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Article ; Online: Construction and Simulation of Biomechanical Model of Human Hip Joint Muscle-Tendon Assisted by Elastic External Tendon by Hill Muscle Model

Xi Luo / Guofeng Cai / Kun Ma / Aiqi Cai

Computational Intelligence and Neuroscience, Vol

2022 Volume 2022

Abstract: Based on the Hill muscle model (HMM), a biomechanical model of human hip muscle tendon assisted by elastic external tendon (EET) was preliminarily established to investigate and analyze the biomechanical transition between the hip joint (HJ) and related ... ...

Abstract	Based on the Hill muscle model (HMM), a biomechanical model of human hip muscle tendon assisted by elastic external tendon (EET) was preliminarily established to investigate and analyze the biomechanical transition between the hip joint (HJ) and related muscle tendons. Using the HMM, the optimal muscle fiber length and muscle force scaling variables were introduced by means of constrained optimization problems and were optimized. The optimized HMM was constructed with human parameters of 170 cm and 70 kg. The biomechanical model simulation test of the hip muscle tendon was performed in the automatic dynamic analysis of mechanical systems (ADAMS) software to analyze and optimize the changes in the root mean square error (RMSE), biological moment, muscle moment distribution coefficient (MDC), muscle moment, muscle force, muscle power, and mechanical work of the activation curves of the hip major muscle, iliopsoas muscle, rectus femoris muscle, and hamstring muscle under analyzing the optimized HMM and under different EET auxiliary stiffnesses from the joint moment level, joint level, and muscle level, respectively. It was found that the trends of the output joint moment of the optimized HMM and the biological moment of the human HJ were basically the same, r2 = 0.883 and RMSE = 0.18 Nm/kg, and the average metabolizable energy consumption of the HJ was (243.77 ± 1.59) J. In the range of 35%∼65% of gait cycle (GC), the auxiliary moment showed a significant downward trend with the increase of EET stiffness, when the EET stiffness of the human body was less than 200 Nm/rad, the biological moment of the human HJ gradually decreased with the increase of EET stiffness, and the MDC of the iliopsoas and hamstring muscles gradually decreased; when the EET stiffness was greater than 200 Nm/rad, the increase of the total moment of the extensor muscles significantly increased, the MDC of the gluteus maximus and rectus muscles gradually increased, and the gluteus maximus and hamstring muscle moments and muscle forces gradually ...
Keywords	Computer applications to medicine. Medical informatics ; R858-859.7 ; Neurosciences. Biological psychiatry. Neuropsychiatry ; RC321-571
Subject code	796
Language	English
Publishing date	2022-01-01T00:00:00Z
Publisher	Hindawi Limited
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Construction and Simulation of Biomechanical Model of Human Hip Joint Muscle-Tendon Assisted by Elastic External Tendon by Hill Muscle Model.

Luo, Xi / Cai, Guofeng / Ma, Kun / Cai, Aiqi

Computational intelligence and neuroscience

2022 Volume 2022, Page(s) 1987345

Abstract	Based on the Hill muscle model (HMM), a biomechanical model of human hip muscle tendon assisted by elastic external tendon (EET) was preliminarily established to investigate and analyze the biomechanical transition between the hip joint (HJ) and related muscle tendons. Using the HMM, the optimal muscle fiber length and muscle force scaling variables were introduced by means of constrained optimization problems and were optimized. The optimized HMM was constructed with human parameters of 170 cm and 70 kg. The biomechanical model simulation test of the hip muscle tendon was performed in the automatic dynamic analysis of mechanical systems (ADAMS) software to analyze and optimize the changes in the root mean square error (RMSE), biological moment, muscle moment distribution coefficient (MDC), muscle moment, muscle force, muscle power, and mechanical work of the activation curves of the hip major muscle, iliopsoas muscle, rectus femoris muscle, and hamstring muscle under analyzing the optimized HMM and under different EET auxiliary stiffnesses from the joint moment level, joint level, and muscle level, respectively. It was found that the trends of the output joint moment of the optimized HMM and the biological moment of the human HJ were basically the same,
MeSH term(s)	Biomechanical Phenomena ; Computer Simulation ; Gait/physiology ; Hip Joint/physiology ; Humans ; Muscle, Skeletal/physiology ; Tendons/physiology
Language	English
Publishing date	2022-08-02
Publishing country	United States
Document type	Journal Article
ZDB-ID	2388208-6
ISSN	1687-5273 ; 1687-5273
ISSN (online)	1687-5273
ISSN	1687-5273
DOI	10.1155/2022/1987345
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Article ; Online: Evaluation of a Diagnostic Test of Serum Neutrophil Gelatinase-Associated Lipocalin (NGAL) and Urine KIM-1 in Contrast-Induced Nephropathy (CIN).

Liao, Baoxia / Nian, Wei / Xi, Aiqi / Zheng, Maowei

Medical science monitor : international medical journal of experimental and clinical research

2019 Volume 25, Page(s) 565–570

Abstract: BACKGROUND The aim of this study was to assess changes in serum neutrophil gelatinase-associated lipocalin (NGAL) and urine KIM-1 after percutaneous coronary intervention (PCI). MATERIAL AND METHODS A total of 240 patients receiving coronary stent ... ...

Abstract	BACKGROUND The aim of this study was to assess changes in serum neutrophil gelatinase-associated lipocalin (NGAL) and urine KIM-1 after percutaneous coronary intervention (PCI). MATERIAL AND METHODS A total of 240 patients receiving coronary stent implantation were selected. All patients were divided into 2 groups: a CIN group (n=25) and a non-CIN group (n=215). The serum creatinine (SCr), NGAL, and urine KIM-1 levels of the patients in both groups were measured before and after surgery, and the sensitivity of serum NGAL and urine KIM-1 in diagnosing CIN in the early stage was assessed by the area under receiver operating characteristic (ROC) curve (ROC-AUC). RESULTS In the CIN group, the serum NGAL and urine KIM-1 levels started to rise at 6 h after surgery. The serum NGAL and urine KIM-1 levels in CIN group were significantly higher than those in the non-CIN group at 6, 12, 24, and 48 h after surgery. However, the SCr levels in the CIN group were not higher than those in the non-CIN group at 6 h after surgery. At 6, 12, and 24 h after PCI, the AUCs for serum NGAL and urine KIM-1 were increased compared with that for SCr, while the AUCs for serum NGAL and urine KIM-1 were decreased at 48 h after PCI compared with that for SCr. CONCLUSIONS Serum NGAL and urine KIM-1 levels in the patients after coronary stent implantation can reflect the changes in renal functions early, thus providing a certain basis for the early diagnosis of CIN.
MeSH term(s)	Acute Kidney Injury/chemically induced ; Acute-Phase Proteins/urine ; Aged ; Area Under Curve ; Biomarkers/blood ; China ; Contrast Media/adverse effects ; Coronary Angiography ; Creatinine/analysis ; Creatinine/blood ; Diagnostic Tests, Routine ; Early Diagnosis ; Female ; Hepatitis A Virus Cellular Receptor 1/analysis ; Humans ; Kidney/metabolism ; Lipocalin-2/analysis ; Lipocalin-2/blood ; Male ; Middle Aged ; Percutaneous Coronary Intervention ; ROC Curve
Chemical Substances	Acute-Phase Proteins ; Biomarkers ; Contrast Media ; HAVCR1 protein, human ; Hepatitis A Virus Cellular Receptor 1 ; Lipocalin-2 ; Creatinine (AYI8EX34EU)
Language	English
Publishing date	2019-01-19
Publishing country	United States
Document type	Journal Article
ZDB-ID	1439041-3
ISSN	1643-3750 ; 1234-1010
ISSN (online)	1643-3750
ISSN	1234-1010
DOI	10.12659/MSM.912569
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Article ; Online: Effects of non⁃surgical periodontal treatment on level of vaspin and TNF⁃α in gingival crevicular fluid of type 2 diabetic patients with chronic periodontitis

WANG Lihong / ZHANG Wenbiao / XI Lijun / BAO Aiqi / HUANG Shiguang

口腔疾病防治, Vol 25, Iss 6, Pp 360-

2017 Volume 364

Abstract: Objective To investigate the changes of vaspin and TNF⁃α levels in gingival crevicular fluid (GCF) of type 2 diabetic (T2DM) patients with chronic periodontitis (CP) after non⁃surgical periodontal treatment. Methods 60 subjects were divided into 4 groups: ...

Abstract	Objective To investigate the changes of vaspin and TNF⁃α levels in gingival crevicular fluid (GCF) of type 2 diabetic (T2DM) patients with chronic periodontitis (CP) after non⁃surgical periodontal treatment. Methods 60 subjects were divided into 4 groups: DM ⁃CP group (patients with both T2DM and CP, n＝15); CP group (CP patients without T2DM, n＝15); DM group (T2DM patients without CP, n＝15), and CTRL group (systemically and periodontally healthy individuals, n＝15). The clinical parameters of periodontal tissue and GCF were measured before and 8 weeks after non⁃surgical periodontal treatment. The levels of vaspin and TNF⁃α were measured by ELISA. Results The lev⁃ els of vaspin and TNF⁃α in CP group were significantly higher than those in CTRL group (P < 0.05), while the levels of vaspin and TNF⁃α in CP group were significantly decreased after treatment (P < 0.05). There was a statistically signifi⁃ cant positive correlation between the total amount of vaspin and the total amount of TNF⁃α, the level of HbA1c, gingival index (GI) and probing depth (PD) (P < 0.05). Conclusion The results shows that vaspin and TNF⁃α are greatly de⁃creased in periodontitis after non⁃surgical periodontal treatment. It suggests that vaspin and TNF⁃ α in GCF may serve as inflammatory markers for the diagnosis and prognosis of diabetes and periodontitis.
Keywords	Visceral adipose tissue⁃derived serine protease inhibitor ; Tumor necrosis factor⁃alpha ; Gingival cre⁃ vicular fluid ; Periodontitis ; Type 2 diabetes mellitus ; Medicine ; R
Subject code	610
Language	Chinese
Publishing date	2017-06-01T00:00:00Z
Publisher	Editorial Department of Journal of Prevention and Treatment for Stomatological Diseases
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Epidemiological and clinical characteristics of discharged patients infected with SARS-CoV-2 on the Qinghai Plateau.

Xi, Aiqi / Zhuo, Ma / Dai, Jingtao / Ding, Yuehe / Ma, Xiuzhen / Ma, Xiaoli / Wang, Xiaoyi / Shi, Lianmeng / Bai, Huanying / Zheng, Hongying / Nuermberger, Eric / Xu, Jian

Journal of medical virology

2020 Volume 92, Issue 11, Page(s) 2528–2535

Abstract: Since the outbreak of coronavirus disease 2019 (COVID-19), caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) was first reported in Wuhan, a series of confirmed cases of COVID-19 were found on the Qinghai-Tibet plateau. We aimed ... ...

Abstract	Since the outbreak of coronavirus disease 2019 (COVID-19), caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) was first reported in Wuhan, a series of confirmed cases of COVID-19 were found on the Qinghai-Tibet plateau. We aimed to describe the epidemiological, clinical characteristics, and outcomes of all confirmed cases in Qinghai, a province at high altitude. The region had no sustained local transmission. Of all 18 patients with confirmed SARS-CoV-2 infection, 15 patients comprising four transmission clusters were identified. Three patients were infected by direct contact without travel history to Wuhan. Of 18 patients, 10 patients showed bilateral pneumonia and two patients showed no abnormalities. Three patients with comorbidities such as hypertension, liver diseases, or diabetes developed severe illness. High C-reactive protein levels and elevations of both alanine aminotransferase and aspartate aminotransferase were observed in three severely ill patients on admission. All 18 patients were eventually discharged, including the three severe patients who recovered after treatment with noninvasive mechanical ventilation, convalescent plasma, and other therapies. Our findings confirmed human-to-human transmission of SARS-CoV-2 in clusters. Patients with comorbidities are more likely to develop severe illness.
MeSH term(s)	Adolescent ; Adult ; COVID-19/epidemiology ; COVID-19/physiopathology ; COVID-19/transmission ; Child ; China/epidemiology ; Comorbidity ; Female ; Humans ; Male ; Middle Aged ; Pandemics ; Patient Discharge/statistics & numerical data ; Retrospective Studies ; Tibet/epidemiology ; Young Adult
Keywords	covid19
Language	English
Publishing date	2020-07-28
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	752392-0
ISSN	1096-9071 ; 0146-6615
ISSN (online)	1096-9071
ISSN	0146-6615
DOI	10.1002/jmv.26032
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Article ; Online: Epidemiological and clinical characteristics of discharged patients infected with SARS‐CoV‐2 on the Qinghai Plateau

Xi, Aiqi / Zhuo, Ma / Dai, Jingtao / Ding, Yuehe / Ma, Xiuzhen / Ma, Xiaoli / Wang, Xiaoyi / Shi, Lianmeng / Bai, Huanying / Zheng, Hongying / Nuermberger, Eric / Xu, Jian

Journal of Medical Virology ; ISSN 0146-6615 1096-9071

2020

Keywords	Virology ; Infectious Diseases ; covid19
Language	English
Publisher	Wiley
Publishing country	us
Document type	Article ; Online
DOI	10.1002/jmv.26032
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Smilax china L.: A review of its botany, ethnopharmacology, phytochemistry, pharmacological activities, actual and potential applications

Wang, Meng / Bai, Qian-Xiang / Zheng, Xiu-Xi / Hu, Wen-Jing / Wang, Shuang / Tang, Hai-Peng / Yu, Ai-Qi / Yang, Bing-You / Kuang, Hai-Xue

Journal of Ethnopharmacology. 2024 Jan., v. 318 p.116992-

2024

Abstract: Smilax china L., an extensively used traditional Chinese medicine, is known as Baqia in China. It has been used to treat various inflammatory disorders, particularly pelvic inflammation. The present paper aims to provide an up-to-date review at the ... ...

Abstract	Smilax china L., an extensively used traditional Chinese medicine, is known as Baqia in China. It has been used to treat various inflammatory disorders, particularly pelvic inflammation. The present paper aims to provide an up-to-date review at the advancements of the investigations on the ethnopharmacology, phytochemistry, pharmacological effect and actual and potential applications of S. china. Besides, the possible tendency and perspective for future research of this plant are discussed, as well. This article uses “Smilax china L.” “S. china” as the keyword and collects relevant information on Smilax china L. plants through electronic searches (Elsevier, PubMed, ACS, CNKI, Google Scholar, Baidu Scholar, Web of Science), relevant books, and classic literature about Chinese herb. 134 chemical constituents, among which steroid saponins and flavonoids are the predominant groups, have been isolated and identified from S. china. S. china with its active compounds is possessed of wide-reaching biological activities, including anti-inflammatory, anti-cancer, anti-oxidant, detoxify nicotine, anti-diabetes, anti-obesity, anti-hyperuricaemia, anti-hypertension, promoting skin wound and barrier repair and anti-bacterial activity. Besides, S. china is also applied to other fields, such as food industry and detection technology. Based on the review of the existing phytochemical studies on Smilax china L., the structural characterization of Smilax china L. extract can continue to be the focus of future research. Pharmacological studies in vitro and in vivo have demonstrated some of the traditional uses of Smilax china L. extract, while other traditional uses still need to be confirmed by research.
Keywords	Oriental traditional medicine ; Smilax china ; antibacterial properties ; antioxidants ; flavonoids ; food industry ; inflammation ; nicotine ; steroid saponins ; China ; Smilax china L. ; Botany ; Ethnopharmacology ; Phytochemistry ; Pharmacological activity ; Application
Language	English
Dates of publication	2024-01
Publishing place	Elsevier B.V.
Document type	Article ; Online
ZDB-ID	134511-4
ISSN	1872-7573 ; 0378-8741
ISSN (online)	1872-7573
ISSN	0378-8741
DOI	10.1016/j.jep.2023.116992
Database	NAL-Catalogue (AGRICOLA)

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Article: Epidemiological and clinical characteristics of discharged patients infected with SARS-CoV-2 on the Qinghai Plateau

Xi, Aiqi / Zhuo, Ma / Dai, Jingtao / Ding, Yuehe / Ma, Xiuzhen / Ma, Xiaoli / Wang, Xiaoyi / Shi, Lianmeng / Bai, Huanying / Zheng, Hongying / Nuermberger, Eric / Xu, Jian

J. med. virol

Abstract	Since the outbreak of coronavirus disease 2019 (COVID-19), caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) was first reported in Wuhan, a series of confirmed cases of COVID-19 were found on the Qinghai-Tibet plateau. We aimed to describe the epidemiological, clinical characteristics, and outcomes of all confirmed cases in Qinghai, a province at high altitude. The region had no sustained local transmission. Of all 18 patients with confirmed SARS-CoV-2 infection, 15 patients comprising four transmission clusters were identified. Three patients were infected by direct contact without travel history to Wuhan. Of 18 patients, 10 patients showed bilateral pneumonia and two patients showed no abnormalities. Three patients with comorbidities such as hypertension, liver diseases, or diabetes developed severe illness. High C-reactive protein levels and elevations of both alanine aminotransferase and aspartate aminotransferase were observed in three severely ill patients on admission. All 18 patients were eventually discharged, including the three severe patients who recovered after treatment with noninvasive mechanical ventilation, convalescent plasma, and other therapies. Our findings confirmed human-to-human transmission of SARS-CoV-2 in clusters. Patients with comorbidities are more likely to develop severe illness.
Keywords	covid19
Publisher	WHO
Document type	Article
Note	WHO #Covidence: #326885
Database	COVID19

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Article ; Online: Epidemiological and clinical characteristics of discharged patients infected with SARS-CoV-2 on the Qinghai plateau

Xi, AIqi / Ma, Zhuo / Dai, Jingtao / Ding, Yuehe / Ma, Xiuzhen / Ma, Xiaoli / Wang, Xiaoyi / Shi, Lianmeng / Bai, Huanying / Zheng, Hongying / Nuermberger, Eric / Xu, Jian

Abstract	Since the outbreak of coronavirus disease 2019 (COVID-19), caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) was first reported in Wuhan, a series of confirmed cases of COVID-19 were found on the Qinghai-Tibet plateau. We aimed to describe the epidemiological, clinical characteristics, and outcomes of all confirmed cases in Qinghai, a province at high altitude. With efficient measures to stop the spread of coronavirus, no new cases were found in Qinghai Province for 60 consecutive days between Feb 6 and April 6, 2020. Of all 18 patients with confirmed SARS-CoV-2 infection, 15 patients comprising 4 transmission clusters were identified. Three patients were infected by direct contact without travel history to Wuhan. Seven patients were asymptomatic on admission. Of 18 patients, 10 patients showed bilateral pneumonia and 2 patients showed no abnormalities. Three patients with comorbidities such as hypertension, liver diseases or diabetes developed severe illness. High C-reactive protein levels and elevations of both ALT and AST were observed in 3 severely ill patients on admission. All 18 patients were eventually discharged, including the 3 severe patients who recovered after treatment with non-invasive mechanical ventilation, convalescent plasma and other therapies. Our findings confirmed human-to-human transmission of SARS-CoV-2 in clusters. The strategies of early diagnosis, early isolation, and early treatment are important to prevent the spread of COVID-19 and improve the cure rate. Patients with comorbidities are more likely to develop severe illness and could benefit from convalescent plasma transfusion.
Keywords	covid19
Publisher	MedRxiv; WHO
Document type	Article ; Online
DOI	10.1101/2020.04.23.20077644
Database	COVID19

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Article ; Online: Epidemiological and clinical characteristics of discharged patients infected with SARS-CoV-2 on the Qinghai plateau

Xi, AIqi / Ma, Zhuo / Dai, Jingtao / Ding, Yuehe / Ma, Xiuzhen / Ma, Xiaoli / Wang, Xiaoyi / Shi, Lianmeng / Bai, Huanying / Zheng, Hongying / Nuermberger, Eric / Xu, Jian

medRxiv

Abstract	Since the outbreak of coronavirus disease 2019 (COVID-19), caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) was first reported in Wuhan, a series of confirmed cases of COVID-19 were found on the Qinghai-Tibet plateau. We aimed to describe the epidemiological, clinical characteristics, and outcomes of all confirmed cases in Qinghai, a province at high altitude. With efficient measures to stop the spread of coronavirus, no new cases were found in Qinghai Province for 60 consecutive days between Feb 6 and April 6, 2020. Of all 18 patients with confirmed SARS-CoV-2 infection, 15 patients comprising 4 transmission clusters were identified. Three patients were infected by direct contact without travel history to Wuhan. Seven patients were asymptomatic on admission. Of 18 patients, 10 patients showed bilateral pneumonia and 2 patients showed no abnormalities. Three patients with comorbidities such as hypertension, liver diseases or diabetes developed severe illness. High C-reactive protein levels and elevations of both ALT and AST were observed in 3 severely ill patients on admission. All 18 patients were eventually discharged, including the 3 severe patients who recovered after treatment with non-invasive mechanical ventilation, convalescent plasma and other therapies. Our findings confirmed human-to-human transmission of SARS-CoV-2 in clusters. The strategies of early diagnosis, early isolation, and early treatment are important to prevent the spread of COVID-19 and improve the cure rate. Patients with comorbidities are more likely to develop severe illness and could benefit from convalescent plasma transfusion.
Keywords	covid19
Language	English
Publishing date	2020-04-29
Publisher	Cold Spring Harbor Laboratory Press
Document type	Article ; Online
DOI	10.1101/2020.04.23.20077644
Database	COVID19

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