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  1. Article: Epidemiological Data From the COVID-19 Outbreak in Spain for the Promotion of Tobacco Smoking Cessation Policies.

    Vázquez, Javier Correa / Redolar-Ripoll, Diego

    Tobacco use insights

    2020  Volume 13, Page(s) 1179173X20924028

    Keywords covid19
    Language English
    Publishing date 2020-05-08
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2532401-9
    ISSN 1179-173X
    ISSN 1179-173X
    DOI 10.1177/1179173X20924028
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Epidemiological Data From the COVID-19 Outbreak in Spain for the Promotion of Tobacco Smoking Cessation Policies

    Javier Correa Vázquez / Diego Redolar-Ripoll

    Tobacco Use Insights, Vol

    2020  Volume 13

    Keywords Public aspects of medicine ; RA1-1270 ; covid19
    Language English
    Publishing date 2020-05-01T00:00:00Z
    Publisher SAGE Publishing
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  3. Article ; Online: Epidemiological Data From the COVID-19 Outbreak in Spain for the Promotion of Tobacco Smoking Cessation Policies

    Vázquez, Javier Correa / Redolar-Ripoll, Diego

    Tobacco Use Insights

    2020  Volume 13, Page(s) 1179173X2092402

    Keywords covid19
    Language English
    Publisher SAGE Publications
    Publishing country us
    Document type Article ; Online
    ZDB-ID 2532401-9
    ISSN 1179-173X
    ISSN 1179-173X
    DOI 10.1177/1179173x20924028
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  4. Article: Influence of Diabetes Mellitus and Nutritional Parameters on Clinical and Functional Aspects and Quality of Life in Patients Hospitalized Due to Exacerbation of Chronic Obstructive Pulmonary Disease.

    Correa-Gutiérrez, Cristhian Alonso / Ji, Zichen / Aragón-Espinosa, Patricia / Rodrigues-Oliveira, Sarah / Zeng, Luyi / Meizoso-Pita, Olalla / Sevillano-Collantes, Cristina / Hernández-Vázquez, Julio / Puente-Maestu, Luis / de Miguel-Díez, Javier

    Journal of clinical medicine

    2023  Volume 12, Issue 21

    Abstract: Patients with chronic obstructive pulmonary disease (COPD) may experience exacerbations. During severe exacerbations, nutritional and endocrinological comorbidities can play an important role in the clinical and functional aspects of these patients. The ... ...

    Abstract Patients with chronic obstructive pulmonary disease (COPD) may experience exacerbations. During severe exacerbations, nutritional and endocrinological comorbidities can play an important role in the clinical and functional aspects of these patients. The aim of this study was to analyse the influence of the presence of diabetes mellitus (DM) and nutritional parameters on the deterioration of symptoms and quality of life during a severe exacerbation in patients with COPD. An observational study was conducted on COPD patients admitted due to an exacerbation. The COPD Assessment Test (CAT) questionnaire was administered, and clinical and functional parameters were compared based on the presence of nutritional and endocrinological alterations. A total of 50 patients were included, of whom 30 (60%) were male. The mean age was 70.5 years (standard deviation (SD) 9.6). The median CAT score during exacerbation was 25 (interquartile range (IQR) 17.5-30), and the baseline score was 13.5 (IQR 7-19), which represented a statistically significant difference (
    Language English
    Publishing date 2023-10-31
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2662592-1
    ISSN 2077-0383
    ISSN 2077-0383
    DOI 10.3390/jcm12216874
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: LRP5, SLC6A3, and SOX10 Expression in Conventional Ameloblastoma

    Correa-Arzate, Lorena / Portilla-Robertson, Javier / Ramírez-Jarquín, Josué Orlando / Jacinto-Alemán, Luis Fernando / Mejía-Velázquez, Claudia Patricia / Villanueva-Sánchez, Francisco Germán / Rodríguez-Vázquez, Mariana

    Genes (Basel). 2023 July 26, v. 14, no. 8

    2023  

    Abstract: Cell proliferation and invasion are characteristic of many tumors, including ameloblastoma, and are important features to target in possible future therapeutic applications. Objective: The objective of this study was the identification of key genes and ... ...

    Abstract Cell proliferation and invasion are characteristic of many tumors, including ameloblastoma, and are important features to target in possible future therapeutic applications. Objective: The objective of this study was the identification of key genes and inhibitory drugs related to the cell proliferation and invasion of ameloblastoma using bioinformatic analysis. Methods: The H10KA_07_38 gene profile database was analyzed by Rstudio and ShinyGO Gene Ontology enrichment. String, Cytoscape-MCODE, and Kaplan–Meier plots were generated, which were subsequently validated by RT-qPCR relative expression and immunoexpression analyses. To propose specific inhibitory drugs, a bioinformatic search using Drug Gene Budger and DrugBank was performed. Results: A total of 204 significantly upregulated genes were identified. Gene ontology enrichment analysis identified four pathways related to cell proliferation and cell invasion. A total of 37 genes were involved in these pathways, and 11 genes showed an MCODE score of ≥0.4; however, only SLC6A3, SOX10, and LRP5 were negatively associated with overall survival (HR = 1.49 (p = 0.0072), HR = 1.55 (p = 0.0018), and HR = 1.38 (p = 0.025), respectively). The RT-qPCR results confirmed the significant differences in expression, with overexpression of >2 for SLC6A3 and SOX10. The immunoexpression analysis indicated positive LRP5 and SLC6A3 expression. The inhibitory drugs bioinformatically obtained for the above three genes were parthenolide and vorinostat. Conclusions: We identify LRP5, SLC6A3, and SOX10 as potentially important genes related to cell proliferation and invasion in the pathogenesis of ameloblastomas, along with both parthenolide and vorinostat as inhibitory drugs that could be further investigated for the development of novel therapeutic approaches against ameloblastoma.
    Keywords bioinformatics ; cell proliferation ; drugs ; gene ontology ; genes ; odontogenic neoplasms ; pathogenesis ; therapeutics
    Language English
    Dates of publication 2023-0726
    Publishing place Multidisciplinary Digital Publishing Institute
    Document type Article ; Online
    ZDB-ID 2527218-4
    ISSN 2073-4425
    ISSN 2073-4425
    DOI 10.3390/genes14081524
    Database NAL-Catalogue (AGRICOLA)

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  6. Article ; Online: LRP5, SLC6A3, and SOX10 Expression in Conventional Ameloblastoma.

    Correa-Arzate, Lorena / Portilla-Robertson, Javier / Ramírez-Jarquín, Josué Orlando / Jacinto-Alemán, Luis Fernando / Mejía-Velázquez, Claudia Patricia / Villanueva-Sánchez, Francisco Germán / Rodríguez-Vázquez, Mariana

    Genes

    2023  Volume 14, Issue 8

    Abstract: Cell proliferation and invasion are characteristic of many tumors, including ameloblastoma, and are important features to target in possible future therapeutic applications.: Objective: The objective of this study was the identification of key genes ... ...

    Abstract Cell proliferation and invasion are characteristic of many tumors, including ameloblastoma, and are important features to target in possible future therapeutic applications.
    Objective: The objective of this study was the identification of key genes and inhibitory drugs related to the cell proliferation and invasion of ameloblastoma using bioinformatic analysis.
    Methods: The H10KA_07_38 gene profile database was analyzed by Rstudio and ShinyGO Gene Ontology enrichment. String, Cytoscape-MCODE, and Kaplan-Meier plots were generated, which were subsequently validated by RT-qPCR relative expression and immunoexpression analyses. To propose specific inhibitory drugs, a bioinformatic search using Drug Gene Budger and DrugBank was performed.
    Results: A total of 204 significantly upregulated genes were identified. Gene ontology enrichment analysis identified four pathways related to cell proliferation and cell invasion. A total of 37 genes were involved in these pathways, and 11 genes showed an MCODE score of ≥0.4; however, only SLC6A3, SOX10, and LRP5 were negatively associated with overall survival (HR = 1.49 (
    Conclusions: We identify LRP5, SLC6A3, and SOX10 as potentially important genes related to cell proliferation and invasion in the pathogenesis of ameloblastomas, along with both parthenolide and vorinostat as inhibitory drugs that could be further investigated for the development of novel therapeutic approaches against ameloblastoma.
    MeSH term(s) Humans ; Ameloblastoma/genetics ; Vorinostat ; Cell Proliferation/genetics ; Computational Biology ; SOXE Transcription Factors/genetics ; Low Density Lipoprotein Receptor-Related Protein-5 ; Dopamine Plasma Membrane Transport Proteins
    Chemical Substances parthenolide (2RDB26I5ZB) ; Vorinostat (58IFB293JI) ; SOXE Transcription Factors ; LRP5 protein, human ; Low Density Lipoprotein Receptor-Related Protein-5 ; SLC6A3 protein, human ; Dopamine Plasma Membrane Transport Proteins ; SOX10 protein, human
    Language English
    Publishing date 2023-07-26
    Publishing country Switzerland
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2527218-4
    ISSN 2073-4425 ; 2073-4425
    ISSN (online) 2073-4425
    ISSN 2073-4425
    DOI 10.3390/genes14081524
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article ; Online: Enfermedades crónicas degenerativas como factor de riesgo de letalidad por COVID-19 en México.

    Ángeles Correa, María Guadalupe / Villarreal Ríos, Enrique / Galicia Rodríguez, Liliana / Vargas Daza, Emma Rosa / Frontana Vázquez, Gabriel / Monrroy Amaro, Sergio Javier / Pinal, Viridiana Ruiz / Álvarez, Javier Dávalos / Santibáñez Beltrán, Shaid

    Revista panamericana de salud publica = Pan American journal of public health

    2022  Volume 46, Page(s) e40

    Abstract: Objective: To determine the relative risk of a lethal outcome associated with chronic degenerative conditions in patients with COVID-19.: Methods: A cohort study was conducted using electronic medical records belonging to patients who tested positive ...

    Title translation Chronic degenerative conditions as risk factors for lethal COVID-19Doenças crônicas degenerativas como fator de risco para letalidade por COVID-19.
    Abstract Objective: To determine the relative risk of a lethal outcome associated with chronic degenerative conditions in patients with COVID-19.
    Methods: A cohort study was conducted using electronic medical records belonging to patients who tested positive for COVID-19 on RT-PCR while receiving care as outpatients or inpatients in a social security system facility between March 2020 and March 2021. Two study groups were formed. The exposed group was divided into four subgroups, each of which was diagnosed with one and only one chronic condition (diabetes, hypertension, obesity, or chronic kidney disease); the unexposed group was obtained from the medical records of patients without comorbidities. A total of 1 114 medical records were examined using simple random sampling. Once the minimum sample size was reached, the relative risk was calculated for each chronic condition. Combinations of two, three, and four conditions were created, and each of them was included in the analysis.
    Results: In the absence of a chronic degenerative condition, the prevalence of a lethal outcome from COVID-19 is 3.8%; in the presence of type 2 diabetes mellitus, 15.8%; in the presence of arterial hypertension, 15.6%; and in the presence of obesity, 15.0%. For diabetes and hypertension combined, the prevalence of a lethal outcome is 54.1%; for diabetes and obesity combined, 36.8%, and for obesity and hypertension combined, 28.1%.
    Conclusion: In patients with COVID-19, the relative risk of a lethal outcome is 4.17 for those with diabetes, 4.13 for those with hypertension, and 3.96 for those with obesity. For two chronic conditions combined, the relative risk doubles or triples. The relative risk of a lethal outcome is 14.27 for diabetes plus hypertension; 9.73 for diabetes plus obesity, and 7.43 for obesity plus hypertension. Chronic conditions do not present alone; they generally occur together, hence the significance of the relative risks for lethal outcomes presented in this paper.
    Language Spanish
    Publishing date 2022-05-02
    Publishing country United States
    Document type English Abstract ; Journal Article
    ZDB-ID 1376934-0
    ISSN 1680-5348 ; 1020-4989
    ISSN (online) 1680-5348
    ISSN 1020-4989
    DOI 10.26633/RPSP.2022.40
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

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    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
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    ab Jg. 2022: Lesesaal (EG)

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  9. Article ; Online: Influence of Diabetes Mellitus and Nutritional Parameters on Clinical and Functional Aspects and Quality of Life in Patients Hospitalized Due to Exacerbation of Chronic Obstructive Pulmonary Disease

    Cristhian Alonso Correa-Gutiérrez / Zichen Ji / Patricia Aragón-Espinosa / Sarah Rodrigues-Oliveira / Luyi Zeng / Olalla Meizoso-Pita / Cristina Sevillano-Collantes / Julio Hernández-Vázquez / Luis Puente-Maestu / Javier de Miguel-Díez

    Journal of Clinical Medicine, Vol 12, Iss 21, p

    2023  Volume 6874

    Abstract: Patients with chronic obstructive pulmonary disease (COPD) may experience exacerbations. During severe exacerbations, nutritional and endocrinological comorbidities can play an important role in the clinical and functional aspects of these patients. The ... ...

    Abstract Patients with chronic obstructive pulmonary disease (COPD) may experience exacerbations. During severe exacerbations, nutritional and endocrinological comorbidities can play an important role in the clinical and functional aspects of these patients. The aim of this study was to analyse the influence of the presence of diabetes mellitus (DM) and nutritional parameters on the deterioration of symptoms and quality of life during a severe exacerbation in patients with COPD. An observational study was conducted on COPD patients admitted due to an exacerbation. The COPD Assessment Test (CAT) questionnaire was administered, and clinical and functional parameters were compared based on the presence of nutritional and endocrinological alterations. A total of 50 patients were included, of whom 30 (60%) were male. The mean age was 70.5 years (standard deviation (SD) 9.6). The median CAT score during exacerbation was 25 (interquartile range (IQR) 17.5–30), and the baseline score was 13.5 (IQR 7–19), which represented a statistically significant difference ( p < 0.001). Patients with iron deficiencies had a lower total CAT score ( p = 0.041), specifically for items related to daily activity ( p = 0.009) and energy ( p = 0.007). Diabetic patients exhibited a greater decline in pulmonary function during exacerbation ( p = 0.016), while patients with high thyroid-stimulating hormone (TSH) levels had a shorter hospital stay ( p = 0.016). For COPD patients admitted due to an exacerbation, the metabolic assessment is useful and relevant in the clinical set-up, as endocrinological comorbidities negatively affect clinical and functional aspects of these patients.
    Keywords chronic obstructive pulmonary disease ; diabetes mellitus ; nutrition ; quality of life ; Medicine ; R
    Subject code 610 ; 616
    Language English
    Publishing date 2023-10-01T00:00:00Z
    Publisher MDPI AG
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  10. Article: Gestational Diabetes Mellitus Subtypes Classified by Oral Glucose Tolerance Test and Maternal and Perinatal Outcomes: Results of a Mexican Multicenter Prospective Cohort Study "Cuido Mi Embarazo".

    Ortega-Montiel, Janinne / Martinez-Juarez, Luis A / Montoya, Alejandra / Morales-Juárez, Linda / Gallardo-Rincón, Héctor / Galicia-Hernández, Victoria / Garcia-Cerde, Rodrigo / Ríos-Blancas, María Jesus / Álvarez-Hernández, Diego-Abelardo / Lomelin-Gascon, Julieta / Martínez-Silva, Gisela / Illescas-Correa, Lucía M / Diaz Martinez, Daniel A / Magos Vázquez, Francisco Javier / Vargas Ávila, Edwin / Carmona-Ramos, Ma Concepción / Mújica-Rosales, Ricardo / Reyes-Muñoz, Enrique / Tapia-Conyer, Roberto

    Diabetes, metabolic syndrome and obesity : targets and therapy

    2024  Volume 17, Page(s) 1491–1502

    Abstract: Purpose: This study explores the impact of gestational diabetes mellitus (GDM) subtypes classified by oral glucose tolerance test (OGTT) values on maternal and perinatal outcomes.: Patients and methods: This multicenter prospective cohort study (May ... ...

    Abstract Purpose: This study explores the impact of gestational diabetes mellitus (GDM) subtypes classified by oral glucose tolerance test (OGTT) values on maternal and perinatal outcomes.
    Patients and methods: This multicenter prospective cohort study (May 2019-December 2022) included participants from the Mexican multicenter cohort study
    Results: Of 2,056 Mexican pregnant women in the CME cohort, 294 (14.3%) had GDM; 53.7%, 34.4%, and 11.9% were classified as GDM-Sensitivity, GDM-Secretion, and GDM-Mixed subtypes, respectively. Women with GDM were older (p = 0.0001) and more often multiparous (p = 0.119) vs without GDM. Cesarean delivery (63.3%; p = 0.02) and neonate LGA (10.7%; p = 0.078) were higher in the GDM-Mixed group than the overall GDM group (55.6% and 8.4%, respectively). Pre-term birth was more common in the GDM-Sensitivity group than in the overall GDM group (10.2% vs 8.5%, respectively; p=0.022). At 6 months postpartum, prediabetes was more frequent in the GDM-Sensitivity group than in the overall GDM group (31.6% vs 25.5%). Type 2 diabetes was more common in the GDM-Mixed group than in the overall GDM group (10.0% vs 3.3%).
    Conclusion: GDM subtypes effectively stratified maternal and perinatal risks. GDM-Mixed subtype increased the risk of cesarean delivery, LGA, and type 2 diabetes postpartum. GDM subtypes may help personalize clinical interventions and optimize maternal and perinatal outcomes.
    Language English
    Publishing date 2024-03-26
    Publishing country New Zealand
    Document type Journal Article
    ZDB-ID 2494854-8
    ISSN 1178-7007
    ISSN 1178-7007
    DOI 10.2147/DMSO.S450939
    Database MEDical Literature Analysis and Retrieval System OnLINE

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