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  1. Article ; Online: Characteristics of Independent Academic Medical Center Faculty.

    Joshi, Amit R T / Trickey, Amber W / Kallies, Kara / Jarman, Benjamin / Dort, Jonathan / Sidwell, Richard

    Journal of surgical education

    2016  Volume 73, Issue 6, Page(s) e48–e53

    Abstract: Objective: Little is known about the characteristics of teaching faculty in US surgical residencies based at Independent Academic Medical Centers (IAMCs). The purpose of this study was to survey teaching faculty at IAMCs to better define their common ... ...

    Abstract Objective: Little is known about the characteristics of teaching faculty in US surgical residencies based at Independent Academic Medical Centers (IAMCs). The purpose of this study was to survey teaching faculty at IAMCs to better define their common characteristics.
    Study design: An online, anonymous survey was distributed through program officials at 96 IAMCs to their faculty and graduates. Respondents were asked about their demographic information, training history, board certification, clinical practice, and exposure to medical students. Student t-tests and chi-square tests were calculated to evaluate associations between faculty characteristics.
    Setting: Independent Academic Medical Center general surgery training programs PARTICIPANTS: A total of 128 faculty at 14 IAMCs participated in the study.
    Results: In total, 128 faculty from 14 programs responded to the survey. The mean age of faculty respondents was 52 years and 81% were men. 58% were employed by a nonuniversity hospital, and 28% by a multispecialty practice. 79% of respondents were core faculty. The mean length of time since graduation from surgery residency was 19 years. 86% were currently board certified. 55% of those who were currently board certified had an additional certification. 45% had trained in an IAMC, 50% in an university program, and 5% in a military program. 73% were actively practicing general surgeons, with the majority (70%) performing between 101 and 400 cases annually. The vast majority of faculty (90%) performed <200 endoscopies annually, with 44% performing none. 84% and 35% provided ER and trauma coverage, respectively. 81% listed mentorship as their primary motivation for teaching residents. 23% received a stipend for this teaching. 95% were involved in medical student teaching. Faculty who completed training at university programs had more additional certifications compared with those with IAMC training (67% vs. 43%, p = 0.007). Certification differences by program type were consistent across age and time since residency completion. Age was not associated with residency program type (p = 0.87) nor additional certifications (p = 0.97).
    Conclusions: IAMC faculty and graduates are overwhelmingly involved in general surgery, and most faculty have additional certifications. 90% of faculty have clinical exposure to medical students. Faculty at IAMCs were as likely to have been trained at an university program as an IAMC. In a time of increasing surgeon subspecialization and anxiety about the ability of 5-year training programs to train well-rounded surgeons, IAMCs appear to be a repository of consistent general surgical training.
    Language English
    Publishing date 2016-11
    Publishing country United States
    Document type Review ; Journal Article
    ZDB-ID 2277538-9
    ISSN 1878-7452 ; 1931-7204
    ISSN (online) 1878-7452
    ISSN 1931-7204
    DOI 10.1016/j.jsurg.2016.05.006
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article: Influenza virus resistance to neuraminidase inhibitors.

    Mendel, D B / Sidwell, R W

    Drug resistance updates : reviews and commentaries in antimicrobial and anticancer chemotherapy

    2006  Volume 1, Issue 3, Page(s) 184–189

    Abstract: The recent reports from Hong Kong of an avian influenza virus which caused the death of six people has served to remind us of the constant threat of pandemics posed by influenza. Recently, structure-based drug design has resulted in the discovery of a ... ...

    Abstract The recent reports from Hong Kong of an avian influenza virus which caused the death of six people has served to remind us of the constant threat of pandemics posed by influenza. Recently, structure-based drug design has resulted in the discovery of a new class of antiviral agents which specifically target the influenza virus neuraminidase. Two neuraminidase inhibitors are currently undergoing clinical evaluation for the prevention and treatment of influenza virus infection in man. Here we review the results of in vitro and in vivo studies relating to the potential development of resistance to this new class of compounds.
    Language English
    Publishing date 2006-11-09
    Publishing country Scotland
    Document type Journal Article
    ZDB-ID 1474513-6
    ISSN 1532-2084 ; 1368-7646
    ISSN (online) 1532-2084
    ISSN 1368-7646
    DOI 10.1016/s1368-7646(98)80038-1
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article: SUSCEPTIBILITY OF WILD RODENTS TO EXPERIMENTAL INFECTION WITH COXIELLA BURNETII.

    SIDWELL, R W / GEBHARDT, L P

    The American journal of tropical medicine and hygiene

    2003  Volume 12, Page(s) 435–439

    MeSH term(s) Animals ; Complement Fixation Tests ; Coxiella burnetii ; Disease Susceptibility ; Guinea Pigs ; Mice ; Q Fever ; Rats ; Research ; Rodentia ; Splenomegaly ; Utah
    Language English
    Publishing date 2003-09-08
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2942-7
    ISSN 1476-1645 ; 0002-9637
    ISSN (online) 1476-1645
    ISSN 0002-9637
    DOI 10.4269/ajtmh.1963.12.435
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: New global indicator for workers' health: mortality rate from diseases attributable to selected occupational risk factors.

    Pega, Frank / Al-Emam, Rola / Cao, Bochen / Davis, Cynthia W / Edwards, Sally J / Gagliardi, Diana / Fassa, Anaclaudia Gastal / Hassan, Mohd N / Hosseinpoor, Ahmad Reza / Iavicoli, Sergio / Jandaghi, Jaffar / Jarosinska, Dorota I / Kgalamono, Spo M / Rad, Mona Khaleghy / Khodabakshi, Mostafa / Li, Xinxin / Marinaccio, Alessandro / Mbayo, Guy / Rowshani, Zohreh /
    Sanabria, Natasha M / Sidwell-Wilson, Kerry / Solar, Orielle H / Streicher, Kai N / Sun, Xin / Asl, Rahim Taghizadeh / Yadegari, Mehrdad / Zhang, Siyu / Zungu, Muzimkhulu / Momen, Natalie C

    Bulletin of the World Health Organization

    2023  Volume 101, Issue 6, Page(s) 418–430Q

    Abstract: Through sustainable development goals 3 and 8 and other policies, countries have committed to protect and promote workers' health by reducing the work-related burden of disease. To monitor progress on these commitments, indicators that capture the work- ... ...

    Abstract Through sustainable development goals 3 and 8 and other policies, countries have committed to protect and promote workers' health by reducing the work-related burden of disease. To monitor progress on these commitments, indicators that capture the work-related burden of disease should be available for monitoring workers' health and sustainable development. The World Health Organization and the International Labour Organization estimate that only 363 283 (19%) of 1 879 890 work-related deaths globally in 2016 were due to injuries, whereas 1 516 607 (81%) deaths were due to diseases. Most monitoring systems focusing on workers' health or sustainable development, such as the global indicator framework for the sustainable development goals, include an indicator on the burden of occupational injuries. Few such systems, however, have an indicator on the burden of work-related diseases. To address this gap, we present a new global indicator: mortality rate from diseases attributable to selected occupational risk factors, by disease, risk factor, sex and age group. We outline the policy rationale of the indicator, describe its data sources and methods of calculation, and report and analyse the official indicator for 183 countries. We also provide examples of the use of the indicator in national workers' health monitoring systems and highlight the indicator's strengths and limitations. We conclude that integrating the new indicator into monitoring systems will provide more comprehensive and accurate surveillance of workers' health, and allow harmonization across global, regional and national monitoring systems. Inequalities in workers' health can be analysed and the evidence base can be improved towards more effective policy and systems on workers' health.
    MeSH term(s) Humans ; Occupational Health ; Risk Factors ; Sustainable Development ; Policy ; Global Health
    Language English
    Publishing date 2023-05-01
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 80213-x
    ISSN 1564-0604 ; 0042-9686 ; 0366-4996 ; 0510-8659
    ISSN (online) 1564-0604
    ISSN 0042-9686 ; 0366-4996 ; 0510-8659
    DOI 10.2471/BLT.23.289703
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: Factors and Influences That Determine the Choices of Surgery Residency Applicants.

    Jarman, Benjamin T / Joshi, Amit R T / Trickey, Amber W / Dort, Jonathan M / Kallies, Kara J / Sidwell, Richard A

    Journal of surgical education

    2015  Volume 72, Issue 6, Page(s) e163–71

    Abstract: Objective: We sought to evaluate characteristics of residency applicants selected to interview at independent general surgery programs, identify residency information resources, assess if there is perceived bias toward university or independent programs, ...

    Abstract Objective: We sought to evaluate characteristics of residency applicants selected to interview at independent general surgery programs, identify residency information resources, assess if there is perceived bias toward university or independent programs, and determine what types of programs applicants prefer.
    Study design: An electronic survey was sent to applicants who were selected to interview at a participating independent program. Open-ended responses regarding reasons for program-type bias were submitted. Multivariable logistic regression models were estimated to identify applicant characteristics associated with program-type preference.
    Setting: Independent general surgery residency programs.
    Participants: A total, of 1220 applicants were selected to interview at one of 33 independent programs.
    Results: In total, 670 surveys were completed (55% response rate). Demographics of respondents were similar to the full invited population. Median United States Medical Licensing Examination Step 1 and Step 2 scores were between 230 to 239 and 240 to 249, respectively. Most applicants reported receiving general information about surgery residency programs and specific information about independent programs from residency program websites. 34% of respondents perceived an imbalanced representation of program types, with 96% of those reporting bias toward university programs.
    Conclusions: Applicants selected to interview at independent programs are competitive for general surgery training and primarily use residency program websites for information gathering. Bias is common toward university programs for a variety of perceived reasons. This information will be useful in applicant evaluation and selection, serve as a stimulus to update program websites, and challenge independent program directors to work to alleviate bias against their programs.
    MeSH term(s) Adult ; Career Choice ; Female ; General Surgery/education ; Humans ; Internship and Residency ; Male ; Surveys and Questionnaires ; United States ; Young Adult
    Language English
    Publishing date 2015-11
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2277538-9
    ISSN 1878-7452 ; 1931-7204
    ISSN (online) 1878-7452
    ISSN 1931-7204
    DOI 10.1016/j.jsurg.2015.05.017
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: Applicant Characteristics Associated With Selection for Ranking at Independent Surgery Residency Programs.

    Dort, Jonathan M / Trickey, Amber W / Kallies, Kara J / Joshi, Amit R T / Sidwell, Richard A / Jarman, Benjamin T

    Journal of surgical education

    2015  Volume 72, Issue 6, Page(s) e123–9

    Abstract: Objectives: This study evaluated characteristics of applicants selected for interview and ranked by independent general surgery residency programs and assessed independent program application volumes, interview selection, rank list formation, and match ... ...

    Abstract Objectives: This study evaluated characteristics of applicants selected for interview and ranked by independent general surgery residency programs and assessed independent program application volumes, interview selection, rank list formation, and match success.
    Design: Demographic and academic information was analyzed for 2014-2015 applicants. Applicant characteristics were compared by ranking status using univariate and multivariable statistical techniques. Characteristics independently associated with whether or not an applicant was ranked were identified using multivariable logistic regression modeling with backward stepwise variable selection and cluster-correlated robust variance estimates to account for correlations among individuals who applied to multiple programs.
    Setting: The Electronic Residency Application Service was used to obtain applicant data and program match outcomes at 33 independent surgery programs.
    Participants: All applicants selected to interview at 33 participating independent general surgery residency programs were included in the study.
    Results: Applicants were 60% male with median age of 26 years. Birthplace was well distributed. Most applicants (73%) had ≥1 academic publication. Median United States Medical Licensing Exams (USMLE) Step 1 score was 228 (interquartile range: 218-240), and median USMLE Step 2 clinical knowledge score was 241 (interquartile range: 231-250). Residency programs in some regions more often ranked applicants who attended medical school within the same region. On multivariable analysis, significant predictors of ranking by an independent residency program were: USMLE scores, medical school region, and birth region. Independent programs received an average of 764 applications (range: 307-1704). On average, 12% interviews, and 81% of interviewed applicants were ranked. Most programs (84%) matched at least 1 applicant ranked in their top 10.
    Conclusions: Participating independent programs attract a large volume of applicants and have high standards in the selection process. This information can be used by surgery residency applicants to gauge their candidacy at independent programs. Independent programs offer a select number of interviews, rank most applicants that they interview, and successfully match competitive applicants.
    MeSH term(s) Adult ; Female ; General Surgery/education ; Humans ; Internship and Residency/classification ; Male ; Personnel Selection ; United States
    Language English
    Publishing date 2015-11
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2277538-9
    ISSN 1878-7452 ; 1931-7204
    ISSN (online) 1878-7452
    ISSN 1931-7204
    DOI 10.1016/j.jsurg.2015.04.021
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article: Epidemiological aspects of venezuelan equine encephalitis virus infections.

    Sidwell, R W / Gebhardt, L P / Thorpe, B D

    Bacteriological reviews

    2005  Volume 31, Issue 1, Page(s) 65–81

    Language English
    Publishing date 2005-12-06
    Publishing country United States
    Document type Journal Article
    ZDB-ID 207943-4
    ISSN 0005-3678
    ISSN 0005-3678
    DOI 10.1128/br.31.1.65-81.1967
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article ; Online: Attenuation of TCR-induced transcription by Bach2 controls regulatory T cell differentiation and homeostasis.

    Sidwell, Tom / Liao, Yang / Garnham, Alexandra L / Vasanthakumar, Ajithkumar / Gloury, Renee / Blume, Jonas / Teh, Peggy P / Chisanga, David / Thelemann, Christoph / de Labastida Rivera, Fabian / Engwerda, Christian R / Corcoran, Lynn / Kometani, Kohei / Kurosaki, Tomohiro / Smyth, Gordon K / Shi, Wei / Kallies, Axel

    Nature communications

    2020  Volume 11, Issue 1, Page(s) 252

    Abstract: Differentiation and homeostasis of ... ...

    Abstract Differentiation and homeostasis of Foxp3
    MeSH term(s) Animals ; Basic-Leucine Zipper Transcription Factors/deficiency ; Basic-Leucine Zipper Transcription Factors/metabolism ; Cell Differentiation/immunology ; Chromatin/metabolism ; Colitis/immunology ; Disease Models, Animal ; Epigenesis, Genetic/immunology ; Forkhead Transcription Factors/metabolism ; Gastrointestinal Tract/immunology ; Gene Expression Regulation/immunology ; Homeostasis/immunology ; Interferon Regulatory Factors/deficiency ; Interferon Regulatory Factors/metabolism ; Interleukin-10/biosynthesis ; Lymphocyte Activation ; Mice ; Mice, Inbred C57BL ; Mice, Mutant Strains ; Receptors, Antigen, T-Cell/metabolism ; Signal Transduction/immunology ; T-Lymphocyte Subsets/immunology ; T-Lymphocyte Subsets/metabolism ; T-Lymphocytes, Regulatory/immunology ; T-Lymphocytes, Regulatory/metabolism
    Chemical Substances Bach2 protein, mouse ; Basic-Leucine Zipper Transcription Factors ; Chromatin ; Forkhead Transcription Factors ; Foxp3 protein, mouse ; IL10 protein, mouse ; Interferon Regulatory Factors ; Receptors, Antigen, T-Cell ; interferon regulatory factor-4 ; Interleukin-10 (130068-27-8)
    Language English
    Publishing date 2020-01-14
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2553671-0
    ISSN 2041-1723 ; 2041-1723
    ISSN (online) 2041-1723
    ISSN 2041-1723
    DOI 10.1038/s41467-019-14112-2
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article: In vitro and in vivo assay systems for study of influenza virus inhibitors.

    Sidwell, R W / Smee, D F

    Antiviral research

    2000  Volume 48, Issue 1, Page(s) 1–16

    Abstract: Evaluation of potential influenza virus inhibitors may utilize multiple steps. First would be to determine if the viral target (e.g. influenza virus neuraminidase) being focused upon will be inhibited in the appropriate assay. Standard in vitro antiviral ...

    Abstract Evaluation of potential influenza virus inhibitors may utilize multiple steps. First would be to determine if the viral target (e.g. influenza virus neuraminidase) being focused upon will be inhibited in the appropriate assay. Standard in vitro antiviral assays, used next in antiviral evaluations, may utilize inhibition of viral plaques, viral cytopathic effect (CPE), and viral hemagglutinin or other protein, with inhibition of viral yield used in follow-up evaluations. The CPE can be determined visually and by dye uptake. Animal models used for study of potential influenza virus inhibitors include the ferret, the laboratory mouse, and the chicken, with a variety of parameters used to indicate the severity of the infection and its inhibition by therapy. Multiple parameters are recommended in any in vivo antiviral evaluation. The ferret and the mouse infection models have been useful in studying the development of drug resistance and the relative virulence of drug-resistant viruses. The influenza mouse model has also been of value for the evaluation of immunomodulating effects of test compounds and for the study of the utility of antiviral drugs for use against influenza virus infections in the immunocompromised host. In considering the use of any animal model, species differences in drug pharmacology and metabolism must be taken into account. This review has described the systems which have been used most frequently by antiviral investigators, using, as examples, recent studies with the clinically approved influenza virus neuraminidase inhibitors oseltamivir and zanamivir.
    MeSH term(s) Animals ; Antiviral Agents/pharmacology ; Antiviral Agents/therapeutic use ; Cytopathogenic Effect, Viral ; Disease Models, Animal ; Humans ; Immunocompromised Host ; Influenza A virus/drug effects ; Influenza A virus/pathogenicity ; Influenza B virus/drug effects ; Influenza B virus/pathogenicity ; Influenza, Human/drug therapy ; Influenza, Human/virology ; Microbial Sensitivity Tests/methods ; Viral Plaque Assay
    Chemical Substances Antiviral Agents
    Language English
    Publishing date 2000-10
    Publishing country Netherlands
    Document type Journal Article ; Research Support, Non-U.S. Gov't ; Research Support, U.S. Gov't, P.H.S. ; Review
    ZDB-ID 306628-9
    ISSN 1872-9096 ; 0166-3542
    ISSN (online) 1872-9096
    ISSN 0166-3542
    DOI 10.1016/s0166-3542(00)00125-x
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article ; Online: Author Correction: Sex-specific adipose tissue imprinting of regulatory T cells.

    Vasanthakumar, Ajithkumar / Chisanga, David / Blume, Jonas / Gloury, Renee / Britt, Kara / Henstridge, Darren C / Zhan, Yifan / Torres, Santiago Valle / Liene, Sebastian / Collins, Nicholas / Cao, Enyuan / Sidwell, Tom / Li, Chaoran / Spallanzani, Raul German / Liao, Yang / Beavis, Paul A / Gebhardt, Thomas / Trevaskis, Natalie / Nutt, Stephen L /
    Zajac, Jeffrey D / Davey, Rachel A / Febbraio, Mark A / Mathis, Diane / Shi, Wei / Kallies, Axel

    Nature

    2021  Volume 591, Issue 7851, Page(s) E26

    Language English
    Publishing date 2021-02-16
    Publishing country England
    Document type Published Erratum
    ZDB-ID 120714-3
    ISSN 1476-4687 ; 0028-0836
    ISSN (online) 1476-4687
    ISSN 0028-0836
    DOI 10.1038/s41586-020-2251-7
    Database MEDical Literature Analysis and Retrieval System OnLINE

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