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  1. Article ; Online: Spatiotemporal characteristics analysis of multi-factorial air pollution in the Jing-Jin-Ji region based on improved sequential ICI method and novel grey spatiotemporal incidence models.

    Sun, Jing / Dang, Yaoguo / Wang, Junjie / Hua, Chao

    Environmental research

    2024  , Page(s) 118948

    Abstract: ... of the properties of the new models. Finally, in the Jing-Jin-Ji region, the novel models are used to study ...

    Abstract Air pollution shares the attributes of multi-factorial influence and spatiotemporal complexity, leading to air pollution control assistance models easily falling into a state of failure. To address this issue, we design a framework containing improved data fusion method, novel grey incidence models and air pollution spatiotemporal analysis to analyze the complex characteristics of air pollution under the fusion of multiple factors. Firstly, we improve the existing data fusion method for multi-factor fusion. Subsequently, we construct two grey spatiotemporal incidence models to examine the spatiotemporal characteristics of multi-factorial air pollution in network relationships and changing trends. Furthermore, we propose two new properties that can manifest the performance of grey incidence analysis, and we provide detailed proof of the properties of the new models. Finally, in the Jing-Jin-Ji region, the novel models are used to study the network relationships and trend changes of air pollution. The findings are as follows: (1) Two highly polluted belts in the region require attention. (2) Although the air pollution network under multi-factorial fusion obeys the first law of geography, the network density and node density exhibit significant variations. (3) From 2013 to 2021, all pollutants except O
    Language English
    Publishing date 2024-04-20
    Publishing country Netherlands
    Document type Journal Article
    ZDB-ID 205699-9
    ISSN 1096-0953 ; 0013-9351
    ISSN (online) 1096-0953
    ISSN 0013-9351
    DOI 10.1016/j.envres.2024.118948
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: The future of carbon neutrality from a scientific research perspective: an interview with Jing-Hai Li.

    Chen, Li-Hua

    National science review

    2023  Volume 10, Issue 9, Page(s) nwad007

    Abstract: Since China announced that it will strive to achieve carbon peak by 2030 and carbon neutrality by 2060, it has become the focus of the whole society. The implementation of carbon peaking and carbon neutrality goals requires a range of revolutionary ... ...

    Abstract Since China announced that it will strive to achieve carbon peak by 2030 and carbon neutrality by 2060, it has become the focus of the whole society. The implementation of carbon peaking and carbon neutrality goals requires a range of revolutionary technologies and involves an array of key scientific questions. A great deal of research has focused on the development of new concepts and innovative technologies on carbon science and sustainable development
    Language English
    Publishing date 2023-01-09
    Publishing country China
    Document type Journal Article
    ZDB-ID 2745465-4
    ISSN 2053-714X ; 2053-714X
    ISSN (online) 2053-714X
    ISSN 2053-714X
    DOI 10.1093/nsr/nwad007
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Protective effects of Jing-Si-herbal-tea in inflammatory cytokines-induced cell injury on normal human lung fibroblast

    Wang, Chien-Hao / Yang, Jai-Sing / Chen, Chao-Jung / Su, San-Hua / Yu, Hsin-Yuan / Juan, Yu-Ning / Chiu, Yu-Jen / Ho, Tsung-Jung

    Tzu chi medical journal

    2024  Volume 36, Issue 2, Page(s) 152–165

    Abstract: Objectives: The protective effects and related mechanisms of Jing-Si herbal tea (JSHT) were ...

    Abstract Objectives: The protective effects and related mechanisms of Jing-Si herbal tea (JSHT) were investigated in cellular damage mediated by pro-inflammatory cytokines, including interleukin (IL)-1β, IL-6, and tumor necrosis factor-α, on normal human lung fibroblast by multiomic platform analysis.
    Materials and methods: The
    Results: In
    Conclusion: The findings from our research indicate that JSHT holds promise as a therapeutic agent, potentially offering advantageous outcomes in treating virus infections through various mechanisms. Furthermore, the primary bioactive components in JSHT justify extended research in antiviral drug development, especially in the context of addressing coronavirus.
    Language English
    Publishing date 2024-03-26
    Publishing country India
    Document type Journal Article
    ZDB-ID 2452925-4
    ISSN 2223-8956 ; 2223-8956
    ISSN (online) 2223-8956
    ISSN 2223-8956
    DOI 10.4103/tcmj.tcmj_267_23
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Revealing the "Yin-Jing" mystery veil of Platycodon grandiflorum by potentiating therapeutic effects and lung-oriented guidance property.

    Liang, Jun / Li, Ya-Ge / Chai, Yan-Qun / Zhang, Yi / Gao, Xue / Zhu, Xin-Hua / Sun, Xi-Zhe / Wang, Wen-Fei / Kuang, Hai-Xue / Xia, Yong-Gang

    Journal of ethnopharmacology

    2023  Volume 322, Page(s) 117587

    Abstract: ETHNIC PHARMACOLOGICAL RELEVANCE: "Yin-Jing" medicine (YJM) has been widely used by both ancient ... molecular biology methods to confirm the "Yin-Jing" effect of PG, and further clarify its material basis and related ... used to reveal the "Yin-Jing" mechanism of action. Western blot assay (WB) was employed ...

    Abstract ETHNIC PHARMACOLOGICAL RELEVANCE: "Yin-Jing" medicine (YJM) has been widely used by both ancient and modern Chinese medicine practitioners during long-term clinical practice. However, it remains unclear how to best guide other medicines to the targeted organs in a traditional Chinese medicine (TCM) prescription. Here, in an attempt to explain the scientific connotation of the YJM property (YJMP) attributed to a basic TCM theory, Platycodon grandiflorum (PG) was chosen as a case study to reveal the mystery of YJMP theory.
    Aim of the study: The main purpose of this study is to employ modern chemical and molecular biology methods to confirm the "Yin-Jing" effect of PG, and further clarify its material basis and related possible mechanism.
    Materials and methods: The ammonia-induced lung injury rat model was utilized to determine the optimal dosage of traditional prescription Hui Yan Zhu Yu decoction (HYZYD) using Wright Giemsa staining, HE staining, Masson staining, and TUNEL analysis. With the same way, PG was confirmed to have potentiating therapeutic effect (PTE) by comparison with HYZYD and [HYZYD-PG]. TMT proteomics was used to reveal the "Yin-Jing" mechanism of action. Western blot assay (WB) was employed for verification of differentially expressed proteins. Additionally, four non-crossing fragmentations (Fr. A-D) were characterized by RPLC/SEC-ELSD and HILIC-ESI
    Results: The HYZYD-M (medium dose group) significantly improved the lung injury level in a pneumonia model of rats. PG enhanced the therapeutic effect of HYZYD ascribed to Yin-Jing PTE functions. TMT proteomics revealed a category of differentially expressed proteins ascribed to Golgi-ER between HYZYD and [HYZYD-PG]. Fr. C (i.e., saponins) and Fr. D (i.e., lipids) were determined as therapeutic fragmentations via the LPS-induced A549 cell injury model; however, Fr. B (fructooligosaccharides and small M
    Conclusions: Fr. B is believed to be a key YJMP material basis of PG attributed to Yin-Jing PTE with characteristic of lung-oriented guidance property, whereas another abound Fr. C was determined to have synergistic effects rather than Yin-Jing material basis.
    MeSH term(s) Rats ; Animals ; Platycodon/chemistry ; Lung Injury ; Medicine, Chinese Traditional ; Chromatography, High Pressure Liquid/methods ; Lung
    Language English
    Publishing date 2023-12-16
    Publishing country Ireland
    Document type Journal Article
    ZDB-ID 134511-4
    ISSN 1872-7573 ; 0378-8741
    ISSN (online) 1872-7573
    ISSN 0378-8741
    DOI 10.1016/j.jep.2023.117587
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: Human adipose-derived stem cells preconditioned with a novel herbal formulation Jing Shi attenuate doxorubicin-induced cardiac damage.

    Hsieh, Dennis Jine-Yuan / Tsai, Bruce Chi-Kang / Barik, Parthasarathi / Shibu, Marthandam Asokan / Kuo, Chia-Hua / Kuo, Wei-Wen / Lin, Pi-Yu / Shih, Cheng-Yen / Lin, Shinn-Zong / Ho, Tsung-Jung / Huang, Chih-Yang

    Aging

    2023  Volume 15, Issue 17, Page(s) 9167–9181

    Abstract: ... with novel herbal formulation Jing Si (JS) improved protective ability of stem cells against doxorubicin ...

    Abstract Pathological cardiac hypertrophy is a considerable contributor to global disease burden. Chinese herbal medicine (CHM) has been used to treat cardiovascular diseases since antiquity. Enhancing stem cell-mediated recovery through CHM represents a promising approach for protection against doxorubicin (Dox)-induced cardiac hypertrophy. Herein, we investigated whether human adipose-derived stem cells (hADSCs) preconditioned with novel herbal formulation Jing Si (JS) improved protective ability of stem cells against doxorubicin-induced cardiac damage. The effect of JS on hADSC viability and migration capacity was determined via MTT and migration assays, respectively. Co-culture of hADSC or JS-preconditioned hADSCs with H9c2 cells was analyzed with immunoblot, flow cytometry, TUNEL staining, LC3B staining, F-actin staining, and MitoSOX staining. The
    MeSH term(s) Humans ; Animals ; Rats ; Rats, Sprague-Dawley ; Heart ; Stem Cells ; Doxorubicin/toxicity ; Cardiomegaly
    Chemical Substances Doxorubicin (80168379AG)
    Language English
    Publishing date 2023-09-02
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ISSN 1945-4589
    ISSN (online) 1945-4589
    DOI 10.18632/aging.205026
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: A strategy for rapid discovery of traceable chemical markers in herbal products using MZmine 2 data processing toolbox: A case of Jing Liqueur.

    Zhou, Jing / Liu, Feng-Jie / Li, Xin-Xin / Li, Ping / Yang, Hua / Liu, Yuan-Cai / Chen, Yan-He / Wei, Chao-Dan / Li, Hui-Jun

    Chinese herbal medicines

    2021  Volume 13, Issue 3, Page(s) 430–438

    Abstract: ... to rapidly screen the traceable markers for herbal product authentication.: Methods: Commercial Jing ... materials to Jing Liqueur product were rapidly screened out. Among them, 52 markers detected by HPLC-QTOF-MS ... of traceable markers was finally generated to ensure the authentication and quality consistency of Jing Liqueur ...

    Abstract Objective: The quality evaluation of herbal products remains a big challenge. Traceable markers are the core concept of the authentication of herbal products. However, the discovery of traceable markers is labor-intensive and time-consuming. The aim of this study is to develop a convenient approach to rapidly screen the traceable markers for herbal product authentication.
    Methods: Commercial Jing Liqueur and its 22 species of herbal ingredients were analyzed using HPLC-QTOF-MS and GC-MS to characterize nonvolatile and volatile chemicals. The acquired data were imported into MZmine 2 software for mass detection, chromatogram building, deconvolution and alignment. The aligned data were exported into a csv file and then traceable markers were selected using the built-in filter function in Excel. Finally, the traceable markers were identified by searching against online databases or publications, some of which were confirmed by reference standards.
    Results: A total of 288 chemical features transferred from herbal materials to Jing Liqueur product were rapidly screened out. Among them, 52 markers detected by HPLC-QTOF-MS were annotated, while nine volatile markers detected by GC-MS were annotated. Moreover, 30 of these markers were confirmed by comparing with reference standards. A chemical fingerprint consisting of traceable markers was finally generated to ensure the authentication and quality consistency of Jing Liqueur.
    Conclusion: A strategy for rapid discovery of traceable markers in herbal products using MZmine 2 software was developed.
    Language English
    Publishing date 2021-05-28
    Publishing country Singapore
    Document type Journal Article
    ISSN 2589-3610
    ISSN (online) 2589-3610
    DOI 10.1016/j.chmed.2021.05.004
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article: Combined effect of traditional Chinese herbal-based formulations Jing Si herbal tea and Jing Si nasal drop inhibits adhesion and transmission of SARS-CoV2 in diabetic SKH-1 mice.

    Chiang, Chien-Yi / Kuo, Wei-Wen / Lin, Yu-Jung / Kuo, Chia-Hua / Shih, Cheng-Yen / Lin, Pi-Yu / Lin, Shinn-Zong / Ho, Tsung-Jung / Huang, Chih-Yang / Shibu, Marthandam Asokan

    Frontiers in pharmacology

    2022  Volume 13, Page(s) 953438

    Abstract: Multiple studies show increased severity of SARS-CoV2-infection in patients with comorbidities such as hypertension and diabetes. In this study, we have prepared two herbal-based formulations, a pleiotropic herbal drink (Jin Si Herbal Tea, JHT) and a ... ...

    Abstract Multiple studies show increased severity of SARS-CoV2-infection in patients with comorbidities such as hypertension and diabetes. In this study, we have prepared two herbal-based formulations, a pleiotropic herbal drink (Jin Si Herbal Tea, JHT) and a nasal drop (Jin Si nasal drop, JND), to provide preventive care against SARS-CoV2 infection. The effect of JHT and JND was determined in SARS-CoV2-S-pseudotyped lentivirus-infected bronchial and colorectal cell lines and in SKH-1 mouse models. For preliminary studies, ACE2 receptor abundant bronchial (Calu-3) and colorectal cells (Caco-2) were used to determine the effect of JHT and JND on the host entry of various variants of SARS-CoV2-S-pseudotyped lentivirus. A series of experiments were performed to understand the infection rate in SKH-1 mice (6 weeks old, n = 9), find the effective dosage of JHT and JND, and determine the combination effect of JHT and JND on the entry and adhesion of various variant SARS-CoV2-S-pseudotyped lentiviruses, which included highly transmissible delta and gamma mutants. Furthermore, the effect of combined JHT and JND was determined on diabetes-induced SKH-1 mice against the comorbidity-associated intense viral entry and accumulation. In addition, the effect of combined JHT and JND administration on viral transmission from infected SKH-1 mice to uninfected cage mate mice was determined. The results showed that both JHT and JND were effective in alleviating the viral entry and accumulation in the thorax and the abdominal area. While JHT showed a dose-dependent decrease in the viral load, JND showed early inhibition of viral entry from day 1 of the infection. Combined administration of 48.66 mg of JHT and 20 µL of JND showed rapid reduction in the viral entry and reduced the viral load (97-99%) in the infected mice within 3 days of treatment. Moreover, 16.22 mg of JHT and 20 µL JND reduced the viral infection in STZ-induced diabetic SKH-1 mice. Interestingly, combined JHT and JND also inhibited viral transmission among cage mates. The results, therefore, showed that combined administration of JHT and JND is a novel and an efficient strategy to potentially prevent SARS-CoV2 infection.
    Language English
    Publishing date 2022-11-08
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2587355-6
    ISSN 1663-9812
    ISSN 1663-9812
    DOI 10.3389/fphar.2022.953438
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article: Corrigendum: The traditional Chinese medicine formula Jing Guan Fang for preventing SARS-CoV-2 infection: from clinical observation to basic research.

    Ping, Yueh-Hsin / Yeh, Hsin / Chu, Li-Wei / Lin, Zhi-Hu / Hsu, Yin-Chieh / Lin, Lie-Chwen / Hsu, Chung-Hua / Fu, Shu-Ling / Lin, Tung-Yi

    Frontiers in pharmacology

    2023  Volume 14, Page(s) 1272615

    Abstract: This corrects the article DOI: 10.3389/fphar.2022.744439.]. ...

    Abstract [This corrects the article DOI: 10.3389/fphar.2022.744439.].
    Language English
    Publishing date 2023-08-28
    Publishing country Switzerland
    Document type Published Erratum
    ZDB-ID 2587355-6
    ISSN 1663-9812
    ISSN 1663-9812
    DOI 10.3389/fphar.2023.1272615
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article: The Traditional Chinese Medicine Formula Jing Guan Fang for Preventing SARS-CoV-2 Infection: From Clinical Observation to Basic Research.

    Ping, Yueh-Hsin / Yeh, Hsin / Chu, Li-Wei / Lin, Zhi-Hu / Hsu, Yin-Chieh / Lin, Lie-Chwen / Hsu, Chung-Hua / Fu, Shu-Ling / Lin, Tung-Yi

    Frontiers in pharmacology

    2022  Volume 13, Page(s) 744439

    Abstract: ... Jing Guan Fang (JGF), based on ancient medical texts, and examines the efficacy and the mechanism ...

    Abstract COVID-19 is a global epidemic. Developing adjuvant therapies which could prevent the virus from binding to cells may impair viral infection. This study produces a traditional Chinese medicine formula, Jing Guan Fang (JGF), based on ancient medical texts, and examines the efficacy and the mechanism by which JGF prevents viral infections. JGF reduces COVID-19 like symptoms. Functional studies show that JGF inhibits the formation of syncytium and reduces the formation of viral plaque. JGF is not toxic
    Language English
    Publishing date 2022-03-21
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2587355-6
    ISSN 1663-9812
    ISSN 1663-9812
    DOI 10.3389/fphar.2022.744439
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article ; Online: Epidemiological characteristics of varicella and vaccination status in the cases in Jing’an District, Shanghai from 2017 to 2019

    ZHANG Xiaojuan / QUAN Li / AO Jianjun / HUA Ruijue / HUANG Jin

    Shanghai yufang yixue, Vol 35, Iss 2, Pp 122-

    2023  Volume 125

    Abstract: ... in Jing’an District from 2017 to 2019, so as to provide reference basis for the strategy of prevention and ... the epidemiological characteristics of varicella in Jing’an District. The differences between the vaccinated group and ...

    Abstract ObjectiveTo analyze the epidemiological characteristics and the vaccination status of the cases in Jing’an District from 2017 to 2019, so as to provide reference basis for the strategy of prevention and control of varicella epidemic.MethodsDescriptive epidemiological methods were used to analyze the epidemiological characteristics of varicella in Jing’an District. The differences between the vaccinated group and the unvaccinated group were compared by statistical methods.ResultsA total of 2 508 cases of varicella were reported with an average annual incidence of 78.7/105 from 2017 to 2019. There was no significant difference in the incidence among the three years(χ2=5.535,P=0.063). There were 1 308 males and 1 200 females, and sex ratio was 1.1∶1. The highest incidence occurred in the age group from 5 to 9 years old (562 cases, 479.3/105). Two annual peaks occured in May and November. The incidence in the aged 18 and below decreased year by year. There was significant difference in the proportion among the three years(χ2=78.129, P<0.001). The median interval from vaccination to onset was 5 years among the vaccinated cases. There was significant difference in the cases who received two doses of vaccine in three years(χ2=90.902, P<0.001).ConclusionWe should strengthen the monitoring system and pay more attention to the epidemiological characteristics of varicella. The protective efficacy of two-doses vaccine needs to be systematically evaluated.
    Keywords varicella ; epidemiological characteristics ; immunization program ; vaccination ; Medicine ; R
    Language Chinese
    Publishing date 2023-02-01T00:00:00Z
    Publisher Shanghai Preventive Medicine Association
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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