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Article ; Online: Ozone Treatment for the Management of Caries in Primary Dentition: A Systematic Review of Clinical Studies.

Veneri, Federica / Filippini, Tommaso / Consolo, Ugo / Vinceti, Marco / Generali, Luigi

2024 Volume 12, Issue 3

Abstract: Dental caries in children is a frequent and debilitating condition, whose management is often challenging. The aim of this systematic review was to investigate the effectiveness of ozone applications for the treatment of caries in primary dentition. ... ...

Abstract	Dental caries in children is a frequent and debilitating condition, whose management is often challenging. The aim of this systematic review was to investigate the effectiveness of ozone applications for the treatment of caries in primary dentition. According to PRISMA guidelines, a systematic literature search was performed up to 6 January 2024. Clinical studies using ozone to treat caries of deciduous teeth were considered for inclusion. Out of the 215 records retrieved, seven studies were eventually included in the review, all of which used gaseous ozone. Four studies were judged at high risk of bias, two at low risk, and one of some concerns. The great heterogeneity of designs, outcomes, and protocols made it impossible to conduct a meta-analysis. Despite some limitations, the evidence yielded by the included studies suggests that ozone application, regardless of the protocol applied, is comparable to other interventions in terms of clinical outcomes and anti-bacterial activity, with no reported adverse effects and good patient acceptance. Therefore, ozone application may be a non-invasive approach to treat caries in primary dentition, especially in very young and poorly cooperative patients. Further standardized and rigorous studies are, however, needed to identify the best clinical protocols for this specific field.
Language	English
Publishing date	2024-03-06
Publishing country	Switzerland
Document type	Journal Article ; Review
ZDB-ID	2681351-8
ISSN	2304-6767 ; 2304-6767
ISSN (online)	2304-6767
ISSN	2304-6767
DOI	10.3390/dj12030069
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Article: Depth of reading within the gingival sulcus of seven intraoral scanners: an in vitro study.

Monaco, Carlo / Arena, Antonio / Marziali, Andrea / Consolo, Ugo

International journal of computerized dentistry

2023 Volume 27, Issue 1, Page(s) 27–35

Abstract: Aim: The present in vitro study aimed to evaluate the depth of reading of intraoral scanners (IOSs) within the gingival sulcus.: Materials and methods: A knife-edge preparation for a full crown was performed on a Frasaco model. The gingival sulcus of ...

Abstract	Aim: The present in vitro study aimed to evaluate the depth of reading of intraoral scanners (IOSs) within the gingival sulcus. Materials and methods: A knife-edge preparation for a full crown was performed on a Frasaco model. The gingival sulcus of the scanned model was modified using a dedicated software program (Model Creator, exocad DentalCAD 2.4 Plovdiv) by setting the apical width (AW), coronal width (CW), and gingival sulcus depth (D). Two dental models with different gingival sulcus depths (1 or 2 mm) were printed using the digital light processing (DLP) technique. Each model was scanned 10 times. Seven different IOSs were used: Emerald, Trios 3, Carestream 3600, Dental Wings DWIO, CondorScan, True Definition Scanner (TDS), and Cerec Omnicam. Measurements of D values were performed using 3Shape 3D viewer software. The normality of the data distribution was evaluated using the Shapiro-Wilk test (P < 0.05). The nonparametric Levene's test was used to check for homoscedasticity. The data were statistically analyzed using the Kruskal-Wallis test (α = 0.05) and the Nemenyi test. Results: All IOSs were able to read within the 1-mm-deep gingival sulcus, albeit with some statistically significant differences (P < 0.001). TDS and Trios 3 were able to read within the 2-mm-deep gingival sulcus (P < 0.001). Conclusions: The depth of reading of different IOSs can vary significantly. In the model with a 2-mm gingival sulcus, even in the absence of oral fluids, the depth of reading was incomplete, suggesting that deep preparations into the gingival sulcus are difficult to detect with IOSs.
MeSH term(s)	Humans ; Imaging, Three-Dimensional ; Reading ; Dental Impression Technique ; Computer-Aided Design ; Models, Dental ; Dental Arch
Language	English
Publishing date	2023-03-14
Publishing country	England
Document type	Journal Article
ZDB-ID	1463532-x
ISSN	1463-4201
ISSN	1463-4201
DOI	10.3290/j.ijcd.b3963071
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Zs.A 5052: Show issues

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Article ; Online: Color match of single-shade restorations after professional dental bleaching: An

Forabosco, Eleonora / Generali, Luigi / Mancuso, Edoardo / Kaleci, Shaniko / Consolo, Ugo / Checchi, Vittorio

Journal of conservative dentistry and endodontics

2024 Volume 27, Issue 3, Page(s) 280–285

Abstract: Background: Restorative dentistry aims to reproduce natural tooth shades through resin composites that must be layered to obtain colors, opacities, and translucencies, and therefore, clinical success is operator skill dependent.: Aims: The purpose of ...

Abstract	Background: Restorative dentistry aims to reproduce natural tooth shades through resin composites that must be layered to obtain colors, opacities, and translucencies, and therefore, clinical success is operator skill dependent. Aims: The purpose of this study is to evaluate the color shift of single-shade composite restorations before and after dental bleaching. Materials and methods: Eighty human extracted posterior teeth were restored with four single-shade composites (Omnichroma OM; Clearfil Majesty ES-2 Universal CL; Essentia Universal ES; Venus Diamond One VE) ( Statistical analysis: Categorical variables were analyzed using Pearson Chi-square, and data from color coordinates were analyzed using one-way analysis of variance and Tukey's multiple comparison test with Bonferroni correction. Paired Results: Instrumental evaluations revealed statistically significant differences between materials ( Conclusion: Single-shade composites seem to match with the surrounding bleached tooth.
Language	English
Publishing date	2024-03-06
Publishing country	India
Document type	Journal Article
ISSN	2950-4708
ISSN (online)	2950-4708
DOI	10.4103/JCDE.JCDE_295_23
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Article ; Online: Optimal time to definitive enucleation of large cysts following marsupialization: A single center, retrospective study.

Bellini, Pierantonio / Ricci, Angelo / Setti, Giacomo / Veneri, Federica / Losi, Luca / Chester, Johanna / Consolo, Ugo

Journal of stomatology, oral and maxillofacial surgery

2024 , Page(s) 101837

Abstract: Objectives: Optimal time to enucleation following marsupialization of large odontogenic mandibular cysts is undefined. We aim to assess volume reduction throughout follow-up, to indicate optimal time to enucleation. Secondary objectives include the ... ...

Abstract	Objectives: Optimal time to enucleation following marsupialization of large odontogenic mandibular cysts is undefined. We aim to assess volume reduction throughout follow-up, to indicate optimal time to enucleation. Secondary objectives include the identification of factors influencing cyst reduction. Study design: We retrospectively enrolled 15 patients with mandibular cysts of different histological types treated with marsupialization at our center between 2018 and 2022. Cyst volume was assessed with cone-beam computed tomography (CBCT) and a semi-automatic segmentation algorithm, at baseline and between 6 and 8 months post marsupialization. Results: The overall mean cyst volume reduction percent (VR%) was 57.7 % or 0.2 % per day. VR% at 8 months was significantly higher than those assessed at 6 and 7 months (67.1% vs 47.1 %, p = 0.003). Time to CBCT was the only independent variable influencing cyst VR%. Conclusion: Our study proves that the optimal time to enucleation for mandibular cyst is 8 months, independent of histological cyst type, patient age, baseline cyst volume and the number of pre-operative residual bone walls.
Language	English
Publishing date	2024-03-18
Publishing country	France
Document type	Journal Article
ZDB-ID	2916276-2
ISSN	2468-7855 ; 2468-8509
ISSN (online)	2468-7855
ISSN	2468-8509
DOI	10.1016/j.jormas.2024.101837
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Article ; Online: Effect of bleaching on the color match of single-shade resin composites.

Forabosco, Eleonora / Consolo, Ugo / Mazzitelli, Claudia / Kaleci, Shaniko / Generali, Luigi / Checchi, Vittorio

Journal of oral science

2023 Volume 65, Issue 4, Page(s) 232–236

Abstract: Purpose: To evaluate the color match of single-shade resin composites before and after bleaching procedures, through instrumental and visual analyses.: Methods: Class V cavities were created on the buccal surfaces of 80 extracted human molars, ... ...

Abstract	Purpose: To evaluate the color match of single-shade resin composites before and after bleaching procedures, through instrumental and visual analyses. Methods: Class V cavities were created on the buccal surfaces of 80 extracted human molars, restored with 4 single-shade composites (Omnichroma; Clearfil Majesty ES-2 Universal; Essentia Universal; Venus Diamond One). A spectrophotometer (VITA Easyshade V) was used to evaluate the tooth/resin color match before (T Results: Spectrophotometric evaluations revealed statistically significant differences between materials at T Conclusion: Data seem to indicate that single shade composites are able to shift their color when the surrounding tooth undergoes bleaching effects. Single-shade composites seem to achieve a good color match with the surrounding tooth structure, before and after professional bleaching.
MeSH term(s)	Humans ; Color ; Composite Resins/chemistry ; Tooth Bleaching/methods ; Spectrophotometry/methods ; Dental Caries ; Molar ; Materials Testing
Chemical Substances	Composite Resins
Language	English
Publishing date	2023-08-03
Publishing country	Japan
Document type	Journal Article
ZDB-ID	1434462-2
ISSN	1880-4926 ; 1343-4934
ISSN (online)	1880-4926
ISSN	1343-4934
DOI	10.2334/josnusd.23-0159
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Article ; Online: COVID-19 Dentistry-Related Aspects: A Literature Overview.

Checchi, Vittorio / Bellini, Pierantonio / Bencivenni, Davide / Consolo, Ugo

International dental journal

2021 Volume 71, Issue 1, Page(s) 21–26

Abstract: A new coronavirus (Sars-CoV-2) was detected in China at the end of 2019 and has since caused a worldwide pandemic. This virus is responsible for an acute respiratory syndrome (COVID-19), distinguished by a potentially lethal interstitial bilateral ... ...

Abstract	A new coronavirus (Sars-CoV-2) was detected in China at the end of 2019 and has since caused a worldwide pandemic. This virus is responsible for an acute respiratory syndrome (COVID-19), distinguished by a potentially lethal interstitial bilateral pneumonia. Because Sars-CoV-2 is highly infective through airborne contamination, the high infection risk in the dental environment is a serious problem for both professional practitioners and patients. This literature overview provides a description of the clinical aspects of COVID-19 and its transmission, while supplying valuable information regarding protection and prevention measures.
MeSH term(s)	COVID-19 ; China/epidemiology ; Coronavirus Infections ; Dentistry ; Humans ; SARS-CoV-2
Language	English
Publishing date	2021-01-12
Publishing country	England
Document type	Journal Article ; Review
ZDB-ID	218262-2
ISSN	1875-595X ; 0020-6539
ISSN (online)	1875-595X
ISSN	0020-6539
DOI	10.1111/idj.12601
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Article ; Online: Long-term stability (21-30 years) of root coverage outcomes using sub-epithelial connective tissue grafts at single or multiple gingival recessions: A longitudinal case series.

Bertoldi, Carlo / Consolo, Ugo / Lalla, Michele / Zaffe, Davide / Tanza, Donato / Cairo, Francesco / Cortellini, Pierpaolo

Journal of clinical periodontology

2023 Volume 51, Issue 1, Page(s) 2–13

Abstract: Aim: To evaluate outcomes and predictive factors for the long-term stability of root coverage using a sub-epithelial connective tissue graft.: Materials and methods: One-hundred and two healthy subjects (221 gingival recessions, GRs) were treated ... ...

Abstract	Aim: To evaluate outcomes and predictive factors for the long-term stability of root coverage using a sub-epithelial connective tissue graft. Materials and methods: One-hundred and two healthy subjects (221 gingival recessions, GRs) were treated from 1987 to 1996. Keratinized tissue width (KTW), GR depth (RD), GR width (RW) and GR area (RA) were evaluated at baseline (M0) and at 1 month (M1), 1 year (M2), 11 years (M3), 21 years (M4) and 27 years (M5) after surgery. Primary outcomes consisted of complete root coverage (cRC) and relative dimensional changes in recession depth (measured in mm [c%-RD]), recession width (measured in mm [c%-RW]) and recession area (measured in mm Results: cRC was 88.7% at 1 year (M2), 59.8% at M3, 44.4% at M4 and 51.9% at M5. Average c%-RD was 95.2% at 1 year, 81.9% at M3, 71.5% at M4 and 81.7% at M5. KTW increased after surgery and over time and was positively correlated with favourable outcomes. Increased baseline RA was associated with less favourable clinical outcomes. Conclusions: The sub-epithelial connective tissue graft is effective in the treatment of GRs and facilitates long-term stability of clinical outcomes. Wider baseline RA was a strong predictor of unfavourable short- and long-term RC outcomes.
MeSH term(s)	Humans ; Gingival Recession/surgery ; Gingiva/surgery ; Treatment Outcome ; Follow-Up Studies ; Connective Tissue/transplantation ; Tooth Root/surgery
Language	English
Publishing date	2023-10-05
Publishing country	United States
Document type	Journal Article
ZDB-ID	188647-2
ISSN	1600-051X ; 0303-6979
ISSN (online)	1600-051X
ISSN	0303-6979
DOI	10.1111/jcpe.13882
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Article: Zirconia Hybrid Dental Implants Influence the Biological Properties of Neural Crest-Derived Mesenchymal Stromal Cells.

Tagliaferri, Nadia / Pisciotta, Alessandra / Orlandi, Giulia / Bertani, Giulia / Di Tinco, Rosanna / Bertoni, Laura / Sena, Paola / Lunghi, Alice / Bianchi, Michele / Veneri, Federica / Bellini, Pierantonio / Bertacchini, Jessika / Conserva, Enrico / Consolo, Ugo / Carnevale, Gianluca

Nanomaterials (Basel, Switzerland)

2024 Volume 14, Issue 5

Abstract: Dental implants are regularly employed in tooth replacement, the good clinical outcome of which is strictly correlated to the choice of an appropriate implant biomaterial. Titanium-based implants are considered the gold standard for rehabilitation of ... ...

Abstract	Dental implants are regularly employed in tooth replacement, the good clinical outcome of which is strictly correlated to the choice of an appropriate implant biomaterial. Titanium-based implants are considered the gold standard for rehabilitation of edentulous spaces. However, the insurgence of allergic reactions, cellular sensitization and low integration with dental and gingival tissues lead to poor osseointegration, affecting the implant stability in the bone and favoring infections and inflammatory processes in the peri-implant space. These failures pave the way to develop and improve new biocompatible implant materials. CERID dental implants are made of a titanium core embedded in a zirconium dioxide ceramic layer, ensuring absence of corrosion, a higher biological compatibility and a better bone deposition compared to titanium ones. We investigated hDPSCs' biological behavior, i.e., cell adhesion, proliferation, morphology and osteogenic potential, when seeded on both CERID and titanium implants, before and after cleansing with two different procedures. SEM and AFM analysis of the surfaces showed that while CERID disks were not significantly affected by the cleansing system, titanium ones exhibited well-visible modifications after brush treatment, altering cell morphology. The proliferation rate of DPSCs was increased for titanium, while it remained unaltered for CERID. Both materials hold an intrinsic potential to promote osteogenic commitment of neuro-ectomesenchymal stromal cells. Interestingly, the CERID surface mitigated the immune response by inducing an upregulation of anti-inflammatory cytokine IL-10 on activated PBMCs when a pro-inflammatory microenvironment was established. Our in vitro results pave the way to further investigations aiming to corroborate the potential of CERID implants as suitable biomaterials for dental implant applications.
Language	English
Publishing date	2024-02-20
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2662255-5
ISSN	2079-4991
ISSN	2079-4991
DOI	10.3390/nano14050392
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Article ; Online: Fluoride Exposure and Skeletal Fluorosis: a Systematic Review and Dose-response Meta-analysis.

Veneri, Federica / Iamandii, Inga / Vinceti, Marco / Birnbaum, Linda S / Generali, Luigi / Consolo, Ugo / Filippini, Tommaso

Current environmental health reports

2023 Volume 10, Issue 4, Page(s) 417–441

Abstract: Purpose of review: We performed a systematic review and meta-analysis on the relation between fluoride exposure and skeletal fluorosis (SF) using a novel statistical methodology for dose-response modeling.: Recent findings: Skeletal fluorosis, a ... ...

Abstract	Purpose of review: We performed a systematic review and meta-analysis on the relation between fluoride exposure and skeletal fluorosis (SF) using a novel statistical methodology for dose-response modeling. Recent findings: Skeletal fluorosis, a major health issue that is endemic in some regions, affects millions of people worldwide. However, data regarding the dose-response relation between fluoride exposure and SF are limited and outdated. We included twenty-three studies in the meta-analysis. When comparing the highest versus the lowest fluoride category, the summary risk ratio (RR) for SF prevalence was 2.05 (95% CI 1.60; 2.64), with a value of 2.73 (95% CI 1.92; 3.90) for drinking water and 1.40 (95% CI 0.90; 2.17) for urinary fluoride. The RR by the risk of bias (RoB) was 2.37 (95% CI 1.56; 3.58) and 1.78 (95% CI 1.34; 2.36) for moderate and high RoB studies, respectively. The dose-response curve based on a one-stage cubic spline regression model showed an almost linear positive relation between exposure and SF occurrence starting from relatively low concentrations up to 5 mg/L and 2.5 mg/L, respectively, for water and urinary fluoride, with no substantial increase above this threshold. The RR for developing moderate-severe forms increases at 5.00 mg/L and 2.5 mg/L of water and urinary fluoride, respectively. Better-quality studies are needed to confirm these results, but greater attention should be given to water fluoride levels to prevent SF, in addition to the other potential adverse effects of fluoride exposure.
MeSH term(s)	Humans ; Fluorides/analysis ; Fluorosis, Dental/epidemiology ; Fluorosis, Dental/etiology ; Drinking Water/adverse effects ; Drinking Water/analysis ; Prevalence
Chemical Substances	Fluorides (Q80VPU408O) ; Drinking Water
Language	English
Publishing date	2023-10-20
Publishing country	Switzerland
Document type	Meta-Analysis ; Systematic Review ; Journal Article ; Review
ISSN	2196-5412
ISSN (online)	2196-5412
DOI	10.1007/s40572-023-00412-9
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Article ; Online: Fluoride exposure and cognitive neurodevelopment: Systematic review and dose-response meta-analysis.

Veneri, Federica / Vinceti, Marco / Generali, Luigi / Giannone, Maria Edvige / Mazzoleni, Elena / Birnbaum, Linda S / Consolo, Ugo / Filippini, Tommaso

Environmental research

2023 Volume 221, Page(s) 115239

Abstract: Many uncertainties still surround the possible harmful effect of fluoride exposure on cognitive neurodevelopment in children. The aim of this systematic review and meta-analysis was to characterize this relation through a dose-response approach, by ... ...

Abstract	Many uncertainties still surround the possible harmful effect of fluoride exposure on cognitive neurodevelopment in children. The aim of this systematic review and meta-analysis was to characterize this relation through a dose-response approach, by comparing the intelligence quotient (IQ) scores in the highest versus the lowest fluoride exposure category with a random-effects model, within a one-stage dose-response meta-analysis based on a cubic spline random-effects model. Out of 1996 potentially relevant literature records, 33 studies were eligible for this review, 30 of which were also suitable for meta-analysis. The summary mean difference of IQ score, comparing highest versus lowest fluoride categories and considering all types of exposure, was -4.68 (95% confidence interval-CI -6.45; -2.92), with a value of -5.60 (95% CI -7.76; -3.44) for drinking water fluoride and -3.84 (95% CI -7.93; 0.24) for urinary fluoride. Dose-response analysis showed a substantially linear IQ decrease for increasing water fluoride above 1 mg/L, with -3.05 (95% CI -4.06; -2.04) IQ points per 1 mg/L up to 2 mg/L, becoming steeper above such level. A weaker and substantially linear decrease of -2.15 (95% CI -4.48; 0.18) IQ points with increasing urinary fluoride emerged above 0.28 mg/L (approximately reflecting a water fluoride content of 0.7 mg/L). The inverse association between fluoride exposure and IQ was particularly strong in the studies at high risk of bias, while no adverse effect emerged in the only study judged at low risk of bias. Overall, most studies suggested an adverse effect of fluoride exposure on children's IQ, starting at low levels of exposure. However, a major role of residual confounding could not be ruled out, thus indicating the need of additional prospective studies at low risk of bias to conclusively assess the relation between fluoride exposure and cognitive neurodevelopment.
MeSH term(s)	Child ; Humans ; Fluorides/toxicity ; Intelligence ; Prospective Studies ; Drinking Water ; Cognition
Chemical Substances	Fluorides (Q80VPU408O) ; Drinking Water
Language	English
Publishing date	2023-01-10
Publishing country	Netherlands
Document type	Systematic Review ; Meta-Analysis ; Journal Article ; Review
ZDB-ID	205699-9
ISSN	1096-0953 ; 0013-9351
ISSN (online)	1096-0953
ISSN	0013-9351
DOI	10.1016/j.envres.2023.115239
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