12, Issue 17, Page(s) e029960

    Abstract: Background Chronic disease, such as heart failure, influences cellular metabolism and shapes circulating metabolites. The relationships between key energy metabolites and chronic diseases in aging are not well understood. This study aims to determine the ...

    Abstract Background Chronic disease, such as heart failure, influences cellular metabolism and shapes circulating metabolites. The relationships between key energy metabolites and chronic diseases in aging are not well understood. This study aims to determine the relationship between main components of energy metabolism with all-cause mortality and incident heart failure. Methods and Results We analyzed the association between plasma metabolite levels with all-cause mortality and incident heart failure among US older adults in the CHS (Cardiovascular Health Study). We followed 1758 participants without heart failure at baseline with hazard ratios (HRs) of analyte levels and metabolic profiles characterized by high levels of ketone bodies for all-cause mortality and incident heart failure. Multivariable Cox analyses revealed a dose-response relationship of 50% increase in all-cause mortality between lowest and highest quintiles of ketone body concentrations (HR, 1.5 [95% CI, 1.0-1.9];
    MeSH term(s) Humans ; Aged ; Incidence ; Heart Failure/diagnosis ; Heart Failure/epidemiology ; Cardiovascular Diseases ; Aging ; Ketone Bodies
    Chemical Substances Ketone Bodies
    Language English
    Publishing date 2023-08-23
    Publishing country England
    Document type Journal Article ; Research Support, N.I.H., Extramural
    ZDB-ID 2653953-6
    ISSN 2047-9980 ; 2047-9980
    ISSN (online) 2047-9980
    ISSN 2047-9980
    DOI 10.1161/JAHA.123.029960
    Database MEDical Literature Analysis and Retrieval System OnLINE

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